ライフサイエンスコーパス: E2F transcription factor

1 hat p14(ARF) can control the activity of the E2F transcription factor.

2 or protein (Rb), which in turn regulates the E2F transcription factor.

3 hat can be bypassed by overexpression of the E2F transcription factor.

4 s transcriptional activation mediated by the E2F transcription factor.

5 cell death, which is likely mediated by the E2F transcription factor.

6 he S phase by modulating the activity of the E2F transcription factor.

7 sed genes that are likely coregulated by the E2F transcription factor.

8 dk inhibitors to Cdks, and downregulation of E2F transcription factor.

9 lation of CCNE1 by miR-874 is independent of E2F transcription factors.

10 ar proliferation and apoptosis by regulating E2F transcription factors.

11 acterize the functional link between MIF and E2F transcription factors.

12 s its function through its interactions with E2F transcription factors.

13 ediated by their ability to inhibit specific E2F transcription factors.

14 igenesis, in part, through interactions with E2F transcription factors.

15 nt fashion, likely through the pRB-dependent E2F transcription factors.

16 proliferation through the regulation of the E2F transcription factors.

17 cell proliferation by binding and inhibiting E2F transcription factors.

18 of the cell cycle and which are regulated by E2F transcription factors.

19 inding to and regulating the activity of the E2F transcription factors.

20 showed that MageB2 enhances the activity of E2F transcription factors.

21 ion, termed hypo-phosphorylation, to release E2F transcription factors.

22 ulated during cell cycle progression through E2F transcription factors.

23 a family members suggested the regulation of E2F transcription factors.

24 enic plants with altered levels of different E2F transcription factors.

25 ssion, principally through regulation of the E2f transcription factors.

26 (RB) regulates S-phase cell cycle entry via E2F transcription factors.

27 sensitivity to apoptosis through binding to E2F transcription factors.

28 origenesis largely through regulation of the E2F transcription factors.

29 t in response to the activation of the other E2F transcription factors.

30 elial cells, that mouse DDB2 is regulated by E2F transcription factors.

31 sis through inhibitory interactions with the E2F transcription factors.

32 ed cell cycle progression, expression of the E2F transcription factor 1 (E2F1) and loss of retinoblas

33 E2F transcription factor 1 (E2F1) is an important regula

34 ls increased, whereas Bcl2, pRb protein, and E2F transcription factor 1 (E2F1) levels decreased.

35 ies utilizing MDM2 inhibitors, we noted that E2F transcription factor 1 (E2F1) was down regulated upo

36 reased expression of key cell cycle inducers E2F transcription factor 1 and cyclin E1.

37 xpression, which inhibits Src, and increased E2F transcription factor 1 expression, which regulates b

38 This role for RB1 was linked to both E2F transcription factor 1-driven upregulation of the an

39 for tumor progression and that it did so via E2F transcription factor 1-mediated regulation of androg

40 e homolog) and E2F1, E2F2 and E2F3 (encoding E2F transcription factors 1, 2 and 3, respectively).

41 We found evidence that E2F transcription factor 3 (E2F3) drives these changes i

42 egulators cell division cycle 34 (Cdc34) and E2F transcription factor 5 (E2F5).

43 The E2F transcription factor, a heterodimer of E2F and DP su

44 oiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and d

45 kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S

46 dy of evidence has shown that the control of E2F transcription factor activity is critical for determ

47 Deregulated E2F transcription factor activity occurs in the vast maj

48 mbers, p107 and p130, function by repressing E2F transcription factor activity to limit the expressio

49 Given the role of RB in controlling E2F transcription factor activity, we investigated the r

50 Rb family of proteins, which in turn control E2F transcription factor activity.

51 bladder cancer, including the activation of E2F transcription factor and subsequent Ezh2 expression

52 ate specific activator and repressor MYB and E2F transcription factors and indicate the possibility o

53 t this site overlaps with a binding site for E2F transcription factors and is subtly distinct from a

54 tion through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins.

55 It also coactivates certain non-E2F transcription factors and promotes differentiation.

56 We find that e1a displaces RBs from E2F transcription factors and promotes p300 acetylation

57 from G(1) to S phase is mainly controlled by E2F transcription factors and RB family proteins.

58 lastoma (Rb) family members interacting with E2F transcription factors and recruiting heterochromatin

59 cycle progression, in part, by sequestering E2F transcription factors and repressing E2F-responsive

60 (pRb) mediates cell cycle control by binding E2F transcription factors and repressing expression from

61 pRb) restrains cell proliferation by binding E2f transcription factors and repressing the expression

62 tein (pRb), which normally functions to bind E2F transcription factors and restrict expression of gen

63 that Dnmt1 is transcriptionally regulated by E2F transcription factors and that retinoblastoma protei

64 s, resulting in the dissociation of pRb from E2F transcription factors and the premature cell progres

65 in noncycling cells by complexes between the E2F transcription factors and the retinoblastoma (Rb) tu

66 Much circumstantial evidence implicates both E2F transcription factors and the retinoblastoma protein

67 ls exit the cell cycle through the action of E2F transcription factors and the retinoblastoma tumor s

68 te cell-cycle exit through inhibition of the E2F transcription factors and the transcriptional repres

69 luding those encoding the G1/S cyclin D3 and E2F transcription factors and their targets.

70 y dependent upon its capacity to inhibit the E2F transcription factors and thereby cell proliferation

71 Rb and related proteins act as regulators of E2F transcription factors, and RbAp48 may act with such

72 The c-Myc and E2F transcription factors are among the most potent regu

73 Mammalian E2F transcription factors are composed of E2F and DP sub

74 E2F transcription factors are critical regulators of cel

75 E2F transcription factors are critical, conserved regula

76 E2F transcription factors are generally believed to be p

77 E2F transcription factors are implicated in diverse cell

78 E2F transcription factors are important regulators of ce

79 E2F transcription factors are important regulators of th

80 en together, these data demonstrate that the E2F transcription factors are integral to HER2+ tumor de

81 The E2F transcription factors are key cell cycle regulators

82 The E2F transcription factors are key downstream targets of

83 The E2f transcription factors are key downstream targets of

84 E2F transcription factors are key participants in the re

85 E2F transcription factors are key players in the regulat

86 E2F transcription factors are key regulators of cell pro

87 E2F transcription factors are known regulators of the ce

88 E2F transcription factors are major regulators of cell p

89 e consequences on downstream targets such as E2F transcription factors are not known.

90 The E2F transcription factors are thought to be key downstre

91 E2F transcription factors are thought to influence the G

92 A variety of studies implicate the E2F transcription factor as a critical regulator of the

93 Activation of E2F transcription factors at the G1-to-S phase boundary,

94 n activities are mediated by their different E2F transcription factor binding partners.

95 core promoter region contains two functional E2F transcription factor binding sites.

96 line) raised cyclin D1 expression, increased E2F transcription factor binding to cyclin D1 promoter,

97 Rb negatively regulates multiple E2F transcription factors, but the role of the different

98 y abrogating the transcription repression of E2F transcription factors by the retinoblastoma suscepti

99 pic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplica

100 E2F transcription factors can activate or actively repre

101 Current models posit that E2F transcription factors can be divided into members th

102 ferating EC, which display repression of the E2F transcription factor coincident with TNF-induced apo

103 ry pathways (the Rb-like protein RBF and the E2F transcription factor complex components dE2F and dDP

104 verexpression also alters the composition of E2F transcription factor complexes.

105 The E2F transcription factor couples the coordinate expressi

106 fects during the S and G2 phases and induces E2F transcription factor-dependent cell death.

107 t on Sp1 is specific, in that the Stat-3 and E2F transcription factors did not undergo degradation un

108 RB family mutant TECs, increased activity of E2F transcription factors drives increased expression of

109 Thus we have uncovered new functions for E2F transcription factors during development, including

110 Pocket proteins regulate the activity of E2F transcription factors during G1-S transition.

111 The activating E2F transcription factors, E2F1-3, contribute to these e

112 predicted miR-142 target genes, the atypical E2F transcription factors E2f7 and E2f8, were most highl

113 Atypical E2F transcription factors (E2F7 and E2F8) function as ke

114 While the E2F transcription factors (E2Fs) have a clearly defined

115 lock cell cycle progression by inhibition of E2F transcription factors, experiments were conducted to

116 Drosophila contains two members of the E2F transcription factor family (E2f and E2f2), which co

117 e functional interaction between pRB and the E2F transcription factor family appears to be critical.

118 The E2F transcription factor family is known to play a key r

119 The E2F transcription factor family plays a crucial and well

120 pRB-independent, noncanonical member of the E2F transcription factor family that acts as a transcrip

121 tify E2F7 as a novel member of the mammalian E2F transcription factor family that has properties of a

122 s p105RB (retinoblastoma, acting through the E2F transcription factor family) and p53 regulate cell p

123 l as that of the DNA-bending capacity of the E2F transcription factor family, in the activation of tr

124 gene product (pRB), including members of the E2F transcription factor family.

125 The affected genes include the E2F transcription factor family.

126 ion by binding and inhibiting members of the E2F transcription factor family.

127 ylate the retinoblastoma protein and release E2F transcription factors for progression through cell c

128 een suggested that the subsequent release of E2F transcription factors from inhibitory complexes may

129 cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protei

130 myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket"

131 The E2F transcription factor has demonstrated a role in G0 e

132 The family of E2F transcription factors have an essential role in medi

133 Because interactions between p130 and E2F transcription factors have been proposed to play a r

134 ammals, a large number of proteins including E2F transcription factors have been shown to interact wi

135 E2f transcription factors have distinct roles in the con

136 The E2F transcription factors have emerged as critical apopt

137 the pRB family and its principal target, the E2F transcription factor, have focused on cells that hav

138 best-known target of RB protein (pRB) is the E2F transcription factor; however, many other chromatin-

139 horylation prevents its association with the E2F transcription factor; however, the molecular basis f

140 Our understanding of roles for the E2F transcription factor in regulating apoptosis has pro

141 stand whether Rb function can be mediated by E2F transcription factors in a BM-derived hematopoietic

142 ress this and to further analyze the role of E2F transcription factors in development we have phenoty

143 USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was

144 ignatures to predict involvement of specific E2F transcription factors in Myc-induced tumors.

145 ignatures, we predicted a role for activator E2F transcription factors in Neu-induced tumors.

146 thods, we predicted a role for the activator E2F transcription factors in the mouse mammary tumor vir

147 hematopoietic-specific miR-142 and atypical E2F transcription factors in the regulation of mature T

148 E2F transcription factors, including E2F3, directly modu

149 The E2F transcription factors induce the expression of many

150 otein's activities in growth suppression and E2F transcription factor inhibition.

151 dependent expression of an antagonist of the E2F transcription factor inhibits viral replication in n

152 The E2F transcription factor integrates cellular signals and

153 The E2F transcription factor is a key cell cycle regulator.

154 The activity of the E2F transcription factor is controlled by physical assoc

155 The activity of the E2F transcription factor is regulated in part by pRB, th

156 E2F transcription factor is subject to stringent regulat

157 The family of E2F transcription factors is the key downstream target o

158 E2F transcription factors may play a pivotal role in the

159 These results suggest that E2F transcription factors may play a role in promoting m

160 o-oncoprotein, is cell-cycle regulated by an E2F transcription factor-mediated repression mechanism o

161 E2F transcription factors play a critical role in cell c

162 The E2F transcription factors play a critical role in coordi

163 E2F transcription factors play a critical role in the co

164 The E2F transcription factors play a key role in the regulat

165 E2F transcription factors play a major role in controlli

166 The E2F transcription factors play an essential role in regu

167 E2F transcription factors play an important role in the

168 E2F transcription factors play an important role in the

169 aken together, these results reveal that the E2F transcription factors play key roles in mediating tu

170 E2F transcription factors play pivotal roles in controll

171 The E2F transcription factor plays a major role in cell cycl

172 The E2F transcription factor plays a pivotal role in the tim

173 atypical E2F family member E2F7 as the only E2F transcription factor potently up-regulated during on

174 ons, in part, by binding to and inactivating E2F transcription factors, preventing expression of E2F-

175 Unphosphorylated Rb can associate with E2F transcription factors, preventing transcription of g

176 Since the E2F transcription factors provide growth impetus for the

177 E2F transcription factors regulate a variety of cellular

178 E2F transcription factors regulate genes expressed at th

179 E2F transcription factors regulate genes involved in cel

180 E2F transcription factors regulate the progression of th

181 o the human pRb tumor suppressor protein and E2F transcription factors, resulting in the dissociation

182 th RB proteins displaces them from DNA-bound E2F transcription factors, reversing their repression of

183 ression, activation of the Notch pathway via E2F transcription factors serves as a negative feedback

184 Certain E2F transcription factor species play a pivotal role in

185 long been known to target regulation of the E2F transcription factors, the downstream target of the

186 oblastoma (pRB) family proteins regulate the E2F transcription factors; their complexes regulate crit

187 additional roles of this pathway, especially E2F transcription factors themselves, in tumor progressi

188 Activation of E2F transcription factors, through disruption of the ret

189 CR2 binds RB family members, de-repressing E2F transcription factors, thus activating genes require

190 e Yap1/Tead2 complex acts cooperatively with E2F transcription factors to activate a cell cycle and D

191 l its growth-inhibitory effects and enabling E2F transcription factors to activate genes required for

192 , p107, and p130 pocket proteins bind to the E2F transcription factors to control gene expression.

193 These results provide a mechanism for E2F transcription factors to overcome pRb-mediated domin

194 a hypophosphorylated state, associates with E2F transcription factors to prevent the activation of g

195 ation by G1-CDK of Whi5/Rb inhibitors of SBF/E2F transcription factors triggers irreversible S-phase

196 ulates the G1-S transition by binding to the E2F transcription factors, until cyclin-dependent kinase

197 ists to support the tenet that activation of E2F transcription factors, via alterations in the p16-cy

198 N-MYC promoter in cycling cells required the E2F transcription factor, we show that E2F-1 and HBP1 re

199 specificity of function within the family of E2F transcription factors, we have identified proteins t

200 Cellular genes regulated by the E2F transcription factors were strongly activated by the

201 sphorylated pRb binds to and inactivates the E2F transcription factor, which controls the expression

202 In contrast to the E2F transcription factors, which bind the p107 C-termina

203 GF signaling regulated the expression of the E2F transcription factors, which directly bound to and a

204 n proliferating cells include members of the E2F transcription factors, which mediate the expression

205 ly proteins binds to distinct members of the E2F transcription factors, which regulate the expression

206 ssing adenovirus E2 promoter binding factor (E2F) transcription factors, which drive the expression o

207 wn that prohibitin represses the activity of E2F transcription factors while enhancing p53-mediated t