ライフサイエンスコーパス: E3 protein

1 binding motif (dsRBM) of the vaccinia virus E3 protein.

2 arget proteins is accomplished by the E2 and E3 proteins.

3 codons into all three reading frames of the E3 proteins.

4 ae that belongs to the hect domain family of E3 proteins.

5 to be leaky and could produce low levels of E3 proteins.

6 utant virus failed to produce any detectable E3 proteins.

7 uld be able to produce only one of the three E3 proteins.

8 hat each could produce only one of the three E3 proteins.

9 s from this laboratory demonstrated that the E3 proteins 10.4K and 14.5K, which form a complex in the

10 E3 proteins 10.4K, 14.5K, and 14.7K function to protect

11 udy, we demonstrate that an additional viral E3 protein, 6.7K, functions in the specific modulation o

12 The E3 proteins also prevented TNF-induced cytolysis and rel

13 ific human E2s and the Hect domain family of E3 proteins and suggest that selective physical interact

14 Two mutants produced only one class of E3 protein as predicted from their specific mutations an

15 pmE314, that was null for the expression of E3 proteins as determined by immunoprecipitation with E3

16 RNA (dsRNA) accumulation, whereas the viral E3 protein can bind dsRNA.

17 A human WW domain-containing hect (WW-hect) E3 protein closely related to Rsp5, Rpf1/hNedd4, also bi

18 receptor-mediated apoptosis and suggest the E3 protein complex has evolved to regulate the signaling

19 experiments revealed that the absence of the E3 proteins did not alter the tropism of the mutant viru

20 Here we utilize the E3 proteins, diverse and rapidly evolving transmembrane-

21 The adenovirus (Ad) 14.7-kDa E3 protein (E3-14.7K), which can inhibit tumor necrosis

22 omodulatory activity of a species D-specific E3 protein, E3/49K.

23 MPXV) genome encodes a homologue of the VACV E3 protein, encoded by the F3L gene, the MPXV gene is pr

24 Immunoprecipitation of E3 proteins from infections of mouse 3T6 cells using an

25 Insertion of additional cysteines based on E3 proteins from other alphaviruses resulted in either s

26 genesis were unsuccessful because one of the E3 proteins, gp11K, is synthesized as a fusion protein f

27 E3 proteins had their greatest effect on the inhibition

28 The vaccinia virus (VACV) E3 protein has been shown to be important for blocking a

29 l cooperativity between specific E2 and Hect E3 proteins has not yet been determined.

30 th the E3 mutant viruses to determine if the E3 proteins have an effect on the pathogenicity of the v

31 common immune evasion functions of species C E3 proteins have been described.

32 Hect E3 proteins have been proposed to consist of two broad f

33 Several HECT and RING E3 proteins have now also been linked to the induction a

34 y wild-type virus colocalized with the viral E3 protein in cytoplasmic viral factories.

35 lot analysis demonstrated that the amount of E3 protein in fibroblasts from the patient and her fathe

36 We have found that the E3 protein in Sindbis virus contains one disulfide bond

37 kinase 1) have been implicated as ubiquitin E3 protein ligases that affect protein stability.

38 sting that distinct sets of immunomodulatory E3 proteins may influence their interaction with the hum

39 suggesting that Rpf1 and/or another WW-hect E3 protein mediates UV-induced degradation of the large

40 that is present in many otherwise dissimilar E3 proteins of the ubiquitin system.

41 In addition to E1B and E3 proteins, other early and late proteins that regulate

42 demonstrate that the N terminus of the VACV E3 protein prevents DAI-mediated induction of necroptosi

43 Ubiquitin ligases, or E3 proteins, promote ubiquitination by effecting the spe

44 ould associate efficiently with another Hect-E3 protein, RSP5.

45 The E3 protein sets are named E3-14.7K (14,700 kDa) and E3-1

46 Furthermore, additional regions of the E3 protein that have no direct contact with E2 play crit

47 Unlike all other E3 proteins that act on infected cells, E3/49K seems to

48 lish the UBR box family as a unique class of E3 proteins that recognize N-degrons or structurally rel

49 a member of a family of functionally related E3 proteins that share a conserved carboxyl-terminal reg

50 n might have further enhanced the ability of E3 proteins to prevent T1D, an ADP-inactivated E3 constr

51 e-promoting complex (APC) is a multi-subunit E3 protein ubiquitin ligase that is responsible for the

52 The Parkin gene (PRKN) encodes an E3 protein-ubiquitin ligase for which loss of function i

53 d describe immunomodulatory activities of an E3 protein uniquely expressed by a single Ad species.

54 vel immunomodulatory function for E3/49K, an E3 protein uniquely expressed by species D Ads.

55 The E3 protein was found to protrude midway between the cent

56 A fourth mutant that should produce no E3 proteins was also constructed.

57 ls using an antiserum specific for all three E3 proteins was used to examine the effect of the introd

58 clones paralleled the reduction in mRNA, and E3 proteins were unaltered.

59 defective Ad vectors that express individual E3 proteins were used to establish that the RID and E3-6

60 Furthermore, our map reveals the unexpected E3 protein, which is cleaved and generally thought to be