ライフサイエンスコーパス: E3 ubiquitin ligase

1 es), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases).

2 -Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase.

3 to prevent NEMO interactions with the cIAP1 E3 ubiquitin ligase.

4 the AhR acts as a transcription factor or an E3 ubiquitin ligase.

5 , a substrate receptor component of the CRL4 E3 ubiquitin ligase.

6 y by targeting the protein to the SCF(Fbw1a) E3 ubiquitin ligase.

7 of a ubiquitously expressed multifunctional E3 ubiquitin ligase.

8 s, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase.

9 e substrate-binding subunit of SCF(cyclin F) E3 ubiquitin ligase.

10 nteracted with the F-box protein 45 (FBXO45) E3 ubiquitin ligase.

11 through the action of Huwe1, a HECT-domain, E3 ubiquitin ligase.

12 factor EME1 by hijacking the host CRL4-DCAF1 E3 ubiquitin ligase.

13 is a transcriptional regulator as well as an E3 ubiquitin ligase.

14 RNF126 is an E3 ubiquitin ligase.

15 a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase.

16 te recognition subunit of the Cullin-3-based E3 ubiquitin ligase.

17 ated substrate specificity on the CRL4(CRBN) E3 ubiquitin ligase.

18 D40 domain of DCAF1 in complex with the CRL4 E3 ubiquitin ligase.

19 to be localized, and that it functions as an E3 ubiquitin ligase.

20 additional stress-modifying function of this E3-ubiquitin ligase.

21 on of selective inhibitors against RING type E3 ubiquitin ligases.

22 rowing ubiquitin chain, which is mediated by E3 ubiquitin ligases.

23 al PPXY motifs that mediate interaction with E3 ubiquitin ligases.

24 he PI3-kinase induced signalling network and E3 ubiquitin ligases.

25 sites and screen for DNA ligase I-associated E3 ubiquitin ligases.

26 cognition of eukaryotic pathogens to include E3 ubiquitin ligases.

27 on rather than serving as only a hallmark of E3 ubiquitin ligase activation.

28 Our experiments show that mLANA's E3 ubiquitin ligase activity is necessary for efficient

29 egation in the absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

30 opment of pharmacological inhibitors of LANA E3 ubiquitin ligase activity may allow strategies to int

31 Here, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive comp

32 ization of a mutant, pub1-1, affected by the E3 ubiquitin ligase activity of PUB1, we have shown that

33 t the L. pneumophila effector GobX possesses E3 ubiquitin ligase activity that is mediated by a centr

34 bution of different domains of BRCA1 and its E3 ubiquitin ligase activity to HDR and drug resistance.

35 ated interactions also modulate TRIM5alpha's E3 ubiquitin ligase activity, by stereochemically restri

36 epigenetic modification directly regulating E3 ubiquitin ligase activity.

37 ith homologous to the E6-AP Cterminus (HECT) E3 ubiquitin ligase activity.

38 DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation

39 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SP

40 Casitas B-lineage lymphoma (CBL) is an E3 ubiquitin ligase and a molecule of adaptor that we ha

41 e found that genetic alterations of FBW7, an E3 ubiquitin ligase and a tumor suppressor frequently mu

42 We characterize here a cullin 4-based E3 ubiquitin ligase and its substrate receptor, VprBP/DC

43 nteracts with PARKIN, a previously described E3 ubiquitin ligase and mitophagy effector, on depolariz

44 These studies demonstrate that UBE3B is an E3 ubiquitin ligase and reveal that the enzyme is regula

45 les that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependen

46 r cell signaling mediators, such as kinases, E3 ubiquitin ligases and phosphatases, and gene ontologi

47 indicates that HopM1 interacts with several E3 ubiquitin ligases and proteasome subunits.

48 that counteracts ubiquitination by different E3 ubiquitin ligases and regulates alpha-synuclein degra

49 to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes.

50 tion is regulated by the interaction between E3 ubiquitin ligases and their target substrates.

51 T subunit Spt16 is ubiquitylated by San1 (an E3 ubiquitin ligase) and degraded by the 26S proteasome.

52 ed inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendl

53 CUL9 is a member of the cullin family of E3 ubiquitin ligases, and it localizes predominantly in

54 like Nedd4, is a member of the HECT class of E3 ubiquitin ligases, and the resultant physical and fun

55 Finally, the Siah2 E3 ubiquitin ligase antagonizes drebrin function, sugges

56 Although E3 ubiquitin ligases are deemed to play key roles in nor

57 Loss-of-function mutations in CBL E3 ubiquitin ligases are found in a wide range of myeloi

58 E3 ubiquitin ligases are key enzymes within the ubiquiti

59 2 (parkin), which encodes Parkin protein, an E3 ubiquitin ligase, are associated with autosomal reces

60 modular SCF (Skp1, Cul1, F-box protein)-type E3 ubiquitin ligases as mediators of PKR destruction by

61 man CaV2.1 subunit by identifying RNF138, an E3 ubiquitin ligase, as a novel CaV2.1-binding partner.

62 Parkin, a E3 ubiquitin ligase associated with familial Parkinson's

63 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cellular hypoxic

64 lunted proteolytic degradation downstream of E3 ubiquitin ligase binding to RGS2.

65 The yeast E3 ubiquitin ligase Bre1 (human RNF20/40) pairs with the

66 TrkA is ubiquitinated, among other E3 ubiquitin ligases, by Nedd4-2.

67 transport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for

68 h assay vectors, thereby enabling readout of E3 ubiquitin ligase catalytic activity within the cellul

69 ECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-

70 Arabidopsis (Arabidopsis thaliana) COP1/SPA E3 ubiquitin ligase causes the degradation of multiple r

71 regulators of T cell activation, such as the E3 ubiquitin ligase Cbl-b, have been reported to lead to

72 Here we report that the E3 ubiquitin ligase CBLB directs polyubiquitination of d

73 d cell biology approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed throughout

74 n of hERG complexes containing Hsp70 and the E3 ubiquitin ligase CHIP requires the interaction of Bag

75 re we show that the CBM complex includes the E3 ubiquitin ligases cIAP1 and cIAP2, which are essentia

76 or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitina

77 s of these photoreceptors, such as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription facto

78 nuously ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the prote

79 of Vpr involved in binding to the DCAF1/DDB1/E3 ubiquitin ligase complex and prevention of cell cycle

80 BOK is ubiquitylated by the AMFR/gp78 E3 ubiquitin ligase complex and targeted for proteasomal

81 t the interaction of Vpr with the DCAF1/DDB1 E3 ubiquitin ligase complex and the yet-to-be-identified

82 e ZIM-domain (JAZ) repressor proteins and an E3 ubiquitin ligase complex containing the F-box CORONAT

83 Thus, the SCF(FBXO17) E3 ubiquitin ligase complex negatively regulates inflamm

84 nable to interact with either the DCAF1/DDB1 E3 ubiquitin ligase complex or a host factor hypothesize

85 gether, our data indicates that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic traffick

86 Mms1 is part of the E3 ubiquitin ligase complex that is linked to replicatio

87 domain (which in mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the in

88 ), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immuno

89 dulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces Aiolos and Ikaros p

90 t as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for

91 P, the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradati

92 bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

93 proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex.

94 KLHL3) and cullin 3 (CUL3)] form a RING-type E3-ubiquitin ligase complex that modulates WNK1 and WNK4

95 from A3G-mediated restriction by forming an E3-ubiquitin ligase complex to polyubiquitinate A3G and

96 Here, we demonstrate that NSs requires E3 ubiquitin ligase complexes of the SCF (Skp1, Cul1, F-

97 iviral kinase PKR by recruitment of SCF-type E3 ubiquitin ligases containing FBXW11 and beta-TRCP1 as

98 MARCH5, an OMM-associated E3 ubiquitin ligase, controls mitochondrial function.

99 We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to

100 We found that miR-424 targets the E3 ubiquitin ligase COP1 and identified STAT3 as a key s

101 We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 an

102 This approach identified the E3 ubiquitin ligase CRL2(Lrr1), a specific p97 complex,

103 expectedly intimate relationship between the E3 ubiquitin ligase CRL4(CRBN) and p97 pathways.

104 veral Merlin downstream effectors, including E3 ubiquitin ligase CRL4(DCAF1).

105 onoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved

106 as substrate receptors for the Cullin5-RING E3 ubiquitin ligase (CRL5) and through a variety of CRL5

107 The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of 20%

108 ich is an important regulator of cullin-RING E3 ubiquitin ligases (CRLs).

109 275-290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit

110 TRIMs, which are E3 ubiquitin ligases, displayed propensity to associate

111 hat the Casitas B-cell lymphoma (CBL) family E3 ubiquitin ligases down-regulate JAK2 stability and si

112 ctor alpha, a well established target of VHL E3 ubiquitin ligase, ECV (Elongins/Cul2/VHL).

113 ngly, shRNA-mediated suppression of Atg5, an E3 ubiquitin ligase essential for autophagosome elongati

114 rs of the really interesting new gene (RING) E3 ubiquitin ligase family bind to both substrate and ub

115 cing DeltaNp63 protein stability through the E3 ubiquitin ligase, Fbw7.

116 on because of no or little expression of the E3 ubiquitin ligase FBXO10, as well as transcriptional u

117 Inhibition of proteasome, GSK3 or the E3 ubiquitin ligase, FBXW7, prevented mSREBP1 reduction

118 study reports the first identification of an E3 ubiquitin ligase for CaV2.1, RNF138.

119 ein, TRIM32, has been reported earlier as an E3 ubiquitin ligase for dysbindin in skeletal muscle.

120 Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha

121 The role of cullin E3-ubiquitin ligases for muscle homeostasis is best know

122 Here, we have purified the major E3 ubiquitin ligases from human cells responsible for re

123 ption factor, it also possesses an intrinsic E3 ubiquitin ligase function that targets, e.g., the ste

124 duplex binding to RC3H2 cross-talks with its E3 ubiquitin ligase function using an in vitro auto-ubiq

125 ligand-activated AhR but did not affect its E3 ubiquitin ligase function.

126 ression of the Foxp3 gene and anergy-related E3 ubiquitin ligase genes.

127 In addition, we demonstrate that E3 ubiquitin ligase GP78 preferentially binds to deacety

128 Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8(+) T cel

129 stration of a role in writing m(6) A for the E3 ubiquitin ligase HAKAI is likely to be of considerabl

130 included MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI.

131 Nedd4 family E3 ubiquitin ligases have been shown to restrict T-cell

132 ion of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

133 ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

134 be mediated through an interaction with the E3 ubiquitin ligase HRD1, as immunoprecipitation of Tomo

135 Here, we show that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-con

136 scover that this process depends on the HECT E3 ubiquitin ligase Hyd/UBR5, which is required for Wnt

137 Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 prot

138 we identify transcriptional induction of the E3 ubiquitin ligase IDOL in human and rodent cells as th

139 Acting as an E3-ubiquitin ligase, IDOL promotes ubiquitylation and su

140 re, GRB10 associated with IRS-2, NEDD4.2 (an E3-ubiquitin ligase), IL-4Ralpha, and gammaC after IL-4

141 terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2

142 ted factor 2 (TRAF2), a scaffold protein and E3 ubiquitin ligase important for inflammatory signaling

143 UL1), suggesting a role for SKP, CUL1, F-box E3 ubiquitin ligase in TCP14 proteolysis.

144 -containing SCF (SKP1-cullin1-F-box protein) E3 ubiquitin ligase in the nucleus, but not in the cytop

145 Our findings indicate that lenalidomide has E3 ubiquitin ligase inhibitory effects that extend to RN

146 We further found that GP78, an E3 ubiquitin ligase, interacted with the C-terminal regi

147 entally down-regulated protein 4 (NEDD4), an E3 ubiquitin ligase, interacts with the hinge and ligand

148 tion network.Protein stability modulation by E3 ubiquitin ligases is an important layer of functional

149 MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tu

150 complex or cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation.

151 w that Ndfip1, a coactivator of Nedd4-family E3 ubiquitin ligases, is required for Treg cell stabilit

152 e Skp1/Cullin-1/F-box protein (SCF)-class of E3-ubiquitin ligases, is a natural substrate of this enz

153 e we show that Ndfip1, a co-activator of the E3 ubiquitin ligase Itch, restricts the frequency and pa

154 specifically with the WW domain of the host E3 ubiquitin ligase ITCH.

155 targeted for degradation by the co-recruited E3 ubiquitin ligase ITCH.

156 ta activation-impaired GLI1 binding with the E3 ubiquitin ligase-ITCH, leading to decreased K48-linke

157 ated through the action of the multi-subunit E3 ubiquitin ligase known as the anaphase-promoting comp

158 yc stability, likely by inhibiting HUWE1, an E3 ubiquitin ligase known to target degradation of sever

159 4L mapping to the HECT domain of the encoded E3 ubiquitin ligase lead to PNH associated with toe synd

160 Mutations in the gene encoding Parkin, an E3 ubiquitin ligase, lead to juvenile-onset Parkinson's

161 for recognition by Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligases leading to subsequent proteasomal d

162 binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination

163 PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker.

164 igh-content imaging approach, identified the E3 ubiquitin ligase, Ltn1 of the ribosome quality contro

165 Here we show that the E3 ubiquitin ligase MARCH1 impairs cellular insulin acti

166 We report that the OMM-associated E3 ubiquitin ligase MARCH5 controls dynamin-related prot

167 he Golgi network and vesicles containing the E3 ubiquitin ligase MARCH8 and mMHCII.

168 al cells by its two negative regulators--the E3 ubiquitin ligase MDM2 and its homolog MDMX.

169 ted the kinase Akt, which then activated the E3 ubiquitin ligase Mdm2.

170 usly identified TRIM21 as an IFNgamma-driven E3 ubiquitin ligase mediating the deposition of ubiquiti

171 4.1-like 5 (Epb41l5) as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essenti

172 e, we show that STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferen

173 The E3 ubiquitin ligases MULAN and MARCH5 coordinate ubiquit

174 The E3 ubiquitin ligase Mule is often overexpressed in human

175 We found that the E3 ubiquitin ligase murf1 is upregulated in ncx1-deficie

176 The E3-ubiquitin ligase murine double minute (MDM)-2 is a no

177 at miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adul

178 we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on ly

179 in a clathrin-dependent manner involving the E3 ubiquitin ligase Nedd4-2 (neural precursor cell expre

180 e receptors via a mechanism depending on the E3 ubiquitin ligase Nedd4.

181 es ubiquitination of Kv1.3, catalyzed by the E3 ubiquitin-ligase Nedd4-2.

182 Moreover, we determined that the HECT E3 ubiquitin ligase, Nedd4L, interacts with TRP120 durin

183 ex protein Stardust (Sdt) as a target of the E3 ubiquitin ligase Neuralized (Neur) in Drosophila mela

184 PIPKIgammai5 directly interacts with the E3 ubiquitin ligase neuronal precursor cell-expressed de

185 ES 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect chromatin organization, in

186 potent small-molecule inhibitor of Ring1A/B E3-ubiquitin ligase or siRNA-mediated suppression of Cbx

187 genes, in particular the genes encoding the E3 ubiquitin ligase Parkin (PARK2, also known as PRKN) a

188 These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-i

189 Mutations in E3 ubiquitin ligase Parkin have been linked to familial

190 mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to e

191 The E3 ubiquitin ligases PARKIN and MUL1 play redundant role

192 As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of

193 In this study, we examined the role of the E3 ubiquitin ligase Pellino-1 in endotoxin tolerance and

194 Here, we report that the peroxisomal E3 ubiquitin ligase peroxin 2 (PEX2) is the causative ag

195 o our knowledge, this is the first report of E3 ubiquitin ligase phosphorylation inhibiting E3 ligase

196 Sel1L, an adapter of the transmembrane Hrd1 E3 ubiquitin ligase postulated to be the retrotranslocon

197 evidence demonstrates that the MYOD-induced E3 ubiquitin ligase Praja1 (PJA1) is involved in regulat

198 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitinati

199 The same E3 ubiquitin ligase promotes the destabilization of comp

200 ession and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant de

201 E3 ubiquitin ligases provide substrate selectivity in ub

202 w that a P. yoelii gene encoding a HECT-like E3 ubiquitin ligase (Pyheul) influences parasitemia and

203 The E3 ubiquitin ligase RAD18 activates TLS by promoting rec

204 In cultured cancer cells the E3 ubiquitin ligase Rad18 activates Trans-Lesion Synthes

205 s the stability of the DNA damage responsive E3 ubiquitin ligase RAD18.

206 TRIM E3 ubiquitin ligases regulate a wide variety of cellular

207 RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic process

208 In contrast, a different E3 ubiquitin ligase regulates FEN-1 turnover.

209 We describe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ub

210 lin RING ligase (CRL), the largest family of E3 ubiquitin ligase, requires cullin neddylation for its

211 the anaphase-promoting complex (APC/C), the E3 ubiquitin ligase responsible for initiating chromosom

212 (GS) triggers recognition by the CRL4(CRBN) E3 ubiquitin ligase, resulting in its ubiquitylation and

213 We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger doma

214 Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similar

215 hat RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related

216 oteomics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersecti

217 The atypical E3 ubiquitin ligase RNF31 is highly expressed in human b

218 estigated the effects of lenalidomide on the E3 ubiquitin ligase RNF41.

219 nses depend on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 plus E2 ubiquitin-c

220 The E3 ubiquitin ligase, Roquin, is involved in immune regul

221 By counteracting the E3 ubiquitin ligase Rsp5, Ubp2 and Ubp15 prevent hyperub

222 ive ubiquitylation of target proteins by the E3 ubiquitin ligase, Rsp5.

223 ation of Myc Box I and ubiquitination by the E3 ubiquitin ligase SCF(FbxW7) However, N-Myc protein (t

224 1 internalization is dependent on a specific E3 ubiquitin ligase, Siah-1A.

225 depended on poly-ubiquitination, but not the E3 ubiquitin ligase Siah1.

226 Meanwhile, we show that E3 ubiquitin ligase Smurf1 directly interacts with PIPKI

227 Here, we identify the E3 ubiquitin ligase Smurf2 as a physiologic regulator of

228 psis RING (really interesting new gene) type E3 ubiquitin ligase SP1 [suppressor of plastid protein i

229 recurrent mutations in the gene encoding the E3 ubiquitin ligase SPOP.

230 Mechanistic studies revealed that the E3 ubiquitin ligase, STUB1, could influence metformin re

231 The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-ty

232 Here, we show that the E3 ubiquitin ligase subunit Not4/Mot2 of the evolutionar

233 -RESPONSE BRIC-A-BRACK/TRAMTRACK/BROAD (LRB) E3 ubiquitin ligases target phytochrome B (phyB) and PIF

234 ng Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for des

235 TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the

236 RNF126 is an E3 ubiquitin ligase that collaborates with the BAG6 sort

237 ng enzyme for triterpene biosynthesis and an E3 ubiquitin ligase that controls HMGR1 levels, respecti

238 ICP0 contains a RING-type E3 ubiquitin ligase that degrades the ND10 organizer PML

239 TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase that functions as a key mediator of

240 mprove cytotoxic T-cell activity.Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signal

241 HDAC1 precedes VC and it is mediated by MDM2 E3 ubiquitin ligase that initiates HDAC1 K74 ubiquitinat

242 eport that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylate

243 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

244 lation of the anaphase-promoting complex, an E3 ubiquitin ligase that mediates high-fidelity chromoso

245 actor 6 (TRAF6) is an adaptor protein and an E3 ubiquitin ligase that mediates the activation of mult

246 WD domain 2 (RFWD2, also termed COP1) is an E3 ubiquitin ligase that modifies specific target protei

247 me (APC/C) is a large multimeric cullin-RING E3 ubiquitin ligase that orchestrates cell-cycle progres

248 Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amp

249 Here we identify KIB1 as an F-box E3 ubiquitin ligase that promotes the degradation of BIN

250 s simplex virus 1 (HSV-1) ICP0 protein is an E3 ubiquitin ligase that promotes the degradation of sev

251 uires UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newl

252 n, encoded by a tumor suppressor gene, is an E3 ubiquitin ligase that targets Hif-1alpha and Epas1 to

253 n between EBOV VP40 (eVP40) and WWP1, a host E3 ubiquitin ligase that ubiquitinates VP40 and regulate

254 e SCF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin ligases that are important for eukaryotic p

255 Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo

256 may be regulated by a cell cycle-associated E3-ubiquitin ligase, the anaphase-promoting complex.

257 mechanisms to hijack components of cellular E3 ubiquitin ligases, thus modulating the ubiquitination

258 f the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53.

259 SIVsm paralogue Vpx, hijack the CRL4(DCAF1) E3 ubiquitin ligase to alleviate some of these condition

260 hosphorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading

261 ied elements that are important for the ICP0 E3 ubiquitin ligase to differentially recognize two of i

262 lated protein decay, wherein UPF1 acts as an E3 ubiquitin ligase to repress human skeletal muscle dif

263 is by hijacking the cellular DDB1-containing E3 ubiquitin ligase to target the 'structural maintenanc

264 f this light version of the RQC complex, the E3 ubiquitin ligase Tom1.

265 We identify the E3 ubiquitin ligase TRAIP as a new factor at active and

266 ulation of ubiquitinated TLR4 and binding of E3 ubiquitin ligase Triad3A to TLR4 was increased signif

267 Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of

268 n host-binding partner of this effector, the E3-ubiquitin ligase TRIM32.

269 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination a

270 terminal domain and is unable to recruit the E3 ubiquitin ligase TRIM62.

271 Here we identify the brain-enriched E3 ubiquitin ligase TRIM9 as a novel regulator of embryo

272 Here we demonstrate that the E3 ubiquitin ligase TRIM9 regulates these developmental

273 t VP35 interacts with TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family.

274 Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-ex

275 We show that CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that couples th

276 part, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

277 wever, unlike DENV, ZIKV did not require the E3 ubiquitin ligase UBR4 to induce STAT2 degradation.

278 ogous to the E6-AP carboxyl terminus) family E3 ubiquitin ligase, UBR5, as a novel ubiquitin ligase f

279 Here, we report that the E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD and

280 n of eVP40 and mVP40 recruits the host Nedd4 E3 ubiquitin ligase via its WW domains to facilitate bud

281 moting complex, a major cell cycle-regulated E3 ubiquitin ligase, was discovered in the control of ax

282 tribution and recruitment of Nedd4-1, a HECT E3 ubiquitin ligase we previously demonstrated to target

283 Because SOCS1 is an E3 ubiquitin ligase, we examined the effect of proteasom

284 UBE3A is an E3 ubiquitin ligase well known for its role in the prote

285 se-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase, well known for its role in cell-cyc

286 argets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as well as dened

287 n assembly complex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of li

288 n, RECQL4 is ubiquitinated by the DDB1-CUL4A E3 ubiquitin ligase, which facilitates its accumulation

289 PUB1, an E3 ubiquitin ligase, which interacts with and is phospho

290 is the substrate binding subunit of the VHL E3 ubiquitin ligase, which targets hydroxylated alpha su

291 This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three f

292 7, betaTrCP, and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress steady-

293 roteins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protein substrates wi

294 UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autis

295 Smurf1 is an E3 ubiquitin ligase whose role in selective bacterial au

296 hat restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression in GBM also correl

297 We identified the HECT family E3 ubiquitin ligase WWP1 and all four of its WW domains

298 elated protein 6 (LRP6) are regulated by the E3 ubiquitin ligases zinc and ring finger 3 (ZNRF3) and

299 The membrane-associated E3 ubiquitin ligase ZNRF2 is released into the cytosol u

300 Our results thus demonstrate E3-ubiquitin ligase ZNRF4-mediated RIP2 degradation as a