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1 s abolished by base substitutions within the E box motif.
2 y linker scanning mutagenesis to comprise an E box motif.
3 ent consisting of two GATA sites flanking an E box motif.
4 from erythroid cell nuclear extracts to the E box motif.
5 red for regulatory activity and including an E-box motif.
6 dem sterol response elements and an upstream E-box motif.
7 GATA site separated by 10 base pairs from an E-box motif.
8 to this element, which contains an imperfect E-box motif.
9 composite DNA element containing WGATAR and E-box motifs.
10 sponsive elements and, in the case of Esr10, E-box motifs.
11 ription factors including those that bind to E-box motifs.
12 ding to active transcriptional repression at E-box motifs.
13 both phenomena require at least two adjacent E-box motifs.
15 activities, we demonstrate that the -65/-60 E-box motif (5'-CATGTG-3') is functionally required for
16 (Fra2) protein binding to an ABCA1 promoter E-box motif, a site known to negatively regulate macroph
17 e strict spatial configuration in the double E-box motif aligns two TWIST-E47 dimers on the same face
18 es three transcription factor binding sites (E-box motifs, along with YY1 and C/EBP-beta binding site
19 e that NEUROD2 and MYOD bind a shared CAGCTG E box motif and E box motifs specific for each factor: C
20 dependent on highly conserved ETS, GATA, and E-box motifs, and chromatin immunoprecipitation showed h
22 f the ChoRE sequence indicated that two half E box motifs are critical for the response to glucose.
23 o the TATA and initiator elements, conserved E-box motifs are located in the beta-globin downstream p
24 deletion and mutation analyses identified an E box motif as a positive regulatory element, which was
25 ed their ability to bind to a single perfect E-box motif as a heterodimer with ChREBP, but no longer
26 reviously unsuspected role for an intragenic E-box motif as a negative regulatory element contributin
28 of this action of ADD1/SREBP1 is through an E-box motif at -64 to -59, contained with a sequence ide
30 related to, but distinct from, the standard E-box motif bound by the MyoD family of transcriptional
31 nding domain, that was highly similar to two E box motifs, but no known "E box" trans-factors were id
32 sequences primarily enriched for a specific E-Box motif (CAGCTG) and for secondary motifs used by So
33 , and Mesdc2, are enriched for a palindromic E-box motif, CAGCTG, indicating that it is a physiologic
34 show that mSharp-1 specifically binds to the E box motif (CANNTG) as a homodimer and acts as a potent
35 promoter deletion analyses revealed that an E-box motif conferring carbohydrate response element-bin
36 conjunction with its flanking sequence, this E box motif confers VSMC-specific enhancer activity to a
37 the TFII-D complex with the basal promoter, E-box motifs contribute to the efficient formation of tr
40 oth factors bind specifically to a subset of E-box motifs (E2-box: CAGGTG/CACCTG) in target promoters
42 nscription start site and the 5' GATA and 3' E-box motifs flanking the EPO-R transcription start site
43 first exon/intron junction, encompassing an E-box motif, has a unique dual role in basal transcripti
44 R (DS), the PU.1-NFEM-5 site, and the core's E-box motif, identifying bound transcription factors pri
45 the upstream stimulatory factor (USF) to an E-box motif immediately upstream from the BSAP site on t
48 informatic analysis showed enrichment of the E-box motif in the dataset, and c-Myc and DeltaEGFR were
49 his study is supported by the presence of an E-box motif in the same position in the chicken TGF-beta
50 scription factors USF1 and USF2 bind to this E-box motif in vitro when nuclear extracts from each of
51 trates a strong association between PAX3 and E-box motifs in these binding sites, suggestive of a com
52 rected mutagenesis, we demonstrate that this E-box motif is necessary for the promoter activity, not
53 ted nucleotide sequence contains a consensus E-box motif, known to regulate diverse eukaryotic genes,
55 of B cell lineage-specific factor E2A to an E-box motif located immediately downstream of the two cl
57 ficant enrichment and conservation of CABVTG E-box motifs near Twist ChIP-seq signal summits, prefere
58 requires a glutamic acid residue within the E box motif of SpaA, a feature that is found to be conse
60 SH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-
62 e we report characterization of an essential E-box motif, positioned at -50/-45 between a previously
63 e response element (ChoRE) consisting of two E box motifs separated by 5 bp that is necessary and suf
64 nd MYOD bind a shared CAGCTG E box motif and E box motifs specific for each factor: CAGGTG for MYOD a
65 ishes HS I function, whereas mutation of the E-box motif still allows reporter gene expression in bot
66 ponse element-binding protein (ATF/CREB) and E-box motifs, suggesting that PIF may modulate the trans
67 ledge, this is the first demonstration of an E box motif that mediates gene expression restricted to
68 ays demonstrated quantitative binding to the E box motifs that correlated with myc levels in the elec
69 hat is bound by CREB and ATF-1 as well as an E-box motif that is bound by upstream stimulatory factor
70 utants located, in the proximal promoter, an E-box motif that supported the DEC1-mediated repression.
71 xperiments demonstrated that different Twist E-box motif types are not fully interchangeable, suggest
73 ences between -170 to -146, which contain an E-box motif, were necessary for high level expression in
74 gion from nt -63 to -84 demonstrated that an E box motif, which binds the basic helix-loop-helix prot
75 the enhancer contains a direct repeat of two E-Box motifs, which contributes most strongly to basal a
76 er bHLH proteins, recognizes a unique double E-box motif with two E-boxes spaced preferentially by 5
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