ライフサイエンスコーパス: DOPAC

1 DOPAC and HVA changes were measured at 1 day and were re

2 DOPAC and norepinephrine concentrations were determined

3 DOPAC concentrations were significantly lower in caudate

4 DOPAC levels remained stable, arguing against an AAO-ind

5 DOPAC levels significantly increased in adults after 15

6 DOPAC was detected as the major degradation product of H

7 DOPAC was used as an index of dopaminergic activity.

8 DOPAC/DA ratio, an indicator of dopaminergic neuronal ac

9 tabolite 18F-dihydroxyphenylacetic acid (18F-DOPAC).

10 e ratio of myocardial 18F-DA to arterial 18F-DOPAC provided an index of vesicular uptake.

11 ne (NE) and 3,4-dihydroxyphenyl-acetic acid (DOPAC) in the brain frontal cortex were measured in 20-m

12 to the presence of 3,4-dihydroxyacetic acid (DOPAC) in the brain extracellular fluid.

13 he levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-methoxytyramine (3-MT) in the striatum.

14 of dopamine, 3-4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and in the DOPAC/dopa

15 metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in caudate nucleus re

16 metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were elevated over t

17 metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were found to be dec

18 metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).

19 metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).

20 metabolite [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] levels and tyrosine

21 in dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and serotonin.

22 ine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) at all doses and the serotonin (5-HT) metabolite,

23 oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH), but is also par

24 striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned a

25 of dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations were determined from the 6-OHDA le

26 dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) content in the subareas of the neostriatum and nu

27 (5-HIAA) and 3,4-dihydroxyphenylacetic acid (DOPAC) from their respective amines in isolated mitochon

28 ycol (DHPG), and dihydroxyphenylacetic acid (DOPAC) in hypothalamic paraventricular nucleus (PVN) mic

29 (5-HIAA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in isolated hamster or rat liver mitochondria.

30 y metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in mouse retina.

31 opamine (DA) and dihydroxyphenylacetic acid (DOPAC) in striatum and nucleus accumbens than susceptibl

32 on of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence (ME) and various regions o

33 on of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence (ME), as well as the anter

34 A metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence which contains terminals o

35 dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) in the paraventricular nucleus (PVN) of the hypot

36 compounds on 3,4-dihydroxyphenylacetic acid (DOPAC) levels correlated very well with their affinity f

37 dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the striatum, and a greater increase in

38 id (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) reflected changes in tissue DA concentrations, in

39 nd ascorbate and dihydroxyphenylacetic acid (DOPAC) rejection at the overoxidized polypyrrole-coated

40 estraint stress, dihydroxyphenylacetic acid (DOPAC) to DA ratios in the mPfx, NAs and ST increased in

41 the ratio of 3,4-dihydroxyphenylacetic acid (DOPAC) to DA.

42 e, DOPA, and 3,4-dihydroxyphenylacetic acid (DOPAC) to inhibit proteasomal activity.

43 d the metabolite dihydroxyphenylacetic acid (DOPAC) were elevated (by 98% and 65%, respectively) in t

44 e metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) were measured by HPLC with electrochemical detect

45 levels of DA and dihydroxyphenylacetic acid (DOPAC) were not different in striata collected from mela

46 ntrations of 3,4-dihydroxyphenylacetic acid (DOPAC)) in terminals of these neurons in the median emin

47 scorbate and 3,4-dihydroxyphenylacetic acid (DOPAC), a major dopamine metabolite, near the infusion s

48 ntrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a normal product of the metabolism of dopamine,

49 pamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 4-hydroxy-3-methoxyphenylacetic acid (HVA) w

50 amine (DA), 3, 4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) by 76%, 53% and 40%,

51 pamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and HVA levels in rats that exhibited low levels

52 metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), as well as serotonin and 5-hydroxyindole acetic

53 r dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxyindoleacetic a

54 c acid (HVA) and dihydroxyphenylacetic acid (DOPAC), in five brain regions from suicide victims with

55 metabolite, 3, 4-dihydroxyphenylacetic acid (DOPAC), in the median eminence and the three pituitary l

56 ne (L-DOPA), 3,4-dihydroxyphenylacetic acid (DOPAC), methyldopamine, and tyramine, which gave negligi

57 sulphate and 3,4-dihydroxyphenylacetic acid (DOPAC)-sulphate were the main metabolites, followed by D

58 dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC).

59 bic acid and 3,4-dihydroxyphenylacetic acid (DOPAC).

60 ar levels of 3,4-dihydroxyphenylacetic acid (DOPAC).

61 ts metabolite dihydroxy-O-phenylacetic acid (DOPAC) were extracted from medial prefrontal cortex (mPF

62 ltering discriminated against ascorbic acid, DOPAC, and acidic pH changes, three common interferences

63 found in the brain, including ascorbic acid, DOPAC, and serotonin.

64 ic activity (3,4-dihydroxyphenylacetic acid; DOPAC) of A11 DA neurons innervating the lumbar spinal c

65 re was no sexual difference in the activity (DOPAC/DA ratio) of these DA neurons under basal conditio

66 y transmission, light exposure did not alter DOPAC levels in the nob mice.

67 Although, DOPAC decreased in both groups following AMPH injection,

68 attenuation of the response to ascorbate and DOPAC, common interferences of dopamine in vivo.

69 Internal standards DA-d4 and DOPAC-d5 result in standard curve linearity for DA from

70 Concentrations of DA and DOPAC from tissues and the concentration of PRL in plasm

71 re dissected and the concentration of DA and DOPAC in each was measured by HPLC-EC.

72 examined the effect of anesthesia on DA and DOPAC levels in the retina in vivo and find that basal d

73 al dopaminergic tone (i.e.: increased DA and DOPAC levels) and improves behavioral performance (i.e.:

74 When combining the DA and DOPAC measures from these two experiments, the data sugg

75 re no changes in the concentration of DA and DOPAC of the IL due to the suckling stimulus.

76 , a decrease in the concentrations of DA and DOPAC was detected in the inner zone of the AL (AL-IZ).

77 nimals, basal extracellular levels of DA and DOPAC were significantly decreased in two groups of aged

78 icantly reduced striatal TH activity, DA and DOPAC, but there were no significant differences in the

79 ficantly alter the striatal levels of DA and DOPAC, while it slightly reduced HVA concentration.

80 n combination, on striatal dopamine (DA) and DOPAC levels, and the density of tyrosine hydroxylase (T

81 levels were not significantly decreased, and DOPAC and HVA levels were decreased by only 65% and 30%,

82 .8-fold and PVN microdialysate NE, DHPG, and DOPAC by 1.2, 0.6 and 0.5-fold.

83 O on plasma and microdialysate NE, DHPG, and DOPAC.

84 ine (EPI), DHPG, dihydroxyphenylalanine, and DOPAC levels by 4.3, 7.3, 2.5, 0.6 and 1.8-fold and PVN

85 Elevated cysteinyl adducts to L-DOPA and DOPAC are seen early and are followed by increased stria

86 Dopamine, DOPA, and DOPAC underwent tyrosinase-catalyzed oxidation to genera

87 nt reduction in corpus striatal dopamine and DOPAC but not norepinephrine.

88 duced striatal reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition o

89 alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar

90 mphetamine-induced depletion of dopamine and DOPAC in red wine treated mice.

91 uced a significant depletion of dopamine and DOPAC in the striatum.

92 dependent reduction of striatal dopamine and DOPAC levels but did not alter HVA, 5-HT, or 5-HIAA.

93 Dopamine and DOPAC levels in striatal tissue were analyzed using HPLC

94 However, dopamine and DOPAC levels were significantly lower in the nob mice co

95 rvival, and striatal and nigral dopamine and DOPAC levels, were evaluated 2 weeks after the lesions.

96 ereotypy, and nucleus accumbens dopamine and DOPAC release responses to an injection of saline follow

97 led to a reduction of striatal dopamine and DOPAC that were both non-significantly greater than that

98 L concentrations while diminishing DOPET and DOPAC levels.

99 mster ethanol intake also inhibit 5-HIAA and DOPAC formation.

100 significant increases in the 5-HIAA/5-HT and DOPAC/DA ratios, often used as measures of turnover.

101 tion, DA was not altered but DOPAC level and DOPAC/DA turnover ratios were significantly reduced.

102 ssue DA levels, but reduced DOPAC levels and DOPAC/DA ratios.

103 the increase in the DOPAC and HVA levels and DOPAC/dopamine ratio induced by L-DOPA in the substantia

104 while the striatal DOPAC and HVA levels and DOPAC/dopamine ratio were significantly reduced as compa

105 r DA from 0.05-100 ng/mL (LOD = 6 pg/mL) and DOPAC from 0.5-100 ng/mL (LOD = 162 pg/mL).

106 of other catecholamine derivatives, such as DOPAC and 3,4-dihydroxyphenylethyleneglycol.

107 er mTBI or injection, DA was not altered but DOPAC level and DOPAC/DA turnover ratios were significan

108 phate were the main metabolites, followed by DOPAC and homovanillic acid (HVA).

109 epinephrine (Epi) or monoamine catabolites (DOPAC, 5-HIAA) at any ammonia concentrations tested.

110 One striatum was examined for DA, DOPAC, and HVA levels using HPLC-EC and the contralatera

111 gdala and hippocampus, and dopamine (HVA/DA, DOPAC/DA) in prefrontal cortex.

112 al cortex of adult rats, basal levels of DA, DOPAC and HVA did not differ across prenatal treatments;

113 TH-induced hyperthermia and depletion of DA, DOPAC and HVA.

114 ysis revealed a significant depletion of DA, DOPAC, and HVA at all time points.

115 In the adult, basal levels of DA, DOPAC, HVA and 5-HIAA in n. accumbens did not differ acr

116 NDN activity, defined by DA:DOPAC ratio in nerve terminals, was determined by HPLC-E

117 th estrogen had the opposite effect of DHTP, DOPAC/DA and MHPG/NE ratios increased to a greater level

118 its metabolites, 3,4-dihydroxyphenylalanine (DOPAC) and homovanillic acid (HVA); norepinephrine (NE)

119 sine hydroxylase-immunoreactivity, dopamine, DOPAC, and serotonin than wild-type mice.

120 ridone on ex vivo tissue levels of dopamine, DOPAC, HVA, 5-HT and 5-HIAA in multiple brain regions.

121 (at 6 and 12 h) increase in median eminence DOPAC concentrations in these animals which was blocked

122 administration of PRL-AB on median eminence DOPAC concentrations suggesting that the tonic stimulato

123 olactinemia) failed to alter median eminence DOPAC concentrations unless prolactin exposure was reins

124 ion of mRNA encoding TH and DAT, and enteric DOPAC (the specific dopamine metabolite).

125 ere accompanied by declines in extracellular DOPAC concentrations, and these declines were the same 2

126 haloperidol exposure increased extracellular DOPAC, and this haloperidol-stimulated DOPAC increase wa

127 Measurement of extracellular DOPAC, a dopamine metabolite, following l-DOPA injection

128 uenced the effect of D-AMPH on extracellular DOPAC, as the D-AMPH-related decreases in DOPAC were gre

129 HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were

130 e compounds with 1,2-dihydroxyphenyl groups (DOPAC and catechol), their 1,4-dihydroxyphenyl isomers (

131 se in DA turnover, as indicated by a higher (DOPAC+HVA)/DA ratio, seems to be associated to rotenone-

132 at the lowest dose of risperidone; however, DOPAC showed a dose dependent increase.

133 24 h after IBO, DOPAC concentrations in striatum and HVA levels in the f

134 by DNQX was not associated with a change in DOPAC/DA level in the nucleus accumbens or the striatum.

135 on of striatal DA (as measured by changes in DOPAC) may be altered.

136 e catabolism (as assessed by the decrease in DOPAC and HVA levels) in the striatum and substantia nig

137 was accompanied by a pronounced decrease in DOPAC concentrations in the median eminence of females,

138 PAC in the median eminence and a decrease in DOPAC in the nucleus accumbens; surgical deafferentation

139 ar DOPAC, as the D-AMPH-related decreases in DOPAC were greater for a concentration when it was admin

140 trast to that of dopamine, no differences in DOPAC concentrations between estrogen and non-estrogen-t

141 nelorane caused a dose-dependent increase in DOPAC in the median eminence and a decrease in DOPAC in

142 Light caused a similar increase in DOPAC/DA ratio but interindividual variation was signifi

143 prevented the open field induced increase in DOPAC/DA, MHPG/NE, and 5-HIAA/5-HT ratio.

144 increases were characterized by increases in DOPAC, HVA, MHPG and 5-HIAA coupled with decreases in DA

145 ced an increase in DA utilization (increased DOPAC/DA ratio) in mPFC and NAS, but not striatum.

146 Lower DOPAC concentrations were largely restricted to those su

147 e CSF measured higher levels of DA and lower DOPAC/DA ratios among the heavy drinkers at the same tim

148 found a reduction in the dopamine metabolite DOPAC in the striatum of these mice.

149 w levels of dopamine (DA) and its metabolite DOPAC.

150 centrations of DA and its primary metabolite DOPAC were determined by high-performance liquid chromat

151 re was an increase in a dopamine metabolite, DOPAC and histologically, DA axons in the striatum were

152 iatal content of dopamine or its metabolite, DOPAC.

153 lar levels of dopamine, dopamine metabolites DOPAC and HVA, and the major 5-HT metabolite 5-HIAA, in

154 ochemical analyses of DA and its metabolites DOPAC and HVA show that exercise also functionally prote

155 t depletion of dopamine, and its metabolites DOPAC and HVA, as well as the significant formation of 3

156 ls of striatal dopamine and its metabolites (DOPAC and HVA) following MPTP treatment as determined by

157 ults; however, the levels of DA metabolites, DOPAC, HVA, and the serotonin metabolite, 5-HIAA, were m

158 e depletion of dopamine and its metabolites, DOPAC and HVA and the formation of 3-NT in PC12 cells.

159 The levels of dopamine and its metabolites, DOPAC and HVA were analyzed by HPLC equipped with electr

160 In contrast, MPOA DOPAC concentrations did not increase in prepubertal mal

161 ess, 6-OHDA-induced increases in neostriatal DOPAC/DA and HVA/DA ratios were normalized by age/food-d

162 of alpha-Syn, due to non-covalent binding of DOPAC to alpha-Syn monomer.

163 n the NL, a decrease in the concentration of DOPAC was detected due to the suckling stimulus.

164 The concentration of DOPAC was increased in the ME and NL, decreased in the I

165 nt-treated suicides, lower concentrations of DOPAC were observed in the basal ganglia, reaching stati

166 oxidation of DOPAC, and the oxidized form of DOPAC (the quinone) is responsible for the fibrillation

167 of ALDH by daidzein reduced the formation of DOPAC and increased the accumulation of DOPAL.

168 D-AMPH also resulted in diminished levels of DOPAC in the aged rats compared to the young rats.

169 mg/kg s.c.) also increased tissue levels of DOPAC, HVA and 5-HIAA by 169, 221 and 134% of basal leve

170 istration of LY379268, mPFC tissue levels of DOPAC, HVA and 5-HIAA were increased in a dose-dependent

171 Oxidation of DOPAC by tyrosinase generated furanoquinone, which was a

172 Syn accelerates the spontaneous oxidation of DOPAC, and the oxidized form of DOPAC (the quinone) is r

173 In addition, the presence of DOPAC leads to the oxidation of the methionine residues

174 o the H(2)O(2) production as a by-product of DOPAC oxidation.

175 arying estrogen treatments on striatal DA or DOPAC concentrations.

176 In addition, there were no changes of DA or DOPAC in the outer zone of the AL (AL-OZ) due to sucklin

177 r basal tissue concentrations of dopamine or DOPAC or the DOPAC:dopamine ratio in either the nucleus

178 effects on mitochondria-catalyzed 5-HIAA or DOPAC formation and hamster ethanol intake reveals a pos

179 ion-the stronger the inhibition on 5-HIAA or DOPAC formation, the greater the ethanol intake suppress

180 ethanol intake and inhibition of 5-HIAA (or DOPAC) formation by six structural analogues of daidzin

181 suggest that HT and its degradation product DOPAC could have a relevant role in preventing the forma

182 Moreover, both dopamine turnover ratios (DOPAC/DA, HVA/DA) and the serotonin turnover ratio (5-HI

183 mTBI increased tissue DA levels, but reduced DOPAC levels and DOPAC/DA ratios.

184 ed dopamine turnover, as judged from reduced DOPAC levels, in depressed suicides, although we cannot

185 Co-treatment with MA further reduced DOPAC/DA ratios in striatum.

186 lular DOPAC, and this haloperidol-stimulated DOPAC increase was also greatly attenuated at 6 compared

187 droxydopamine-induced reductions in striatal DOPAC levels in all age groups.

188 al dopamine was increased while the striatal DOPAC and HVA levels and DOPAC/dopamine ratio were signi

189 rcle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantl

190 ible explanation for this phenomenon is that DOPAC stabilizes the normally transient oligomers and pr

191 of the alpha-Syn Y39W variant suggests that DOPAC binds non-covalently to the same N-terminal region

192 The DOPAC concentrations on the non-lesioned side of the str

193 The data obtained from the DOPAC determinations imply that this capacity of estroge

194 In animals injected with oPRL at 0900 h, the DOPAC/DA ratio increased in the ME, IL and NL within 1 h

195 bitors also counteracted the increase in the DOPAC and HVA levels and DOPAC/dopamine ratio induced by

196 Although there were no changes in the DOPAC to DA ratio (i.e., turnover), DOPAC levels also fo

197 Moreover, a secondary increase in the DOPAC/DA ratio in the IL and NL occurred during the afte

198 lopride caused a significant increase in the DOPAC/DA ratio in the striatum and nucleus accumbens in

199 mouse retinae a significant increase in the DOPAC/DA ratio is observed following in vivo light stimu

200 OPAC) and homovanillic acid (HVA) and in the DOPAC/dopamine ratio in the putamen, caudate and substan

201 pressure stress significantly increased the DOPAC:dopamine ratio in the nucleus accumbens shell of l

202 e concentrations of dopamine or DOPAC or the DOPAC:dopamine ratio in either the nucleus accumbens cor

203 Co-treatment with MA further reduced the DOPAC/DA ratio.

204 xidative metabolic conversion of dopamine to DOPAC by the mitochondrial enzyme, monoamine oxidase.

205 HT should previously be oxidized to DOPAC (3,4-dihydroxyphenylacetic acid) which reacts with

206 35% postreperfusion increase in DA turnover (DOPAC + HVA/DA) at 5 min after reperfusion.

207 s in the DOPAC to DA ratio (i.e., turnover), DOPAC levels also followed this pattern.

208 both stressed and non-stressed groups, while DOPAC levels were unaffected by treatment group.