ライフサイエンスコーパス: DNA topoisomerase

1 an nuclear gene that encodes a mitochondrial DNA topoisomerase.

2 olution reaction catalyzed by vaccinia virus DNA topoisomerase.

3 tions in TOP3, encoding the SGS1-interacting DNA topoisomerase.

4 esis stalls prematurely in the absence of T4 DNA topoisomerase.

5 ng form to another, an enzyme now known as a DNA topoisomerase.

6 f interacting effectively with more than one DNA topoisomerase.

7 plate-based assays for DNA gyrase and other DNA topoisomerases.

8 istence of nuclear and mitochondrial type IB DNA topoisomerases.

9 cytotoxicity of antitumor drugs that target DNA topoisomerases.

10 tion of antitumor agents that target type II DNA topoisomerases.

11 een drug structure and activity with type II DNA topoisomerases.

12 group and stimulates DNA cleavage by type II DNA topoisomerases.

13 cleotides either persist or are processed by DNA topoisomerase 1 (Top1) by either error-free or mutag

14 However, while the inhibition of DNA topoisomerase 1 activity by FL118 was no better than

15 taneous SSc with pulmonary fibrosis and anti-DNA topoisomerase 1 autoantibodies.

16 ssociated with nuclear DEK3 also established DNA topoisomerase 1alpha and proteins of the cohesion co

17 cleic acid processing enzymes, in particular DNA topoisomerase 2 (TOP2).

18 report that D loops can also be disrupted by DNA topoisomerase 3 (Top3), and this disruption depends

19 Mice lacking DNA topoisomerase 3beta are predisposed to a shortened l

20 A type II DNA topoisomerase, a DNA polymerase beta, and a structur

21 ducts on the religation reaction of vaccinia DNA topoisomerase, a prototypal type IB topoisomerase (T

22 ngs have revealed unexpected roles of type I DNA topoisomerases, a subclass of these enzymes, in regu

23 Type II DNA topoisomerases actively reduce the fractions of knot

24 Such enzymes-DNA topoisomerases-alter DNA topology by catalysing the

25 nd ssDNA substrate is revealed for a type IA DNA topoisomerase, although there is no evidence of ssDN

26 synthesis, penicillin-binding proteins, and DNA topoisomerases; among these are inhibitors of bacter

27 robe the topological conversion catalysed by DNA topoisomerase and to study the DNA replication under

28 dducts provide a novel set of tools to study DNA topoisomerases and emphasize the importance of conta

29 I, is located at the active site of type IA DNA topoisomerases and near the active site tyrosine.

30 stal structures of complexes between type IA DNA topoisomerases and single-stranded DNA suggest that

31 e has focused on the biological functions of DNA topoisomerases, and several findings have revealed u

32 DNA topoisomerases are a class of enzymes that alter the

33 Type II DNA topoisomerases are ATP-dependent enzymes that cataly

34 DNA topoisomerases are believed to promote transcription

35 Type II DNA topoisomerases are essential and ubiquitous enzymes

36 DNA topoisomerases are essential enzymes that can overwi

37 Type IIA DNA topoisomerases are essential enzymes that use ATP to

38 Bacterial DNA topoisomerases are essential for bacterial growth an

39 DNA Topoisomerases are essential to resolve topological

40 The DNA topoisomerases are excellent targets for chemotherap

41 Type IB DNA topoisomerases are found in all eukarya, two familie

42 DNA topoisomerases are important clinical targets for an

43 intenance of chromosomes (SMC) complexes and DNA topoisomerases are major determinants of chromosome

44 DNA topoisomerases are nature's tools for resolving the

45 Type I DNA topoisomerases are ubiquitous enzymes involved in ma

46 Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the super

47 Antibacterial quinolones inhibit type II DNA topoisomerases by stabilizing covalent topoisomerase

48 At least one type IA DNA topoisomerase can be found in every bacterium, makin

49 Type IB DNA topoisomerases can eliminate torsional stresses prod

50 Type II DNA topoisomerases catalyse DNA double-strand cleavage,

51 Type II DNA topoisomerases catalyze changes in DNA topology and

52 These inhibitors stabilize covalent DNA-topoisomerase cleavage complexes that ultimately cau

53 DNA topoisomerases constitute a large family of enzymes

54 My interest in DNA rings and DNA topoisomerases continued throughout my years at the

55 DNA topoisomerases contribute to various cellular activi

56 DNA topoisomerases control DNA topology by breaking and

57 DNA topoisomerases control the topology of DNA (e.g., th

58 DNA topoisomerases control the topology of DNA.

59 observed from the comparison of the type IA DNA topoisomerase crystal structures.

60 Quinolones inhibit bacterial type II DNA topoisomerases (e.g. DNA gyrase) and are among the m

61 Vaccinia type I DNA topoisomerase exhibits a strong site-specific ribonu

62 Vaccinia DNA topoisomerase forms a covalent DNA-(3'-phosphotyrosy

63 Vaccinia DNA topoisomerase forms a covalent DNA-(3'-phosphotyrosy

64 Vaccinia DNA topoisomerase forms a covalent DNA-(3'-phosphotyrosy

65 Vaccinia DNA topoisomerase forms a covalent DNA-(3'-phosphotyrosy

66 The action of various DNA topoisomerases frequently results in characteristic

67 The type I DNA topoisomerase from vaccinia virus (vTopo) forms a re

68 any stress response genes, fts family genes, DNA topoisomerase genes, and central-carbon metabolism g

69 Bacteria frequently possess two type IIA DNA topoisomerases, gyrase and topo IV, which maintain c

70 analysis of gyrase B of the beta subunit of DNA topoisomerase (gyrB), and 16S rRNA and subunit A of

71 Autoreactive anti-DNA topoisomerase I (anti-Topo I) Abs are commonly detec

72 Escherichia coli DNA topoisomerase I (encoded by the topA gene) is import

73 SSc patients who had either circulating anti-DNA topoisomerase I (P=7.58x10(-17)/4.84x10(-16)) or ant

74 n (CPT) and its derivatives target mammalian DNA topoisomerase I (top1) and are among the most effect

75 These deletion events are dependent on DNA topoisomerase I (Top1) and are initiated by Top1 inc

76 s such as DNA replication and transcription, DNA topoisomerase I (Top1) catalyzes the relaxation of D

77 In eukaryotes, DNA topoisomerase I (Top1) catalyzes the relaxation of s

78 When a replication fork collides with a DNA topoisomerase I (Top1) cleavage complex, the covalen

79 DNA topoisomerase I (TOP1) has an important role in main

80 The inhibition of DNA topoisomerase I (Top1) has proven to be a successful

81 il (FU), is most closely correlated with the DNA topoisomerase I (Top1) inhibitor camptothecin in the

82 modified DNA lesions have been shown to trap DNA topoisomerase I (TOP1) into covalent cleavage comple

83 s containing wild-type and mutant alleles of DNA topoisomerase I (TOP1) into the haploid yeast gene-d

84 Eukaryotic DNA topoisomerase I (Top1) is a monomeric protein clamp

85 DNA topoisomerase I (Top1) is the target of camptothecin

86 DNA topoisomerase I (TOP1) mediates the induction of rad

87 Human nuclear DNA topoisomerase I (top1) plays a crucial role in DNA r

88 t (H(432)R) enhanced cell sensitivity to the DNA topoisomerase I (Top1) poison camptothecin.

89 e show rapid recruitment, within minutes, of DNA topoisomerase I (TOP1) to a large cohort of AR-regul

90 The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA

91 DNA topoisomerase I (Top1p) catalyzes changes in DNA top

92 DNA topoisomerase I (Top1p) catalyzes the relaxation of

93 Eukaryotic DNA topoisomerase I (Top1p) catalyzes the relaxation of

94 DNA topoisomerase I (Top1p) catalyzes topological change

95 Eukaryotic DNA topoisomerase I (Top1p) has important functions in D

96 ssesses two type I topoisomerase activities, DNA topoisomerase I (Topo I) and III (Topo III).

97 Autoantibodies to DNA topoisomerase I (topo I) are associated with diffuse

98 Human DNA topoisomerase I (topo I) is an essential mammalian e

99 hydrophilic N-terminal domain of eukaryotic DNA topoisomerase I (topo I) is dispensable for catalyti

100 DNA topoisomerase I (topo I) is involved in the regulati

101 responses to various autoantigens, including DNA topoisomerase I (Topo I), have been implicated.

102 anticancer drugs slow the religation step of DNA topoisomerase I (topo I).

103 ation, YCS4 function is required to localize DNA topoisomerase I and II to chromosomes.

104 vity to their Escherichia coli counterparts, DNA topoisomerase I and III (ecTopo I, ecTopo III).

105 These genes, encoding DNA topoisomerase I and IIIalpha (bcTopo I, bcTopo IIIal

106 the active site tyrosine of Escherichia coli DNA topoisomerase I are conserved among the type IA topo

107 DNA from the 5' side of a nick generated by DNA topoisomerase I at a ribonucleoside monophosphate re

108 The DNA topoisomerase I enzyme of Mycobacterium tuberculosis

109 xtraction, regions of the DNA polymerase and DNA topoisomerase I genes were amplified by PCR, sequenc

110 logical probe, we find that Escherichia coli DNA topoisomerase I has low RNA topoisomerase activity a

111 icting results regarding the essentiality of DNA topoisomerase I in cells grown in media of low osmol

112 ults thus implicate an indispensable role of DNA topoisomerase I in E. coli cells grown in media of a

113 the rDNA and clarifies a structural role of DNA topoisomerase I in the epigenetic regulation of rDNA

114 The proposed mechanism of type IA DNA topoisomerase I includes conformational changes by t

115 lkynyl side chains display excellent E. coli DNA topoisomerase I inhibition properties with IC50 valu

116 been synthesized and their Escherichia coli DNA topoisomerase I inhibition, binding to B-DNA duplex,

117 The anticancer agent camptothecin (CPT) is a DNA topoisomerase I inhibitor that causes fork collapse

118 ramatically sensitizes glioblastoma cells to DNA topoisomerase I inhibitor-mediated apoptosis.

119 mutant after treatment with camptothecin, a DNA topoisomerase I inhibitor.

120 matography and overlay blotting that E. coli DNA topoisomerase I interacts directly with the RNA poly

121 DNA topoisomerase I is an essential nuclear enzyme invol

122 Camptothecin (CPT) that targets DNA topoisomerase I is one of the most promising broad-s

123 Bacterial DNA topoisomerase I is responsible for preventing the hy

124 Eukaryotic DNA topoisomerase I manipulates the higher order structu

125 with enhanced sensitivity to self-poisoning DNA topoisomerase I mutant (Top1T722Ap), which mimics th

126 Although they are known to trap DNA topoisomerase I on DNA, form cleavable complexes, an

127 patients with SSc who are positive for anti-DNA topoisomerase I or anticentromere autoantibodies.

128 inus of this alpha helix in Escherichia coli DNA topoisomerase I showed that flexibility around this

129 rity, results from the synthesis of a mutant DNA topoisomerase I that is itself temperature-sensitive

130 ts, such as the 3'-phosphotyrosyl linkage of DNA topoisomerase I to DNA.

131 tigens and also revealed increased levels of DNA topoisomerase I transcripts in SSc fibroblasts compa

132 The viability of the topA mutants lacking DNA topoisomerase I was thought to depend on the presenc

133 aining a deletion of topA (the gene encoding DNA topoisomerase I) a compensatory mutation is found in

134 stidine residue, His-365 in Escherichia coli DNA topoisomerase I, is located at the active site of ty

135 merase and the C-terminal domains of E. coli DNA topoisomerase I, which are homologous to the zinc ri

136 l result in severely compromised enzymes and DNA topoisomerase I-camptothecin dependent lethality.

137 t study, we investigated the role of Ku86 in DNA topoisomerase I-mediated radiosensitization induced

138 nhibit RNA topoisomerase activity of E. coli DNA topoisomerase I.

139 ding of the modified DNA substrates by human DNA topoisomerase I.

140 mplate and DNA synthesis absolutely required DNA topoisomerase I.

141 upercoiled in Escherichia coli cells lacking DNA topoisomerase I.

142 chain and amino acids of the active site of DNA topoisomerase I.

143 shown previously to act as poisons of human DNA topoisomerase I.

144 Commonly used antitumor agents, such as DNA topoisomerase I/II poisons, kill cancer cells by cre

145 results, E. coli cells lacking both type IA DNA topoisomerases I and III are found to be nonviable,

146 eplisomes with camptothecin (CPT)-stabilized DNA-Topoisomerase I adducts activates an ATR-dependent p

147 NA-protein cross-links, which include stable DNA-topoisomerase I cleavable complexes.

148 Vaccinia DNA topoisomerase IB (TopIB) relaxes supercoils by formi

149 duced, purified, and characterized mimivirus DNA topoisomerase IB (TopIB), which we find to be a stru

150 s is TOP1MT, which encodes the mitochondrial DNA topoisomerase IB, involved in mtDNA relaxation.

151 yet another example of this in their unusual DNA topoisomerase IB.

152 enite-induced apoptosis was shown to involve DNA topoisomerase II (Top II) as selenite-induced apopto

153 sformed cells involves thiol modification of DNA topoisomerase II (Top2) based on the following obser

154 The breakage/reunion reaction of DNA topoisomerase II (TOP2) can be interrupted by DNA in

155 DNA topoisomerase II (TOP2) cleavable complexes represen

156 DNA topoisomerase II (Top2) is an essential nuclear enzy

157 DNA topoisomerase II (Top2) is the target of some of the

158 DNA topoisomerase II (TOP2) plays a pivotal role in fait

159 formed during replication are decatenated by DNA topoisomerase II (TOP2), and this process is activel

160 Drugs that target DNA topoisomerase II (Top2), including etoposide (VP-16)

161 atch repair pathway, whereas another for the DNA topoisomerase II (TOP2A) poison etoposide identified

162 , 9, 12, and 13) were shown to inhibit human DNA topoisomerase II (topo II) activity at 5 microM.

163 sion of DNA topoisomerase IIbeta, one of two DNA topoisomerase II activities known to exist in mammal

164 The only DNA topoisomerase II activity conclusively demonstrated

165 Despite the likely requirement for a DNA topoisomerase II activity during synthesis of mitoch

166 ent study, we report the discovery of a type DNA topoisomerase II activity in bovine mitochondria.

167 from LLC-Pk was created in which endogenous DNA topoisomerase II alpha (topoII alpha) protein was do

168 ized and evaluated for their effects against DNA topoisomerase II and KB or 1-resistant KB-7d tumor c

169 The enzyme DNA topoisomerase II associates with gene promoter regio

170 Human DNA topoisomerase II binding protein 1 (TopBP1) contains

171 Induction of DNA topoisomerase II cleavage complexes in CEM and K562

172 oside and both etoposide metabolites induced DNA topoisomerase II cleavage complexes in the hematopoi

173 ransfer; however, consistent with reciprocal DNA topoisomerase II cleavage events in MLL and AF-4 in

174 etoposide, but also its metabolites, enhance DNA topoisomerase II cleavage near MLL translocation bre

175 The MLL genomic breakpoint was a functional DNA topoisomerase II cleavage site in an in vitro assay.

176 anslocation breakpoints in MLL and AF-4 were DNA topoisomerase II cleavage sites.

177 toposide metabolite- and doxorubicin-induced DNA topoisomerase II cleavage was examined in normal hom

178 ibitor-related leukemias is a consequence of DNA topoisomerase II cleavage.

179 DNA topoisomerase II completely removes DNA intertwining

180 The DNA topoisomerase II copurifies with mitochondria and di

181 mal breakage resulting from stabilization of DNA topoisomerase II covalent complexes by epipodophyllo

182 Repair of etoposide-stabilized DNA topoisomerase II covalent complexes may initiate MLL

183 TA-3' sequences were reciprocally cleaved by DNA topoisomerase II in the presence of etoposide, etopo

184 derivatives (11-23) were designed to enhance DNA topoisomerase II inhibition, overcome drug resistanc

185 F/SF and then exposed to Adriamycin (ADR), a DNA topoisomerase II inhibitor, exhibit an altered patte

186 DNA lesions generated by etoposide, a DNA topoisomerase II inhibitor, or by exonuclease treatm

187 Few t(9;11) translocations in DNA topoisomerase II inhibitor-related leukemias have be

188 al breakage leading to MLL translocations in DNA topoisomerase II inhibitor-related leukemias is a co

189 DNA topoisomerase II is a molecular machine that couples

190 DNA topoisomerase II modulates DNA topology by relieving

191 omosomal recombination by simple exchange of DNA topoisomerase II subunits and DNA-strand transfer; h

192 Assuming that DNA topoisomerase II was the mediator of the breakage, p

193 by which merbarone, a catalytic inhibitor of DNA topoisomerase II, can block tumor cell growth withou

194 F-beta activated kinase (TAK)1, TAB1, c-FOS, DNA topoisomerase II, DNA polymerase alpha, dihydrofolat

195 e phosphosites evolved from acidic residues (DNA topoisomerase II, enolase, and C-Raf) show that the

196 processing of the staggered nicks induced by DNA topoisomerase II, including exonucleolytic deletion

197 ty-two IIV-3 genes, including those encoding DNA topoisomerase II, NAD-dependent DNA ligase, SF1 heli

198 The human DNA topoisomerase II-binding protein 1 (TopBP1) protein

199 amage the MLL breakpoint cluster region in a DNA topoisomerase II-dependent manner like the parent dr

200 topopyrones A-D also act as poisons of human DNA topoisomerase II.

201 ential targets have been proposed, including DNA topoisomerases II (Top2).

202 is egg extract, we found that SUMOylation of DNA topoisomerase IIalpha (TOP2A) CTD regulates the loca

203 The chelator caused selective poisoning of DNA topoisomerase IIalpha (top2alpha) as measured by an

204 evidence that the C-terminal domain (CTD) of DNA topoisomerase IIalpha (Topo II) provides a novel fun

205 DNA topoisomerase IIalpha (Topo IIalpha) ensures genomic

206 Expression of the human DNA topoisomerase IIalpha (topo IIalpha) gene is positiv

207 DNA topoisomerase IIalpha (Topo IIalpha) is the target o

208 DNA topoisomerase IIalpha (TopoIIalpha) is an essential

209 d for both G(1)/S and G(2)/M phases and that DNA topoisomerase IIalpha (topoIIalpha) was a potential

210 examined in vitro upon incubation with human DNA topoisomerase IIalpha and etoposide, etoposide catec

211 e first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells a

212 tal structures of the ATPase domain of human DNA topoisomerase IIalpha in different nucleotide-bound

213 ith adriamycin (also known as doxorubicin, a DNA topoisomerase IIalpha inhibitor) induced a series of

214 nd WNT4) to protection against adriamycin (a DNA topoisomerase IIalpha inhibitor) using RNA interfere

215 variant showed increased sensitivity to two DNA topoisomerase IIalpha inhibitors, but not to other c

216 Here we show that DNA topoisomerase IIalpha is associated with the holo-po

217 T boxes (ICBs) within the promoter region of DNA topoisomerase IIalpha results in control of cell dif

218 examined in vitro upon incubation with human DNA topoisomerase IIalpha, ATP, and either etoposide, et

219 lones encoding N-terminal fragments of human DNA topoisomerase IIalpha.

220 ined corticogenesis in mouse embryos lacking DNA topoisomerase IIbeta (IIbeta) in the brain or in all

221 suggesting the involvement of proteasome and DNA topoisomerase IIbeta (Top2beta).

222 d that Beclin 1 could directly interact with DNA topoisomerase IIbeta and was recruited to the DSB si

223 Here we report that DNA topoisomerase IIbeta binding protein 1 (TopBP1) regu

224 TopBP1 (DNA topoisomerase IIbeta binding protein I) contains mul

225 Random mutagenesis of human DNA topoisomerase IIbeta cDNA, followed by selection in

226 chondrial activity is a truncated version of DNA topoisomerase IIbeta, one of two DNA topoisomerase I

227 Our data mechanistically link DNA topoisomerase IIbeta-dependent dsDNA breaks and the

228 rs, including activating protein 1, requires DNA topoisomerase IIbeta-dependent, transient, site-spec

229 l) methane sulfonamide (mAMSA) targets human DNA topoisomerase IIbeta.

230 ly important and has been implicated in Sgs1-DNA topoisomerase III (Top3) interaction.

231 of DNA helicases are known to interact with DNA topoisomerase III (Top3).

232 cases human BLM and yeast Sgs1 interact with DNA topoisomerase III and are thought to act on stalled

233 Escherichia coli DNA topoisomerase III belongs to the type IA family of D

234 g between the appearance of chromosome-bound DNA topoisomerase III beta and Rad51, a protein known to

235 ocytes of wild-type mice also indicates that DNA topoisomerase III beta becomes prominently associate

236 of chromosomal defects in germ cells lacking DNA topoisomerase III beta, and this interpretation is s

237 ruption of the mouse TOP3 beta gene encoding DNA topoisomerase III beta, one of the two mammalian typ

238 DNA topoisomerase III from Escherichia coli belongs to t

239 resolution, of an inactive mutant of E. coli DNA topoisomerase III in a non-covalent complex with an

240 Because the DNA topoisomerase III isozymes are likely to interact wi

241 -/-) mice points to the possibility that the DNA topoisomerase III isozymes might be involved in the

242 xc had low amino acid sequence similarity to DNA topoisomerase III, an enzyme that relaxes DNA superc

243 ns: PG0104, which is highly similar (57%) to DNA topoisomerase III, and PG0121, which has high simila

244 erase IIIalpha and Schizosaccharomyces pombe DNA topoisomerase III.

245 that possess topoisomerase IB appear to lack DNA topoisomerase III.

246 The human TOP3alpha gene encoding DNA topoisomerase IIIalpha (hTop3alpha) has two potentia

247 se, forms a complex with two other proteins, DNA topoisomerase IIIalpha and RMI1.

248 amino acid sequences of mouse and Drosophila DNA topoisomerase IIIalpha and Schizosaccharomyces pombe

249 e embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viab

250 Mice lacking DNA topoisomerase IIIbeta have a shorter life expectancy

251 ruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out.

252 Given the presence of at least one type IA DNA topoisomerase in all forms of life examined to date,

253 e universal presence of at least one type IA DNA topoisomerase in all organisms.

254 The presence of a type IA DNA topoisomerase in the mitochondria of other eukaryote

255 es, in terms of a specific role of a type IA DNA topoisomerase in the resolution of meiotic double-Ho

256 characteristics of different subfamilies of DNA topoisomerases, in terms of a specific role of a typ

257 erapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the ind

258 irreversibly damaging DNA by trapping nicked DNA-topoisomerase intermediates could make potent antivi

259 functions normally carried out by gyrase and DNA topoisomerase IV in other bacteria.

260 e isolates contained mutations in both parC (DNA topoisomerase IV) and gyrA (DNA gyrase), which were

261 ies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of a

262 e III beta, one of the two mammalian type IA DNA topoisomerases, leads to a progressive reduction in

263 DNA topoisomerases manage chromosome supercoiling and or

264 DNA topoisomerases manage chromosome supercoiling and or

265 ty of the chromosome, which is controlled by DNA topoisomerases, modulates global gene expression.

266 The absence of IIbeta, a type II DNA topoisomerase normally expressed in postmitotic cell

267 DNA topoisomerases play essential roles in many DNA meta

268 DNA topoisomerases play key roles in decatenation.

269 Type IIA DNA topoisomerases play multiple essential roles in the

270 Type IA DNA topoisomerases possess several domains forming a tor

271 DNA gyrase is a DNA topoisomerase present in bacteria and plants but not

272 mains and the same catalytic residue used in DNA topoisomerase reaction; however, it does not absolut

273 red from complexes of mtDNA and protein, the DNA topoisomerase relaxes a negatively, supercoiled DNA

274 d Top1 proteins, a histone deacetylase and a DNA topoisomerase, respectively, we investigated whether

275 DNA topoisomerases solve the topological problems associ

276 Reverse gyrase is a DNA topoisomerase specific for hyperthermophilic bacteri

277 ondrial topoisomerase I (Top1mt) is the only DNA topoisomerase specific for mitochondria in vertebrat

278 The gene for a DNA topoisomerase subunit of T4 has been split by a 1-kb

279 omains similar to those in cellular type IIA DNA topoisomerases, suggestive of novel ATP-dependent fu

280 Gyrase is a type II DNA topoisomerase that introduces negative supercoils in

281 Vaccinia virus encodes a type I DNA topoisomerase that is highly conserved in all known

282 diverse species of bacteria encode a type IB DNA topoisomerase that resembles vaccinia virus topoisom

283 Type II DNA topoisomerases (TOP2) regulate DNA topology by gener

284 DNA topoisomerase (topo) I is an essential nuclear prote

285 DNA topoisomerase (topo) IIalpha gene expression or acti

286 an analysis of the ATPase activity of human DNA topoisomerase (topo) IIbeta.

287 opsis requires a plant homologue of archaeal DNA topoisomerase (topo) VI.

288 Type II Human DNA Topoisomerases (topos II) play an essential role in

289 Type II DNA topoisomerases (topos) are essential and ubiquitous

290 Type II DNA topoisomerases (topos) catalyse changes in DNA topol

291 Here we show that genes for mitochondrial DNA topoisomerases (type IB) exist only in vertebrates.

292 We recently identified 24 HhH motifs in DNA topoisomerase V (Topo V).

293 in is a eukaryotic homologue of the archaeal DNA topoisomerase VIA subunit (topo VIA).

294 Vaccinia DNA topoisomerase (vTopo) catalyzes highly specific nucl

295 Vaccinia DNA topoisomerase (vTopo) is a prototypic eukaryotic typ

296 Vaccinia DNA topoisomerase (vTopo) is a prototypic pox virus fami

297 IIIbeta is a member of the type IA family of DNA topoisomerases, which generates a single-stranded br

298 omerase III belongs to the type IA family of DNA topoisomerases, which transiently cleave single-stra

299 richia coli belongs to the type IA family of DNA topoisomerases, which transiently cleave ssDNA via f

300 Type IA DNA topoisomerases work with a unique mechanism of stran