ライフサイエンスコーパス: DNA-dependent protein kinase

1 ion with the Ku-70/80 regulatory subunits of DNA-dependent protein kinase.

2 sia mutated (ATM), ATM and Rad3-related, and DNA-dependent protein kinase.

3 (PIKK) family, which includes ATM, ATR, and DNA-dependent protein kinase.

4 ht, assigning new nonrepair functions to the DNA-dependent protein kinase.

5 e been identified, including ATM/ATR and the DNA-dependent protein kinase.

6 bind DNA double-strand breaks and activates DNA-dependent protein kinase.

7 specific enzymatic machinery, exemplified by DNA-dependent protein kinase.

8 ylation of sites within the ABCDE cluster of DNA-dependent protein kinase.

9 hosphorylation events, primarily mediated by DNA-dependent protein kinase.

10 the DNA-binding subunits, Ku70 and Ku80, of DNA-dependent protein kinase.

11 These findings suggest that DNA-dependent protein kinase activity and gap junction e

12 Notably, inhibiting DNA-dependent protein kinase activity reverses the genom

13 rthermore, we document a complete deficit in DNA-dependent protein kinase activity that can be explai

14 DLX4 interacted with Ku proteins, stimulated DNA-dependent protein kinase activity, and increased err

15 paired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequentl

16 of a deficiency in the catalytic subunit of DNA-dependent protein kinase, an enzyme involved in the

17 Such removal was completely dependent on DNA-dependent protein kinase and ATP and was largely dep

18 l modification, including phosphorylation by DNA-dependent protein kinase and cleavage by caspase 3.

19 he double-strand break repair (DSBR) protein DNA-dependent protein kinase and cooperates with binding

20 mal extracts were indistinguishable, as were DNA-dependent protein kinase and DNA end binding activit

21 reas D-NHEJ depends on the activities of the DNA-dependent protein kinase and DNA ligase IV/XRCC4, co

22 This process, which was DNA-dependent protein kinase and Ku dependent, may in pa

23 -telangiectasia mutated (ATM) kinase and the DNA-dependent protein kinase and was associated with pro

24 H2AX, ataxia telangiectasia mutated protein, DNA-dependent protein kinase, and CHK2 after IR, suggest

25 ling, including poly(ADP-ribose) polymerase, DNA-dependent protein kinase, and Mi-2.

26 CAF-1 was a substrate for DNA-dependent protein kinase, and the 14-3-3 interaction

27 ciated with the KU70/80 complex, part of the DNA-dependent protein kinase, and the phosphoserine/thre

28 T- and Rad9-related protein kinases, but not DNA-dependent protein kinase, appeared to play a redunda

29 elangiectasia cells, indicating that ATR and DNA-dependent protein kinase are the kinases primarily i

30 Ku protein and the catalytic subunit of the DNA-dependent protein kinase, are known targets of autoa

31 copy, we identified the catalytic subunit of DNA-dependent protein kinase as a CRY-interacting protei

32 rs within these signalling cascades, such as DNA-dependent protein kinase, ataxia-telangiectasia muta

33 the phosphatidylinositol 3-kinases, DNA-PK (DNA-dependent protein kinase), ATM (ataxia telangiectasi

34 Phosphorylation of core-forming residues by DNA-dependent protein kinase blocks binding of soluble F

35 that, in contrast to deoxyribonucleic acid (DNA)-dependent protein kinase catalytic subunit (DNA-PKc

36 e DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(C

37 The DNA-dependent protein kinase catalytic subunit (DNA-PK(C

38 reak signaling/repair proteins ATM, ATR, and DNA-dependent protein kinase catalytic subunit (DNA-PK(c

39 MOF was found to be associated with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

40 oth wild-type mice and mice deficient in the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

41 vated activation of a key DSB repair enzyme, DNA-dependent protein kinase catalytic subunit (DNA-PKcs

42 itiated by DSB detection by Ku70/80 (Ku) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

43 ases ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

44 y recruitment of core NHEJ factors including DNA-dependent protein kinase catalytic subunit (DNA-PKcs

45 We find that DNA-dependent Protein Kinase catalytic subunit (DNA-PKcs

46 Deficiency in both ATM and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

47 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs

48 nds and facilitating an interaction with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

49 ated in V3 CHO cells, which are deficient in DNA-dependent protein kinase catalytic subunit (DNA-PKcs

50 ted (ATM), ATM- and Rad3-related for HR, and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

51 pins at double-strand breaks is processed by DNA-dependent protein kinase catalytic subunit (DNA-PKcs

52 Since DNA-dependent protein kinase catalytic subunit (DNA-PKcs

53 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs

54 model, we tested whether the NHEJ component DNA-dependent protein kinase catalytic subunit (DNA-PKcs

55 Importantly, DNA-dependent protein kinase catalytic subunit (DNA-PKcs

56 Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

57 The kinase activity of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

58 w in this study that AID associates with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

59 Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

60 ia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

61 res the XRCC4-ligase IV complex, Ku, and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

62 ical experiments, we find that Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

63 y variable fragment (scFv) that binds to the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

64 RNF144A, an E3 ubiquitin ligase for DNA-dependent protein kinase catalytic subunit (DNA-PKcs

65 y with SCID mice, which are defective in the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

66 nRNP-A1 in telomere protection also involves DNA-dependent protein kinase catalytic subunit (DNA-PKcs

67 Ku then recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

68 PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs

69 Artemis, a protein which, when coupled with DNA-dependent protein kinase catalytic subunit (DNA-PKcs

70 n in the expression of the catalytic subunit DNA-dependent protein kinase catalytic subunit (DNA-PKcs

71 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs

72 mologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs

73 DNA-dependent protein kinase catalytic subunit (DNA-PKcs

74 ase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

75 ATM and DNA-dependent protein kinase catalytic subunit (DNA-PKcs

76 irpins before joining by C-NHEJ requires the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

77 The DNA-dependent protein kinase catalytic subunit (DNA-PKcs

78 DNA-dependent protein kinase catalytic subunit (DNA-PKcs

79 Our previous study suggested that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

80 ith purified proteins in vitro, we show that DNA-dependent protein kinase catalytic subunit (DNA-PKcs

81 DNA-dependent protein kinase catalytic subunit (DNA-PKcs

82 hairpin opening activity is dependent on the DNA-dependent protein kinase catalytic subunit (DNA-PKcs

83 DNA-dependent protein kinase catalytic subunit (DNA-PKcs

84 he radiation-induced phosphorylation of both DNA-dependent protein kinase catalytic subunit (DNA-PKcs

85 DNA-dependent protein kinase catalytic subunit (DNA-PKcs

86 Additionally, our studies identify DNA-dependent protein kinase catalytic subunit (DNAPKcs,

87 gation of the hypomorphic BALB/c alleles for DNA-dependent protein kinase catalytic subunit (Prkdc) a

88 ne complexes identified a complex containing DNA-dependent protein kinase catalytic subunit [DNA-PK(c

89 al deoxynucleotide transferase, Artemis, and DNA-dependent protein kinase catalytic subunit activity

90 ene is shown to be associated with decreased DNA-dependent protein kinase catalytic subunit activity

91 H2AX Ser-139 can also be phosphorylated by DNA-dependent protein kinase catalytic subunit and ataxi

92 All DNA ends are cut when both the DNA-dependent protein kinase catalytic subunit and Ku ac

93 rtemis-P70 mutant protein interacts with the DNA-dependent protein kinase catalytic subunit and retai

94 omologous end joining factors, including the DNA-dependent protein kinase catalytic subunit and the X

95 is association occurred independently of the DNA-dependent protein kinase catalytic subunit and was h

96 e DNA damage, KLF8 was phosphorylated by the DNA-dependent protein kinase catalytic subunit and, subs

97 a mutated (ATM), ATM and Rad3 related (ATR), DNA-dependent protein kinase catalytic subunit ataxia (D

98 H2AX and RAD51 foci, and elevated numbers of DNA-dependent protein kinase catalytic subunit foci, sug

99 s resection, while depletion of 53BP1, Ku or DNA-dependent protein kinase catalytic subunit leads to

100 volves the ataxia telangiectasia mutated and DNA-dependent protein kinase catalytic subunit serine/th

101 es, and our data indicate that the DNA-PKcs (DNA-dependent protein kinase catalytic subunit) PRD is i

102 The kinase activity of DNA-PKcs (the DNA-dependent protein kinase catalytic subunit) toward h

103 angiectasia and Rad3 related), and DNA-PKcs (DNA-dependent protein kinase catalytic subunit), are the

104 ), ATR (ATM and Rad3 related), and DNA-PKcs (DNA-dependent protein kinase catalytic subunit).

105 Ku, DNA-dependent protein kinase catalytic subunit, and XRCC

106 ch depends upon the interaction of KLF8 with DNA-dependent protein kinase catalytic subunit, PIASs, a

107 oding region of Prkdc, the gene encoding the DNA-dependent protein kinase catalytic subunit, which is

108 in deficiencies of NHEJ factors ARTEMIS and DNA-dependent protein kinase catalytic subunit, with def

109 ors involved in NHEJ in mammals (Ku70, Ku80, DNA-dependent protein kinase catalytic subunit, Xrcc4, D

110 Here, the NHEJ proteins Ku, DNA-dependent protein kinase catalytic subunit, XRCC4/Li

111 hly deleted joins consistently obtained from DNA-dependent protein kinase catalytic subunit-deficient

112 ion requires the Ku70/80 heterodimer and the DNA-dependent protein kinase catalytic subunit.

113 say development for 83 potential SNPs in the DNA-dependent protein kinase catalytic subunit.

114 normal cells, regardless of the presence of DNA-dependent protein kinase catalytic subunit.

115 endent kinetics of the NHEJ factors Ku80 and DNA-dependent protein kinase catalytic subunits (DNA-PKc

116 Ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunits (DNA-PKc

117 efficiency by functioning in a complex with DNA-dependent protein kinase, catalytic subunit (DNA-PKc

118 asma membrane and interacts with cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKc

119 tasia mutated activation and accumulation of DNA-dependent protein kinase, catalytic subunit pS2056 f

120 low SCE was reversed by inhibiting DNA-PKcs (DNA-dependent protein kinase, catalytic subunit).

121 assays and to the up-regulation of Ku70 and DNA-dependent protein kinase, catalytic subunit, essenti

122 both rearranged and germline Dbeta2 sites in DNA-dependent protein kinase, catalytic subunit-competen

123 nally primed 5'Dbeta2 promoter activity in a DNA-dependent protein kinase, catalytic subunit-dependen

124 y the kinase function of the Ku70, Ku80, and DNA-dependent protein kinase complex and is conveyed to

125 heterodimeric DNA end-binding subunit of the DNA-dependent protein kinase complex, is nevertheless co

126 A ligase IV, Artemis, and Ku80 components in DNA-dependent protein kinase complex.

127 We suggest that the SCID DNA-dependent protein kinase deficiency not only reduces

128 d) deficient cells and markedly decreased in DNA-dependent protein kinase-deficient cells but is not

129 ion for the selective repair defects seen in DNA-dependent protein kinase-deficient mutants.

130 (ataxia telangiectasia mutated)- and DNAPK (DNA-dependent protein kinase)-dependent manner in the ab

131 telangiectasia and Rad3-related protein, and DNA-dependent protein kinase did not influence ligand ex

132 res DNA-PK(cs), the catalytic subunit of the DNA-dependent protein kinase DNA-PK.

133 ated PKs, including the catalytic subunit of DNA-dependent protein kinase (DNA-PK(CS)) and ATM, sensi

134 ily, which includes the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)) and ATR [2].

135 The catalytic subunit of DNA-dependent protein kinase (DNA-PK(CS)) is required fo

136 When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)), the recently

137 possessing a functional catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)).

138 stronger inhibition had no relationship with DNA-dependent protein kinase (DNA-PK) activity but corre

139 e counterparts, which has no relationship to DNA-dependent protein kinase (DNA-PK) activity but corre

140 n of telomeric repeat binding factor TRF2 or DNA-dependent protein kinase (DNA-PK) activity causes en

141 ld gel electrophoresis and 6-10-fold reduced DNA-dependent protein kinase (DNA-PK) activity in vitro

142 ily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activity, a critic

143 We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecu

144 n and DPYD repression by p53 is dependent on DNA-dependent protein kinase (DNA-PK) and Ataxia telangi

145 e identified the DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangi

146 Here, we report that the DNA-dependent protein kinase (DNA-PK) and p53 are able t

147 70-Ku80 complex is the regulatory subunit of DNA-dependent protein kinase (DNA-PK) and plays an essen

148 DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribo

149 The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribos

150 pair of radiation-damaged DNA, including the DNA-dependent protein kinase (DNA-PK) and the Ku, Artemi

151 ts are consistent with previous reports that DNA-dependent protein kinase (DNA-PK) and the nonhomolog

152 ly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved i

153 y cross-complementation group 4 (XRCC4), and DNA-dependent protein kinase (DNA-PK) are essential mamm

154 Here we identify DNA-dependent protein kinase (DNA-PK) as a DNA sensor th

155 ially regulate FoxA2 activity, we identified DNA-dependent protein kinase (DNA-PK) as a FoxA2-associa

156 DNA-dependent protein kinase (DNA-PK) becomes activated

157 xia-telangiectasia mutated protein (ATM) and DNA-dependent protein kinase (DNA-PK) but not ATM- and R

158 Importantly, inactivation of DNA-dependent protein kinase (DNA-PK) by wortmannin gene

159 e repair, Ku binds DNA ends and recruits the DNA-dependent protein kinase (DNA-PK) catalytic subunit

160 tization in NK314-treated cells deficient in DNA-dependent protein kinase (DNA-PK) catalytic subunit,

161 tro by fractions from cells with a defective DNA-dependent protein kinase (DNA-PK) catalytic subunit.

162 Further, the association of TRBP with the DNA-dependent protein kinase (DNA-PK) complex and DNA-in

163 roscopy analysis, we identified the trimeric DNA-dependent protein kinase (DNA-PK) complex as the maj

164 spectrometric protein sequencing revealed a DNA-dependent protein kinase (DNA-PK) complex including

165 The DNA-dependent protein kinase (DNA-PK) complex is a serin

166 The DNA-dependent protein kinase (DNA-PK) complex, which is

167 air of DSBs is predominantly mediated by the DNA-dependent protein kinase (DNA-PK) complex.

168 In directly irradiated cells, ATR, ATM, and DNA-dependent protein kinase (DNA-PK) deficiency resulte

169 report the involvement of HMGA2 in impairing DNA-dependent protein kinase (DNA-PK) during the nonhomo

170 ified several polypeptides that constitute a DNA-dependent protein kinase (DNA-PK) enzyme complex, a

171 DNA ligase IV (Lig4) and the DNA-dependent protein kinase (DNA-PK) function in nonhom

172 During NHEJ, the DNA-dependent protein kinase (DNA-PK) functions as a "ga

173 In vitro phosphorylation of IGFBP-3 by DNA-dependent protein kinase (DNA-PK) has been reported

174 ure-activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined

175 nositol 3-kinase-like kinases, including the DNA-dependent protein kinase (DNA-PK) in particular.

176 NP-U), is phosphorylated on serine 59 by the DNA-dependent protein kinase (DNA-PK) in response to DNA

177 the nonhomologous end-joining (NHEJ) protein DNA-dependent protein kinase (DNA-PK) in the effective e

178 The DNA-dependent protein kinase (DNA-PK) inhibitor, NU7741,

179 Here we demonstrate that DNA-dependent protein kinase (DNA-PK) is a member of the

180 DNA-dependent protein kinase (DNA-PK) is a serine/threon

181 DNA-dependent protein kinase (DNA-PK) is an essential co

182 DNA-dependent protein kinase (DNA-PK) is critical for NH

183 We reported that DNA-dependent protein kinase (DNA-PK) is critical for th

184 The DNA-dependent protein kinase (DNA-PK) is one of the cent

185 The DNA-dependent protein kinase (DNA-PK) is the most abunda

186 DNA-dependent protein kinase (DNA-PK) is thought to be i

187 the Ataxia Telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) kinases.

188 There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signa

189 DNA-dependent protein kinase (DNA-PK) mediates double-st

190 Inhibition of the DNA repair proteins DNA-dependent protein kinase (DNA-PK) or poly(ADP-ribose

191 DNA-dependent protein kinase (DNA-PK) orchestrates DNA r

192 ough ataxia telangiectasia-mutated (ATM) and DNA-dependent protein kinase (DNA-PK) phosphorylate RPA2

193 tated (ATM), ATM and Rad3-related (ATR), and DNA-dependent protein kinase (DNA-PK) phosphorylate SMAR

194 DNA-dependent protein kinase (DNA-PK) phosphorylates sev

195 s1), here we report that the kinases ATR and DNA-dependent protein kinase (DNA-PK) play more signific

196 DNA-dependent protein kinase (DNA-PK) plays a major role

197 The DNA-dependent protein kinase (DNA-PK) plays an essential

198 DNA-dependent protein kinase (DNA-PK) plays an essential

199 Herein, we report that the DNA-dependent protein kinase (DNA-PK) regulates the DNA

200 y of ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) signaling that res

201 Compound 401 is a synthetic inhibitor of DNA-dependent protein kinase (DNA-PK) that also targets

202 hium treatment not only increased IR-induced DNA-dependent protein kinase (DNA-PK) threonine 2609 foc

203 Recent studies have established that DNA-dependent protein kinase (DNA-PK) undergoes a series

204 The DNA-dependent protein kinase (DNA-PK) was identified as

205 petition between HR and NHEJ, because of the DNA-dependent protein kinase (DNA-PK)'s cellular abundan

206 viral integration involved the activation of DNA-dependent protein kinase (DNA-PK), a central integra

207 was partially surmounted by antagonizing the DNA-dependent protein kinase (DNA-PK), a critical enzyme

208 lates the nuclear/cytoplasmic trafficking of DNA-dependent protein kinase (DNA-PK), a critical kinase

209 The multi-subunit DNA-dependent protein kinase (DNA-PK), a crucial player

210 DNA-dependent protein kinase (DNA-PK), a holoenzyme that

211 the catalytic and regulatory subunits of the DNA-dependent protein kinase (DNA-PK), a key enzyme in t

212 ly interacted with and limited activation of DNA-dependent protein kinase (DNA-PK), a PI3K-related fa

213 kinases ataxia telangiectasia-mutated (ATM), DNA-dependent protein kinase (DNA-PK), and ataxia telang

214 Although CD133, DNA-dependent protein kinase (DNA-PK), and MDR1 are elev

215 onstitutively associated with PKCepsilon and DNA-dependent protein kinase (DNA-PK), and this associat

216 tion or depletion of ATM or MDC1, but not of DNA-dependent protein kinase (DNA-PK), antagonizes the g

217 revious work showed that, in the presence of DNA-dependent protein kinase (DNA-PK), Artemis slowly tr

218 Double-stranded DNA-dependent protein kinase (DNA-PK), ataxia telangiect

219 DNA-dependent protein kinase (DNA-PK), composed of Ku70,

220 A key component of this pathway is DNA-dependent protein kinase (DNA-PK), consisting of a c

221 DNA-dependent protein kinase (DNA-PK), consisting of a c

222 DNA-dependent protein kinase (DNA-PK), consisting of Ku

223 The DNA-dependent protein kinase (DNA-PK), consisting of Ku

224 se Ku and DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), form a complex at

225 u70/80 (Ku) functions in NHEJ as part of the DNA-dependent protein kinase (DNA-PK), genetic evidence

226 ases ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK), histone H2AX phos

227 A third PI3 kinase, DNA-dependent protein kinase (DNA-PK), is also activated

228 ds to DNA double-strand breaks and activates DNA-dependent protein kinase (DNA-PK), leading to DNA da

229 eak repair protein complexes were activated: DNA-dependent protein kinase (DNA-PK), NBS1-MRE11-RAD50,

230 Here, we report that DNA-dependent protein kinase (DNA-PK), the core componen

231 malian target of rapamycin kinase (TORK) and DNA-dependent protein kinase (DNA-PK), was evaluated in

232 U7441) as a potent inhibitor (IC = 30 nM) of DNA-dependent protein kinase (DNA-PK), we have investiga

233 In NHEJ, DNA-dependent protein kinase (DNA-PK), which is comprise

234 NF90 and NF45 are known to interact with the DNA-dependent protein kinase (DNA-PK), which is involved

235 itory activity against the DNA repair enzyme DNA-dependent protein kinase (DNA-PK), with a view to el

236 DNA-dependent protein kinase (DNA-PK)-defective severe c

237 pendent apoptosis (programmed cell death) in DNA-dependent protein kinase (DNA-PK)-deficient scid pre

238 essing a dominant mutant hRAD54 protein in a DNA-dependent protein kinase (DNA-PK)-deficient severe c

239 cell cycle arrest and causes apoptosis when DNA-dependent protein kinase (DNA-PK)-mediated non-homol

240 AZ12253801 radiosensitized DNA-dependent protein kinase (DNA-PK)-proficient but not

241 ses: ataxia-telangiectasia-mutated (ATM) and DNA-dependent protein kinase (DNA-PK).

242 proteins, including AREB6-like proteins and DNA-dependent protein kinase (DNA-PK).

243 from telomeres promotes a DDR that involves DNA-dependent protein kinase (DNA-PK).

244 elated kinases (PIKK), such as ATM, ATR, and DNA-dependent protein kinase (DNA-PK).

245 ic subunit, Ku86, and Ku70 are components of DNA-dependent protein kinase (DNA-PK).

246 -PKcs) constitute a protein complex known as DNA-dependent protein kinase (DNA-PK).

247 entify IRF-3 as the first in vivo target for DNA-dependent protein kinase (DNA-PK).

248 ect prevented by wortmannin, an inhibitor of DNA-dependent protein kinase (DNA-PK).

249 cells with high levels of C-1027 (10 nM) is DNA-dependent protein kinase (DNA-PK).

250 homologous end joining, the latter requiring DNA-dependent protein kinase (DNA-PK).

251 n in retinal endothelial cells (REC) through DNA-dependent protein kinase (DNA-PK).

252 f histone H2AX at serine 139 (gamma-H2AX) by DNA-dependent protein kinase (DNA-PK).

253 Protein expression levels of the DNA-dependent protein kinase (DNA-PK)/Ku-dependent nonho

254 hromen-4-one (NU7441), a potent inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 42 +/- 2 nM

255 hat Artemis forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs) in the absence o

256 is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically in

257 The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is rapidly phosp

258 replication stress, the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is rapidly phosp

259 We have previously described DNA-dependent protein kinase (DNA-PKcs) mutations in hor

260 The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) plays an importa

261 ) from mice lacking the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) results in defec

262 gene coding for the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) that is involved

263 ATM) kinase and the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs), regulate cellul

264 h are deficient for the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), suggesting that

265 derivative lacking the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), the predominant

266 n reduced levels of the catalytic subunit of DNA-dependent protein kinases (DNA-PKcs), a component of

267 Kcs), a kinase that forms part of a complex (DNA-dependent protein kinase [DNA-PK]) crucial for DNA d

268 ce ataxia telangiectasia mutated- (ATM-) and DNA-dependent protein kinase- (DNA-PK-) dependent produc

269 pair, we demonstrate that phosphorylation by DNA-dependent protein kinase enhances RPAp34 turnover at

270 efects in DNA-PKcs (catalytic subunit of the DNA dependent protein kinase) expression.

271 nomic caretakers and included members of the DNA-dependent protein kinase holoenzyme (Ku70, Ku80, DNA

272 activating phosphorylation of ATM, CHK2, and DNA-dependent protein kinase in response to IR.

273 M (ataxia telangiectasia mutated) or DNA-PK (DNA-dependent protein kinase), in cisplatin-induced p53

274 rmants that express the catalytic subunit of DNA-dependent protein kinase, in which hairpin end openi

275 DNA-dependent protein kinase including its catalytic sub

276 We found that WRN nuclease is stimulated by DNA-dependent protein kinase independently of kinase act

277 ts NHEJ function and strikingly similar to a DNA-dependent protein kinase interaction motif in human

278 cted phosphorylation sites for ATM, Akt, and DNA-dependent protein kinase kinases; nuclear localizati

279 in vivo did not require the repair proteins DNA-dependent protein kinase, Ku80, or XRCC4.

280 tion, including the catalytic subunit of the DNA-dependent protein kinase, Ku86, and Rad50; and (iii)

281 BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated (DNA-PK-mediated)

282 , BRCA-mediated homologous recombination and DNA-dependent protein kinase-mediated nonhomologous end-

283 y does not require, and may be inhibited by, DNA-dependent protein kinase-mediated phosphorylation, t

284 s on this phosphorylation for release from a DNA-dependent protein kinase-mediated reaction checkpoin

285 A specific inhibitor to the DNA-dependent protein kinase, NU7026, inhibits androgen

286 cells with the inhibitors of the DDR kinases DNA-dependent protein kinase or ataxia-telangiectasia mu

287 We suggest that DNA-dependent protein kinase phosphorylation of the andr

288 We mapped a novel and unique DNA-dependent protein kinase phosphorylation site proxim

289 ope in XRCC4 and found that it encompassed a DNA-dependent protein kinase phosphorylation site, which

290 on was found to be through the inhibition of DNA-dependent protein kinase phosphorylation.

291 14-3-3 interaction in vitro is dependent on DNA-dependent protein kinase phosphorylation.

292 me teleost species another protein kinase, Z-DNA-dependent protein kinase (PKZ), plays a similar role

293 Furthermore, CoAA is associated with the DNA-dependent protein kinase-poly(ADP-ribose) polymerase

294 s in recombination activating gene 2 (rag2), DNA-dependent protein kinase (prkdc), and janus kinase 3

295 s, which are differentially regulated by the DNA-dependent protein kinase, provides a possible explan

296 at are defective in the catalytic subunit of DNA-dependent protein kinase retain elevated levels of p

297 hibitor treatment induces phosphorylation of DNA-dependent protein kinase substrates and stimulates e

298 Since Ku70 is a subunit of the DNA-dependent protein kinase that is responsible both fo

299 ults, we found that the catalytic subunit of DNA-dependent protein kinase was degraded as a function

300 ffected DSB repair, although an inhibitor of DNA-dependent protein kinase was highly effective at red