ライフサイエンスコーパス: DOPC

1 DOPC lipid layers, containing small amounts of biotin-DO

2 DOPC/SM and POPC/SM binary mixtures yielded PWR spectra

3 mperature, T(mix) = 25-35 degrees C (for 1:1 DOPC/DPPC with 15%, 20%, 25%, and 30% Chol).

4 xed with 30% cholesterol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

5 serve phase transitions in vesicles of 1:1:1 DOPC/DPPC/sterol within giant unilamellar vesicles.

6 lipid ratios mixed with 30% cholesterol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

7 Conversely, if 1:2 DOPC/DPPC raft-like model membranes are used, cholestero

8 terol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

9 using giant unilamellar vesicles made of 7:3 DOPC/DOPG.

10 s at elevated tensions, about 3 mN/m for 30% DOPC/70% DPPC.

11 DPPC-rich liquid-ordered (L(o)) phase and a DOPC-rich liquid-disordered (L(d)) phase.

12 ments of the G(t)/rhodopsin interaction in a DOPC/DOPE (25:75) bilayer at pH 5 demonstrated that ligh

13 single halothane molecule partitioned into a DOPC lipid bilayer were performed to probe the free ener

14 ion of placental alkaline phosphatase into a DOPC/SM binary bilayer occurred with preferential insert

15 omposition used here was a modification of a DOPC/DPPC/cholesterol mixture known to form micrometer-s

16 Lastly, a simulation in P2(1) of a DOPC/melittin membrane showed significant passage of lip

17 yl phosphatidylethanolamine and gramicidin A-DOPC, small-angle x-ray scattering and (31)P-nuclear mag

18 yl phosphatidylethanolamine and gramicidin A-DOPC, which form the negatively curved hexagonal-II (H(I

19 e, R0 = -26 A (experimentally ~ -29.2 A) and DOPC leaflets preferring to be approximately flat (R0= -

20 es used are predominantly DOPC/DPPC/Chol and DOPC/BSM/Chol, which have been previously shown to produ

21 for two ternary mixtures (DOPC/DSPC/CHOL and DOPC/DPPC/CHOL) at different cholesterol concentrations.

22 nd lipid:cholesterol mixtures (SOPC:chol and DOPC:chol).

23 erol and CTAB (1/1 mol %) or cholesterol and DOPC (2/8 mol %) and incorporating two membrane dyes wer

24 hosphatidyl choline (DPPC), cholesterol, and DOPC are also presented.

25 and -20 degrees C for DPPC, DMPC, DLPC, and DOPC, respectively.

26 polypeptide in mechanically-aligned DMPC and DOPC bilayers.

27 ilamellar vesicles (GUVs) made from DOPC and DOPC/DOPE mixtures.

28 the extent of DRM formation in DOPC/DPPC and DOPC/SM bilayers and ordered lipid phase separation in m

29 hatidylcholine) in their outer leaflets, and DOPC in their inner leaflets.

30 ngle spinning conditions resolves the SM and DOPC headgroup resonances allowing for extraction of the

31 mol %), a mixture of SM (sphingomyelin) and DOPC (dioleoylphosphatidylcholine) in their outer leafle

32 creased by addition of phospholipids such as DOPC, DOPE, and DOPS and asolectin to detergent-containi

33 With phospholipids such as DOPC, giant unilamelar vesicles (GUV) are formed.

34 n-glyero-3-phosphocholine (DOPC), as well as DOPC vesicles, were used as model cell membranes.

35 ansducin (G alpha beta gamma) in an all-atom DOPC (1,2-dioleoylsn-glycero-3-phosphocholine) membrane-

36 n a protic environment, calix[6]tube 4 binds DOPC much more strongly than 5 and 6, thanks to the high

37 ing that 24:1 SM is able to accommodate both DOPC and CHO, forming a single phase.

38 In both DOPC and DEuPC vesicles DD and KK substitutions abolishe

39 The results show that in both DOPC- and DMoPC-containing bilayers, membrane-inserted r

40 tion of phase domains as POPC is replaced by DOPC.

41 e, cholesterol is preferentially solvated by DOPC if it is available, but if DOPC is replaced by POPC

42 e of inhomogeneity (DI) was similar for Chol/DOPC vesicles prepared by both procedures.

43 yl-sn-glycero-3-phosphochol ine/cholesterol (DOPC/DPPC/Chol), which is a model for the outer leaflet

44 idylethano lamine/sphingomyelin/cholesterol (DOPC/DOPE/SM/CH, 35:30:15:30) sonicated vesicles.

45 prepare compositionally uniform cholesterol/DOPC liposomes to avoid the problem of lipid demixing.

46 yl choline or dioleoyl phosphatidyl choline (DOPC).

47 itions of egg sphingomyelin, trans DOPC, cis DOPC, and cholesterol.

48 By comparing DOPC- with POPC-made membranes, we observed that the rat

49 nd robust digital optical phase conjugation (DOPC) implementation for suppressing multiple light scat

50 um, and a digital optical phase conjugation (DOPC) system characterizes and plays back the wavefront

51 10 mol % cholesterol for bilayers containing DOPC or POPC and was accompanied by maintenance of a con

52 bilayers in L-S phase coexistence containing DOPC, POPC, and DLPC, respectively.

53 finally it became aggregated in conventional DOPC, POPC, and DMPC membranes due to hydrophobic mismat

54 ary disorder of the acyl chains of neat L(d) DOPC bilayers.

55 vesicles fused in the presence of PEG as did DOPC SUV, but unperturbed LUV did not.

56 bis-SorbPC and dioleoylphosphatidylcholine (DOPC) revealed a similar NMCL when the bis-SorbPC conten

57 ter leaflet and dioleoylphosphatidylcholine (DOPC), POPC, 1-palmitoyl-2-oleoyl-phosphatidyl-L-serine

58 mine (DOPE) and dioleoylphosphatidylcholine (DOPC), the proteins produced a dose-related effect on cu

59 cholesterol and dioleoylphosphatidylcholine (DOPC).

60 ine (DPPC), and dioleoylphosphatidylcholine (DOPC).

61 C approximately dioleoylphosphatidylcholine (DOPC)<1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol

62 been compared: dioleoylphosphatidylcholine (DOPC) small unilamellar vesicles (SUV) and large unilame

63 eductase (CPR), dioleoylphosphatidylcholine (DOPC), an ionic detergent, and cytochrome b(5) (b(5)).

64 choline (DMPC), dioleoylphosphatidylcholine (DOPC), and 1-palmitoyl-2-oleoyl-phosphatidylcholine (POP

65 ant width, i.e. dioleoylphosphatidylcholine (DOPC) bilayers), while poly(LeuAla) core peptides formed

66 amine (DOPE) in dioleoylphosphatidylcholine (DOPC) bilayers.

67 orientations in dioleoylphosphatidylcholine (DOPC)and dilauroylphosphatidylcholine (DLPC) bilayer mem

68 exchanged into dioleoylphosphatidylcholine (DOPC) GUVs, lateral diffusion in the bSM-containing oute

69 , low-Tm lipid (dioleoylphosphatidylcholine (DOPC) or 1-palmitoyl 2-oleoyl phosphatidylcholine (POPC)

70 plied to a neat dioleoylphosphatidylcholine (DOPC) bilayer at 66% relative humidity and to the same b

71 les composed of dioleoylphosphatidylcholine (DOPC) adopted a topography in which the polyLeu sequence

72 n the system of dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylethanolamine (DOPE) did no

73 xture either of dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylglycerol (DOPG) or of dimy

74 imolar ratio of dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) and vari

75 les composed of dioleoylphosphatidylcholine (DOPC), all of the peptides with single substitutions ado

76 m consisting of dioleoylphosphatidylcholine (DOPC), egg sphingomyelin (eSM), and cholesterol (Chol).

77 s consisting of dioleoylphosphatidylcholine (DOPC), palmitoyloleoylphosphatidylcholine (POPC), sphing

78 cal properties, dioleoylphosphatidylcholine (DOPC), dioleoylphosphatidylethanolamine (DOPE), dioleoyl

79 , together with dioleoylphosphatidylcholine (DOPC), to the photochemistry of membrane-bound rhodopsin

80 aturated lipid (dioleoylphosphatidylcholine, DOPC).

81 -forming lipid (dioleoylphosphatidylcholine; DOPC).

82 -ns duration, of dioleylphosphatidylcholine (DOPC), sphingomyelin (SM), and cholesterol (Chol) system

83 a fully hydrated dioleylposphatidylcholine (DOPC) bilayer.

84 een the ordered SM region and the disordered DOPC region in the ternary system and accelerates the pr

85 ase regime occurs at relatively narrow DOPC/(DOPC+POPC) ratios.

86 hase window shifts to higher values of DOPC/(DOPC+POPC) when CHOL concentration is increased, and coe

87 with the four lipid components DOTAP, DOPE, DOPC, and DSPE-PEG(2000).

88 simulations of human VDAC isoform 1 in DOPE/DOPC mixed bilayers in 1 M KCl solution with transmembra

89 In the case of neutral DOPE/DOPC recombinants, calculations of the membrane surface

90 ts for bovine rhodopsin recombined with DOPE/DOPC mixtures (0:100 to 75:25) as a function of pH to ex

91 nary membrane vesicles composed of DOPG:DOPE:DOPC with a charge density fixed at typical bacterial va

92 a drastically lower threshold ratio of DOPE:DOPC = 1.5:1.

93 ctive AMO requires a threshold ratio of DOPE:DOPC = 4:1, and the nonspecifically active AMO requires

94 titrations were also done using DOTAP, DOTAP:DOPC, and DOTAP:DOPE mixtures.

95 erent single-component lipid bilayers (DPPC, DOPC, and DOPE).

96 domethacin enhanced phase separation in DPPC/DOPC/Chol (1:1:1) and DPPC/Chol membranes in a temperatu

97 For one model mixture in particular, DPPC/DOPC/Chol, we have mapped phase boundaries for the full

98 of the phase diagram of the tensionless DPPC/DOPC/Cholesterol lipid bilayer.

99 , we constructed a phase diagram of the DPPC/DOPC/ergosterol system at 20 vol % ethanol.

100 oyl-sn-glycero-3-phosphocholine (DOPC):DSPC, DOPC:1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC),

101 leoyl-phos phatidylcholine/cholesterol (DSPC/DOPC/POPC/CHOL) mixture displays a nanoscopic-to-macrosc

102 ns were depleted in unsaturated lipid (i.e., DOPC) and thus rich in cholesterol.

103 The addition of 40% cholesterol to either DOPC or DPPC changes the WAXS pattern due to an increase

104 When 40% cholesterol is added to either DOPC or DPPC, S(x-ray) more than doubles, consistent wit

105 n of positively charged ethylphosphocholine (DOPC+) vesicles into poly(dimethylsiloxane) (PDMS) micro

106 f a T20-gp41 complex embedded in an explicit DOPC membrane was constructed, and molecular dynamics si

107 orescein, which is coembedded into the fluid DOPC membrane.

108 obile fraction and diffusion coefficient for DOPC+ membranes remain virtually unchanged during this p

109 at an initial rate, which is comparable for DOPC and DPPC but is doubled for POPC.

110 es into the bilayers in increasing order for DOPC, POPC, and DPPC, while the amount of enzyme adsorbe

111 lowing a diffusion-limited growth regime for DOPC and in the case of POPC a homogeneous nucleation pr

112 A high selectivity for DOPC over dodecylphosphocholine (DPC) was also observed,

113 h increasing water content for DOPS than for DOPC, indicating greater perturbation of interlamellar w

114 er fluctuations are smaller in DOPS than for DOPC, showing that B and/or K(C) are larger.

115 r destruction at 25 degrees C decreases from DOPC to POPC and is dramatically reduced for DPPC.

116 and molecular packing density in going from DOPC to POPC to SM single component bilayers, as expecte

117 iments reveal that this reduced leakage from DOPC/DOPG vesicles cannot be explained by a reduced bind

118 giant unilamellar vesicles (GUVs) made from DOPC and DOPC/DOPE mixtures.

119 Furthermore, DOPC-encapsulated siRNA targeting the oncoprotein EphA2

120 1,2-dioleoyl-sn-glycerophosphatidylcholine (DOPC) exhibit the well-known lamellar phase at 90 mol %

121 1,2-dioleoyl-sn-glycerophosphatidylcholine (DOPC) were used to prepare complexes with DNA.

122 or bacterial toxin was developed with 5% GM1/DOPC+ membranes in PDMS channels, and a detection limit

123 POPG approximately DEPC/DEPG > DPePC/DPePG > DOPC/DOPG.

124 solvated by DOPC if it is available, but if DOPC is replaced by POPC, cholesterol is preferentially

125 In DOPC vesicles, most peptides repositioned so that the lo

126 ts maximum at P/L approximately 1/15-1/12 in DOPC bilayers.

127 n 3 for His(12) and about 3-5 for His(14) in DOPC membranes.

128 with the solubility limit of cholesterol in DOPC bilayers as independently measured by light scatter

129 ctrostatic domains induced by cholesterol in DOPC bilayers.

130 gnment and wavefront-matching constraints in DOPC, reflecting the requirement that the forward- and r

131 By contrast, in DOPC bilayers the affinity of G(t) for light-activated r

132 lve these nanoscale electrostatic domains in DOPC monolayers.

133 Fusion was enhanced in DOPC SUV at low peptide surface occupancy but hindered a

134 cally reduced the extent of DRM formation in DOPC/DPPC and DOPC/SM bilayers and ordered lipid phase s

135 nografted mice with miR-200c incorporated in DOPC nanoliposomes, we demonstrate anti-tumor activities

136 hannel, which was followed by an increase in DOPC and POPC or a further decrease in DLPC and DMPC bil

137 nalysis, for which the trans (cis) isomer in DOPC (DPPC) presents a fast decay time.

138 Nevertheless, in DOPC, we could estimate an apparent kink angle of approx

139 the magic angle) experiments carried out in DOPC/DOPE mixed lipid bilayers reveal a tilt angle of th

140 e exception of the KK-substituted peptide in DOPC vesicles, which formed a truncated TM segment.

141 igned spectrum of (15)N-labeled Leu39 PLB in DOPC/DOPE phospholipid bilayers was 220 ppm and is chara

142 to 9 A (a 13 residue hydrophobic sequence in DOPC bilayers).

143 a PP substitution maintained the TM state in DOPC vesicles, but in DEuPC vesicles the level of format

144 meter of a headgroup spin label DPP-Tempo in DOPC in excess water and partially dehydrated (10 wt % w

145 Remarkably, this was seen as well in DOPC-reconstituted Glu(134)- and Gln(134)-containing bov

146 fluorochrome Alexa 555 was encapsulated into DOPC liposomes and shown to be taken up by the tumor as

147 We propose that siRNA incorporated into DOPC nanoparticles could be delivered systemically and u

148 ally, exposure of membranes made of lamellar DOPC to halothane in concentrations close to clinically

149 ed; (ii) hydrogen-bonding between the lipid (DOPC) and the headgroup of 1, although extensive, is qui

150 aturated lipid (DPPC), an unsaturated lipid (DOPC), and ergosterol in the presence of high ethanol (2

151 anoliposomes prepared from different lipids (DOPC, POPC and DPPC) by thin film hydration method, were

152 at a vesicle system composed of four lipids, DOPC/DOPE/SM/CH, fused optimally at a 35/30/15/20 molar

153 oning between gel DPPC and disordered liquid DOPC domains with corresponding topography of domain str

154 ientations in the different lipid membranes (DOPC for the liquid disordered phase and DPPC for the ge

155 dylcholine (PC) layers in the microchannels, DOPC+ membranes show exceptionally strong resistance to

156 behavior of pure DPPC, pure DOPC, and mixed DOPC-beta-sitosterol bilayers solvated in a vitrificatio

157 Simulations of mixed DOPC/DOPE bilayers show that increase of the DOPE mole f

158 on as demonstrated for two ternary mixtures (DOPC/DSPC/CHOL and DOPC/DPPC/CHOL) at different choleste

159 ons of two different ternary lipid mixtures, DOPC/DPPC/Chol and POPC/PSM/Chol.

160 it the well-known lamellar phase at 90 mol % DOPC.

161 ted phase regime occurs at relatively narrow DOPC/(DOPC+POPC) ratios.

162 double-bond and water distributions of neat DOPC bilayers led to distributions that agreed with the

163 ation follows a diffusion law in the case of DOPC and a linear variation in the case of POPC.

164 dsorption trends indicate that the charge of DOPC+ membranes allows for tuning of solution conditions

165 Lipid bilayer membranes composed of DOPC, DPPC, and a series of sterols demix into coexistin

166 aped gel domains in GUV bilayers composed of DOPC/DPPC or DLPC/DPPC are observed by confocal fluoresc

167 s well-adapted to the native conformation of DOPC.

168 With an increasing mol fraction of DOPC, the response to the proteins increased, reaching a

169 urse of the PY-Ch E/M ratio during fusion of DOPC/PE/Ch small unilamellar vesicles showed a transient

170 ly(ethylene glycol) (PEG)-mediated fusion of DOPC:DL(18:3)PC (85:15) small, unilamellar vesicles (SUV

171 nti-Stokes Raman scattering (CARS) images of DOPC/DPPC-d62 bilayers.

172 ixture of DOPC/SM/Chol, and a 1:1 mixture of DOPC/SM.

173 olesterol (Chol) systems, a 1:1:1 mixture of DOPC/SM/Chol, and a 1:1 mixture of DOPC/SM.

174 upported membranes consisting of mixtures of DOPC and cholesterol exhibit large-area striping reminis

175 unilamellar vesicles composed of mixtures of DOPC or DPPC and cholesterol are not sensitive to choles

176 phase behavior is observed for monolayers of DOPC/DPPC/Chol and for monolayers of POPC/PSM/Chol.

177 With respect to the membrane normal of DOPC or DPPC lipid bilayer membranes, GWALP23-R14 shows

178 Increasing the PLR of DOPC proteoliposomes up to 1:200 increased their osmotic

179 rface charge, since the isoelectric point of DOPC is ca. 4.

180 It will be shown that the presence of DOPC and/or cholesterol greatly impacts the headgroup mo

181 red domain changes the packing properties of DOPC bilayer at a distance as large as approximately 8 n

182 (GUVs) containing phase-separated regions of DOPC (soft, liquid) and DPPC (stiff, gel), with choleste

183 As demonstrated in the study, use of DOPC nanoliposomes for anti-miR delivery serves as a bet

184 ated phase window shifts to higher values of DOPC/(DOPC+POPC) when CHOL concentration is increased, a

185 The deposition of MWNTs on DOPC vesicles under favorable deposition conditions did

186 sing DOTAP with either neutral lipid DOPE or DOPC.

187 Vesicles prepared from pure DPPC or DOPC, with gel to liquid-crystal transition temperatures

188 ixtures with dioleoyl-PC (DOPC) and DPPC, or DOPC and sphingomyelin (SM).

189 molecules do not show a preference for SM or DOPC.

190 assignments of SLN in mechanically oriented DOPC/DOPE lipid bilayers as mapped by 2D (15)N PISEMA ex

191 asymmetric vesicles composed of SM outside, DOPC inside (SMo/DOPCi) or SM outside, 2:1 mol:mol POPE:

192 eractions between P(4,5)BP and PtdIns(4,5)P2/DOPC+/PEG-PE membrane were observed as expected, while c

193 afts) in tertiary mixtures with dioleoyl-PC (DOPC) and DPPC, or DOPC and sphingomyelin (SM).

194 of 1,2-dioleoyl-sn-glycero-3-phophocholine (DOPC).

195 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) for efficient in vivo siRNA delivery.

196 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) nanoliposomes, we show that miR-192 delivery leads

197 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC)] to decrease melanoma growth and metastasis in viv

198 ed 1,2-dioleoyl-l-alpha-phosphatidylcholine (DOPC) vesicles at neutral pH, but spontaneous transmembr

199 taining either dioleoyl phosphatidylcholine (DOPC) or the neutral and phospholipids isolated from cal

200 cidin-modified dioleoyl phosphatidylcholine (DOPC)-coated electrodes.

201 cholesterol in dioleoyl-phosphatidylcholine (DOPC) lipid bilayers at high cholesterol concentration (

202 nanoliposomes (dioleoyl phosphatidylcholine, DOPC) containing small interfering RNA (siRNA) targeted

203 ipid (DMPC, dimyristoyl phosphatidylcholine; DOPC, dioleoyl phosphatidylcholine) to the negatively ch

204 y(ethylene glycol)-phosphatidylethanolamine (DOPC+/PEG-PE) system stands out as the best performer th

205 er 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) (fluid at room temperature) or 1,2-dipalmitoyl-sn-

206 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) containing 4 mol % biotinylated-cap-1,2-dioleoyl-s

207 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in nonpolar solvents.

208 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid bilayer were investigated by both second-har

209 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer.

210 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipids, with embedded alpha-helical peptide bundle

211 se 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes contacting a titanium dioxide substrate.

212 ng 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) nanoliposomes resulted in increased tumor growth a

213 ade of dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin

214 a 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) phospholipid bilayer via multi-nanosecond molecula

215 g 1,2-di-oleoyl-sn-glycero-3-phosphocholine (DOPC) phospholipid vesicles using a standard fluorescent

216 nt 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) vesicles on porous anodic aluminum oxide (AAO) mem

217 ), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1,2-dierucoyl-sn-glycero-3-phosphocholine (DE

218 ), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and cholesterol was studied with static and magic

219 nic 1,2-dioleoyl-sn-glyero-3-phosphocholine (DOPC), as well as DOPC vesicles, were used as model cell

220 ol 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), binds directly to S6K and causes an approximately

221 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), could be readily distinguished by evaluating diff

222 ol/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), focusing on the importance of the hydrophobic par

223 d, 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-based proteoliposomes were found to have excellent

224 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

225 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

226 in 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

227 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

228 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DP

229 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) bilayer

230 s [1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)

231 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/cholesterol and 1,2-dipalmitoyl-sn-glycero-3-phosp

232 s (1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC):DSPC, DOPC:1,2-dipalmitoyl-sn-glycero-3-phosphocho

233 o a 1,2-dioleoyl-sn-glycero-3-phosphocoline (DOPC) bilayer.

234 ar dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of lo

235 whereby tN-Ras binding was higher on planar DOPC than POPC membranes, but inversely higher on curved

236 protein in three lipid membranes, POPC/POPG, DOPC/DOPG, and DOPE.

237 The lipid mixtures used are predominantly DOPC/DPPC/Chol and DOPC/BSM/Chol, which have been previo

238 t degree of nonspecific adsorption to a pure DOPC bilayer, compared to avidin and streptavidin.

239 investigate the behavior of pure DPPC, pure DOPC, and mixed DOPC-beta-sitosterol bilayers solvated i

240 minimal effect on the phase behavior of pure DOPC at any temperature.

241 ts of detection on the dehydrated/rehydrated DOPC+/PEG-PE membranes were determined to be 33 nM for a

242 nal phase even when DOPE completely replaces DOPC.

243 on within the more ordered, cholesterol-rich/DOPC-poor/GM1-rich micrometer-scale phase, while GM1-ric

244 nding, disordered, cholesterol-poor/PSM-rich/DOPC-rich interdomain phase.

245 were found in mice treated with PAR-1 siRNA-DOPC.

246 ministration of S1MP loaded with-EphA2-siRNA-DOPC substantially reduced tumor burden, angiogenesis, a

247 ministration of S1MP loaded with EphA2-siRNA-DOPC.

248 eeks of treatment with EphA2-targeting siRNA-DOPC (150 microg/kg twice weekly) reduced tumor growth w

249 When EphA2-targeting siRNA-DOPC was combined with paclitaxel, tumor growth was dram

250 he atomistic simulations in a fully solvated DOPC lipid bilayer, the first (CNpNC) channel preserves

251 properties by using different lipids (SOPC, DOPC, or POPC) and lipid:cholesterol mixtures (SOPC:chol

252 In experiments with the lipids SOPC, DOPC, DPPC, and cholesterol we demonstrated that 1H MAS

253 myosin Va are able to transport fluid-state DOPC vesicles at velocities significantly faster (>700 n

254 kness between the domain and the surrounding DOPC bilayer.

255 x at a position corresponding to a synthetic DOPC lipid molecule in the cyanobacterial complex.

256 es, but inversely higher on curved POPC than DOPC membranes.

257 are less sensitive to osmotic pressure than DOPC headgroups, which is consistent with a larger K(C)

258 It is well-known that DOPC forms bilayers, whereas DOPE has a propensity to ad

259 ting that MWNTs did not severely disrupt the DOPC bilayers upon attachment.

260 For the DOPC-melittin system, the experimental transbilayer dist

261 ngated conformation of 1 is preferred in the DOPC bilayer environment; however, many other conformati

262 FCS data for the phospholipid probes in the DOPC fluid phase require two components (fast and slow).

263 outer leaflet decreased, whereas that in the DOPC-containing inner leaflet was largely unchanged, con

264 ort the observation of two new phases in the DOPC-DOPE system: a rhombohedral phase and a distorted h

265 pts a mixed strand/helix conformation in the DOPC/DOPG membrane, and is primarily a beta-strand in th

266 62-DPPC in the coexisting domains inside the DOPC/d62-DPPC (1:1) supported bilayers incorporated with

267 molecules spontaneously partitioned into the DOPC bilayer and then preferentially occupied regions cl

268 gh the insertion was less efficient into the DOPC bilayer.

269 n" state when the probe is inserted into the DOPC membrane, while it is in the "off" state in the DPP

270 tidylethanolamine (DOPE) introduced into the DOPC membrane.

271 The ordering of the DOPC acyl chains by cholesterol leads to retraction of t

272 Specific deuteration of the DOPC acyl-chain methyl groups and neutron diffraction me

273 kably smaller than the area 72.5 A(2) of the DOPC analog, despite the extra electrostatic repulsion e

274 lecules affect the hydrocarbon chains of the DOPC lipid, by lowering of the hydrocarbon tilt angles.

275 focal microscopy reveals that only 1% of the DOPC+ membrane in the microchannels was removed by the d

276 We provide a phase diagram of the DOPC/eSM/Chol mixture and predict the location of the cr

277 At high ionic strength the DOPC and DOPA lipids appear uniformly mixed.

278 xhibits a major population that moves to the DOPC bilayer surface and a minor population that occupie

279 MSMP siRNA, delivered in vivo using the DOPC nanoliposomes, restored tumor sensitivity to anti-V

280 tion was also observed at pH 2, at which the DOPC SLBs exhibited positive surface charge, since the i

281 demonstrated that binding of Abeta (1-42) to DOPC bilayer, enriched with 20% cholesterol, resulted in

282 The measured adsorption rate for SBN to DOPC was 2.7 +/- 0.2 x 10(3) s(-1) M(-1) and the desorpt

283 Trans DOPC also alters the membrane curvature distribution; th

284 Trans DOPC induces some vesicles to form multidomain, invagina

285 Here, we test the effect of trans DOPC (dielaidoyl phosphatidylcholine or DEPC) on the mor

286 Addition of trans DOPC does not alter the l(o)/l(d) area fractions, indica

287 n in the l(o) phase in the presence of trans DOPC.

288 ing compositions of egg sphingomyelin, trans DOPC, cis DOPC, and cholesterol.

289 of meridional curvatures in GUVs with trans DOPC is suggestive of higher membrane bending rigidity.

290 uced in the absence of PEG or in unperturbed DOPC LUV even in the presence of PEG.

291 with the extent of acyl chain unsaturation (DOPC:POPC ratio).

292 holesterol concentration, and of POPC versus DOPC, on the formation of ultrananodomains versus larger

293 alline phase transition temperature, whereas DOPC displays only minor variations in these lipid mixtu

294 icking and nuclear accumulation of DNA while DOPC-containing formulations remained within the late en

295 c, inverted hexagonal lipid structures while DOPC promotes more stable laminar structures.

296 ection efficiency than those formulated with DOPC, both in vitro and in vivo.

297 th DPPC and cholesterol, and immiscible with DOPC.

298 egregation property as DPPC when mixing with DOPC.

299 e segregation in ternary lipid mixtures with DOPC and CHO.

300 es of mixed anionic (DOPG) and zwitterionic (DOPC) content.