ライフサイエンスコーパス: EF hand domain

1 terminal helix and the linker connecting two EF-hand domains).

2 Lys-53, and Arg-57) within the mouse PLCzeta EF-hand domain.

3 in the SUPC2 Ccore relative to the isolated EF-hand domain.

4 g site in the HPC2 Cterm, located within its EF-hand domain.

5 e intrinsic binding affinity of the isolated EF-hand domain.

6 cooperative Ca(2+)-binding sites within its EF-hand domain.

7 but has no effect on calcium affinity of the EF-hand domain.

8 connecting the Ca2+-binding loops in the two-EF-hand domain.

9 g to an IQ motif immediately adjacent to the EF-hand domain.

10 ependence of the Ca2+-binding sites in a two-EF-hand domain.

11 or stabilizing the "open" conformation of an EF-hand domain.

12 +) binding sites across the beta-sheet of an EF-hand domain.

13 nstead required the pleckstrin homology (PH)-EF-hand domain.

14 n-D28k is a calcium binding protein with six EF hand domains.

15 duplication, and possess four Ca(2+)-binding EF hand domains.

16 ium binding and requires functionally intact EF-hand domains.

17 ked to the overall conformation of different EF-hand domains.

18 wo helix-loop-helix motifs characteristic of EF-hand domains.

19 dramatic departure from that of Ca(2+)-bound EF-hand domains.

20 by a central linker; each lobe contains two EF-hand domains.

21 cium-binding proteins, contains six putative EF-hand domains.

22 rp-21 to the solution in a non-metal-binding EF-hand domain 1 that interacts with RetGC.

23 Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 binding.

24 fragment of PLC delta1 that encompasses the EF-hand domain also bound to micelles containing AA usin

25 The EF-hand domains also mediate the interaction with FV and

26 ns in the cationic residues within the first EF-hand domain and the XY linker region dramatically red

27 lar basis for the coupling of the intrinsic (EF-hand domain) and extrinsic (calmodulin) components of

28 tains a leader sequence, an LDLa domain, two EF-hand domains, and a conserved C-terminal HDEL sequenc

29 Here we show that the C-terminal EF-hand domains are both necessary and sufficient for MC

30 tetrameric oligomeric state in which a fused EF hand domain arranges around the catalytic PPase domai

31 calgranulins share conserved calcium-binding EF-hand domains, associate noncovalently as homodimers a

32 eracts extensively with the carboxy-terminal EF-hand domain (C-lobe) of the partner protomer.

33 a missense mutation occurs in the C-terminal EF hand domain (C2384Y).

34 f these novel proteins contain known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19)

35 fferential calcium binding affinities of the EF-hand domains compared with those of CaM suggest that

36 Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays i

37 pair, span 40 kb within a novel transcript, EF-hand domain containing 2 (EFHC2).

38 Here we identified the small EF hand domain-containing protein Ca(2+) and integrin-bi

39 B1-interacting partners identified a related EF hand domain-containing protein, calcineurin B, the re

40 in the PC2 Cterm, there is a calcium-binding EF-hand domain, crucial for the calcium-dependent activi

41 the EF-hand motifs or deletion of the entire EF-hand domain did not affect the Ca(2+)-dependent activ

42 racterized the conformational changes in its EF-hand domain due to trimer formation.

43 3 degrees rotation of helix 3 in the typical EF-hand domain (EF2) upon the addition of calcium.

44 at resembles the calcium-binding loop of the EF-hand domain found in many calcium-binding proteins.

45 k calcium affinity reported for the isolated EF-hand domain; high affinity binding is observed only i

46 inding of calcium to RGS3, as deletion of an EF-hand domain in RGS3 abolishes both the desensitizatio

47 Although the role of the EF-hand domain in RyR1 function has been studied extensi

48 functional significance of the corresponding EF-hand domain in RyR2.

49 ilon revealed previously unrecognized PH and EF-hand domains in the amino terminus.

50 an additional 60 residues C-terminal to the EF-hand domain, including the IQ motif that is central t

51 SAXS data suggest structural flexibility in EF hand domains indicative of conformational plasticity

52 otion in PLC-beta by cross-linking it to the EF hand domain inhibits stimulation by Gbetagamma withou

53 These results indicate that, although the EF-hand domain is not required for RyR2 activation by cy

54 The intrinsic EF-hand domain is shown here to interact with the IQ mot

55 Downstream of the EF-hand domain lies a coiled-coil region, which is invol

56 On the other hand, deletion of the EF-hand domain markedly suppressed the luminal Ca(2+) ac

57 Ectopic expression of SLC25A23 EF-hand-domain mutants exhibits a dominant-negative phen

58 With the EF hand domains of Miro1 mutated to prevent Ca2+ binding

59 aracterized binding interactions between the EF-hand domain of alpha-actinin (Act-EF34) and peptides

60 Mutation of this EF-hand domain of junctate impaired its Ca(2+) binding a

61 Recombinant EF-hand domain of phospholipase C delta1 has a moderate

62 ese results suggest that the function of the EF-hand domain of PLC delta1 is to bind lipid and to all

63 of the net positive charge within the first EF-hand domain of PLCzeta significantly alters in vivo C

64 r SOICR termination, whereas deletion of the EF-hand domain of RyR2 increased both the activation and

65 were maintained in the absence of the fourth EF-hand domain of the light chain, and were sensitive to

66 Two regions target the penta-EF-hand domains of calpain and the third occupies the su

67 Calcium binding to the EF-hand domains of CP increases the Mn(II) affinity of t

68 Our results suggest that the EF-hand domains of MCFD2 contain separate binding sites

69 Furthermore, we show that the Ca(2+)-sensing EF-hand domains of Miro1 are important for regulating mi

70 urbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could

71 a(2+) binding to its canonical binding site (EF-hand domain) of polycystin 2, a Ca(2+)-dependent chan

72 rin molecule contains four helix-loop-helix 'EF-hand' domains, of which three can bind calcium.

73 ty to bind free calcium, via calcium binding EF-hand domains on the protein, or to bind calcium compl

74 h an amino acid substitution in a functional EF-hand domain or a truncation of this motif by aberrant

75 ail consists of three functional regions: an EF-hand domain (PC2-EF, 720-797), a flexible linker (798

76 We find that calcium binding to the EF-hand domains promotes autophosphorylation, which nega

77 existence of the four-helix bundle common to EF-hand domain proteins.

78 eptide binds between helices I and IV in the EF-hand domain, similar to the binding of target peptide

79 ized to different structural elements of the EF-hand domains suggest that Ca(2+)-induced folding is i

80 vels, and an immediately adjacent C-terminal EF-hand domain that directly binds Ca(2+).

81 cTnC contains two EF-hand domains (the N and C domain of cTnC, cNTnC and c

82 2 has been shown to contain a Ca(2+)-binding EF-hand domain, the molecular basis of PC2 channel gatin

83 ure has the overall architecture of a paired EF-hand domain, the NaV1.2 C-terminal domain does not bi

84 Ca(2+) binding to the cytosolic EF-hand domain triggers conformational changes coupled t

85 ned the solution structure of the C-terminal EF-hand domain using multidimensional heteronuclear NMR.

86 The binding of an IQ motif peptide to the EF-hand domain was characterized by isothermal titration

87 Recently, the PLCdelta1 EF-hand domain was shown to bind to anionic phospholipid

88 The functionality of Scarf EF-hand domains was assayed with a radioactive Ca2+-bind

89 drastically reduces calcium affinity of the EF-hand domain, whereas the Brugada mutation A1924T sign

90 mic reticulum membrane, where a Ca2+-binding EF-hand domain within the N-terminal of the protein lies