ライフサイエンスコーパス: E3 ligase

1 t mutations in the RING domain of LRSAM1 (an E3 ligase).

2 m their functions by recruiting CRL4 (DCAF1) E3 ligase.

3 d functionally interacts with the PIAS3 SUMO E3 ligase.

4 pendent manner by redirecting the CRL4-DCAF1 E3 ligase.

5 ryptochrome 1 (CRY1), a known target of DDB1 E3 ligase.

6 uired for the activation of Vpx-CRL4 (DCAF1) E3 ligase.

7 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.

8 ct polyubiquination and degradation by CUL4B E3 ligase.

9 essively degraded by an overactive oncogenic E3 ligase.

10 quitinated by the action of the Hrd1 RING-H2 E3 ligase.

11 ts as a small ubiquitin-like modifier (SUMO) E3 ligase.

12 deacetylase 6 (HDAC6) serves as an ubiquitin E3 ligase.

13 of a ligand for the von Hippel-Lindau (VHL) E3 ligase.

14 72, preventing WHSC1 degradation by CRL4Cdt2 E3 ligase.

15 rtant for the assembly of the HIV-1 Vpr-CRL4 E3 ligase.

16 a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase.

17 ivating enzymes, E2 conjugating enzymes, and E3 ligases.

18 vators or inhibitors of PARKIN and other RBR E3 ligases.

19 messenger RNA expressions of muscle-specific E3 ligases.

20 which elucidates the intricate nature of RBR E3 ligases.

21 s E2 that can function with a broad range of E3 ligases.

22 es robust EIN3 degradation by SCF(EBF1/EBF2) E3 ligases.

23 ediate with ubiquitin similarly to HECT-type E3 ligases.

24 d HHARI suggests a general mechanism for RBR E3 ligases.

25 monstrated to work together with Cullin RING E3 ligases.

26 ncoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbe

27 association with the Cullin-4-RING ubiquitin E3 ligase-4 (CRL4) complex, nucleosomes, and chromatin r

28 ironment, such as nutrient loss, through SCF E3 ligase activities, and responds by initiating active

29 ssociation from ARF, thereby inhibiting Mule E3 ligase activity and TNF-induced JNK activation and ce

30 ubiquitin ligase phosphorylation inhibiting E3 ligase activity by impairing E2-E3 complex formation.

31 Here, we report that TRAF6 E3 ligase activity contributes to but is not essential f

32 mice or novel CRISPR/Cas9 mice without CHIP E3 ligase activity had greater AQP2 abundance and altere

33 used on understanding the regulation of ICP0 E3 ligase activity in the degradation of different ICP0

34 These findings demonstrate that the E3 ligase activity of mLANA contributes to gammaherpesvi

35 ARF binds to and thereby inhibits the E3 ligase activity of Mule in the steady state.

36 of Miro1 protein, a downstream target of the E3 ligase activity of Parkin, was also increased in cell

37 24 autoubiquitinates in vitro, demonstrating E3 ligase activity of the RING domain(s).

38 is 1 (cIAP1) and subsequent induction of the E3 ligase activity of this IAP family member.

39 and this ability invariably depends upon the E3 ligase activity of TRIM56.

40 lin 5/SOCS (EC5S(mLANA)) complex and mLANA's E3 ligase activity on host NF-kappaB and Myc.

41 Hence, pharmacological inhibition of viral E3 ligase activity through targeting SOCS box motifs is

42 TACs) containing a VHL ligand can hijack the E3 ligase activity to induce degradation of target prote

43 stile host proteins for degradation with its E3 ligase activity, and it disrupts repressor complexes

44 luenza virus activity was independent of the E3 ligase activity, B-box, or coiled-coil domain.

45 cing to a conserved JmjC-domain protein with E3 ligase activity, but no demethylase activity.

46 hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquit

47 , all intermediates are compatible with SUMO E3 ligase activity, suggesting that the RanBP2/RanGAP1*S

48 in vitro unexpectedly revealed robust SMURF2 E3 ligase activity, with biochemical properties previous

49 l roles of TRAF6 that are independent of its E3 ligase activity.

50 degrading hostile factors with its intrinsic E3 ligase activity.

51 ltiple SIMs that play important roles in the E3 ligase activity.

52 us activity of TRIM56 was independent of the E3 ligase activity.

53 show that the RING domain of rapsyn contains E3 ligase activity.

54 tylation, without affecting Ltn1's intrinsic E3 ligase activity.

55 roteasome in a manner dependent on AvrPtoB's E3 ligase activity.

56 found that Src attenuates the SCF(beta-TrCP) E3-ligase activity in blunting Taz proteasomal degradati

57 ls from mouse and human, we show that cullin E3-ligase activity is necessary for each step of the mus

58 Epistasis analysis revealed that the Dsc E3 ligase acts on SREBP prior to cleavage by Rbd2.

59 in the GAN gene, which encodes gigaxonin, an E3 ligase adapter that targets intermediate filament (IF

60 atient tissues is accompanied by a ubiquitin E3-ligase, AMFR, mediating loss of 11beta-hydroxysteroid

61 this activity was dependent on both its RING E3 ligase and ADP-ribosylation factor (ARF) GTPase activ

62 mall viral protein can play a role as a SUMO E3 ligase and E4-like SUMO elongase to impact a variety

63 s, respectively, and requires the CUL3-based E3 ligase and its adaptor proteins, NPR3 and NPR4, which

64 radation via tighter binding to the cereblon E3 ligase and provides an example of the effect of E3 li

65 ion by a Cullin 1/SKP1-related A/Archipelago E3 ligase and subsequent proteasomal degradation.

66 NOTCH2 into ARMMs is facilitated by the ITCH E3 ligase and the metalloprotease ADAM10, both of which

67 (RBR) E3s constitute one of three classes of E3 ligases and are defined by a RING-HECT-hybrid mechani

68 l strategy to inhibit or activate RING/U-box E3 ligases and provides a resource for the research comm

69 versity among E1 activating, E2 conjugating, E3 ligase, and deubiquitinating (DUB) enzymes offers an

70 uggest that neddylation modification and CRL E3 ligase are attractive gastric cancer targets, and MLN

71 SCF E3 ligases are activated in many cancers and inhibitors

72 ion/ubiquitome analysis indicates that these E3 ligases are enzymatically active and ubiquitinate the

73 E3 ligases are gaining importance as targets to small mo

74 t substrate elements (degrons) recognized by E3 ligases are highly disordered: short linear motifs re

75 Because a number of E3 ligases are known to target factors important for lun

76 cluding Ube2S E2-conjugating enzyme and RNF8 E3 ligase, are responsible for the assembly of Lys11-lin

77 Here we identified the UBR5 E3 ligase as a downstream factor of BMI1.

78 of activated STAT (PIAS) RING family of SUMO E3 ligases, as essential for mitotic chromosomal SUMOyla

79 tment efficiently inhibited Vpr-CRL4 (DCAF1) E3 ligase assembly and Vpr-mediated HLTF degradation or

80 wever, the mechanism of Vpx/Vpr-CRL4 (DCAF1) E3 ligase assembly is still poorly understood.

81 nation is an important regulator of Vpx-CRL4 E3 ligase assembly.

82 thus confirming the functional importance of E3-ligase autoinhibition.

83 w that MCPH1 interacts with and promotes the E3 ligase betaTrCP2 to degrade Cdc25A independent of DNA

84 liana The peptidase is activated by two RING E3 ligases, Big Brother (BB) and DA2, which are subseque

85 ase and provides an example of the effect of E3 ligase binding affinity with relevance to other drug

86 a novel regulatory paradigm of an ubiquitin E3 ligase cascade.

87 ated by degradation, requiring the ubiquitin E3 ligase Cbl.

88 The E3 ligase cellular inhibitor of apoptosis protein 2 (cIA

89 Here we targeted the catalytic domain of E3 ligase, CHIP, to YFP-tagged KCNQ1 +/- KCNE1 subunits

90 ), a critical component of the Cullin4B-RING E3 ligase complex (CRL4B), is overexpressed in human ost

91 te, causing the assembly of the UV-DDB-CUL4A E3 ligase complex (DDB1-DDB2-CUL4A-RBX1).

92 Until now, a single E3 ligase complex (LUBAC), one specific deubiquitinase (

93 raction between the RanBP2-RanGAP1-UBC9 SUMO E3 ligase complex and NUSAP1.

94 oteomics to identify the SCF(Slmb) ubiquitin E3 ligase complex as a novel SMN binding partner.

95 ing protein ZRF1 mediates remodeling of this E3 ligase complex directly at the DNA lesion site, causi

96 of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A ubiquitina

97 Here, we report how a ubiquitin E3 ligase complex specific to DNA repair is remodeled at

98 of SPOP, a key subunit of the CUL3 ubiquitin E3 ligase complex, as a SETD2-interacting protein.

99 Golgi through the combined action of the Dsc E3 ligase complex, the rhomboid protease Rbd2, and the e

100 II on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-beta r

101 nction, during Golgi localization of the Dsc E3 ligase complex.

102 gen requires the Golgi membrane-anchored Dsc E3 ligase complex.

103 for proteosomal degradation by the ubiquitin E3 ligase complex.

104 n Hippel-Lindau tumor suppressor protein, an E3 ligase component and an indication of HIF-1alpha hydr

105 rtion or protein degradation mediated by the E3 ligase component FBXL5.

106 DTX3L, functioning as a heterodimeric Notch E3 ligase, concertedly downregulate NOTCH1 activity and

107 Most metazoan E3 ligases contain a signature RING domain that promotes

108 PIASy adds to the growing list of SUMO E3 ligases containing multiple SIMs that play important

109 Ubiquitin E3 ligases control every aspect of eukaryotic biology by

110 Selective disruption of viral CRL4 (DCAF1) E3 ligase could be a promising antiviral strategy.

111 Balachandran et al. show that the E3 ligase CRL2(ZYG11) degrades cyclin B1, allowing mitot

112 Hundreds of human cullin-RING E3 ligases (CRLs) modify thousands of proteins with ubiq

113 The cullin-RING E3 ligases (CRLs) regulate diverse cellular processes in

114 in 1alpha (HP1alpha) by recruiting ubiquitin E3 ligase CUL4B to HP1alpha.

115 vered reveal critical states of the HOIP RBR E3 ligase cycle, and comparison with Parkin and HHARI su

116 replication compartments, and ICP0, a viral E3 ligase, degrades both PML and SP100.

117 tion of HSV-1 gene expression, ICP0, a viral E3 ligase, degrades both PML and Sp100.

118 ing using virulence factors that function as E3 ligases, deubiquitinases or as enzymes that directly

119 bc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2.

120 A functional HECT E3 ligase domain with a conserved catalytic site was ide

121 n events may be mediated by DDT-dependent E2/E3 ligases (e.g. RAD18 and SHPRH/HLTF).

122 SUMO E3 ligases enhance transfer of SUMO from the charged E2

123 Knockdown of each of these E3 ligases enhances LT stability and promotes MCV genome

124 Importantly, the caspase and the E3 ligase execute this function in a non-additive manner

125 The "FA core complex" contains the RING-E3 ligase FANCL and seven other essential proteins that

126 equent degradation during mitosis due to the E3 ligase, Fbw7alpha.

127 lve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2.

128 S3 acts as the small ubiquitin-like modifier E3 ligase for FOXP2 sumoylation.

129 ly unknown Hsp70-independent quality control E3 ligase for hERG.

130 4 is implicated as the responsible ubiquitin E3 ligase for HSF1 degradation through UPS.

131 ding domains of PPARgamma and is a bona fide E3 ligase for PPARgamma.

132 murine double minute-2 (Mdm2), the ubiquitin E3 ligase for PSD-95, which results in nuclear export an

133 d factor 6 (TRAF6) is identified as a direct E3 ligase for PSD-95, which, together with the E2 comple

134 d F-box, is a substrate of beta-TrCP1 and an E3 ligase for SKP2.

135 and Ubc9, and function as an intramolecular E3 ligase for SUMOylation of the cell cycle regulatory d

136 oteins from cells identifies HUWE1 as a main E3 ligase for this chain type, and we show that mitofusi

137 cation DNA repair proteins to the CRL4-DCAF1 E3 ligase for ubiquitin-dependent proteasomal degradatio

138 pressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known.

139 Screening the putative E3 ligases for interaction with LYK5 identified PLANT U-

140 the cytosol is ubiquitinated by cullin-RING E3 ligases for subsequent proteasomal processing.

141 Selective disruption of Vpx- or Vpr-CRL4 E3 ligase function was achieved by zinc sequestration us

142 RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligases function with Ub E2s through a RING/HECT hybr

143 esent evidence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regulator that

144 We show that SUMO E3 ligase GEI-17/PIAS is required for KLP-19 recruitment

145 mice with a loss-of-function mutation of the E3 ligase gene beta-Trcp2, the balance of PERIOD degrada

146 me pathway mediated by the ubiquitin-protein E3 ligase glycoprotein 78 (GP78), which interacts direct

147 The Cbl E3 ligase has been linked to the down-modulation of surf

148 Ring-between-ring (RBR) E3 ligases have been implicated in autoimmune disorders

149 We found that E3 ligase HDM2 promotes NEDDylation of HBx to enhance HB

150 In conclusion, we revealed that E3 ligase HDM2 promotes NEDDylation of HBx to enhance HB

151 stinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin mo

152 the observed need for a general base in the E3 ligase HOIP, which synthesizes linear ubiquitin chain

153 RING-between-RING (RBR) family of RING-type E3 ligases, however, breaks this paradigm by forming a c

154 as a scaffold to bring more pVHL/associated E3 ligase in proximity of HIF1alpha and increase its ubi

155 The reexpression of E3 ligase-inactive TRAF6 mutants partially restored IL-1

156 s required for signaling in cells expressing E3 ligase-inactive TRAF6 mutants.

157 macrophages from knockin mice expressing the E3 ligase-inactive TRAF6[L74H] mutant, but the late-phas

158 abling prediction of the proteome-wide human E3 ligase interaction network.

159 We reveal that phyB manipulates substrate-E3 ligase interactions in a light-dependent manner, thus

160 oes heterodimerization with Dtx3L, a histone E3 ligase involved in DNA damage repair.

161 ugh the antagonizing effects of the effector E3 ligase IpaH1.4 on deposition of M1-linked polyubiquit

162 flexneri type III secretion system effector E3 ligases IpaH1.4 and IpaH2.5, which directly interact

163 Here, we show that TRAF6 E3 ligase is a crucial factor to restrict mitochondrial

164 The activity of cullin E3-ligases is modulated through post-translational modif

165 TAX1BP1 recruits the E3 ligase Itch to MAVS to trigger its ubiquitination and

166 ns showed WBP2 levels were controlled by the E3 ligase ITCH, which bound and target WBP2 for ubiquiti

167 CLP inhibited the activity of the ubiquitin E3 ligase Itch.

168 y of the inhibitor warhead and the recruited E3 ligase largely determine the degradation profiles of

169 ant Htt increases CK2alpha' kinase and Fbxw7 E3 ligase levels, phosphorylating HSF1 and promoting its

170 itical for the interaction of AtWRI1 with an E3 ligase linker protein.

171 The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradig

172 ions within disordered regions that regulate E3 ligase localization, conformation, and enzymatic acti

173 eptides, which undergo ubiquitination by the E3 ligase Ltn1 and proteasomal degradation facilitated b

174 ing Salmonella Typhimurium, we show that the E3 ligase LUBAC generates linear (M1-linked) polyubiquit

175 report an unexpected phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates t

176 has shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS)

177 somal proteins by p17-mediated activation of E3 ligase MDM2 that targets ribosomal proteins and by si

178 results in the degradation of the oncogenic E3 ligase MDM2, and leads to re-activation of the tumour

179 O1 by promoting its binding to the ubiquitin E3 ligase MDM2.

180 Here, we identify SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation.

181 ene silencing, by displacing the RNA-binding E3 ligase, Mex-3 RNA-binding family member B (Mex3b), fr

182 The RNA helicase DDX5, and E3 ligase Mex3b, are important cellular targets for the

183 is mediated through the centriolar satellite E3 ligase Mib1, which interacts with GABARAP through its

184 Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is req

185 ind that PCM1 is essential for tethering the E3 ligase, Mindbomb1 (Mib1), to satellites.

186 Interestingly, the E3 ligase Mms21, which has a major role in genome mainte

187 ly to the RING or U-box domain of a distinct E3 ligase: monomeric UBE4B, phosphorylated active CBL, o

188 We found that the kinase GSK3beta, the E3 ligases MULE and betaTrCP, and the deubiquitinase USP

189 k activity, we demonstrated that a ubiquitin E3 ligase, murine double minute-2 (Mdm2), is required fo

190 PARKIN, an E3 ligase mutated in familial Parkinson's disease, promo

191 Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interact

192 evels are specifically down-regulated by the E3 ligase NEDD4L, which ubiquitylates ULK1 for degradati

193 ic activity is imparted by a conserved novel E3 ligase (NEL) domain that is unique to Gram-negative p

194 tophagy regulatory complex, comprised of the E3 ligase Nrdp1, the deubiquitinase enzyme USP8, and Cle

195 s deleted for FBWX7, which encodes the major E3 ligase of full-length MYC frequently mutated in color

196 uantitatively assess the activity of the RBR E3 ligase PARKIN in a simple experimental setup and in r

197 fenib activates recruitment of the ubiquitin E3 ligase Parkin to damaged mitochondria.

198 Ectopic expression of the ubiquitin E3 ligase Parkin, combined with short-term mitochondrial

199 ified Tat interactors and found that a novel E3 ligase, PJA2, ubiquitinates Tat in a non-degradative

200 Skp1-Cul1-F-box (SCF) E3 ligases play key roles in multiple cellular processes

201 nism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates TLR2 both in

202 we identified SMURF2, among a cohort of Hect E3 ligases previously implicated in TGFbeta signaling.

203 t HBx is modified by NEDD8 and that the HDM2 E3 ligase promotes HBx NEDDylation to enhance HBx stabil

204 trans-QTL, including transcription factors, E3 ligases, protein targeting components, and protein ki

205 leavage leads to destabilization by the RING E3 ligase PROTEOLYSIS 1 (PRT1) of the N-end rule pathway

206 opsis thaliana N-end rule mutant lacking the E3 ligase PROTEOLYSIS6 (PRT6).

207 ion for the turnover of LYK5 mediated by the E3 ligase PUB13.

208 ing domains, and overlaps with RanBP2's SUMO E3 ligase region.

209 NEDDylase") and a subunit of the cullin-RING E3 ligase-regulating COP9 signalosome complex, attenuate

210 her NEDD8-dependent processes such as cullin E3 ligase regulation.

211 lysine side chains is around 10.5 and hence E3 ligases require a mechanism to deprotonate the amino

212 te that the assembly of the Vpx- or Vpr-CRL4 E3 ligase requires a highly conserved zinc-binding motif

213 ayne syndrome group A-DDB1-Cul4A complex, an E3 ligase responsible for CSB ubiquitination.

214 and inhibits the activity of SCF(TIR)(1), an E3 ligase responsible for degradation of the Aux/IAA tra

215 ane proteins signals pexophagy; however, the E3 ligase responsible for mediating ubiquitination is no

216 ATMIN, WRNIP1 and RAD18, the E3 ligase responsible for PCNA monoubiquitination, are s

217 fy RING finger protein 113A (RNF113A) as the E3 ligase responsible for upstream ubiquitin signalling

218 emoving MDM2 simultaneously with the H2AK119 E3 ligase Ring1B/RNF2 further induced these genes and sy

219 endomembrane interactants of the RING-domain E3 ligase, RNF11, we identified SMURF2, among a cohort o

220 al under stress due to downregulation of the E3 ligase RNF144A.

221 and identified tankyrase and its associated E3 ligase RNF146 as positive regulators of YAP signaling

222 romosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and SC protein Zip1 .

223 F508del CFTR via the SUMO-targeted ubiquitin E3 ligase, RNF4 (RING finger protein 4) (1).

224 n late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to

225 by facilitating their ubiquitination by the E3 ligase SCF(beta-TrCP).

226 PRR7 inhibits the ubiquitination of c-Jun by E3 ligase SCF(FBW) (7) (FBW7), increases c-Jun-dependent

227 Through an E3 ligase screen and biochemical studies, we unexpectedl

228 teracts with PRC2 and also binds RNA-binding E3 ligases, serving as a ubiquitination scaffold.

229 nt, both the target ligand and the recruited E3 ligase should be varied to rapidly generate a PROTAC

230 rosylated GAPDH complexes with the ubiquitin-E3-ligase Siah1 and Rheb, a small G protein that activat

231 at DHX15 regulates AR activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent o

232 ng factor Sir4, NE-associated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) prote

233 transferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling.

234 h a p38MAPK-dependent phosphorylation of the E3 ligase, Skp2 at serine-64 residue, as observed by qua

235 nation, we performed a genome-wide screen of E3 ligase small interfering RNA library based on western

236 The activity of the E3 ligase, SMURF2, is antagonized by an intramolecular,

237 ritical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein Kelch-like ECH-assoc

238 and highlight the functional repurposing of E3 ligase substrate receptors independent of the ubiquit

239 of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and c

240 rstanding is confounded by promiscuity among E3 ligase/substrate interactions and ubiquitin code comp

241 t the accumulation of these potential cullin E3-ligase substrates may be partially responsible for th

242 ntify that RAGE is targeted by the ubiquitin E3 ligase subunit F-box protein O10 (FBXO10), which asso

243 RF1 from binding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal degra

244 that functions specifically with Cullin-RING E3 ligases, such as SCF (Skp1-Cullin-F-box).

245 pread to uninfected cells.IMPORTANCE The Cbl E3 ligase suppresses surface signaling responses by indu

246 minus of Hsc70-interacting protein), a U-box E3 ligase, suppresses tumor progression in ovarian carci

247 chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such

248 -mediated viral latency through cellular SCF E3 ligase targeting of viral replication proteins is a u

249 r a new modality of chemical intervention on E3 ligases.Targeting the ubiquitin proteasome system to

250 RNF4 is a compact RING E3 ligase that directs the ubiquitination of polySUMO ch

251 g of SOX9 to the F-box protein FBW7alpha, an E3 ligase that functions in the DNA damage response path

252 in the human papilloma virus context) is an E3 ligase that has an important role in the cellular str

253 The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis

254 llular hypoxic response, to be the ubiquitin E3 ligase that mediates the degradation of Plk3.

255 he CRL4B(DCAF11) complex represents a unique E3 ligase that promotes the ubiquitination of p21(Cip1)

256 mor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an o

257 r CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubi

258 n HEI10, which encodes a conserved ubiquitin E3 ligase that regulates crossovers.

259 dent manner through degradation of cIAP1, an E3 ligase that targets CAS for ubiquitin-dependent prote

260 of apoptosis protein 1 (cIAP1) is a cellular E3 ligase that ubiquitinates NEMO.

261 as mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombi

262 llowed us to identify RNF144A and RNF144B as E3 ligases that assemble K6-, K11-, and K48-linked polyu

263 is part of MDM2 and possibly other ubiquitin E3 ligases that target p53 for degradation.

264 n activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs).

265 SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at l

266 ) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitinati

267 encoded by KSHV (ORF50), can function as an E3 ligase to degrade HLA-DRalpha.

268 px and Vpr are known to utilize CRL4 (DCAF1) E3 ligase to induce the degradation of the host restrict

269 osphorylation inhibits the binding of TRIM21 E3 ligase to PFKP and the subsequent TRIM21-mediated pol

270 CM1 promotes ciliogenesis by tethering a key E3 ligase to satellites and restricting it from centriol

271 ation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is

272 e Homo-PROTACs as an approach to dimerize an E3 ligase to trigger its suicide-type chemical knockdown

273 Over time, Ubiquilins recruit an E3 ligase to ubiquitinate bound clients.

274 ly interacted with ZIC2 and functioned as an E3 ligase to ubiquitinate ZIC2.

275 The results illustrate utility of engineered E3 ligases to elucidate mechanisms underlying ubiquitin

276 1, the mRNA export protein Yra1 and the HECT E3 ligase Tom1.

277 he protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Ai

278 The E3 ligase TRAF6 binds to DCP1a and indirectly regulates

279 ts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as

280 RING-type E3 ligases typically facilitate the transfer of ubiquiti

281 The HECT E3 ligases ubiquitinate numerous transcription factors a

282 HECT-family E3 ligases ubiquitinate protein substrates to control vi

283 hat the ring finger protein 41 (RNF41) as an E3 ligase ubiquitinated and degraded SGT1 in a phosphory

284 ing of the functional interplay between host E3 ligases, ubiquitination, and regulation of EBOV VP40-

285 ts the functional interplay between cellular E3 ligases, ubiquitination, and regulation of VP40-media

286 netic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ

287 UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ub

288 lated by cyclin D-CDK4 and the cullin 3-SPOP E3 ligase via proteasome-mediated degradation.

289 nation analyses indicated that CRL4B(DCAF11) E3 ligase was able to specifically ubiquitinate a CDK in

290 e protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional c

291 if is a novel substrate of the SCF(cyclin F) E3 ligase, where cyclin F mediates the ubiquitination an

292 n blot and identified SCF-FBXO32 to be a new E3 ligase, which is responsible for KLF4 ubiquitination

293 regulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during

294 GFE3 is a fusion between an E3 ligase, which mediates the ubiquitination and rapid d

295 er that the diabetes gene Clec16a encodes an E3 ligase, which promotes nondegradative ubiquitin conju

296 ins Vpx and Vpr to recruit host CRL4 (DCAF1) E3 ligase, which represents a target for novel anti-huma

297 is a RING finger domain-containing ubiquitin E3 ligase whose expression is elevated in autoimmune dis

298 Together, these data identify VHL as an E3 ligase with important cellular functions under both n

299 Here, we demonstrated that CUL4B forms an E3 ligase with RBX1 (RING-box 1), DDB1 (DNA damage bindi

300 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, protects again