ライフサイエンスコーパス: DTNBP1

1 ctor dysbindin, which is encoded by the gene DTNBP1.

2 ntity of the disease-associated haplotype at DTNBP1.

3 xpression of dystrobrevin binding protein 1 (DTNBP1), a well-supported susceptibility gene for schizo

4 tation reducing expression of either COMT or DTNBP1 alone produced working memory advantages, while,

5 of-function mutations in two of these genes, DTNBP1 and BLOC1S3, cause Hermansky-Pudlak syndrome, a h

6 cus on the schizophrenia susceptibility gene DTNBP1 and its product dysbindin, a subunit of the BLOC-

7 for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1).

8 est known as dystrobrevin-binding protein 1 (DTNBP1) and may thus be associated with the dystrophin g

9 oci relates to the genes encoding dysbindin (DTNBP1) and neuregulin (NRG1).

10 e to be strong are those encoding dysbindin (DTNBP1) and neuregulin 1 (NRG1).

11 tion between variants in the dysbindin gene (DTNBP1) and schizophrenia.

12 gene encoding the novel protein dysbindin-1 (DTNBP1) are among the most commonly reported genetic var

13 ly, the weight of evidence supports NRG1 and DTNBP1 as schizophrenia susceptibility loci, though work

14 International HapMap Project (HapMap), about DTNBP1 by specifically typing all associated single-nucl

15 din) and that mutation of the human ortholog DTNBP1 causes a novel form of HPS called HPS-7.

16 eam of the schizophrenia susceptibility gene DTNBP1 confer susceptibility to copper, a metal that in

17 DTNBP1 (dystrobrevin binding protein 1) is a leading can

18 DTNBP1 (dystrobrevin binding protein 1) remains a top ca

19 leotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) ar

20 ibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding

21 ndin protein owing to a deletion in the gene Dtnbp1 (encoding dysbindin) and that mutation of the hum

22 The region of linkage to DTNBP1 expression on chromosome 8 is contiguous with lin

23 nome-wide suggestive evidence for linkage of DTNBP1 expression to chromosome 8p, suggesting a locus t

24 of white European ancestry also index lower DTNBP1 expression, whereas putative 'protective' haploty

25 this reflects variable cis-acting effects on DTNBP1 expression.

26 e risk, at least in part, through effects on DTNBP1 expression.

27 a locus that exerts a trans-acting effect on DTNBP1 expression.

28 putative 'protective' haplotypes index high DTNBP1 expression.

29 of a dys haplotype associated with decreased DTNBP1 expression.

30 cytoskeleton organisation (ACTR3, CDC42BPA, DTNBP1, FERMT2, PRKCZ, RAC1), and cytokine production (F

31 In addition, six genes (DPYSL2, DTNBP1, G30/G72, GRID1, GRM4, and NOS1) showed overlappi

32 nt genes (APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4,

33 as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25,

34 Our data indicate that variation in the DTNBP1 gene confers susceptibility to schizophrenia thro

35 rms or if they are associated with decreased DTNBP1 gene expression.

36 provides further evidence for a role of the DTNBP1 gene in the genetic etiology of schizophrenia.

37 The DTNBP1 gene, encoding dysbindin, is now generally consid

38 These data suggest that DTNBP1 genetic variation influences human intelligence.

39 These data suggest that the effect of DTNBP1 genetic variation may be associated with negative

40 We report an association between DTNBP1 genotype and general cognitive ability (g) in two

41 bindin (dys; dystrobrevin-binding protein 1 (DTNBP1))--implicated through different mechanisms in cor

42 e reported confirmation of an association to DTNBP1 in independent European samples; however, reporte

43 y implicated dystrobrevin-binding protein 1 (DTNBP1) in the etiology of schizophrenia.

44 The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in

45 by mutations in the schizophrenia risk gene Dtnbp1 led to spine deficiency, dysconnectivity in the e

46 wide significant evidence for linkage at the DTNBP1 locus on chromosome 6p22, and demonstrated that t

47 ants that results in a relative reduction in DTNBP1 mRNA expression in human cerebral cortex.

48 tiple previous studies, including dysbindin (DTNBP1), neuregulin (NRG1), and disrupted-in-schizophren

49 schizophrenia-susceptibility gene dysbindin (DTNBP1 on 6p22.3) encodes a neuronal protein that binds

50 sm for pathogenesis in which risk alleles in DTNBP1, or other factors that also downregulate dysbindi

51 e genes that regulate melanosome biogenesis (Dtnbp1, Pldn, Vps33a) also result in increased cis-plati

52 authors tested for an association between a DTNBP1 risk haplotype and a lifetime history of negative

53 issue samples and in the absence of the only DTNBP1 risk haplotype for schizophrenia reported in the

54 Recently, a DTNBP1 risk haplotype, associated with both schizophreni

55 We analyzed seven previously tested DTNBP1 single-nucleotide polymorphisms (SNPs) in a cohor

56 DTNBP1 siRNA decreased dysbindin protein, increased cell

57 We studied the effects of transfection of DTNBP1 siRNA on cell surface levels of dopamine D2 recep

58 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AK

59 interacts with the fly homolog of Dysbindin (DTNBP1) via direct protein-protein interaction in develo

60 DTNBP1 was first identified as a putative schizophrenia-