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2 surveyed >3,700 plasma metabolites (50-1,000 Da) for differential expression in XOR wildtype vs. mice
5 AA is synthesized as a precursor of ~110,000 Da that is N-glycosylated and targeted to the lysosome v
6 1355 Da) and proteins ( approximately 14 000 Da) are demonstrated, with approximately 1-2 orders of m
7 complex that eluted at approximately 151,000 Da upon Superdex 200 size-exclusion chromatography (SEC)
11 l (PEG, molecular weight approximately 8,000 Da, 10(-7)-10(-4) M) increase the half-life of a green f
13 ) with a molecular weight as high as 900 000 Da was successfully detected using the carbon nanofibrou
15 m 500-Da targeted polar molecules to 150,000-Da tagged immunoglobulins into the brain of living mice.
16 including L4 proteins of 22,000- and 33,000-Da apparent molecular mass (L4-22K and -33K proteins) th
22 re isolated for tandem MS analysis using a 1 Da mass isolation window, followed by collision-induced
24 or the 10 LC-MS(2) DDA data sets with > +/-1 Da isolation windows, the median precursor purity score
26 n II-2 which differed in mass by less than 1 Da, the determination of a sequence for protein IB8a tha
27 nd lipids from 92 selected m/z windows (+/-1 Da) with a spatial resolution of better than 150 mum.
28 r the realization of 16-plex reagents with 1 Da spacing between reporter ions and up to 28-plex at 6
29 low molecular weight ( approximately 30-100 Da) contaminants representative of those detected in wat
30 served that three molecules ranging from 100 Da to 70 kDa permeated into a preclinical glioblastoma m
34 a for 20 Da wide mass segments across a 1000 Da range, stitched into a single composite mass spectrum
35 permeability at molecular weights above 1000 Da and it appears likely that this cutoff constitutes an
39 ct, matrix-free analysis of small (MW < 1000 Da) lipid compounds, without interferences in the result
42 However, chemical space from 500 to 1000 Da remains virtually unexplored and represents a vast op
43 another intermediate with a [M-H](-) at 102 Da, identified as ONNHCH(2)NHCHO (NO-NDAB), were detecte
46 t pKpQIL_p019 (p019)-an approximately 11,109-Da protein associated with certain blaKPC-containing pla
47 iaceae spectra found an approximately 11,109-Da signal in nine spectra (1.3%), including seven from p
49 molecules, are shifted by + 4, + 8 and + 12 Da, which expose signals across areas of the previously
52 es to accurately determine the mass (202.126 Da) of a compound that is specifically present in this p
53 the gas phase, evident from +64 Da and +128 Da signals that can be assigned to Hb carrying two and f
56 depleted human plasma had an additional 1347 Da over the native albumin extracted from human plasma,
57 all model molecules ( approximately 200-1355 Da) and proteins ( approximately 14 000 Da) are demonstr
58 utral loss chromatograms for 78, 98, and 136 Da allowed the identification of long-chain fatty acids
60 periodicity of the oscillations is about 14 Da which is the most common difference between the masse
61 We show that the intact mass of Rpl1ab is 14 Da larger than its calculated mass with the previously d
66 lion molecular structures between 0 and 1450 Da, which correspond to about 27000 distinct elemental f
67 p202-220, 2127 Da), and 12-mer (p57-68, 1453 Da)] in duodenal biopsy specimens mounted in Ussing cham
70 weight (LMW) molecules (molecular mass < 150 Da) that differ from each other by one or a few N-methyl
73 on reaction pathways: hydroxyl addition (+16 Da), alcoholic oxidation or dehydrogenation (-2 Da), and
75 ns with a peak-to-peak mass difference of 16 Da consistent with the repeating unit of the beta-(1-->3
76 and a mass consistent with ritonavir plus 16 Da, in agreement with the whole-protein mass spectrometr
77 ozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the
78 n provided insufficient mass resolution (162 Da) to observe porosity on the experimental time scale;
79 well as a low molecular weight anatoxin (165 Da, 10(-14) m) are detected selectively and reproducibly
80 (110.18 Da) and 4-fluorobenzenethiol (128.17 Da), or large macromolecules such as anti-mouse IgG (~15
81 ptide FGES198AGAAS with an added mass of 170 Da from cresyl phosphate on serine 198 (Ser198) was dete
82 eights, including small benzenethiol (110.18 Da) and 4-fluorobenzenethiol (128.17 Da), or large macro
83 results were corroborated with glucose (180 Da) and inulin (5000 Da) transdermal flux experiments, w
84 rom pure bis-SorbPC was equivalent to a 1800 Da linear dextran, corresponding to a maximum pore diame
85 arkers [ionic conductance (G), mannitol, 182 Da; horseradish peroxidase, 40 kDa] and gliadin peptides
86 ides, dyes, drugs, lipids, and proteins (186 Da to 8.5 kDa) from various materials including urine, b
87 tic neutral loss pattern of 98, 178, and 196 Da, which enables the distinction between isobaric pyro-
90 isomers formed single unique [M + H](+) (199 Da) parent ions, whereas in MALDI each isomer shows sign
95 idation product with the loss of hydrogen (2 Da mass decrease) for Trp-107 of the heavy chain was ide
97 h (18)O at isoAsp leads to a mass shift of 2 Da, which can be automatically and unambiguously recogni
99 repeatedly cycles through 28 consecutive 20 Da precursor isolation windows detecting all precursor i
100 anic asphalt sample by acquiring data for 20 Da wide mass segments across a 1000 Da range, stitched i
104 molecular weight cutoff (MWCO) of 1000-2000 Da but also have a high pure water permeability (PWP) of
106 seful for analysis of small molecules (<2000 Da) such as those present in petroleum crude oil and pet
109 19-mer (p31-49, 2245 Da; and p202-220, 2127 Da), and 12-mer (p57-68, 1453 Da)] in duodenal biopsy sp
111 boxylic acids with molecular weight (MW) 216 Da (most likely C10H16O5) and MW 214 Da (C10H14O5) was c
114 an increase in mass of the apo-CYP2B4 by 218 Da as determined by electrospray ionization liquid chrom
115 ALDI-TOF revealed a molecular mass of 13,221 Da, and 12-23 aa sequences of OIF had homology with huma
116 ith a relatively small molecular weight (221 Da), provides an optimal building block for developing a
117 -mer (p56-88, 3900 Da), 19-mer (p31-49, 2245 Da; and p202-220, 2127 Da), and 12-mer (p57-68, 1453 Da)
118 ducing compound has an estimated mass of 226 Da, as determined by mass spectrometry, and is referred
119 Neutral loss (NL of 176, 194, 211, and 229 Da) and precursor ion (PI of m/z 141, 159, and 177, in p
123 provides a diagnostic mass difference of 24 Da and enables differentiation of double-bond positional
124 el with a fitted molar mass of 40180 +/- 240 Da (without Mg(2+) ions) or 41290 +/- 330 Da (with Mg(2+
126 orm to detect ultralow-molecular-weight (244 Da) biomolecules at picomolar concentrations using a sta
131 eight hyaluronan (LMW-HA, approximately 2500 Da) promotes endothelial cell (EC) barrier disruption an
132 of 0.50 nm, a molecular weight cutoff of 255 Da, and a reasonably high pure water permeability (A) of
134 educing the size of this analog by about 274 Da resulted in the resumption of the transport activity
135 For large peptides such as melittin (2845 Da), CID of the [M + 3H](3+), [M + 4H](4+), and [M + 5H]
136 ic and multimeric, ranging in mass from 2846 Da (melittin) to 150 kDa (Immunoglobulin G), and we cons
137 haracterized by the presence of a dimer (286 Da) proposed to be formed through the self-reaction of n
138 re modified with a glycan with a mass of 291 Da, while B. thailandensis flagellin protein was modifie
139 de ions have masses ranging from 231 to 2969 Da, Omega(He) of 89-616 A(2), and Omega(N(2)) of 151-801
142 results in a molecular weight increase of 3 Da due to the incorporation of the (18)O atom to the sid
143 confirmed the protein mass and revealed a 30 Da mass difference between proteins from the two species
145 limit of EcChiP to be approximately 200-300 Da for small permeants that pass through by general diff
148 of small molecule fragment disulfides (< 300 Da) that could either activate or inhibit PDK1 by conjug
150 high pressures associated with using the 300-Da membrane, calibration in this small size range, accou
155 LC-TOF/MS) revealed adducts of +162 and +324 Da to both the light and heavy chains, suggesting the pr
159 ctra (SWATH), which uses Q1 windows of 20-35 Da for data-independent fragmentation, was systematicall
164 f ca. 1.8 S and a molecular weight of 14 363 Da were determined for HD5(ox) at pH 7.0, supporting a t
166 linkage, with a single monosaccharide of 376 Da, which we show to be a pseudaminic acid derivative.
167 heptasaccharide, linked through the same 376-Da sugar to the protein backbone, also in O-linkage.
168 olecules (molecular weight approximately 380 Da) that compete with the peptide docking motif for bind
169 ] and gliadin peptides [33-mer (p56-88, 3900 Da), 19-mer (p31-49, 2245 Da; and p202-220, 2127 Da), an
170 g a 62-nucleotide (molecular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-2
171 tural diversity, which ranges from the 803.4 Da thalassospiramide C to the 1291.7 Da thalassospiramid
175 d on several mass ranges between 100 and 400 Da to characterize the functional groups of AOM species.
176 olar and higher molecular weight (HMW; > 400 Da) components abundant in crude and heavy fuel oils (HF
177 o detect low molecular weight (less than 400 Da) chemical and biological analytes under extremely dil
178 from more recent lots are roughly 200 to 400 Da lower than initial measurements made in the early 199
181 of 100% for six proteins (MW 8759 to 68 425 Da), 96-98% for five proteins (MW 11 458 to 36 431 Da),
182 92% for three proteins (MW 15 971 to 36 431 Da), 80-87% for four proteins (MW 42 287 to 162 134 Da),
183 6-98% for five proteins (MW 11 458 to 36 431 Da), 92% for three proteins (MW 15 971 to 36 431 Da), 80
185 tion of diagnostic neutral molecules CO2 (44 Da) and C2H6O2Si (90 Da) for aromatic carboxylic acids.
187 h-molecular weight (molecular weight of >450 Da) products were observed under dry conditions with ind
188 d systematic iron coagulation of large (>450 Da), oxygen-rich, and highly aromatic DOM molecules of t
189 he development of low molecular weight (<450 Da) and nonpeptidic, single-digit micromolar mechanism-b
190 f 40 poly(8:2 FTAC-co-HDA) signals (911-4612 Da) were normalized to the signal intensity of a matrix-
191 ve and apparent permeabilities to TAMRA (467 Da), dextran (70 kDa), and LDL (2000 kDa), as well as hy
194 d glycopeptides, producing an abundant Y1-48 Da ion instead (the nominal mass difference is given rel
198 s of structures in the mass range of 120-500 Da and correctly predicted approximately 70% of the indi
200 wed concentration of the 300-400 and 400-500 Da molecular weight range peptides in the KCl-F1 and KCl
202 of peptides with molecular weights above 500 Da are needed to identify parameters that influence oral
204 ecular weight (typically < approximately 500 Da) drugs can effectively permeate through intact stratu
205 rity of absorption was due to molecules >500 Da, and these contributed an increasing fraction of abso
206 he detection of lower-molecular-weight (<500 Da) biomolecules in highly diluted solutions is still a
207 low background in the low mass region (<500 Da), contrary to citrate stabilized AuNPs (citrate-AuNPs
211 thetically feasible organic molecules of 500 Da molecular weight or less, is estimated to contain ove
213 orophores of a wide range of sizes: from 500-Da targeted polar molecules to 150,000-Da tagged immunog
214 rated with glucose (180 Da) and inulin (5000 Da) transdermal flux experiments, which showed greater p
215 ced cell-to-cell transport of the small (524 Da) fluorescent tracer 8-hydroxypyrene-1,3,6-trisulfonic
216 and had a molecular mass between 375 and 525 Da, which was 150 to 200 Da higher than for an average D
220 re detected, including acetylation and a +57 Da species that could be the addition of a glyoxal moiet
223 he ratios of doublet signals with a static 6 Da mass difference in MALDI-MS and the change in relativ
224 ed glycerol clusters ( greater, similar10(6) Da, greater, similar +/- 100 charges) have been used to
225 accharide with molecular weight of 1.35x10(6)Da and a specific optical rotation of +64 degrees (c 1.0
226 ecular masses of more than approximately 600 Da is thought to be mediated by TonB-dependent, active t
229 tic WEOM molecules that are greater than 600 Da and the reduced binding force of orthophosphate to WE
233 nsition into the gas phase, evident from +64 Da and +128 Da signals that can be assigned to Hb carryi
236 exploits either generation of a signature 69 Da ion from Ile or formation of unique w-ions employing
237 l, co-oligomers with molar masses up to 6901 Da, ultralow molar mass dispersities (D </= 1.00002), an
238 e 803.4 Da thalassospiramide C to the 1291.7 Da thalassospiramide F, results from a complex sequence
241 les of intermediate size (approximately 7000 Da), which possess both the targeting and effector funct
242 of ca. 1.0 S and a molecular weight of 7079 Da, corresponding to a HD5(ox) dimer, were obtained.
243 tal ion current) chromatograms, using the 74 Da fragment ion, which originated from McLafferty rearra
245 l protein containing 71 amino acids (MW 7821 Da) with a reported analgesic potency greater than morph
251 ealed the binding modes of these large (~850 Da) compounds in detail and explained the observed SAR,
253 r large biomolecules such as ubiquitin (8565 Da), the amino acid sequence coverage increases from 39%
254 ed protein with a molecular weight of 25,897 Da, very near the observed molecular weight of the purif
258 gh molecular mass (e.g., between 400 and 900 Da) to less than 10 and in some cases, it was possible t
263 ing studies, we also demonstrate that the 98 Da neutral loss occurs via gas-phase phosphoryl transfer
265 ly we show that mammalian homologs of Ey and Da can functionally replace their Drosophila counterpart
267 ristic Df approximately 2.6, Dm > 1 mum, and Da </= 300 nm that form via the cluster-dense aggregatio
268 on characteristic image parameters: Daisne (Da) modified, based on signal-to-background ratio; Nestl
269 we show that a linked dimer of Daughterless (Da), the only Drosophila class I bHLH protein, activates
270 ks expression of the E protein Daughterless (Da), which heterodimerizes with bHLH proteins to activat
272 T2h, the complex T2h with HIE had decreased Da, increased De, perpendicular in both premyelination a
275 extra-axonal axial and radial diffusivities (Da, De,// and De, perpendicular), to compare WM differen
277 mc lacks a basic DNA-binding domain, the Emc-Da heterodimer cannot bind to and regulate genomic targe
278 d by measuring dialyzable mineral fraction (%Da) resulting from in vitro gastrointestinal digestion.
280 d bromide in sediments containing 8-18% gas (Da,YE) were suppressed by 7-39% compared to the control
283 perpendicular, but no significant change in Da in multiple premyelination regions, indicative of exp
284 ster randomised trial in which 33 clinics in Da Qing, China-serving 577 adults with impaired glucose
288 lar species show a size range of 2-6 million Da and have other similarities to hIAPP protofibrils, bu
291 the widespread Emc expression that restrains Da expression, opposing bHLH-dependent differentiation w
296 Whereas gas voids in sediments reduce the Da for soluble species, they represent a shortcut for lo
297 41 resident physicians performing the Tubes (Da Vinci Intuitive Surgical, Sunnyvale, CA) simulator ex
299 rocheate (Emc), which forms heterodimer with Da, antagonizes the synergistic activation from Da but n
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