ライフサイエンスコーパス: DNA-binding

1 o a [2Fe-2S] form with loss of high-affinity DNA binding.

2 apo-AR), precluding nuclear localization and DNA binding.

3 ction non-competitively to prevent LasR/RhlR DNA binding.

4 ion, whereas the PWWP domain exhibits direct DNA binding.

5 tory effects were not mediated by its direct DNA binding.

6 o DNA, whereas cell penetration is linked to DNA binding.

7 onsensus sequence and preventing nonspecific DNA binding.

8 ensors bind non-cognate metals, which alters DNA binding.

9 on of more Fe(2+)-Fur and, accordingly, more DNA binding.

10 cription factors to compete successfully for DNA binding.

11 o acids R81, R82, and K226 all implicated in DNA binding.

12 threshold, increasing OmpR dimerization and DNA binding.

13 that displays highly selective, major groove DNA binding, (2) a reversible, metal-dependent DNA inter

14 ein kinase kinase (MEK), c-Fos, inhibitor of DNA binding 3, phosphorylated signal transducer and acti

15 ular evidence that the cell cycle arrest and DNA binding activities of IE2 appear to be responsible f

16 has been well studied for over a decade, the DNA-binding activities and the biological functions of t

17 horylation of YY1 at this site abolishes its DNA binding activity in vitro and in vivo.

18 on the lagging strand daughter DNA, but its DNA binding activity mediated loading of Exo1 onto ssDNA

19 n seed formation is tightly regulated by the DNA binding activity of protagonist basic leucine zipper

20 The DNA binding activity of RbkR was stimulated by CTP and s

21 ly expressed had the general single-stranded DNA binding activity of RPA complexes, unlike the telome

22 A corresponding decrease in Nrf2-DNA-binding activity and a general decrease in Nrf2-targ

23 e in cAMP responsive element binding protein DNA-binding activity and induction of Yes-associated pro

24 , or cAMP responsive element binding protein DNA-binding activity prevented the proliferative effects

25 inactivated Cic by selectively disabling its DNA-binding activity, a mutation that causes derepressio

26 In Aiptasia, NF-kappaB protein levels, DNA-binding activity, and tissue expression increase whe

27 53 via phosphorylation and activation of p53 DNA-binding activity.

28 MOylation, although not directly influencing DNA binding, actually increased binding of Dax1 to Sf1 t

29 r duplex containing the CC mismatch reveal a DNA binding affinity of 3.1 x 10(6) M(-1), similar to th

30 In cultured cells, the mutations reduced the DNA binding affinity of FOXI1, which hence, failed to ad

31 TEB had no more DNA binding affinity than Teb1 alone.

32 hymena RPA large subunit paralogs had higher DNA binding affinity than their large subunit alone.

33 hese metal-induced alterations decrease RcnR-DNA binding affinity, leading to rcnAB expression.

34 rization of these variants revealed impaired DNA binding affinity, reduced thermostability, diminishe

35 on exists between the extent of reduction in DNA-binding affinity and the severity of symptoms in XP

36 The measured increase in DNA-binding affinity matches the calculated affinity cha

37 lectrostatic model that shows this change in DNA-binding affinity of these proteins can be fully expl

38 The redox-modulated change in DNA-binding affinity regulates the ability of [4Fe4S] re

39 n of these two residues drastically affected DNA-binding affinity, resulting in rcnA expression in th

40 forming biophysical measurements of in vitro DNA-binding affinity.

41 fter which it takes a long time to reset its DNA-binding affinity.

42 that led to the discovery of Pt complexes as DNA-binding agents that elicit cell arrest, the preclini

43 d residue in a zinc finger motif crucial for DNA binding and are deleterious in a fly model.

44 ve center that plays a key role in substrate DNA binding and catalytic activity.

45 tor, and mutant EBF3 had reduced genome-wide DNA binding and gene-regulatory activity.

46 -terminal tail increases the on-rate of RecQ-DNA binding and has a modest stimulatory effect on the u

47 ivation promoted SMAD3 nuclear accumulation, DNA binding and induced SMAD3-dependent transcriptional

48 Here we measure the single-stranded DNA binding and oligomerization kinetics of wild-type an

49 location but significantly reduced NF-kappaB DNA binding and phosphorylation of NF-kappaB p65.

50 e free energies of specific and non-specific DNA binding and protein-protein cooperativity.

51 because it has a reduced net charge, and in DNA binding and protein-protein interactions because key

52 B), resulting in SIP-dependent modulation of DNA binding and regulatory activity of RopB.

53 EndoIII and MutY to evaluate the effects of DNA binding and solvation on Fe-S bond covalencies (i.e.

54 DNA binding and transcription assays demonstrated that t

55 is of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression

56 Rylation at these sites inhibits C/EBPbeta's DNA binding and transcriptional activities and attenuate

57 r alpha (hRXRalpha) plays a critical role in DNA binding and transcriptional activity through heterod

58 . monocytogenes CadC is a sequence-specific, DNA-binding and cadmium-dependent regulator of CadA, an

59 Here we studied CSB's DNA-binding and nucleosome-remodeling activities at the

60 ylated the NF-kappaB RelA protein to prevent DNA binding, and (c) promoted RelA polyubiquitination an

61 We show that RPS3 inhibits ATPase, DNA binding, and helicase activities of RECQL4 through t

62 at the ATPase domain is the primary site for DNA binding, and is required for nuclease activity.

63 enhanced RORgammat-SRC1 interaction, stable DNA binding, and resultant IL-17A transcription.

64 Of note, transcription factor-DNA-binding arrays and chromatin immunoprecipitation exp

65 smooth muscle cells (SMC) was measured by a DNA-binding assay, and ii) lipopolysaccharide (LPS)-indu

66 In vitro DNA binding assays suggest that Zta has high affinity fo

67 analysis, LPCAT3 promoter assays, and direct DNA binding assays, we have mapped the functional PPAR-r

68 Transcriptional profiling and DNA-binding assays suggested that Cmr directly represses

69 es TGFbeta target promoters independently of DNA binding at NF-kappaB recognition sequences, instead

70 e.g. helicates) in particular display unique DNA-binding behavior, however until recently few example

71 Here, we show that a dynamic competition for DNA binding between nucleosome-forming histones and tran

72 erization, nuclear localization and specific DNA binding but inhibited the transcriptional activity o

73 nsactivator-mediated cytotoxicity depends on DNA binding, but can be overcome by BCL2 overexpression,

74 tation of Arg60 (R60Q) significantly reduced DNA binding, but retained a preference for the 5caC modi

75 t zinc (Zn)-induced allosteric inhibition of DNA binding by the Zn efflux repressor CzrA (chromosomal

76 n, termed the negative regulatory domain for DNA binding, can compensate for the loss of ETS1 binding

77 in-protein interaction, independent of SPDEF DNA binding capacity.

78 the beta lobe domains to close the promoter DNA binding channel and constrain the beta' clamp domain

79 sequesters blunt-ended telomeres within its DNA binding channel, shielding them from other DNA repai

80 d when in complex with RNAP, it occupies the DNA-binding channel of RNAP.

81 The Chromodomain-Helicase-DNA binding (CHD) Type III proteins are a subfamily of S

82 dues and a beta-hairpin within this putative DNA-binding cleft that are essential for catalytic activ

83 LMO2 is a bridging factor within a DNA binding complex and is required for definitive haema

84 eals that TFIID's conversion to a rearranged DNA binding conformation is enhanced in the presence of

85 rdination in the characteristic caliper-like DNA-binding conformation and the second monomer exhibiti

86 regulatory metal coordination in an open non-DNA-binding conformation.

87 Combination of SELEX-seq and genome-wide DNA binding data allows differentiation between targets

88 e expression, DNA accessibility, and protein-DNA binding data to quantify and characterize the effici

89 GR utilizes multiple DNA-binding-dependent and -independent mechanisms to ach

90 egulates a subset of inflammatory genes in a DNA-binding-dependent manner.

91 These data suggest a Su(Hw) code, wherein DNA binding dictates its cofactor recruitment and regula

92 pends on this channel, Ku's requirements for DNA binding differ between DNA repair and telomere prote

93 ity, ability to restore zinc to purified p53 DNA binding domain (DBD), and ability to restore site-sp

94 , which contains a proline-rich region and a DNA binding domain (DBD), is auto-cleaved from the ER me

95 structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its ow

96 We show here that while the central DNA binding domain is essential for anchoring at parS, t

97 nctions is dependent on joint binding to the DNA binding domain of ERCC1 and XPF.

98 peptides that interact specifically with the DNA binding domain of ERG.

99 ed C-terminal linker (IDL) that connects the DNA binding domain with the 9 amino acid C-terminal acid

100 is at a highly conserved residue within the DNA binding domain.

101 3P) predicted to affect the highly conserved DNA binding domain.

102 denosine (G > A) mutation in the mouse MeCP2 DNA binding domain.

103 lved the X-ray crystal structure of an EBNA1 DNA-binding domain (DBD) and discovered a novel hexameri

104 f this protein; a number of mutations in the DNA-binding domain (DBD) are associated with XP disease.

105 The RARbeta ligand-binding domain (LBD) and DNA-binding domain (DBD) are physically connected to fos

106 alpha (RXRalpha), and phosphorylation of the DNA-binding domain (DBD) at Thr-38 in CAR regulates this

107 rofiles reveal that the direct fusion of the DNA-binding domain (DBD) of Fkh1 to Dbf4 restores the Fk

108 This anchor connects the DNA-binding domain (DBD) with the ligand-binding domain

109 ce-dependent effects do not rely on the Chd1 DNA-binding domain and are not due to differences in nuc

110 th an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both source and destin

111 In the apo state, the DNA-binding domain contacts the edge of the nucleosome w

112 chanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however

113 reports on the ability of Rap1-heterologous DNA-binding domain fusion proteins to serve as chimeric

114 ragment, and that the region adjacent to the DNA-binding domain is pivotal to its homo-trimerization.

115 males or heterozygous males with an ERalpha DNA-binding domain mutation knocked in (WT/KI) to produc

116 The eponymous DNA-binding domain of ETS (E26 transformation-specific)

117 Comparative modeling of the DNA-binding domain of human HSF1 facilitated the predict

118 ions affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of

119 C-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expressio

120 rated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and lea

121 nd requires substantial reorientation of the DNA-binding domain with respect to the ATPase domains.

122 Devoid of a DNA-binding domain, FHL2 is a transcriptional cofactor t

123 ly controlled by two regulatory domains: the DNA-binding domain, which interferes with sliding when i

124 f is a gene for a ubiquitously expressed Ets DNA-binding domain-containing transcriptional repressor.

125 ctly phosphorylates YY1 at serine 365 in the DNA-binding domain.

126 e domains: an R domain, an AAA+ domain and a DNA-binding domain.

127 The two separate non-overlapping DNA binding domains in the ERCC1-XPF heterodimer jointly

128 gnition sequence, one in each of its two AP2 DNA binding domains.

129 apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria

130 polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) c

131 obabilistic framework that not only exploits DNA-binding domains and specificities, but also integrat

132 with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a u

133 We demonstrated that, even though their DNA-binding domains are extremely similar, WelLFY and it

134 ation domains, amide exchange throughout the DNA-binding domains is decreased as if the entire domain

135 dge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-lik

136 he mechanisms by which missense mutations in DNA-binding domains of transcription factors can lead to

137 the intrinsic specificities of the AR and GR DNA-binding domains using a refined version of SELEX-seq

138 Although PfAP2-I contains three AP2 DNA-binding domains, only one is required for binding of

139 roperties, IL-10-based modeling predicts two DNA-binding domains, two amphipathic helices, and an in-

140 In our proposed mechanism, DNA-binding-domains (DBD) of R insert in major grooves o

141 microscopy and fluorescence imaging to study DNA binding dynamics of MBD2.

142 genome-wide scale the flg22-induced in vivo DNA binding dynamics of three of the most prominent WRKY

143 hIP-seq and 4sU-RNA-seq to identify aberrant DNA-binding events genome wide and ectopic transcription

144 DNA-binding experiments show that the Ml proteins studie

145 is approach uncovered the chromatin helicase DNA-binding factor CHD1 as a putative synthetic-essentia

146 gulators such as corepressors, coactivators, DNA-binding factors and PTM modifying enzymes.

147 by reliance on base-contacting residues for DNA-binding functionality.

148 based features of proteins to identify their DNA-binding functionality.

149 requires a hierarchical cooperation between DNA binding, H3-H4 deposition and histone tetramerizatio

150 ase kinase kinase 14 (MAP3K14), the NFkappaB DNA binding heterodimer RelB/NFkappaB2, and proteins inv

151 Inhibitor of DNA binding (Id) proteins play important roles in regula

152 In contrast, C2H2-ZF DNA binding in fungi, plants, and other lineages is cons

153 t least six (35%) alter transcription factor-DNA binding in neuroblastoma cells.

154 rL nuclease domain, which allows us to model DNA binding in the nuclease active site.

155 While DNA binding is not essential for H3-H4 tetrasome deposit

156 Prep1 DR expands the DNA binding landscape of C/EBPbeta (CCAAT enhancer bindi

157 These molecules are composed of programmable DNA-binding ligands flexibly tethered to a small molecul

158 Induced circular dichroism (ICD) of DNA-binding ligands is well known to be strongly influen

159 of specific, near-specific, and non-specific DNA binding modes of LacI in vivo, showing that all thes

160 s with promoters via transient and prolonged DNA binding modes that are each regulated by p53.

161 ns share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukaryotes

162 thering the natural Spo11 protein to various DNA-binding modules: full-length DNA binding proteins, z

163 Moreover, DNA-binding motif analysis within the SE segments sugges

164 The presence of transcription factor (TF) DNA binding motifs correlated with specific TF activity

165 -repressed genes often lacking canonical Tcf DNA binding motifs, suggesting a novel mode of direct re

166 end on inadequate knowledge of cell-specific DNA binding motifs.

167 R36W) or Arg35 (R35H/L) completely abolished DNA binding, mutation of Arg60 (R60Q) significantly redu

168 has been gained for its conserved methylated DNA binding N-terminal ZF region; however, a specific ro

169 echanism by which competitive recruitment of DNA-binding nuclear receptors/transcription factors in t

170 acid substitutions have damaging effects on DNA binding of EBF3.

171 Differential DNA binding of MADS domain protein complexes plays a rol

172 ic DNA motif that mediates the homo-trimeric DNA binding of Myrf N-terminal fragments.

173 d rapidly after folic acid injection, as did DNA binding of RelB and NFkappaB2, detected in nuclei is

174 ESAT-6 induced phosphorylation and DNA binding of STAT3 and this was blocked by STAT3 inhib

175 RPA complexes, unlike the telomere-specific DNA binding of Teb1 or the TEB heterotrimer of Teb1, Teb

176 eriments showed that A-ZIP53 can inhibit the DNA binding of three proteins.

177 cate that Prep1 normally acts by restricting DNA binding of transcription factors to adipogenic enhan

178 acts Notch signalling activity by inhibiting DNA-binding of Su(H), potentially affecting both activat

179 that these properties are due to nonspecific DNA binding on its surface, along with a catalytic pocke

180 ing model that delineates how indiscriminate DNA-binding patterns translate into a consistent, organi

181 This analysis revealed that the DNA-binding preferences of AR and GR homodimers differ s

182 This DNA-binding probe exhibits a drastically short lifetime

183 that the interactions unfavorable for duplex DNA binding promote DNA bending in the PAM-proximal regi

184 osphorylation of its N-terminal extension or DNA binding promotes the formation of phase-separated dr

185 phorylation enhances both Ngn3 stability and DNA binding, promoting the increased expression of targe

186 atched A86K mutation profoundly affected the DNA binding properties of the WT construct.

187 The DNA-binding properties of several disease-associated mut

188 gest that for XPA mutants exhibiting altered DNA-binding properties, a correlation exists between the

189 E. coli single strand (ss) DNA binding protein (SSB) is an essential protein that b

190 The single-stranded DNA binding protein (SSB) of Escherichia coli plays esse

191 During DNA replication, the single-stranded DNA binding protein (SSB) wraps single-stranded DNA (ssD

192 o-SMAD1/5 and the expression of inhibitor of DNA binding protein 1 (ID1) were upregulated in HCV-infe

193 Chd1 (Chromodomain Helicase DNA Binding Protein 1) is a conserved ATP-dependent chro

194 We also identified inhibitor of DNA binding protein 2 (ID2) as a key upstream regulator

195 Mutations in the human RBPs TAR-DNA binding protein 43 (TDP-43) and RNA-binding protein

196 TAR DNA binding protein 43 (TDP-43) is another protein linke

197 Tar DNA binding protein 43 (TDP-43) is the principal compone

198 sia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology.

199 monstrated to target a shared substrate, the DNA binding protein BAF, elucidating a signaling pathway

200 tingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active chromatin

201 NA) screening, we identified single-stranded DNA binding protein replication protein A (RPA) as a reg

202 cally by the RNA binding protein TDP-43 (TAR DNA binding protein-43 kDa).

203 egeneration (FTLD) with transactive response DNA-binding protein (TDP) inclusions in 40.5%, FTLD-tau

204 poral lobar degeneration (FTLD) with longTAR DNA-binding protein (TDP)-43-positive neuropil threads a

205 Here, we show that acidic nucleoplasmic DNA-binding protein 1 (And-1) forms complexes with CtIP

206 For the chromodomain helicase DNA-binding protein 1 (Chd1) remodeler, nucleosome slidi

207 We have recently identified Z-DNA-binding protein 1 (ZBP1) as an innate sensor of infl

208 Z-DNA-binding protein 1 (ZBP1), initially reported as an i

209 dapter-inducing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of

210 litated in the genomic context by UV-damaged DNA-binding protein 2 (DDB2), which is part of a multipr

211 interacted with CHD4 (chromodomain helicase DNA-binding protein 4), which is a part of the NuRD comp

212 icates a direct role of transactive-response DNA-binding protein 43 (TDP-43) in the pathology of ALS

213 Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) misfolding is implicated

214 ymptoms, mutations in the DCTN1 gene and TAR DNA-binding protein 43 (TDP-43) pathology.

215 compared to transactivation response element DNA-binding protein 43 (TDP-43) proteinopathy patients w

216 signature with numerous round, hyaline, TAR DNA-binding protein 43 (TDP-43)-positive inclusions.

217 function mutations in chromodomain helicase DNA-binding protein 7 (CHD7(LOF)) and lysine (K) methylt

218 we found that ATPases chromodomain helicase DNA-binding protein 9 (CHD9) and Brahma homologue (BRM,

219 cterize the cell-to-cell transmission of TAR DNA-binding protein and alpha-synuclein, involved in amy

220 hesis with the specificity of a programmable DNA-binding protein by using protein trans-splicing to l

221 he high-mobility group protein B1 (HMGB1), a DNA-binding protein capable of inducing secretion of TNF

222 complex, incorporating the sequence-specific DNA-binding protein Cep3 together with regulatory subuni

223 Here, we report that the damage-specific DNA-binding protein DDB2 is critical for beta-catenin-me

224 onstrated that Hop1 is a structure-selective DNA-binding protein exhibiting high affinity for the Hol

225 lification requires only the single-stranded DNA-binding protein gp32 from bacteriophage T4 and a str

226 Once deposited, mCA is bound by the methyl-DNA-binding protein MECP2 and functions in a rheostat-li

227 ral dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusion

228 nvolving nonstructural proteins, such as the DNA-binding protein P1 and the genome terminal protein (

229 starvation protein A (SspA) complex and the DNA-binding protein pathogenicity island gene regulator

230 In this paper, we present iDNAProt-ES, a DNA-binding protein prediction method that utilizes both

231 ssion yeast cells carrying a mutation in the DNA-binding protein Sap1 show defects in DNA replication

232 cluding the telomeric repeat single-stranded DNA-binding protein Teb1 and its heterotrimer partners T

233 This system provides a model for any DNA-binding protein that can be posttranslationally modi

234 EBNA1 is a sequence-specific DNA-binding protein that is consistently expressed in EB

235 E STATEMENT CCCTC-binding factor (CTCF) is a DNA-binding protein that organizes nuclear chromatin top

236 tly, it was shown that chromodomain helicase DNA-binding protein-7 (CHD7) interacts with RUNX1 and su

237 ble to any type of yeast surface expressible DNA-binding protein.

238 c helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein.

239 otential target site, which may be how other DNA binding proteins can steer selection of advantageous

240 These sequence-specific DNA binding proteins have been primarily characterized a

241 DNA binding proteins such as chromatin remodellers, tran

242 NA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generall

243 to various DNA-binding modules: full-length DNA binding proteins, zinc fingers (ZFs), transcription

244 A occupied by tandem arrays of high-affinity DNA binding proteins.

245 A (ssDNA) and interacting with several other DNA binding proteins.

246 Single-stranded DNA-binding proteins (SSBs) play a key role in genome ma

247 Open chromatin provides access to DNA-binding proteins for the correct spatiotemporal regu

248 cterium Deinococcus radiodurans contains two DNA-binding proteins from starved cells (Dps): Dps1 (DR2

249 ow that dinoflagellate nuclei have recruited DNA-binding proteins in three distinct evolutionary wave

250 DNA-binding proteins play a very important role in the s

251 specifically measuring target site search by DNA-binding proteins via intersegmental translocation.

252 e researchers to use this method to identify DNA-binding proteins.

253 that the unfavorable alignment of C-terminal DNA-binding region in solution contributes to an auto-in

254 DNA and can overcome repulsion between basic DNA binding regions of three bZIP proteins.

255 ecurrent CTCF mutation K365T, which alters a DNA binding residue, and acts as a gain-of-function muta

256 rmation between residues is indeed useful in DNA-binding residue prediction and ensemble learning can

257 rmation between residues is indeed useful in DNA-binding residue prediction.

258 y to nuclear localization, but the conserved DNA binding residues were not required.

259 nal analyses suggest that Vpr interacts with DNA-binding residues in the N-terminal HIRAN domain of H

260 dates the usefulness of PSSM-RT for encoding DNA-binding residues.

261 lambda bacteriophage was performed, and the DNA binding resulted in changes to the photoluminescent

262 an efficient pentamer algorithm by splitting DNA binding sequences into overlapping fragments along w

263 d, only single roadblocks that inhibited ORC-DNA binding showed helicase loading defects.

264 We therefore asked whether the DNA-binding signature of ERalpha differs between endomet

265 nding modes: (SSB)30 and (SSB)60, defined by DNA binding site sizes of 30 and 60 nucleotides, respect

266 ys, and we identified a specific palindromic DNA-binding site 5'-TTGATN4ATCAA-3' in these target sequ

267 nal origin sequence known to be a weaker ORC-DNA-binding site.

268 C and P363S) have a higher affinity to their DNA binding sites, leading to a xylose catabolic activat

269 ssibly due to competitive binding at similar DNA binding sites.

270 Analysis of enriched transcription factor DNA-binding sites in the promoters of differentially exp

271 The DNA-binding sites of estrogen receptor alpha (ERalpha) s

272 assess PDC's ability to interact with STAT5 DNA-binding sites.

273 ction for epistasis between mutations across DNA-binding sites.

274 ial possibilities in terms of trimerization, DNA binding specificities, and transcriptional regulatio

275 Y and its paralogue WelNDLY exhibit distinct DNA-binding specificities, and that, unlike WelNDLY, Wel

276 We validate the importance of DNA binding specificity for organ-specific gene regulati

277 that intrafamily protein interactions affect DNA binding specificity of floral MADS domain proteins.

278 pel-like factor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic tr

279 ow transcription factor dimerization impacts DNA-binding specificity is poorly understood.

280 cocorticoid receptor (GR), which has similar DNA-binding specificity to the androgen receptor (AR).

281 cribed here is the development of an altered DNA-binding specificity variant of Rap1 (Rap1(AS)).

282 ct4 and Oct1, a related protein with similar DNA-binding specificity.

283 directs crosstalk between co-receptors upon DNA binding, stabilizing the activation function 2 (AF2)

284 This conclusion is supported by DNA binding studies performed with different-sized subst

285 sequence, hExo1 resets without relinquishing DNA binding, suggesting a structural basis for its proce

286 , revealing TAF11/TAF13 interaction with the DNA binding surface of TBP.

287 A-AMPPNP dimerization creates a multifaceted DNA-binding surface, allowing it to preferentially bind

288 Such reptation-like motion was confined by DNA binding to high-affinity spots, suggesting a two-ste

289 to IL-15, whereas STAT5 phosphorylation and DNA binding to IL-2 receptor alpha (IL2RA) are reduced o

290 DNA binding to neutrophils' surface (s)TLR9 has been evi

291 (DBD), and ability to restore site-specific DNA binding to purified R175H-DBD in vitro.

292 ol-mediated DNA anchoring, and electrostatic DNA binding to supported lipid bilayers (SLBs) presents

293 thways and up-regulation of the inhibitor of DNA binding transcription factor.

294 ential mechanisms by which sequence-specific DNA-binding transcription factors can alter gene express

295 ystem are met by a relatively small group of DNA-binding transcription factors that work in concert t

296 sical DNA sequence motifs, sequence-specific DNA-binding transcription factors, chromatin signals, an

297 esidues in the C-terminal helix to engage in DNA binding, triggering a major reprogramming of gene ex

298 ed helix beta-hairpin), showed a decrease in DNA binding, unwinding, and annealing, as expected for a

299 d confirmed the direct role of EP in protein-DNA binding using massive sequencing data.

300 RctB contains at least three DNA binding winged-helix-turn-helix motifs, and mutation