ライフサイエンスコーパス: DRM

1 DRM association was the same as a control random transme

2 DRM is also a highly endothermic reaction and requires o

3 DRM is characterized by the formation of aggregates cont

4 DRM is inevitably accompanied by deactivation due to car

5 DRMs can revert to wild-type and remain as minority stra

6 DRMs contained less phosphatidylethanolamine (PE) and ph

7 DRMs isolated from chondrocyte PM were enhanced in gangl

8 gically failed ART, of whom 70% carried >/=1 DRM and 49% had dual-class resistance, with an average o

9 Among participants with >/=1 DRM, HIV-1 susceptibility was reduced in 93% for efavire

10 46 (43.4%) with VL >/= 1000 cps/mL and >/=1 DRMs; no HIV RNA data was available for 32 (30.2%) parti

11 ual-class resistance, with an average of 2.4 DRMs per sequence (range, 1-8).

12 ter along with any other jobs scheduled by a DRM.

13 The evidence that a DRM-causing mutation affects CryAB muscle function and l

14 ent in DRMs, but was less abundant in abcb19 DRMs.

15 s, but virus in several patients accumulated DRMs to drugs not received, such as abacavir, didanosine

16 Overall, 7.3% transmitted and 34.3% acquired DRMs were found, including M184V, thymidine analogue mut

17 etative cells, and somatic tissues, although DRM activity extends into heterochromatin in vegetative

18 yed wild-type levels of membrane binding and DRM association, indicating that NC-mediated Gag multime

19 d Gag binding to total cellular membrane and DRM.

20 er, fluorescence probe microenvironment, and DRM formation were similar to those of cholesterol, othe

21 he FFAs, but was equally abundant in ROS and DRM PE.

22 ount of LAT in the immunological synapse and DRM by posttranslational palmitoylation contributes to t

23 ifferent active site requirement for WGS and DRM is confirmed by the experimental evaluation of the a

24 ed rabbits were treated with 1% Brij 98, and DRMs were isolated via sucrose gradient centrifugation.

25 ane (DRM), a key site of Src inhibition, and DRMs from K6-null keratinocytes were depleted of both ke

26 Proteins of ROS and DRMs were analyzed by SDS-PAGE and Western blot analysis

27 Lipids of ROS and DRMs were separated by two-dimensional, thin-layer chrom

28 cial for protein misfolding diseases such as DRM.

29 suggesting that FAK activation can occur at DRM microdomains.

30 ation of increased diversity or selection at DRM sites compared to other sites and no association bet

31 amides at the ER largely decreases Sig-1R at DRMs and causes translocation of Sig-1R from the MAM to

32 timized the MAS assay to determine subtype B DRMs in dried blood spots (DBS) collected from patients

33 mal models of desmin-related cardiomyopathy (DRM).

34 120G)) causes desmin-related cardiomyopathy (DRM).

35 utation in alpha-B-crystallin (CryAB) causes DRM and is characterized by aggresomes containing CryAB(

36 to oligomerize, associate with non-caveolar DRMs and is distantly related to flotillins.

37 ciated F protein fractionated with classical DRMs with densities of 1.07 to l.14 as defined by flotat

38 rotein eliminated association with classical DRMs.

39 Under current climate, DRMs performed best, although only marginally.

40 may also associate with non-clathrin coated, DRM-enriched vacuoles.

41 The most common DRMs were M184V (53.5%), K103N (28.9%), Y181C (15.5%), a

42 ate groups that were also reported to confer DRM association.

43 hoptries of an apicomplexan parasite contain DRM rafts.

44 In contrast, DRM contained significant levels of crystalline sterol.

45 In contrast, DRM had structural properties similar to those of NR, an

46 This review will cover DRM literature for catalysts based on Rh, Ru, Pt, and Pd

47 Although the dsRNA-binding activity of CPL2 DRM has not been shown to date, T-DNA insertion mutants

48 Sig-1Rs associate with MAM-derived DRMs but not with those from microsomes.

49 ROS-derived DRMs were dramatically enriched in caveolin-1, contained

50 ospholipids and fatty acids from ROS-derived DRMs.

51 Several small studies have described DRMs that emerge in patients receiving dolutegravir.

52 The new assay accurately detected DRMs, including low-abundance mutations that were often

53 Disrupting DRMs by lowering cholesterol or inhibiting de novo synth

54 y, formation of detergent resistant domains (DRM), phase separation, and membrane microsolubilization

55 n assay sensitivity, the length of time each DRM is detectable within individuals.

56 the Drosophila dREAM/Myb-MuvB and C. elegans DRM transcriptional regulatory complexes.

57 y the first two assays but slightly enhanced DRM association.

58 either a part of DRM (cpl2-1) or the entire DRM (cpl2-2) exhibited leaf expansion defects, early flo

59 ngs suggest that CYP1A2 and CPR reside in ER-DRMs and that the unique lipid components of these domai

60 hese studies showed that iota-toxin exploits DRMs for oligomer formation to intoxicate cells.

61 s, while all Ni surface atoms are active for DRM.

62 The most widely used catalysts for DRM are based on Ni.

63 y increasing significantly the stability for DRM.

64 We screened for DRMs during early-acute viremia and examined the diversi

65 ing model of apicomplexan vacuole formation, DRM association, rather than lipid anchors, provides the

66 with detergent-resistant membrane fractions (DRMs).

67 The majority of low-frequency DRM detected using UDS are likely errors inherent to UDS

68 atty acids; the converse was true of CM from DRMs.

69 In general, DRMs were enriched in saturated fatty acids when compare

70 ikely that minority viral variants harboring DRM are transmitted and maintained in the recipient host

71 active, vacuolar uptake of a subset of host DRM proteins.

72 de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood.

73 tor and cytochalasin D-stimulated changes in DRM lipid composition follow first-order kinetics.

74 lide, prevents antigen-stimulated changes in DRM PL composition.

75 argely prevented mitochondrial deficiency in DRM but that contractility was not improved because of m

76 Docosahexaenoic acid was diminished in DRM PS and was not detected in the FFAs, but was equally

77 ase in the recovery of polyunsaturated PL in DRM, particularly in phosphatidylinositol species.

78 cation of misfolded proteins, are present in DRM.

79 tely 73% of CYP1A2 and 68% of CPR resided in DRM fractions, compared with only 33% of total ER protei

80 n presents, may be a therapeutic strategy in DRM as well as in other types of cardiac disease in whic

81 les on alumina, the commonly used support in DRM.

82 However, pUL37x1/vMIA was not detected in DRMs from mitochondria.

83 PECAM localized in DRMs displays reduced phosphorylation and does not suppo

84 ting revealed that Ib oligomers localized in DRMs extracted from Vero, but not MRC-5, cells while mon

85 vely saturated lipid environment observed in DRMs is likely to promote the localization of signaling

86 In the wild type, PIN1 was also present in DRMs, but was less abundant in abcb19 DRMs.

87 N-cadherin and catenins are present in DRMs; however, their DRM distribution is not significant

88 dent rhoptry protein, RhopH2 also resides in DRMs.

89 dulate bilayer order and polarity and induce DRM formation to a similar extent.

90 y, we hypothesized that CryAB(R120G)-induced DRM would also respond favorably to prolonged voluntary

91 or nucleoside and nonnucleoside RT inhibitor DRM.

92 Finally, the 10 internalized DRM proteins show varied lipid and peptidic anchors indi

93 lattice opposes entry of many proteins into DRM rafts.

94 transporters, such as Abcg1, which itself is DRM associated.

95 o density gradient centrifugation to isolate DRMs from the parent membranes.

96 Here we show that isolated DRMs containing the highest cholesterol-to-protein ratio

97 RT initiation, 38 (18%) subjects had a major DRM and an increased proportion of resistance was seen i

98 nto care, as 18% of our population had major DRMs prior to initiation of ART.

99 Interestingly, two subjects had major DRMs to NRTIs, NNRTIs, and 4 mutations in the Gag P2/NC

100 ns (DRMs) in the gag P2/NC CS, and pol major DRMs.

101 ral Society-USA list was used to score major DRMs.

102 lant homolog of flotillin, a major mammalian DRM protein, suggesting a conserved role for this protei

103 mmonly used distributed resource management (DRM) systems, and it can be easily extended to new DRMs.

104 ombined total of 227 drug-related materials (DRM) were detected from all eight test article incubatio

105 ory effect" of the Deese-Roediger-McDermott (DRM) paradigm: studying words that fit a common schema (

106 ssion of the mutation, CryAB(R120G)-mediated DRM is characterized by CryAB and desmin accumulations w

107 , similar to that found with plasma membrane DRMs.

108 components in detergent-resistant membrane (DRM) domains that are related to ordered membrane compar

109 nslocates to a detergent-resistant membrane (DRM) during transmigration.

110 sterols in the detergent-resistant membrane (DRM) fractions obtained from yeast and plant cells repli

111 ocalization in detergent-resistant membrane (DRM) fractions were defective in anergic T cells.

112 o Triton X-100 detergent-resistant membrane (DRM) fractions.

113 the amount of detergent-resistant membrane (DRM) material.

114 ly in platelet detergent-resistant membrane (DRM) rafts but that from Glanzmann's thrombasthenic plat

115 Studies of detergent-resistant membrane (DRM) rafts in mature erythrocytes have facilitated ident

116 or outside of detergent-resistant membrane (DRM) regions at the plasma membrane.

117 nriched in the detergent-resistant membrane (DRM), a key site of Src inhibition, and DRMs from K6-nul

118 is enriched in detergent-resistant membrane (DRM)-forming lipids, including cholesterol and ceramide,

119 be isolated as detergent-resistant membrane (DRM).

120 o produce (i) detergent-resistant membranes (DRM) and detergent-soluble membranes (DSM), (ii) nondete

121 zation to the detergent-resistant membranes (DRM) and HCV particle assembly.

122 sociates with detergent-resistant membranes (DRM) in a p7-dependent manner.

123 viruses with detergent-resistant membranes (DRM) may provide a general mechanism for their retrograd

124 formation of detergent-resistant membranes (DRM).

125 rporated into detergent-resistant membranes (DRMs) but still are delivered apically, suggesting that

126 omposition of detergent-resistant membranes (DRMs) from chondrocyte PM.

127 aised against detergent-resistant membranes (DRMs) from monocytes or activated T cells, but not resti

128 recent years, detergent-resistant membranes (DRMs) have been isolated in in vitro models of lipid raf

129 sociated with detergent-resistant membranes (DRMs) in a manner similar to that of markers of classica

130 d as buoyant, detergent-resistant membranes (DRMs) in OptiPrep density gradients.

131 port that the detergent-resistant membranes (DRMs) play an important role in anchoring Sig-1Rs to the

132 c analysis of detergent-resistant membranes (DRMs) revealed that the galectin lattice opposes entry o

133 ssociate with detergent-resistant membranes (DRMs) that are believed to represent lipid rafts.

134 Triton X-100 detergent-resistant membranes (DRMs) was developed using Arabidopsis (Arabidopsis thali

135 s (DSMs) from detergent-resistant membranes (DRMs), and measured their peptide and lipid compositions

136 as defined by detergent-resistant membranes (DRMs), in non-lipid raft membranes, and in virions showe

137 bly occurs in detergent-resistant membranes (DRMs), while serine 36 phosphorylation takes place in no

138 ociation with detergent-resistant membranes (DRMs).

139 n erythrocyte detergent-resistant membranes (DRMs).

140 nslocate into detergent-resistant membranes (DRMs).

141 analysis using the disjunctive rule merging (DRM) approach on a large and diverse dataset compiled fr

142 production via the dry reforming of methane (DRM) is a highly endothermic process conducted under har

143 Dry (CO2) reforming of methane (DRM) is a well-studied reaction that is of both scientif

144 The dry reforming of methane (DRM), i.e., the reaction of methane and CO2 to form a sy

145 as shift (WGS) and dry reforming of methane (DRM), two key industrial reactions with common elementar

146 The Day Reconstruction Method (DRM) assesses how people spend their time and how they e

147 DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but h

148 d in detergent-resistant lipid microdomains (DRM).

149 Detergent-resistant membrane microdomains (DRM) rich in cholesterol and sphingolipid, termed lipid

150 h detergent-resistant membrane microdomains (DRMs) were extracted with cold Triton X-100.

151 h detergent-resistant membrane microdomains (DRMs), which are known to be involved in their biogenesi

152 -enriched, detergent-resistant microdomains (DRMs).

153 ent, the probability of detecting a minority DRM in the recipient was not increased when the same min

154 er sites and no association between minority DRM and AM.

155 was no correlation between detected minority DRM and clinical failure of first-line ART.

156 ed the association between detected minority DRM and the virologic failure of first-line antiretrovir

157 evidence for sexual transmission of minority DRM (BF = 0.02).

158 The presence of minority DRM during early infection, followed by a rapid decay, i

159 al significance of the detection of minority DRM remains controversial.

160 s variability in the proportions of minority DRM.

161 ent was not increased when the same minority DRM was detected in the source (Bayes factor [BF] = 6.37

162 ission pairs to investigate whether minority DRM detected shortly after transmission were the consequ

163 Bayesian process-based dynamic range model (DRM).

164 Moreover, DRMs in CerS2 null mice displayed properties significant

165 ns a double-stranded (ds)-RNA-binding motif (DRM).

166 sence of minority drug resistance mutations (DRM) may be a consequence of sexual transmission, de nov

167 ation of minority drug resistance mutations (DRM), including among antiretroviral therapy-naive HIV-i

168 l populations with drug-resistant mutations (DRM) are inconsistent with evidence that HIV-1 infection

169 gical failure and drug resistance mutations (DRMs) after 12 or 24 months of ART.

170 Drug resistance mutations (DRMs) can serve as distinct, nonpolymorphic markers for

171 HIV strains with drug-resistance mutations (DRMs) causes public health problems in resource-rich cou

172 apid selection of drug resistance mutations (DRMs) during monotherapy with direct-acting antivirals (

173 mined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-l

174 Cameroonians for drug resistance mutations (DRMs) in the gag P2/NC CS, and pol major DRMs.

175 smitted genotypic drug resistance mutations (DRMs) in this population.

176 e emerging on the drug resistance mutations (DRMs) selected by the most widely used ARVs and on the i

177 000 cps/mL and no drug resistance mutations (DRMs), 46 (43.4%) with VL >/= 1000 cps/mL and >/=1 DRMs;

178 f HIV-1 subtype C drug resistance mutations (DRMs).

179 Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by

180 enerative diseases, desmin-related myopathy (DRM), and congestive heart failure.

181 ion associated with desmin-related myopathy (DRM), results in an altered sarcomeric actin pattern, in

182 ryAB(R120G)) causes desmin-related myopathy (DRM), which is characterized by the formation of desmin-

183 ryAB(R120G)) causes desmin-related myopathy (DRM).

184 ystems, and it can be easily extended to new DRMs.

185 FAK biosensor are stronger than that at non-DRM regions, suggesting that FAK activation can occur at

186 serine 36 phosphorylation takes place in non-DRMs.

187 Treatment-naive subjects harboring NRTI-DRMs had significantly lower CD4 cells than those with N

188 icantly lower CD4 cells than those with NRTI-DRMs on ART (p = 0.042).

189 No NS3 DRMs that confer resistance to GS-9256 and GS-9451 (R155

190 not suppress the identified preexisting NS3 DRMs and thus a need for a combination therapy.

191 In contrast, 100% of DRM in both matrixes were subjected to MS(2) acquisition

192 e incubations, and among those, 5% and 4% of DRM were not triggered for MS(2) acquisition with IDA an

193 al analyses revealed an exponential decay of DRM (BF = 0.05) while genetic diversity increased.

194 studies, we observed increased detection of DRM at low frequencies (average, 0.56%; 95% CI, 0.43 to

195 olesterol dramatically reduced the extent of DRM formation in DOPC/DPPC and DOPC/SM bilayers and orde

196 MS(2) spectra were the real product ions of DRM detected in microsomal samples from IDA, SWATH, and

197 While the majority of DRM (>20%) were consistently transmitted from source to

198 porter mice with a transgenic mouse model of DRM featured by aberrant protein aggregation in cardiomy

199 g enzyme that is upregulated in our model of DRM.

200 press CPL2 variants lacking either a part of DRM (cpl2-1) or the entire DRM (cpl2-2) exhibited leaf e

201 od of sexual transmission and persistence of DRM was assessed using Bayesian-based statistical modeli

202 e, sequence reproducibility, and presence of DRM and accessory mutations (AM).

203 the structural and functional properties of DRM and those of the nondetergent preparations (ACR and

204 fidence intervals (CI) for the proportion of DRM at each site and fitted a binomial mixture model to

205 growth factor (PDGF), the FRET responses of DRM-targeting FAK biosensor are stronger than that at no

206 While transmission of DRM may impact future therapy options for newly infected

207 Subsequent lipid characterization of DRMs via high performance liquid chromatography-triple q

208 more rapid, change in the PL composition of DRMs in the absence of FcepsilonRI activation, indicatin

209 Based on the lipid composition of DRMs, the authors conclude that they would not efficient

210 significant change in the PL composition of DRMs.

211 We previously compared PL compositions of DRMs with plasma membrane vesicles and whole cell lipid

212 Furthermore, the isolation of DRMs from purified intracellular organelles independentl

213 Our results indicate that the preparation of DRMs can yield a very specific set of membrane proteins

214 In this study, we evaluated the presence of DRMs in HCV-infected patients treated with the HCV prote

215 Transmission of DRMs with extremely high FCs (>6%) only occurs from appr

216 Transmission of DRMs with low FCs ( approximately 0.2%) is similar to wi

217 tlenecks substantially limit transmission of DRMs with moderately high FCs ( approximately 0.6%); cha

218 able for association of Gag with membrane or DRM.

219 411) fusion protein translocated to platelet DRM rafts on thrombin activation, but its mutant that wa

220 Predominant DRMs were associated with ART regimens, but virus in sev

221 ividuals; however, the levels of preexisting DRMs are too low to be directly quantified in most patie

222 ws the progression to HF in the CryAB(R120G) DRM model and that PAO accumulation is mediated, at leas

223 olipids, thus forming Triton X-114-resistant DRMs.

224 Relative to ROS, DRMs were enriched in free fatty acids (FFAs) and a spec

225 We determined that although NS2's DRM localization is dependent on p7, p7 was not targeted

226 ng transmission of 10 clinically significant DRMs.

227 construct expressed in cells showed similar DRM association when both were reconstituted into mixed

228 Here, we show that DRM recruitment of SLTx bound to its globotriosylceramid

229 Lipid analysis showed that DRM fractions were enriched in cholesterol and sphingomy

230 These data suggest that DRM association is necessary but not sufficient for vacu

231 A further complication is that DRMs of vastly different protein and cholesterol content

232 The DRM's utility is shown by documenting close corresponden

233 Finally, we find that AGO4 and the DRM methyltransferase genes are required for maintenance

234 nvelopment and postenvelopment events at the DRM to generate infectious HCV production.

235 ocumenting close correspondences between the DRM reports of 909 employed women and established result

236 yclodextrin (MbetaCD) not only disrupted the DRM localization of Core, NS2, and E2 but also specifica

237 ts we demonstrate that alphaB resides in the DRM fraction.

238 background level of p7 was detectable in the DRM fractions.

239 cation-dependent accumulation of ApoE in the DRM fractions.

240 antly increased rather than decreased in the DRM heart.

241 s that comprise pollen-with mutations in the DRM, CMT2, and CMT3 methyltransferases.

242 urated or monounsaturated PL decrease in the DRM, whereas concentrations of PL with two or more doubl

243 omitantly with fibrin translocation into the DRM raft of thrombin-stimulated platelets.

244 Thus, our data support the role of the DRM as a platform for particle assembly process.

245 Since disruption of the DRM localization of NS2 and E2, either due to p7 and NS2

246 Relative fitness of the DRM viruses was shown to be significantly lower than the

247 Based on the DRM growth kinetics during drug treatment, pretreated NS

248 odextrin (MbetaCD) significantly reduced the DRM association of Core, NS2, and E2 and reduced infecti

249 olume of blank rat urine (urine sample), the DRM without MS(2) acquisition increased to 29% and 18%,

250 analysis of the hedonic treadmill shows the DRM's potential for well-being research.

251 oylation of LAT and were selective since the DRM localization and palmitoylation of Fyn were intact.

252 3) lipids with a composition similar to the DRM fractions (V-DRM).

253 h the DRM, recruitment of E2 and ApoE to the DRM may allow the efficient coordination of Core particl

254 ed that NS2 regulates E2 localization to the DRM, consistent with its role in recruiting E2 to the vi

255 or is not involved in NS2 recruitment to the DRM, despite its apparent targeting to this location.

256 pecifically inhibited E2 localization to the DRM, indicating that NS2 regulates this process.

257 ction, these proteins' associations with the DRM likely play an important role during HCV assembly.

258 ining a neuropsychological approach with the DRM task.

259 CV Core protein strongly associates with the DRM, recruitment of E2 and ApoE to the DRM may allow the

260 The DRMs could support viral RNA synthesis on both the endog

261 The DRMs represented 8% and 3%, respectively, of total ROS l

262 The DRMs were also 5-fold increased in sphingolipid-to-prote

263 Recent studies have described the DRMs that emerge in patients receiving tenofovir prodrug

264 Subsequently, these proteins exited the DRMs and were recovered quantitatively in purified virio

265 ith membranes, they do not colocalize in the DRMs.

266 electron-dense bodies characteristic of the DRMs and identify these bodies as aggresomes, which are

267 matography-mass spectrometry showed that the DRMs had a 4-fold higher sterol-to-protein content than

268 nsitive response family, suggesting that the DRMs originated from PM domains.

269 y-tandem mass spectrometry revealed that the DRMs were highly enriched in specific proteins.

270 e ability of core protein to localize to the DRMs did not require other elements of the HCV polyprote

271 catenins are present in DRMs; however, their DRM distribution is not significantly affected by lattic

272 These DRMs were found to be cholesterol-dependent: CPR and CYP

273 widely used ARVs and on the impact of these DRMs on ARV susceptibility and virological response to f

274 Bcl-2 overexpression prolonged life in this DRM model, in the absence of apoptosis, another death pa

275 mediate plant asymmetric methylation through DRM enzymes, is also unclear.

276 tracellular membranes, in marked contrast to DRM that contained the highest level of cross contaminan

277 es show that S-palmitoylation contributes to DRM association of nicastrin and APH-1.

278 n affects CryAB muscle function and leads to DRM-like phenotypes in the fly reveals a conserved stres

279 l-dependent apical sorting is not related to DRM association of GPI-APs.

280 Furthermore, fibrin translocation to DRM rafts was impaired in factor XIII A subunit-deficien

281 SOAT1/Acat1 enzyme and activity localize to DRMs.

282 wnregulated following PECAM translocation to DRMs.

283 e of the methyltransferase domain of tobacco DRM (NtDRM) and reveal a molecular basis for its rearran

284 Reverse-transcriptase DRMs demonstrate that the breadth of variants in transmi

285 dy we investigated the mechanisms underlying DRM association of gamma-secretase subunits.

286 ween CPR and CYP1A2 was measured, V-ER and V-DRM liposomes produced lower apparent K(m) values compar

287 composition similar to the DRM fractions (V-DRM).

288 bunits of the gamma-secretase associate with DRM.

289 monstrated that HIV-1 Gag is associated with DRM and that disruption of Gag-raft interactions impairs

290 cell surface association of bound toxin with DRM.

291 nce of Gag, envelope fails to associate with DRMs.

292 ns also eliminated envelope association with DRMs in 293T cells and in the T-cell line, MOLT 4.

293 we show that HIV-1 envelope association with DRMs is directly influenced by its interaction with Gag.

294 lly, suggesting that GPI-AP association with DRMs is not necessary for apical targeting.

295 tial for efficient envelope association with DRMs, which in turn is essential for envelope budding an

296 us also eliminated envelope association with DRMs.

297 exosomes may reside in its association with DRMs/lipid rafts.

298 LAT in mixed vesicles associated better with DRMs than the peptide.

299 tered the association of viral proteins with DRMs and resulted in an enhanced release of virus partic

300 However, toxin sequestration within DRM of the ER was abolished under reduced GlcCer conditi