ライフサイエンスコーパス: EF hand motif

1 7 contains multiple Ca2+ binding sites (i.e. EF-hand motifs).

2 ependent manner by the addition of the first EF hand motif.

3 immediately after the proposed Ca2+ -binding EF hand motif.

4 if packed against a canonical Ca(2+)-binding EF-hand motif.

5 n of a putative intracellular Ca(2+)-binding EF-hand motif.

6 initiation of metal ion binding at the first EF-hand motif.

7 metal-binding domain, RUBCa, that spans the EF-hand motif.

8 eins containing the predicted Ca(2+)-binding EF-hand motif.

9 ity, we focused here on amino acid 12 of the EF-hand motif.

10 inding sites with sequence similarity to the EF-hand motif.

11 kinase C homology domains and Ca(2+)-binding EF hand motifs.

12 tionary time, focusing primarily on the four EF-hand motifs.

13 C-CaM), and within each domain there are two EF-hand motifs.

14 inated proteins through its carboxy-terminal EF-hand motifs.

15 (apo-CaM), despite the zinc binding to both EF-hand motifs.

16 e domains flanking a pair of calcium-binding EF-hand motifs.

17 indin by NMR showing that it consists of two EF-hand motifs.

18 ggesting that the monovalent ions occupy the EF-hand motifs.

19 rized by the presence of two calcium-binding EF-hand motifs.

20 at contains three functional calcium binding EF-hand motifs.

21 Both proteins contain two pairs of EF-hand motifs.

22 st that the bound monovalent ions occupy the EF-hand motifs.

23 ant sequence homology with Cab45 outside the EF-hand motifs.

24 s, and binds Ca2+ due to the presence of six EF-hand motifs.

25 in an L151F missense mutation affecting the EF hand motif 4 (EF4).

26 )/Mg(2+) binding affinities of parvalbumin's EF-hand motif alter function of cardiac myocytes.

27 The structure consists of four EF-hand motifs although only the first three EF hands ar

28 This domain contains two Ca2+ binding EF hand motifs and has extended similarity to the human

29 ransmembrane helices with a potential single EF-hand motif and four potential SH3-binding motifs in t

30 ) superfamily that harbors two high affinity EF-hand motifs and a C-terminal transmembrane domain.

31 two structural domains containing a pair of EF-hand motifs and thus switching its partner, guanylyl

32 and flexibility of the linker connecting the EF-hand motifs, and the overall energy balance provide t

33 of the protein; two potential Ca(2+)-binding EF-hand motifs; and a Ser-rich region containing a repea

34 helices entering each loop of the classical EF-hand motif are absent from the dockerin domain.

35 GCAP-2 contains four EF-hand motifs arranged in a compact tandem array like t

36 GCAP3 contains two domains with the EF-hand motifs arranged in a tandem array similar to GCA

37 AM structure (residues 78-256) contains four EF-hand motifs arranged in a tandem linear array, simila

38 inactivation machinery, using the alpha(1C) EF hand motif as a signal transducer to activate the put

39 homology (EH) protein-binding domain with an EF-hand motif at the C-terminus.

40 phosphatase in that it contains at least two EF-hand motifs at its carboxy terminus.

41 y of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus.

42 KIC, with its single EF-hand motif, bound Ca2+ at a physiological concentrati

43 id sequence demonstrated the presence of two EF-hand motifs but identified no canonical DNA binding m

44 The C-terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium.

45 It lacks the EF hand motif characteristic of classical calpains but r

46 pha1C and/or a sequence downstream from this EF-hand motif containing a putative calmodulin (CaM)-bin

47 The structures of the EF-hand motifs containing 11-14 amino acid residues in t

48 ptide systems, Ca2+ affinity is maximized in EF-hand motifs containing four carboxylates positioned o

49 and calmodulin (56% similarity), and has two EF-hand motifs corresponding to the two C-terminal Ca2+

50 y of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activitie

51 enesis, we have shown that disruption of the EF-hand motif does not remove Ca2+ inhibition.

52 Strategic design of new EF-hand motif domains to modulate intracellular Ca(2+) s

53 calcium switch, formed by two tandem pseudo-EF-hand motifs (DxDxD), is present just upstream of the

54 Ca(2+) binding domain encompassing a pair of EF-hand motifs (EF1 and EF2) in the skeletal muscle ryan

55 and Hodges, suggests that the affinity of an EF-hand motif for Ca2+ will be maximal with four acidic

56 However, the importance of this EF-hand motif for channel inactivation has become contro

57 motif or through direct binding to a paired EF hand motif in the Nav1 C terminus.

58 The Ca(2+)-binding EF-hand motif in Cdc24, the Cdc42 activator, was essenti

59 Furthermore, we identified a Ca(2+)-binding EF-hand motif in the ER-luminal region of junctate.

60 Mutation of the second EF-hand motif in URE3-BP resulted in the loss of calcium

61 We have also shown that all three EF-hand motifs in AtCBL members are required for the int

62 Calcium binds cooperatively to pairs of EF-hand motifs in each domain (N and C).

63 correspond to the second, third, and fourth EF-hand motifs in the protein.

64 To test whether the EF hand motif is truly a calcium sensor controlling PC2

65 Here, an engineered EF- hand motif is incorporated into the central cytoplas

66 cid cluster (VVTL) within the F helix of the EF-hand motif is itself essential for Ca(2+) inactivatio

67 e coordination sequence, Tb(3+) bound to the EF-hand motif is sensitized specifically, and the effici

68 The Cdc24 EF-hand motif is therefore essential for polarity establ

69 rotein was shown to bind calcium through two EF-hand motifs located on its amino terminus.

70 on appears to be a consensus Ca(2+)-binding, EF-hand motif, located approximately 100 amino acids ups

71 of a specific serine residue, S1486, in the EF hand motif of the CaV1.3 subunit.

72 erves as Ca(2+) sensor for inactivation, the EF-hand motif of alpha(1C) may support the transduction

73 The C1 domain plus the EF-hand motif of RasGRP (C1EF-RasGRP) was markedly less

74 ved hydrophobic pocket within the C-terminal EF-hand motifs of CIB as a potential integrin-binding si

75 We also show that the EF-hand motifs of Miro mediate Ca(2+)-dependent arrest o

76 The two non-functional EF-hand motifs of MlcC pack together to form a globular

77 e investigate the effect of mutations in the EF-hand motifs on the Ca(2+) activation of RyR2.

78 We found that mutations in the EF-hand motifs or deletion of the entire EF-hand domain

79 of Medicago truncatula CCaMK, which contains EF-hand motifs, or this domain together with the autoinh

80 ently accepted model of PC2-C consists of an EF-hand motif overlapping with a short coiled coil; howe

81 A server predicts two domains as follows: an EF-hand motif (PC2-EF) connected by a linker to a previo

82 on and contains one canonical and one pseudo-EF-hand motif per monomer, each of which consists of two

83 no acid protein that contains four conserved EF-hand motifs (predicted to be Ca2+-binding domains) an

84 of 10(8) and 10(4) M(-1), respectively, both EF-hand motifs qualify as Ca(2+)/Mg(2+) sites.

85 from Arabidopsis, which contain one and four EF-hand motifs, respectively, bound Ca2+ but did not aff

86 EF34 and Act-EF1234) containing two and four EF-hand motifs, respectively, were produced, and their f

87 typical structure of CaMs, with two pairs of EF-hand motifs separated by a short linker domain.

88 Here, we investigate whether these EF hand motifs serve as a calcium sensor responsible for

89 Here, an EF-hand motif substitution that had been presumed to des

90 ation sequences (NLS) as well as a conserved EF-hand motif that binds the Wnt receptor-associated sca

91 The fold consists of a pair of EF hand motifs, the second of which binds tightly to cal

92 proteins contain a putative calcium-binding EF-hand motif, the EFX domain, that interacts with the b

93 toyl group on a long N-terminal arm and four EF-hand motifs, three of which bind Ca2+, assembled into

94 on GCAP-2 exchanged the ability of its first EF-hand motif to bind Ca(2+) for the ability to interact

95 alpha-helix (H6) and the proximal structured EF-hand motif using transition-metal ion fluorescence re

96 Two EF-hand motifs, which are associated with the ability to

97 tic studies indicate both GTPase domains and EF-hand motifs, which are exposed to the cytoplasm, are

98 ily of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformati

99 It contains typical EF-hand motifs with Ca2+-binding capability, as confirme