ライフサイエンスコーパス: DNA tumor virus

1 tures of its genome suggest that it is a new DNA tumor virus.

2 steroid receptor superfamily and the HPV-16 DNA tumor virus.

3 r similar to that of T antigens of the small DNA tumor viruses.

4 or suppressor pathway in a manner similar to DNA tumor viruses.

5 s also targeted by oncoproteins expressed by DNA tumor viruses.

6 effects associated with infections with many DNA tumor viruses.

7 made through the use of GEM models for human DNA tumor viruses.

8 the mechanisms of transformation employed by DNA tumor viruses.

9 apillomaviruses are a family of nonenveloped DNA tumor viruses.

10 ession of transforming proteins derived from DNA tumor viruses.

11 ement in latent replication of these related DNA tumor viruses.

12 equired to mediate transformation induced by DNA tumor viruses.

13 c single-stranded DNA elements and mammalian DNA tumor viruses.

14 plication of mammalian cells and their small DNA tumor viruses.

15 by the transforming oncoproteins of several DNA tumor viruses.

16 to have onco-suppressive properties against DNA tumor viruses.

17 ered in many cancers and is also targeted by DNA tumor viruses.

18 om studies using immediate-early proteins of DNA tumor viruses.

19 The oncoproteins of the DNA tumor viruses, adenovirus E1A, simian virus 40 T ant

20 While oncoproteins encoded by small DNA tumor viruses and Epstein-Barr virus (EBV) latent an

21 ression is critical for persistence of these DNA tumor viruses and most likely involved in mediating

22 n factors, bind to origins of replication in DNA tumor viruses and stimulate viral DNA replication in

23 teract with the transforming oncoproteins of DNA tumor viruses and this led to rapid advances in our

24 be effective in malignant diseases for which DNA tumor viruses are etiologic agents and that antitumo

25 All known DNA tumor viruses are known to target and inactivate two

26 Oncoproteins from DNA tumor viruses associate with critical cellular prote

27 is a key target of oncoproteins expressed by DNA tumor viruses, but RNA viruses are not known to regu

28 into the host genome, is a critical step in DNA tumor virus carcinogenesis.

29 Human papillomaviruses (HPV) are small DNA tumor viruses causally associated with cervical canc

30 The study of the small DNA tumor viruses continues to provide valuable new insi

31 xtensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.

32 Most DNA tumor viruses disturb the cell cycle pathways by ess

33 ically interact with oncoproteins encoded by DNA tumor viruses (E7, T-Ag, E1A).

34 Small DNA tumor viruses encode gene products which can functio

35 Many of the small DNA tumor viruses encode transforming proteins that func

36 Viruses of the DNA tumor virus family share the ability to transform ve

37 SV40 is a DNA tumor virus found in some studies to be associated a

38 Evolution of minimal DNA tumor virus' genomes has selected for small viral on

39 The study of DNA tumor viruses has been invaluable in uncovering the

40 Human papillomavirus type 16 (HPV-16), a DNA tumor virus, has a causal role in cervical cancer, a

41 The origins of replication of DNA tumor viruses have a highly conserved feature, namel

42 Studies of DNA tumor viruses have provided important insights into

43 DNA tumor viruses have provided major insights into how

44 sive properties of AAV against adenovirus, a DNA tumor virus, have been well documented.

45 in required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated

46 in required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) strain 484, de

47 Intervention by this DNA tumor virus in cellular translational controls is li

48 dy of the transforming proteins derived from DNA tumor viruses in experimental models of transformati

49 Polyoma virus (Py) differs from other small DNA tumor viruses in not encoding a protein that inactiv

50 Here, we identify the oncogenes of the DNA tumor viruses, including E7 from human papillomaviru

51 Infections with DNA tumor viruses, including members of the polyomavirus

52 factors, and associate with oncoproteins of DNA tumor viruses, including simian virus 40 (SV40) larg

53 te with the transforming proteins of several DNA tumor viruses, including the large T antigen encoded

54 ctions of transforming proteins from several DNA tumor viruses, including two papillomaviruses and tw

55 The papillomavirus (PV) is a double-stranded DNA tumor virus infecting cervix, mouth, and throat tiss

56 f the best-studied oncoproteins encoded by a DNA tumor virus is adenovirus E1A, which modifies the fu

57 neral theme that has emerged from studies of DNA tumor viruses is that otherwise unrelated oncoprotei

58 i's sarcoma-associated herpesvirus (KSHV), a DNA tumor virus, is an etiological agent linked to sever

59 The DNA tumor virus Kaposi's sarcoma associated herpesvirus

60 Infection of cells with SV40, a DNA tumor virus known to abrogate formation of p130- and

61 Simian virus 40 (SV40) is a DNA tumor virus known to induce cancers in laboratory an

62 ex, a hallmark of cellular transformation by DNA tumor viruses, leads to cell proliferation.

63 y that the oncoproteins encoded by the small-DNA tumor viruses may use this mechanism to induce c-Myc

64 Many DNA tumor virus oncogenes are capable of activating and

65 hat shares a subset of the properties of the DNA tumor virus oncoproteins but maintains important dif

66 DNA tumor virus oncoproteins reduce Rb function by eithe

67 t can physically interact with two mammalian DNA tumor virus oncoproteins, simian virus 40 large-T an

68 Unlike other DNA tumor virus oncoproteins, which possess immortalizin

69 critical for growth regulation interact with DNA tumor virus oncoproteins.

70 1 HR1 and HR3 and short regions of two other DNA tumor virus origin-binding proteins, SV40 T antigen

71 In cells infected with DNA tumor viruses, p53 is bound to the viral tumor antig

72 TP-binding proteins in transformation by the DNA tumor virus polyomavirus, the GTP-binding activities

73 Next, we found that SV40, a DNA tumor virus present in approximately 50% of mesothel

74 The oncoproteins of small DNA tumor viruses promote tumorigenesis by complexing wi

75 is the first report of STAT activation by a DNA tumor virus protein.

76 The ability of DNA tumor virus proteins to trigger apoptosis in mammali

77 However, unlike the small DNA tumor virus proteins, individual HCMV IE proteins ta

78 ry cells in which RB has been inactivated by DNA tumor virus proteins.

79 It is unclear how DNA tumor viruses regulate these enzymes and how these i

80 T Ag, which suggests yet another reason why DNA tumor viruses require actively cycling host cells.

81 therefore postulated that immortalization by DNA tumor viruses results in the induction of PTKs funda

82 is increasing evidence that the transforming DNA tumor virus simian virus 40 (SV40) is associated wit

83 Infection of quiescent cells with the DNA tumor virus simian virus 40 induces expression of th

84 ies with oncoproteins encoded by other small DNA tumor viruses such as adenovirus E1A and SV40 large

85 action can be disrupted by oncoproteins from DNA tumor viruses such as adenovirus E1a that bind p107.

86 Oncoproteins from DNA tumor viruses such as adenovirus E1a, simian virus 4

87 ed as the binding site for oncoproteins from DNA tumor viruses such as adenovirus E1a.

88 DNA tumor viruses such as Kaposi's sarcoma-associated he

89 Small DNA tumor viruses such as simian virus 40 (SV40) and pol

90 DNA tumor viruses such as simian virus 40 (SV40) express

91 It is widely accepted that small DNA tumor viruses, such as adenovirus, simian virus 40 a

92 s (HCMV) and IE equivalents encoded by small DNA tumor viruses, such as adenovirus.

93 Although the small DNA tumor virus SV40 (simian virus 40) fails to replicat

94 and KS.IMPORTANCE Here we show that HHV-8, a DNA tumor virus that causes Kaposi's sarcoma, infects th

95 ociated herpesvirus (KSHV) is a lymphotropic DNA tumor virus that induces Kaposi's sarcoma and AIDS-r

96 Adenovirus is a small DNA tumor virus that is a global human pathogen and key

97 Simian virus 40 (SV40) is a potent DNA tumor virus that is known to induce primary brain ca

98 Human papillomaviruses (HPVs) are small DNA tumor viruses that are the causative agent of warts

99 KSHV) and Epstein-Barr virus (EBV) are human DNA tumor viruses that express nuclear antigens [latency

100 also the binding site for oncoproteins from DNA tumor viruses that inactivate Rb.

101 The human papillomaviruses (HPVS) are small DNA tumor viruses that infect epithelial cells and induc

102 Thus, like many of the small DNA tumor viruses, the first protein expressed upon HCMV

103 The mechanism employed by DNA tumor viruses to inhibit p53-dependent transcription

104 terpretation of the p53-Tag complexes and of DNA tumor virus transformation in general.

105 s is also the first demonstration of a human DNA tumor virus upregulating TLR3, a TLR that thus far h

106 In benign lesions induced by the small DNA tumor viruses, viral genomes are typically maintaine

107 The results indicate that unlike other DNA tumor viruses which block apoptosis by inactivation