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1 E. chaffeensis binding to and subsequent infection of mo
2 E. chaffeensis BolA bound to the promoters of genes enco
3 E. chaffeensis bolA complemented a stress-sensitive E. c
4 E. chaffeensis CtrA bound to the promoters of late-stage
5 E. chaffeensis experiences temperature changes during tr
6 E. chaffeensis expresses a sensor kinase, PleC, and a co
7 E. chaffeensis has a multigene family of major outer mem
8 E. chaffeensis inclusions were labeled with the transfer
9 E. chaffeensis induced rapid tyrosine phosphorylation of
10 E. chaffeensis infection activated the phosphatidylinosi
11 E. chaffeensis infection did not result in dramatic chan
12 E. chaffeensis infection in a human monocyte cell line (
13 E. chaffeensis infects mononuclear phagocytes and is tra
14 E. chaffeensis strains induce strikingly variable inflam
15 E. chaffeensis TRP75 and E. canis TRP95 were immunopreci
16 E. chaffeensis was sensitive to closantel, an HK inhibit
17 E. chaffeensis, therefore, can recruit interacting signa
18 E. chaffeensis-specific cytotoxic T cells were not detec
19 responses to E. chaffeensis lipoproteins, 13 E. chaffeensis lipoprotein genes were cloned into a mamm
21 to analyze the antibody responses of the 37 E. chaffeensis indirect fluorescent-antibody assay (IFA)
23 129S6-Cd4(tm1Knw) mice also developed active E. chaffeensis-specific immunoglobulin G responses that
28 The addition of oxytetracycline 6 h after E. chaffeensis infection caused a decrease in TfR mRNA w
31 the hypothesis that immune responses against E. chaffeensis would be different if the mice are challe
35 ss spectrometry identified the protein as an E. chaffeensis 12.3-kDa hypothetical protein, which was
36 ted strongly with antibodies in sera from an E. chaffeensis-infected dog and human monocytotropic ehr
37 rophoretic mobility shift assays revealed an E. chaffeensis-encoded protein that specifically bound t
38 ast two-hybrid analysis demonstrated that an E. chaffeensis type 1 secretion system substrate, TRP32,
47 peptide repeat units from E. canis gp36 and E. chaffeensis gp47 were substantially less immunoreacti
48 peptides are conserved between E. muris and E. chaffeensis OMP-19, and they elicited IFN-gamma produ
49 B4, and virB6) of both A. phagocytophila and E. chaffeensis were arranged downstream from a sodB gene
50 ese five genes in both A. phagocytophila and E. chaffeensis were polycistronically transcribed and co
51 d endocytosis directs A. phagocytophilum and E. chaffeensis to an intracellular compartment secluded
54 his macrophage-tropic bacterium, we assessed E. chaffeensis infections in three mouse strains with di
55 Recently, molecular interactions between E. chaffeensis 47-kDa tandem repeat (TR) protein (TRP47)
56 sferrin receptors (TfRs) accumulated on both E. chaffeensis and E. sennetsu, but not HGE agent, inclu
57 retic mobility shift assays showed that both E. chaffeensis and E. sennetsu infection increased the b
58 which peaked at 24 h postinfection with both E. chaffeensis and E. sennetsu infection in THP-1 or HL-
61 y indistinguishable from infection caused by E. chaffeensis or the agent of human granulocytic ehrlic
62 protein-processing enzymes were expressed by E. chaffeensis cultured in the human promyelocytic leuke
64 r VirB6 proteins and VirB9 were expressed by E. chaffeensis in THP-1 cells, and amounts of these five
68 t canonical and noncanonical Wnt pathways by E. chaffeensis TRP effectors stimulates phagocytosis and
70 n of host cytokine and chemokine profiles by E. chaffeensis strains underlies the distinct host liver
71 nslocation of bacterially encoded protein by E. chaffeensis and to identify a specific binding motif
74 Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeensis, E. ewingii, Rickettsia rickettsii, R. co
79 CL11, which were strongly upregulated during E. chaffeensis infection and were also upregulated by di
83 ntibodies reactive to E. chaffeensis and for E. chaffeensis-specific 16S rRNA gene fragments by an in
86 rs of tandem repeats, were characterized for E. chaffeensis from white-tailed deer (Odocoileus virgin
88 nucleotide salvage pathway is essential for E. chaffeensis replication and that it may be important
93 ge PCR assay, but not by assays specific for E. chaffeensis or the agent of human granulocytic ehrlic
96 not amplify the 200-bp target amplicon from E. chaffeensis, the human granulocytic ehrlichiosis agen
97 esota or Wisconsin were found not to be from E. chaffeensis or E. ewingii and instead to be caused by
98 produce PCR products with DNA extracted from E. chaffeensis-, E. canis-, or E. phagocytophila-infecte
103 cores, identity of the primers to homologous E. chaffeensis sequences, and the availability of simila
104 med if the ELISA is positive), we identified E. chaffeensis or a serologically and antigenically simi
107 the N-terminal TR region (18 amino acids) in E. chaffeensis and the complete TR (24 amino acids) in E
108 own to be surface exposed), were detected in E. chaffeensis cultured in human monocytic leukemia THP-
110 e sequence polymorphisms in several genes in E. chaffeensis strains have been reported, global genomi
112 phosphorylation of Stat1, Jak1, and Jak2 in E. chaffeensis-infected THP-1 cells was examined by immu
113 y that documents that insertion mutations in E. chaffeensis that cause attenuated growth confer prote
116 ssion of penicillin-binding protein (PBP) in E. chaffeensis was analyzed by reverse-transcription pol
117 cted, which was strikingly more prevalent in E. chaffeensis-containing vacuoles than in vacuole-free
122 inhibitor, globomycin, was found to inhibit E. chaffeensis infection and lipoprotein processing in H
123 -butyldimethysilyl)-c-di-GMP (CDGA) inhibits E. chaffeensis internalization into host cells by facili
125 these five proteins were similar in isolated E. chaffeensis-containing vacuoles and vacuole-free E. c
128 eral cytokines and chemokines by leukocytes, E. chaffeensis lacks lipopolysaccharide and peptidoglyca
137 e to that of the nested PCR for detection of E. chaffeensis in infected DH82 cells, experimentally in
138 more sensitive than the PCR for detection of E. chaffeensis regardless of the nature of the specimens
139 Thus, this RT-PCR is useful for detection of E. chaffeensis when a high sensitivity is required.
140 During the intracellular development of E. chaffeensis, both P28 and OMP-1F were expressed mostl
143 f the members of the p28 multigene family of E. chaffeensis, sera from two beagle dogs experimentally
147 These data suggest that the rMAP2 homolog of E. chaffeensis may have potential as a test antigen for
151 c diversity of the P28 among the isolates of E. chaffeensis suggest that P28s may be involved in immu
153 res infected with nine different isolates of E. chaffeensis, blood samples from seven patients with m
157 d in this study suggest that the membrane of E. chaffeensis is very complex, having many expressed pr
158 munofluorescent microscopy in the nucleus of E. chaffeensis-infected host cells and was detected in n
159 f E. canis and the corresponding ortholog of E. chaffeensis (47 kDa) were identified and the proteins
160 p30 of Ehrlichia canis (< or =71.3%), p28 of E. chaffeensis (< or =68.3%), and map1 of Cowdria rumina
161 protein with < or =69.1% identity to P28 of E. chaffeensis, < or =67.3% identity to P30 of E. canis,
162 n or closely related interacting partners of E. chaffeensis TRP32, TRP47, and TRP120 demonstrate a mo
164 d chromatography purified, and native PBP of E. chaffeensis were investigated for their ability to in
166 ts revealed distinct virulence phenotypes of E. chaffeensis strains with defined genome sequences.
169 sponses to another outer membrane protein of E. chaffeensis (GP120) showed similar temporal and quant
171 recognizing four outer membrane proteins of E. chaffeensis (Arkansas strain) including the 25-, 26-,
172 34 sera reacted with any native proteins of E. chaffeensis ranging from 44 to 110 kDa, and 30 sera r
173 gs suggest that the 30-kDa-range proteins of E. chaffeensis represent a family of antigenically relat
175 otal, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell
177 ci was downregulated prior to the release of E. chaffeensis from host THP-1 cells and was upregulated
178 ral responses and the in vivo replication of E. chaffeensis suggests that D. melanogaster is a suitab
180 This is the first demonstration of RNA of E. chaffeensis in infected blood and acquisition-fed mal
181 aling regulates aggregation and sessility of E. chaffeensis within the inclusion through stabilizatio
182 t immunization with the p28 of one strain of E. chaffeensis would confer cross-protection against oth
183 tigenic variants of p28 among the strains of E. chaffeensis and the presence of multiple copies of he
184 o compare the genome sequences of strains of E. chaffeensis and to examine the virulence potentials o
185 ikingly different among the three strains of E. chaffeensis: gamma interferon, CCL5, CXCL1, CXCL2, CX
187 protease HtrA was detected on the surface of E. chaffeensis, and TRP120 was degraded by treatment of
188 d macrophage activation and the synthesis of E. chaffeensis-specific Th1-type immunoglobulin G respon
193 sis, and TRP120 was degraded by treatment of E. chaffeensis with recombinant E. chaffeensis HtrA.
196 lecule inhibitor had a significant impact on E. chaffeensis replication and recruitment of the TRP120
197 tigated the effects of c-di-GMP signaling on E. chaffeensis infection of the human monocytic cell lin
198 nt is unique because it is thus far the only E. chaffeensis recombinant antigen that has been shown t
199 5.8%) goats were positive by diagnostic PCR; E. chaffeensis was isolated in cell culture from one goa
200 To survive and replicate within phagocytes, E. chaffeensis exploits the host cell by modulating a nu
201 his study, we assessed two clonally purified E. chaffeensis mutants with insertions within the genes
202 Genomic DNA was extracted from purified E. chaffeensis strains Wakulla and Liberty, and comparat
205 odies in patients' sera with the recombinant E. chaffeensis 120- and 28-kDa proteins as well as the 1
206 by protein immunoblotting using recombinant E. chaffeensis proteins expressed in Escherichia coli.
211 n particular, despite its small genome size, E. chaffeensis has four tandem virB6 paralogs (virB6-1,
213 isiae) two-hybrid analysis demonstrated that E. chaffeensis-secreted tandem repeat protein 120 (TRP12
215 Therefore, we tested the hypothesis that E. chaffeensis can infect adult Drosophila melanogaster.
229 e (1,620 bp), and a 2-repeat region from the E. chaffeensis P120 gene (520 bp) were expressed in Esch
230 the same chromosomal location; however, the E. chaffeensis VLPT gene (594 bp) has tandem repeats tha
231 ovel tandem repeat DNA-binding domain in the E. chaffeensis 120-kDa tandem repeat protein (TRP120) th
234 ed proteins provides novel insights into the E. chaffeensis surface and lays the foundation for ratio
236 gned based on the N-terminal sequence of the E. chaffeensis 28-kDa protein and the consensus sequence
237 ve genes and that antigenic variation of the E. chaffeensis 28-kDa proteins may result from different
240 rly one-fourth of all predicted genes of the E. chaffeensis genome, validating that they are function
242 el treatment induced lysosomal fusion of the E. chaffeensis inclusion in a human monocytic leukemia c
249 ween TRP32 and host targets localized to the E. chaffeensis morulae or in the host cell cytoplasm adj
251 tly different between mice infected with the E. chaffeensis originating from tick cells or macrophage
254 owed a very high prevalence of antibodies to E. chaffeensis (97 of 112; 87%) and a low prevalence of
257 probable human monocytic ehrlichiosis due to E. chaffeensis also had antibodies to the HGE agent in a
258 that residents of Connecticut are exposed to E. chaffeensis, A. americanum ticks were collected in Co
259 uman leukemia cell line THP-1 was exposed to E. chaffeensis, significant upregulation of IL-8, IL-1be
260 seroreactive to Bartonella henselae, one to E. chaffeensis, and one to R. rickettsii antigen; howeve
261 38 (73.7%) goats had antibodies reactive to E. chaffeensis (>/=1:128), and 6 of 38 (15.8%) goats wer
262 icity were tested for antibodies reactive to E. chaffeensis and for E. chaffeensis-specific 16S rRNA
264 5, an ehrlichial organism closely related to E. chaffeensis isolated from Ixodes ovatus ticks in Japa
265 rlichia muris, a pathogen closely related to E. chaffeensis, resulted in anemia, thrombocytopenia, an
268 These data suggest that the host response to E. chaffeensis depends on the source of the bacteria and
270 tein expression and host immune responses to E. chaffeensis lipoproteins, 13 E. chaffeensis lipoprote
271 veral E. chaffeensis native proteins and two E. chaffeensis recombinant I-site proteins, and this bin
272 Ech_0379 mutant and challenge with wild-type E. chaffeensis 1 month following inoculation with the mu
273 ere tested by immunofluorescence (IFA) using E. chaffeensis antigen and by protein immunoblotting usi
274 ay for immunoglobulin M (IgM) and IgG, using E. chaffeensis antigen, identified 44 and 33% of the iso
278 t could mediate bacterial clearance in vivo, E. chaffeensis-specific mAbs were generated and administ
280 genes suggest a possible mechanism by which E. chaffeensis might evade the host immune defenses.
281 h lysosomes or Golgi-derived vesicles, while E. chaffeensis resides in an early endosomal compartment
282 oxyl-terminal amino acid homology (59%) with E. chaffeensis VLPT and the same chromosomal location; h
283 strongly with TRP120 in HeLa cells and with E. chaffeensis dense-cored morulae and areas adjacent to
285 ; 1 patient had evidence of coinfection with E. chaffeensis and a spotted fever group rickettsia.
287 a pattern different from that of humans with E. chaffeensis infection but similar to that of a dog ex
288 two beagle dogs experimentally infected with E. chaffeensis were evaluated for the presence of specif
289 naive dogs, or when dogs were infected with E. chaffeensis, the animals developed delayed-type hyper
290 cteria and that of macrophages infected with E. chaffeensis, we have identified few genes that are co
293 ce of immunocompetent mice to infection with E. chaffeensis and demonstrate the utility of immunocomp
295 three sera that were IFA positive only with E. chaffeensis, and three sera that were IFA positive on
296 st recombinant P43 (rP43) did not react with E. chaffeensis as detected by indirect fluorescent antib
297 cence contained antibodies that reacted with E. chaffeensis and E. canis antigens in a pattern differ
298 gainst the recombinant proteins reacted with E. chaffeensis P120 and E. canis P140, respectively.
299 nstrated to contain antibodies reactive with E. chaffeensis by indirect immunofluorescence assays (IF
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