ライフサイエンスコーパス: DNA-binding domain

1 3P) predicted to affect the highly conserved DNA binding domain.

2 tivity but requires residues in the receptor DNA binding domain.

3 denosine (G > A) mutation in the mouse MeCP2 DNA binding domain.

4 omain, a central AAA domain and a C-terminal DNA binding domain.

5 of the same sequence in FOXO3 containing the DNA binding domain.

6 ty to activate transcription when fused to a DNA binding domain.

7 al threonine residue in ATF6 upstream of its DNA binding domain.

8 lack either the canonical Asp residue or the DNA binding domain.

9 ation of specific lysine residues in the p53 DNA binding domain.

10 is at a highly conserved residue within the DNA binding domain.

11 y a central conserved region overlapping the DNA binding domain.

12 hich differs by a single arginine within the DNA binding domain.

13 the C-terminus, i.e. juxtaposed to the VirG DNA binding domain.

14 ting gene expression through their conserved DNA binding domain.

15 n was recognized as a new class of conserved DNA-binding domain.

16 homodimer as both a monomer and dimer of the DNA-binding domain.

17 erential activation to the heterologous GAL4 DNA-binding domain.

18 is an atypical nuclear receptor that lacks a DNA-binding domain.

19 utations are missense and are located in the DNA-binding domain.

20 rg399Cys, reside in the highly conserved ETS DNA-binding domain.

21 HOP2, which contains a typical winged helix DNA-binding domain.

22 on and transactivation domains but lacks the DNA-binding domain.

23 ctly phosphorylates YY1 at serine 365 in the DNA-binding domain.

24 etitive movements, which is modulated by the DNA-binding domain.

25 r high sequence conservation within the GATA DNA-binding domain.

26 e domains: an R domain, an AAA+ domain and a DNA-binding domain.

27 KstR show variability in the position of the DNA-binding domain.

28 fectors (TALEs) contain modular programmable DNA binding domains.

29 crystallography studies on the ARF1 and ARF5 DNA binding domains.

30 gnition sequence, one in each of its two AP2 DNA binding domains.

31 predictions and the addition of non-specific DNA binding domains.

32 he N-terminal oligomerization and C-terminal DNA binding domains.

33 n at least three RPA-encoded single-stranded DNA binding domains.

34 rited from the structural analogies of their DNA-binding domains.

35 and dynamics of site discrimination by their DNA-binding domains.

36 -ZFs) comprise the largest class of metazoan DNA-binding domains.

37 binding of target metals to the activity of DNA-binding domains.

38 ed nucleases designed with sequence-specific DNA-binding domains.

39 A through a recognition alpha-helix in their DNA-binding domains.

40 cooperativity between the UHRF1 histone- and DNA-binding domains.

41 es, as we show that acetylation of an ApiAP2 DNA-binding domain ablates its DNA-binding propensity.

42 We show that ARF DNA-binding domains also homodimerize to generate cooper

43 rectly, mainly through its beta-strand rich, DNA-binding domain (AML-(1-175)), with the assistance of

44 peronin TRiC (or CCT), primarily through its DNA binding domain (AML1-175).

45 re that a folding intermediate of AML1-ETO's DNA-binding domain (AML1-175) forms a stable complex wit

46 ortholog, provided that it retains an active DNA binding domain and an intact lysine residue at posit

47 1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS

48 gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mech

49 onal interaction of the linker both with the DNA binding domain and with the SH2 domain, and (ii) the

50 ription factor families contain very similar DNA binding domains and hence have the potential to bind

51 no acid subunits, folding into an N-terminal DNA-binding domain and a C-terminal dimerization domain.

52 ealed a bipartite structure with a separable DNA-binding domain and a non-specific cleavage domain).

53 ce-dependent effects do not rely on the Chd1 DNA-binding domain and are not due to differences in nuc

54 th suppression depends on the CHES1 forkhead DNA-binding domain and correlates with the nuclear local

55 ces conformational changes in RAG-1 within a DNA-binding domain and in the ZnH2 domain, which acts as

56 Whereas most mutations in p53 occur in the DNA-binding domain and lead to its functional inactivati

57 rototype foamy virus featuring an additional DNA-binding domain and longer interdomain linkers, the a

58 es a conserved high-mobility group (HMG) box DNA-binding domain and poorly conserved regions outside

59 ational changes link the C terminus with the DNA-binding domain and provide a biophysical rationale f

60 the linker domain of STAT1 that connect the DNA-binding domain and SH2 domain can prevent transcript

61 d that missense mutations in the zinc-finger DNA-binding domain and the putative ligand-binding domai

62 zation helices in the C-terminal domain, the DNA-binding domains and a consensus DNA-binding site of

63 obabilistic framework that not only exploits DNA-binding domains and specificities, but also integrat

64 with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a u

65 mportant feature of the database is that all DNA-binding domains and their binding sites are fully an

66 nges the relative spatial disposition of the DNA-binding domains and thereby disrupt the protein-DNA

67 rectly regulate the function of the adjacent DNA binding domain, and this interaction is further modu

68 es of CarD: the RNAP interaction domain, the DNA-binding domain, and a conserved tryptophan residue.

69 ered within the portion of REST encoding the DNA-binding domain, and functional analyses showed that

70 sequence showed no relationship to any known DNA-binding domain, and the basis for their ability to r

71 apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria

72 rators, ORE1, ORX1, ORA1, and ORR3, the AraR-DNA binding domain (AraR-DBD) as well as full-length Ara

73 yet are considered undruggable because their DNA binding domains are composed of two extended alpha h

74 sed to Cys2-His2 zinc-finger or TAL effector DNA-binding domains are a class of reagents capable of a

75 presented here revealed that the Rgg protein DNA-binding domains are covalently linked across their d

76 We demonstrated that, even though their DNA-binding domains are extremely similar, WelLFY and it

77 mmunications between the tetramerization and DNA-binding domains are noted.

78 s AldR (Rv2779c) showing that the N-terminal DNA-binding domains are swapped, forming a dimer, and fo

79 discrimination by ETS proteins because their DNA-binding domains are the most divergent in sequence,

80 mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutual

81 Our data identify the DNA-binding domain as an ARF dimerization domain, sugges

82 , we solved the structure of the human LRH-1 DNA-binding domain bound to the same element.

83 isoform, TEAD4-S, which lacks an N-terminal DNA-binding domain, but maintains YAP interaction domain

84 with the DNA via a relatively novel type of DNA-binding domain, called the LytTR domain, which mainl

85 Nucleases containing programmable DNA-binding domains can alter the genomes of model organ

86 th an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both source and destin

87 n identified two domains, one a winged helix DNA-binding domain common for transcription factors, and

88 Crystal structures of the LiaR DNA binding domain complexed to the putative consensus s

89 tivity, only DmSNAP190 possesses a canonical DNA binding domain consisting of 4.5 tandem Myb repeats

90 In the apo state, the DNA-binding domain contacts the edge of the nucleosome w

91 f is a gene for a ubiquitously expressed Ets DNA-binding domain-containing transcriptional repressor.

92 This function is executed by the C-terminal DNA binding domain (CTD) which binds single-stranded (ss

93 While the role of the central core DNA binding domain (DBD) of p53 in site-specific DNA bin

94 ere we present two crystal structures of the DNA binding domain (DBD) of the yeast XPA homolog Rad14

95 was created by interrupting the gene at the DNA binding domain (DBD) with a neocassette.

96 ity, ability to restore zinc to purified p53 DNA binding domain (DBD), and ability to restore site-sp

97 , which contains a proline-rich region and a DNA binding domain (DBD), is auto-cleaved from the ER me

98 an N terminal winged helix-turn-helix (wHTH) DNA binding domain (DBD).

99 ntuitively, high-affinity DNA binding of RPA DNA-binding domain (DBD) A and DBD-B near the fork junct

100 pecific motifs on DNA (C/TAAACA) through its DNA-binding domain (DBD) and activates proliferation- an

101 lved the X-ray crystal structure of an EBNA1 DNA-binding domain (DBD) and discovered a novel hexameri

102 homology 2 domain (SH2), linker domain (LD), DNA-binding domain (DBD) and the coiled-coil domain.

103 f this protein; a number of mutations in the DNA-binding domain (DBD) are associated with XP disease.

104 The RARbeta ligand-binding domain (LBD) and DNA-binding domain (DBD) are physically connected to fos

105 alpha (RXRalpha), and phosphorylation of the DNA-binding domain (DBD) at Thr-38 in CAR regulates this

106 eport the crystal structure of the KSHV LANA DNA-binding domain (DBD) in complex with its high-affini

107 property of the glucocorticoid receptor (GR) DNA-binding domain (DBD) not shared by other members of

108 rofiles reveal that the direct fusion of the DNA-binding domain (DBD) of Fkh1 to Dbf4 restores the Fk

109 The DNA-binding domain (DBD) of Rap1 forms a high affinity c

110 Targeting the DNA-binding domain (DBD) of STAT3, however, has been avo

111 ich motifs located both in the AD and in the DNA-binding domain (DBD) of the related ETS factor ETV4

112 Pot1 contains a dual OB-fold DNA-binding domain (DBD) that fully confers its high aff

113 Broadly sampling DNA-binding domain (DBD) types from multiple eukaryotic

114 This anchor connects the DNA-binding domain (DBD) with the ligand-binding domain

115 -canonical interaction with ER-alpha via its DNA-binding domain (DBD).

116 us and interact with genes via its conserved DNA-binding domain (DBD).

117 m of the transcription initiation site via a DNA-binding domain (DBD).

118 In our proposed mechanism, DNA-binding-domains (DBD) of R insert in major grooves o

119 updated the structural annotation of the TF DNA binding domains (DBDs) following a published hierarc

120 te cell-fate changes, using diverse types of DNA binding domains (DBDs).

121 s) operate by the combined activity of their DNA-binding domains (DBDs) and effector domains (EDs) en

122 ivo Despite structural similarities in their DNA-binding domains (DBDs), LANA homologs from Kaposi sa

123 ts1 and Ets2, rather than differences in the DNA binding domains, determine whether the proteins are

124 The DNA-binding domain dimerization interface observed in ou

125 e 614 in the second zinc finger module of AR-DNA binding domain diminished the effects of H(2)S on AR

126 lustered within the regions of TP53 encoding DNA-binding domains, essential for DNA contact and struc

127 chanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however

128 ding protein 2 (CHD2) mutant affected in its DNA-binding domain exhibits defective association with a

129 e dimerization domain overlaps with both the DNA binding domains, explaining how changes in the dimer

130 regions not only across TFs, but also across DNA-binding domain families with distinct structural fol

131 allows prediction of binding regions across DNA-binding domain families, it is TF agnostic and likel

132 e-nucleotide interactions of different known DNA-binding domain families.

133 ously described for other members of the XRE DNA-binding domain family, but the presence of an interm

134 Devoid of a DNA-binding domain, FHL2 is a transcriptional cofactor t

135 The binding affinity of the mouse Klf4 DNA-binding domain for methylated DNA is only slightly s

136 protein-protein interaction and a conserved DNA-binding domain for parS binding.

137 the reduced affinity of the Mos1 transposase DNA-binding domain for the left IR as compared with the

138 gests that MibR, which contains a C-terminal DNA-binding domain found in the LuxR family of transcrip

139 The homeobox encodes a DNA-binding domain found in transcription factors regula

140 IHSF115 bound to an isolated HSF1 DNA-binding domain fragment.

141 results demonstrate the possibility of using DNA binding domains from bacterial response regulators a

142 reports on the ability of Rap1-heterologous DNA-binding domain fusion proteins to serve as chimeric

143 artificially targeting Fob1 or Sir2 as Gal4 DNA binding domain fusions.

144 that a single amino acid substitution in the DNA-binding domain gave rise to the domestication of 'Mi

145 Transcription factors containing DNA binding domains generally regulate transcription by

146 Mouse Klf4 DNA binding domain has roughly equal affinity for methyl

147 es in alpha-helix 7 and alpha-helix 8 of the DNA binding domain (helix-turn-helix) of RegA directly i

148 Distinct folds associated with predicted DNA-binding domains (HTH1 and HTH2) and phosphoenolpyruv

149 structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its ow

150 Comparison of the positioning of the DNA binding domains in PhnF with that in homologous prot

151 The two separate non-overlapping DNA binding domains in the ERCC1-XPF heterodimer jointly

152 affinity ssDNA-binding by RPA depends on two DNA binding domains in the large subunit of RPA.

153 l development and demonstrate a role for non-DNA binding domains in this process.

154 A crystal structure of the LIN54 DNA-binding domain in complex with a CHR sequence reveal

155 We crystallized the human CTCF DNA-binding domain in complex with a known CTCF-binding

156 we present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0.

157 that conditional inactivation of the Ikaros DNA-binding domain in early pre-B cells arrested their d

158 the most frequently found sequence-specific DNA-binding domain in eukaryotic proteins.

159 We identify a new DNA-binding domain in the large Cac1 subunit of CAF1, wh

160 is inhibited by the B isoform of Fru, whose DNA binding domain interacts with a short region of an L

161 e p53 protein (both full-length and isolated DNA-binding domain) into amyloid-type fibrils in vitro.

162 We show here that while the central DNA binding domain is essential for anchoring at parS, t

163 A functional DNA binding domain is essential for FOXM1 chromatin recr

164 SOX9 affinity is through NF-Y and that SOX9 DNA binding domain is not necessary for SOX9 affinity to

165 o the operator site at which the second LacI DNA-binding domain is bound.

166 The orientation of the DNA-binding domain is mediated by sequences in the N-ter

167 ragment, and that the region adjacent to the DNA-binding domain is pivotal to its homo-trimerization.

168 ation domains, amide exchange throughout the DNA-binding domains is decreased as if the entire domain

169 ID4, a transcriptional regulator lacking a DNA binding domain, is highly up-regulated in CEACAM1-tr

170 , whose members share structurally conserved DNA-binding domains, is variably sensitive to methylatio

171 ructurally, Fox proteins feature a conserved DNA-binding domain known as forkhead.

172 dge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-lik

173 y only a minor role in inhibition, while the DNA binding domain makes a greater contribution.

174 S3, a MYB transcription factor with a single DNA-binding domain, mediates sugar signaling in rice.

175 Heterozygous human NKX2-5 homeodomain (DNA-binding domain) missense mutations are highly penetr

176 r, in cells stably expressing a PR-A or PR-B DNA-binding domain mutant (PRmDBD), P4-mediated transrep

177 ifferent AP-1 consensus sequences, GR and MR DNA-binding domain mutants, and siRNA knockdown or overe

178 A DNA-binding domain mutation (p.G418_E445) in Stat4 (Sign

179 males or heterozygous males with an ERalpha DNA-binding domain mutation knocked in (WT/KI) to produc

180 DNA-binding domain mutations that eliminated the ability

181 In addition to their DNA-binding domains, MYC proteins carry five regions of

182 A novel classification of EBNA1 DNA binding domains, named QCIGP, results from phylogeny

183 truncated RgfA protein lacks the C-terminal DNA binding domain necessary for promoter binding and ge

184 ption factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in humans a

185 features of the BRC repeats tethered to the DNA binding domain of BRCA2.

186 The isolated DNA binding domain of Cdc13 is less effective at shieldi

187 nctions is dependent on joint binding to the DNA binding domain of ERCC1 and XPF.

188 peptides that interact specifically with the DNA binding domain of ERG.

189 tion assay identified point mutations in the DNA binding domain of FOXM1 that inhibit binding to a FK

190 The DNA binding domain of FOXO1 is essential for these funct

191 Two cysteines in the DNA binding domain of LasR do form a disulfide bond when

192 ordered C-terminal region of Artemis and the DNA binding domain of Ligase IV.

193 MANF interacted with the DNA binding domain of p65 through its C-terminal SAP-lik

194 repeats homologous to the Myb repeats in the DNA binding domain of the Myb oncoprotein.

195 We also report that deletion of the DNA binding domain of the S. aureus BirA results in loss

196 By fusing the Chd1 remodeler to the DNA binding domain of the Saccharomyces cerevisiae Ume6

197 Fusion of the enzyme to a site-specific DNA binding domain of transcription activator-like effec

198 d glutamic acid residue located in the basic DNA binding domain of TWIST1, in two subjects with front

199 ccumulated results strongly suggest that the DNA binding domains of both proteins interact to facilit

200 X-ray crystallography of the DNA binding domains of normal WT1, Q369R and Q369H in co

201 r, confirmed that it binds to the N-terminal DNA-binding domain of AbrB, and have provided an initial

202 t occurred some 500 million years ago in the DNA-binding domain of an ancient steroid hormone recepto

203 Consistently, we found that the DNA-binding domain of CENP-B specifically interacted wit

204 was dependent on Rok and independent of the DNA-binding domain of DnaA.

205 The eponymous DNA-binding domain of ETS (E26 transformation-specific)

206 tryptophan substitution in the conserved ETS DNA-binding domain of FLI1.

207 ional structure of the DNA-binding site, the DNA-binding domain of GR and the quaternary structure of

208 status of the Lys 80 residue located in the DNA-binding domain of HSF1 as a critical factor in modul

209 Comparative modeling of the DNA-binding domain of human HSF1 facilitated the predict

210 and a 4.7-Mb multigene deletion involved the DNA-binding domain of IKAROS.

211 DNA-binding domain of NonO is critical for rhodopsin pro

212 a recurrent mutation of threonine 223 in the DNA-binding domain of OCT2.

213 ions, all resulting in coding changes in the DNA-binding domain of P53.

214 the allosteric interaction of MDM2 with the DNA-binding domain of p53; and (iv) it stimulates a nove

215 ough the NTR is generally considered the key DNA-binding domain of PARP-2, we report here that all th

216 and meiotic recombination, we humanized the DNA-binding domain of PRDM9 in C57BL/6 mice.

217 ions affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of

218 Daxx directly binds to the DNA-binding domain of Slug, impeding histone deacetylase

219 The N-terminal region of DNA-binding domain of STAT3 is responsible for the STAT3

220 apped predominantly to the beta-strand rich, DNA-binding domain of Stat3.

221 rs141331848 (c.1337C>T, p.Thr446Ile) in the DNA-binding domain of STAT4.

222 demonstrated that replacement of zinc in the DNA-binding domain of the estrogen receptor (ER) with co

223 -terminal ligand binding domain, but not the DNA-binding domain of the GR.

224 ze a new unlooped state in which the unbound DNA-binding domain of the LacI protein interacts nonspec

225 Deletion of the DNA-binding domain of the transcription factor Ikaros ge

226 poptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and p

227 ription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable

228 The DNA-binding domains of ETS proteins (ETS domains) are hi

229 The isolated DNA-binding domains of IFI16 engage dsDNA without formin

230 plexes defined interactions with the SH2 and DNA-binding domains of STAT3.

231 IP-CoA induces conformational changes of the DNA-binding domains of the dimer that preclude their pro

232 This flexibility allows the DNA-binding domains of the dimer to straddle the operato

233 ctivity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins.

234 able to facilitate contacts between the core DNA-binding domains of the tetramer.

235 he mechanisms by which missense mutations in DNA-binding domains of transcription factors can lead to

236 investigated the response of the zinc finger DNA-binding domains of transcription factors early growt

237 l class of genetic tool based on the modular DNA-binding domains of Xanthomonas TAL proteins, which e

238 ely, on nucleosomal DNA and pack against the DNA-binding domain on DNA exiting the nucleosome.

239 Although PfAP2-I contains three AP2 DNA-binding domains, only one is required for binding of

240 ntly augmented and that its highly conserved DNA binding domain or the human homolog PC4 is sufficien

241 m that is affected by either mutation in the DNA-binding domain or dysregulation by overexpression of

242 effectors dependent on either the yeast Gal4 DNA-binding domain or that of VirG.

243 3, alpha-Synuclein, N-terminal MDM2, and p53 DNA binding domain) or denatured due to solvent conditio

244 al activity can be tuned by mutations in its DNA-binding domain, or silenced by Gal80 when fused to t

245 t in FOXE3 with an altered amino acid in the DNA-binding domain (p.Asp153His) that segregated with di

246 tochrome c, the tumor suppressor protein p53 DNA binding domain (p53 DBD), and the N-terminus of the

247 Here we show that by fusing a programmable DNA-binding domain (pDBD) to Cas9 and attenuating Cas9's

248 the androgen receptor, which encompasses the DNA binding domain plus hinge region.

249 C-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expressio

250 ealed that Redbeta consists of an N-terminal DNA binding domain, residues 1-177, and a flexible C-ter

251 C-terminal region, which contains a putative DNA-binding domain, selectively senses double-stranded D

252 A and Fur as case examples, we also show how DNA-binding domain sequence similarity can yield confoun

253 Mutation of the Fli-1 DNA binding domain significantly reduces transactivation

254 n with transcription activator-like effector DNA binding domains significantly enhances targeted modi

255 , an AtDDF2-specific substitution within the DNA-binding domain significantly reduces binding affinit

256 ly, we predict motifs for many TFs that have DNA-binding domains similar to those already characteriz

257 that the Rap1 C terminus interacts with the DNA-binding domain, suggesting a complex network of inte

258 nt line harboring a point mutation in the GR DNA-binding domain, suggesting a nontranscriptional rout

259 odular arrangement for PriA in which several DNA-binding domains surround its helicase core in a mann

260 tive TF genes previously predicted using the DNA-binding domain TF database, and examine their in vit

261 aracterized by the presence of an N-terminal DNA binding domain that functions in transcriptional reg

262 by artificial fusion of Mediator subunits to DNA binding domains that bind to their promoters has bee

263 rated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and lea

264 each other and demonstrate a position of the DNA-binding domain that is unfavorable for DNA binding.

265 n its dimerization with MAX, which creates a DNA-binding domain that recognizes specific sequences in

266 ween the LOV and basic region leucine zipper DNA-binding domain that together with LOV dimerization r

267 oduction of a fragment within its N-terminal DNA-binding domain (the A-box) that signals through the

268 polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) c

269 ription factor, Z3EV (a fusion of the Zif268 DNA binding domain, the ligand binding domain of the hum

270 As Emc lacks a basic DNA-binding domain, the Emc-Da heterodimer cannot bind t

271 ETS TFs share a DNA-binding domain, the ETS domain.

272 that, despite deep sequence conservation in DNA-binding domains, the functional requirement for thes

273 a way that when DNA binds to the N-terminal DNA-binding domains, the nuclear localization signal bec

274 Foxo1 forms a complex with RORgammat via its DNA binding domain to inhibit RORgammat activity.

275 Assembly of zinc finger DNA-binding domain to a DNA-cleavage domain enables the

276 chers, ranging from evolutionary analysis of DNA-binding domains to predictive function modeling.

277 de linking the amino acid sequences of their DNA-binding domains to TALEN nucleotide targets.

278 roperties, IL-10-based modeling predicts two DNA-binding domains, two amphipathic helices, and an in-

279 ~90 eukaryotic TFs belonging to 22 different DNA-binding domain types.

280 imensional structure of the highly conserved DNA-binding domain using solution NMR spectroscopy, the

281 the intrinsic specificities of the AR and GR DNA-binding domains using a refined version of SELEX-seq

282 ty proportionately, indicating that the VirG DNA binding domain was functional in plants.

283 The structure of the LANA DNA binding domain was recently solved, revealing a posi

284 targeting strategy: a Dlg4/PSD95 zinc finger DNA-binding domain was engineered and fused to effector

285 Although its DNA-binding domain was intact, chromatin immunoprecipita

286 BLIMP1's DNA-binding domain was required for reactivation, but BL

287 We also show that the N-terminal DNA binding domain, which is required for both DNA bindi

288 ly controlled by two regulatory domains: the DNA-binding domain, which interferes with sliding when i

289 TALEs possess a highly repetitive DNA-binding domain, which is notoriously difficult to se

290 cific interactions between the oncoprotein's DNA-binding domain, which may be targeted for therapeuti

291 pendent motions of Omega-loops and PPARgamma-DNA binding domain with contacts susceptible to conforma

292 This shows that interaction of the FOXM1 DNA binding domain with target DNA is essential for recr

293 ed C-terminal linker (IDL) that connects the DNA binding domain with the 9 amino acid C-terminal acid

294 n factor directing reprogramming, contains a DNA binding domain with three consecutive C2H2 zinc fing

295 nd requires substantial reorientation of the DNA-binding domain with respect to the ATPase domains.

296 hares a highly conserved high mobility group DNA-binding domain with the other TOX members.

297 Replacement of their native DNA-binding domains with custom-designed Cys(2)-His(2) z

298 producing a p.Arg418Gly substitution in the DNA-binding domain, with alternative splicing and exon s

299 mmetric dynamics are illustrated in the four DNA-binding domains, with loop L1 switching from inward

300 Targeting of an artificial zinc finger DNA-binding domain (ZF-DBD) to the HS2 tandem MARE cause