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1 DNA adducts reflect the internal exposure to genotoxican
2 DNA binding and transcription assays demonstrated that t
3 DNA damage induced by reactive carbonyls (mainly methylg
4 DNA is a remarkably precise medium for copying and stori
5 DNA methylation aberrations have been implicated in acqu
6 DNA methylation at promoters is an important determinant
7 DNA methylation changes associated with maternal smoking
8 DNA obtained from 20 fresh OSCC biopsies (cases) and 20
9 DNA photocleavage experiments demonstrate that, upon pho
10 DNA repair protein counteracting oxidative promoter lesi
11 DNA replication depends on primase, the specialised poly
12 DNA replication results in the doubling of the genome pr
13 DNA tumor viruses such as Kaposi's sarcoma-associated he
14 ediated isothermal amplification (LAMP) is a DNA amplification approach characterized by high sensiti
16 an apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expre
17 R36W) or Arg35 (R35H/L) completely abolished DNA binding, mutation of Arg60 (R60Q) significantly redu
22 teins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases
25 T1AM), on cell proliferation, cell death and DNA damage was studied in two ovarian cancer cell lines
27 ivation of MutLalpha endonuclease, PCNA- and DNA-dependent activation of MutLalpha ATPase, and MutLal
28 e disorders (eg, ataxia-telangiectasia), and DNA double-strand breaks are crucial to the modulation o
30 ange were determined by spiking B. anthracis DNA into individual PCR mixtures and B. anthracis CFU in
31 lysis revealed pathways including apoptosis, DNA repair and early estrogen response that were differe
36 ge model, but we find no correlation between DNA fragmentation and sample age over the timespans anal
38 ts demonstrate the potential synergy between DNA origami technology and colloidal science, in which t
39 demonstrate that the ability of Lon to bind DNA is determined by its ATPase domain, that this bindin
40 oncentrates (VCs), containing bioinformative DNA and proteins, have been used to study viral diversit
41 ed longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development
42 an average ratio of 29.2% by targeting both DNA strands simultaneously with an over 98.6% coverage.
43 s (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidati
44 pad and the dispensing cycles of the capture DNA probes on the test-zone), the biosensor could detect
45 vestigated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial
47 the interactions between negatively charged DNA and positively charged amino acid residues, the tran
50 , we monitored oxidatively induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apop
54 ctivity is required to activate compensatory DNA synthesis during mitosis and to resolve mitotic inte
58 of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instability and ult
60 la pertussis Ptl systems support conjugative DNA transfer in E. coli and trigger P. aeruginosa T6SS k
61 s of PHF1 and MTF2 with bound CpG-containing DNAs in the presence of H3K36me3-containing histone pept
63 A oligomer was synthesized in a conventional DNA synthesizer, containing neutral nucleotides with a m
66 ning buffers, the concentration of detection DNA probe used in the preparation of FCN-DNA conjugates,
67 tigation of these DMRs revealed differential DNA methylation localized to a 600 bp region in the prom
70 ect ligand binding as blocking events during DNA unzipping, allowing determination of ligand selectiv
76 promotes survival by suppressing endogenous DNA damage, and may control cell fate through the regula
77 biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes th
79 Analysis of enriched transcription factor DNA-binding sites in the promoters of differentially exp
81 ion DNA probe used in the preparation of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the c
82 ion of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the conjugate pad and the dispensing cy
89 owerful weapons in the fight against foreign DNA, such as phages and plasmids, as well as a revolutio
90 utilizes RNA-functionalized AuNPs which form DNA-RNA heteroduplex structures through specific hybridi
92 se of nuclear factor kappa B (NFkappaB) from DNA target sites in a process we have termed molecular s
95 were randomized to receive 4 mg of PENNVAX-G DNA delivered intramuscularly by Biojector or electropor
97 We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation dete
98 table labeling and monitoring of HIV genomic DNA within infected cells during cytoplasmic transit, nu
99 ration of interstrand cross-links in genomic DNA may contribute to aging, neurodegeneration, and canc
100 ensitive enough to detect changes in genomic DNA methylation levels as a function of growth phase in
101 bility to rewrite large stretches of genomic DNA enables the creation of new organisms with customize
104 del without fitting parameters, with genomic DNA sequence being the only input, we further validate t
105 confidence interval [CI], 6.3-21.9%) of HPV DNA detections in genital samples were attributable to v
107 ts, we used somatic variants in hypermutable DNA regions to reconstruct high-confidence phylogenetic
108 erdependent coupled oscillators and identify DNA replication as a critical process in the circadian m
110 ociated with somatic variations, advances in DNA sequencing indicate that cell-specific variants affe
111 because it has a reduced net charge, and in DNA binding and protein-protein interactions because key
113 ther, these data suggest that differences in DNA methylation may partly explain the enantioselectivit
115 esidues in the C-terminal helix to engage in DNA binding, triggering a major reprogramming of gene ex
116 ductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with
118 ost common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs tra
121 junction (HJ) is a hallmark intermediate in DNA recombination and must be processed by dissolution (
125 y, radiation therapy and chemotherapy induce DNA damage to drive cells into apoptosis or senescence a
130 okiol application also inhibited UVB-induced DNA hypermethylation and its elevation of the levels of
132 l comparison of holo-ScNsrR with an apo-IscR-DNA complex shows that the [4Fe-4S] cluster stabilizes a
134 levels of dG-gx-dC and dG-gx-dA in leukocyte DNA were 1.94 +/- 1.20 and 2.10 +/- 1.77 in 10(8) normal
135 fic and it requires only 50 mug of leukocyte DNA isolated from 2-3 mL of blood to accurately quantify
136 plast genome that is composed only of linear DNA molecules is unprecedented among eukaryotes, and hig
138 ve in neutralizing negatively charged linker DNA because it has a reduced net charge, and in DNA bind
142 e when free in solution or with well matched DNA but exhibits a significant luminescence increase in
143 modification coincides with the ATM-mediated DNA damage response that occurs on functional telomeres
145 e is concomitant with defective ATM-mediated DNA repair signaling and accumulation of protein-linked
146 ny of the three major pathways known to mend DNA DSBs, namely homologous recombination (HR), nonhomol
148 tingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active chromatin
150 this gap, we analyzed ancient mitochondrial DNA (mtDNA) from Scythians of the North Pontic Region (N
152 c D2 mice manifested increased mitochondrial DNA lesions (8-oxoguanine) exclusively localized to glom
153 This was tested using a major mitochondrial DNA (mtDNA) survey and sequencing of two nuclear markers
154 excess cytosolic extrusion of mitochondrial DNA along with increased reactive oxygen species and red
157 gation to daughter nuclei by linking mitotic DNA and NPC segregation via the mitotic specific chromat
158 ew class of site-specifically metal-modified DNA films was characterized by UV, circular dichroism (C
159 F60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory gene
160 owing infection with Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced le
162 gher levels of circulating mitochondrial (mt)DNA, soluble thrombomodulin (sCD141) and ICAM-1, reflect
166 red to female MNX mice having FVB/NJ nuclear DNA with either FVB/NJ, C57BL/6J, or BALB/cJ mtDNA.
168 tively induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apoptosis, and the local
169 production stemmed from the accumulation of DNA in the cytoplasm of AT and Artemis-deficient cells.
170 ed liver to have a pattern of acquisition of DNA methylation targeted to candidate enhancers active i
174 MRN-mediated endonucleolytic cleavage of DNA at sites of protein adducts requires ATP hydrolysis
176 in human populations, and the examination of DNA methylation is becoming increasingly common in psych
177 The local sequence-dependent features of DNA found in high-resolution structures introduce irregu
179 re potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPalpha wit
183 first quantitative human genome-wide map of DNA lesions induced by ultraviolet (UV) radiation, the u
187 d lead to fast and automated purification of DNA nanostructures of various shapes and sizes, which wo
190 no acid residues, the translocation speed of DNA can be manipulated by deliberate charge decorations
193 Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median ab
194 ditionally, Cu(II) chelated PyED outcompetes DNA polymerase I to successfully inhibit template strand
196 ssment of one epigenetic mark in particular, DNA methylation, in human populations, and the examinati
197 apeutics for additional infectious pathogens.DNA-delivered monoclonal antibodies (DMAbs) can be produ
199 create NGS libraries from as little as 20 pg DNA with PCR error correcting capabilities, and capture
201 t that chitosan scaffolds containing plasmid DNA encoding VEGF189 and perlecan domain I have the pote
203 ed via freeze drying and loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed
204 ds to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the subs
205 assay, based on random amplified polymorphic DNA (RAPD) analysis was developed for its efficient and
206 tins) are unsaturated imines that are potent DNA damaging agents, thereby confirming an earlier mecha
207 T-IH or during recovery from LT-IH prevented DNA methylation of AOE genes, normalized the expression
209 eiotic recombination, a subset of programmed DNA double-strand breaks (DSBs) are repaired as crossove
210 ction between TopBP1 and Treslin and promote DNA replication despite the presence of a Cdk2 inhibitor
212 ragment in complex with its cognate promoter DNA, revealing the molecular details of promoter recogni
215 ased diagnostic (CRISPR-Dx), providing rapid DNA or RNA detection with attomolar sensitivity and sing
218 tation of Arg60 (R60Q) significantly reduced DNA binding, but retained a preference for the 5caC modi
220 GA motifs in the stem region of TGGAA repeat DNA act as hot spots to facilitate the transition betwee
221 cific single-molecule analysis of replicated DNA technique, we found that depletion of FANCM dramatic
223 nt-based methods, we show that the resulting DNA-wrapped carbon nanotubes can be further sorted to pr
224 duction, with high-throughput 18 S ribosomal DNA sequencing to elucidate the relationship between euk
225 sequences by proximity ligation, forming RNA-DNA chimeric sequences, which are converted to a sequenc
232 erials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has b
233 tion of clean DSBs by cleaving the 5' strand DNA approximately 10-20 nucleotides away from the ends.
234 leoprotein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrapping the nucleosoma
237 d microcapillary into a lower ionic strength DNA sample reservoir induces spontaneous DNA migration a
238 a, Vietnam and Cambodia and after successful DNA extraction fragment of the nuclear rhodopsin gene (R
240 h an emphasis on the enzymes that synthesize DNA and repair discontinuities on the lagging strand of
243 ing chip and the unpaired fragment of target DNA works as a trigger to initiate the nonlinear HCR, fo
244 re broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes, but th
248 of G-quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting targets for supr
249 y permits very efficient use of the template DNA as well as sequence reads, which are nearly all conf
251 of DNA positioning on the nucleosome and the DNA conformation can provide key regulatory signals.
252 ional coupling of recombination steps at the DNA level with specific organizational features of meiot
253 n photoactivation, the conjugate cleaves the DNA backbone specifically near the mismatch site on a 27
255 has been well studied for over a decade, the DNA-binding activities and the biological functions of t
258 not associated with causative changes in the DNA methylome, which appears relatively impervious to dr
260 meiosis share many processes, including the DNA replication, chromosome condensation and precisely r
269 e set of OL maturation genes and reduces the DNA occupancy of YY1, a transcription factor required fo
270 an exogenous source of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1
271 estabilized Miz1-4(A86K) mutant bound to the DNA consensus with a 30-fold increase in affinity (100 n
273 5i), either alone or in combination with the DNA-demethylating agent 5-aza-2'-deoxycytidine (DAC).
276 With the development of new high-throughput DNA sequencing technologies and decreasing costs, large
277 DNA-binding domain that abrogates binding to DNA and leads to complete loss of canonical TH action.
279 rated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and lea
283 crophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction
285 d cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways
286 s in estuarine and marine environments using DNA-SIP and to characterise marine isoprene-degrading ba
290 ontaining >/=105 copies herpes simplex virus DNA/ml collected a median of 5 months apart (IQR: 2-11 m
293 into the study of human genetic disease when DNA sequencing alone is not sufficient to reveal the und
294 high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then
295 Herein, we describe a mechanism whereby DNA and associated DNABII proteins transit from the bact
297 ct measurements on single nucleotides within DNA macromolecules, we demonstrate that the distance ove
299 dapter-inducing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of
300 ta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI)
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