ライフサイエンスコーパス: EHEC

1 EHEC also exhibited the highest total phenolic contents

2 EHEC causes severe bloody diarrhea and hemolytic uremic

3 EHEC colonizes the intestinal tract through a range of v

4 EHEC employs a type III secretion system (T3SS) to trans

5 EHEC encodes the ethanolamine utilization (eut) operon t

6 EHEC encodes the sRNA chaperone Hfq, which is important

7 EHEC harbors SdiA, a regulator that senses acyl-homoseri

8 EHEC soluble factors are sufficient to stimulate macropi

9 EHEC uses a type III secretion system (TTSS) to transloc

10 EHEC virulence is dependent on a Type III secretion syst

11 EHEC was cleared from the rumen within days and from the

12 eeks old were orally inoculated with 1 of 10 EHEC strains or derivatives of two of these strains with

13 ence protein-protein interactions between 15 EHEC effectors and 47 human host proteins.

14 We correlated stx genotypes of 272 EHEC O26 strains isolated in 7 European countries betwee

15 Of the 272 EHEC O26 isolates, 107 (39.3%), 139 (51.1%), and 26 (9.6

16 In addition, EHEC also encodes several non-LEE-encoded effectors and

17 the broadest antimicrobial activity against EHEC and complemented the potency of other colicins.

18 far, there is no vaccine for humans against EHEC infections.

19 group and tested for immunogenicity against EHEC O157:H7 using a murine model of gastrointestinal in

20 In response to AHLs, EHEC represses flagellar genes and the LEE pathogenicity

21 SdiA-AHL chemical signaling aids EHEC in gauging these GI environments, and promotes adap

22 olamine utilization (eut) operon that allows EHEC to metabolize EA and gain a competitive advantage w

23 Furthermore, although EHEC prevalence in produce was highest on farms near are

24 LEE-encoded T3 effectors were elevated in an EHEC hfq deletion mutant.

25 ngly, the gene expression variation shows an EHEC-biased gene alteration including intergenic regions

26 Infection of Swiss cells with an EHEC espW deletion mutant induces a cell shrinkage pheno

27 or developing HUS, such as Shiga toxin 2 and EHEC serotypes traditionally considered to be "high risk

28 Salmonella, Campylobacter, and EHEC outbreaks continue to occur with disturbing regular

29 strategy of extracellular pathogens EPEC and EHEC and shed light on the complexities of the T3SS effe

30 EPEC and EHEC not only induce characteristic attaching and effaci

31 ing (A/E) human pathogenic E. coli (EPEC and EHEC) and the natural mouse pathogen Citrobacter rodenti

32 enterohemorrhagic Escherichia coli (EPEC and EHEC) functions to activate transcription of virulence g

33 enterohemorrhagic Escherichia coli (EPEC and EHEC) share a unique mechanism of colonization that resu

34 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively), C. rodentium exploits a type III se

35 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively), which inhibit Src kinase-dependent

36 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively).

37 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively).

38 ection of deletions in cryptic prophages and EHEC O157 O-islands to screen for novel regulators of T3

39 iled to distinguish the Shigella species and EHEC isolates from E. coli.

40 roides thetaiotaomicron (Bt), is resident at EHEC attachment sites.

41 Additionally, because EHEC is largely prevalent in cattle herds, interference

42 EspF sequences differ between EHEC O157:H7, EHEC O26:H11, and EPEC O127:H6 in terms of

43 The genes present in both EHEC EDL933 and Sakai strains but absent in nonpathogeni

44 tant in intestinal colonization of cattle by EHEC serogroup O5, O111, and O26 strains.

45 ve in suppressing disease symptoms caused by EHEC.

46 n shown to foster intestinal colonization by EHEC in some animal models, but the mechanisms responsib

47 pression, would decrease RAJ colonization by EHEC, cattle were challenged at the RAJ with WT or yenI(

48 hrombotic microangiopathy and HUS induced by EHEC Shiga toxins in these preclinical models, and benef

49 stic attaching and effacing (A/E) lesions by EHEC on epithelial cells, is epinephrine dependent.

50 utative fimbrial structures were produced by EHEC cells grown with EA but not in medium lacking EA.

51 chia coli (EPEC), enterohemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR) infections, are dep

52 Enterohemorrhagic E. coli (EHEC) are often identified as isolates that are LEE+ and

53 Enterohemorrhagic E. coli (EHEC) is an important subset of Shiga toxin-producing (S

54 Enterohemorrhagic E. coli (EHEC) manipulate their human host through at least 39 ef

55 Enterohemorrhagic E. coli (EHEC) responds to AHLs extracted from the bovine rumen.

56 For enterohemorrhagic E. coli (EHEC) serotype O157:H7, we have previously demonstrated

57 cteria, including enterohemorrhagic E. coli (EHEC), and as it is essential for host colonization by m

58 oximately 250,000 enterohemorrhagic E. coli (EHEC), generic E. coli, and Salmonella tests in produce,

59 ssified as either enterohemorrhagic E. coli (EHEC), typical enteropathogenic E. coli (EPEC), or atypi

60 C), also known as enterohemorrhagic E. coli (EHEC).

61 hagic and enteropathogenic Escherichia coli (EHEC and EPEC), as well as the related mouse pathogen Ci

62 orrhagic and uropathogenic Escherichia coli (EHEC and UPEC), Salmonella typhimurium, and Francisella

63 Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are enteric ba

64 osts by enterohaemorrhagic Escherichia coli (EHEC) and might also be important for the etiology of di

65 such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or th

66 rains of enterohemorrhagic Escherichia coli (EHEC) are a group of Shiga toxin-producing food-borne pa

67 ion with enterohemorrhagic Escherichia coli (EHEC) can result in severe disease, including hemorrhagi

68 Enterohemorrhagic Escherichia coli (EHEC) causes hemorrhagic colitis and life-threatening co

69 pathogen enterohemorrhagic Escherichia coli (EHEC) causes severe diarrhea, but the influence of the g

70 Enterohaemorrhagic Escherichia coli (EHEC) colonizes the large intestine, causing attaching a

71 types of enterohemorrhagic Escherichia coli (EHEC) emerge constantly, the mechanisms by which these n

72 cus, and enterohemorrhagic Escherichia coli (EHEC) GspG were elucidated, and all show a calcium ion b

73 s during enterohemorrhagic Escherichia coli (EHEC) infection and may exacerbate renal manifestations.

74 ature of enterohemorrhagic Escherichia coli (EHEC) infections is the production of Shiga toxins (Stx)

75 Enterohemorrhagic Escherichia coli (EHEC) is a commonly occurring foodborne pathogen respons

76 Enterohemorrhagic Escherichia coli (EHEC) is a deadly human pathogen but is a member of the

77 Enterohemorrhagic Escherichia coli (EHEC) is a diarrheagenic pathogen that colonizes the gut

78 Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that can cause severe hea

79 Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen causing hemorrhagic coliti

80 Enterohemorrhagic Escherichia coli (EHEC) is a noninvasive food-borne pathogen that colonize

81 Enterohemorrhagic Escherichia coli (EHEC) is a significant human pathogen and is the cause o

82 Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhag

83 Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen causing gastroe

84 lium by enterohaemorrhagic Escherichia coli (EHEC) is characterized by an attaching and effacing (A/E

85 Enterohemorrhagic Escherichia coli (EHEC) is one of the leading causes of bacterial enteric

86 ecies, 3 enterohemorrhagic Escherichia coli (EHEC) isolates, 2 Yersinia enterocolitica isolates, 2 Ca

87 roducing enterohemorrhagic Escherichia coli (EHEC) O157 in seeded stool samples.

88 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic diarrhea and potentiall

89 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 codes for two interacting DNA binding prot

90 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 colonizes the rectoanal junction (RAJ) in

91 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 has two histidine sensor kinases, QseC and

92 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an important food-borne pathogen respon

93 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 responds to the host-produced epinephrine

94 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains are major human food-borne pathoge

95 trains of enterohemorragic Escherichia coli (EHEC) O157:H7 that are non-sorbitol fermenting (NSF) and

96 focus on enterohemorrhagic Escherichia coli (EHEC) O157:H7, Salmonella, Shigella, Campylobacter, and

97 Enterohemorrhagic Escherichia coli (EHEC) O26 causes diarrhea and hemolytic uremic syndrome

98 Enterohemorrhagic Escherichia coli (EHEC) of serotype O157:H7 has been implicated in food-bo

99 break of enterohemorrhagic Escherichia coli (EHEC) on an open farm infected 93 persons, and approxima

100 Enterohemorrhagic Escherichia coli (EHEC) produce ribosome-inactivating Shiga toxins (Stx1,

101 athogen enterohaemorrhagic Escherichia coli (EHEC) relies on inter-kingdom chemical sensing systems t

102 duced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intes

103 hment of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells is critical for col

104 ion with enterohemorrhagic Escherichia coli (EHEC) was confirmed in 79% of cases.

105 Hfq in enterohaemorrhagic Escherichia coli (EHEC), a group of non-invasive intestinal pathogens.

106 EhaG from enteropathogenic Escherichia coli (EHEC), and UpaG from uropathogenic E. coli (UPEC), we pr

107 athogens enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), and Citrobacter

108 jejuni, enterohemorrhagic Escherichia coli (EHEC), or Salmonella spp.

109 ncluding enterohemorrhagic Escherichia coli (EHEC), which utilizes the effector protein EspF(U) to as

110 hosts by Enterohemorrhagic Escherichia coli (EHEC).

111 ssion in enterohemorrhagic Escherichia coli (EHEC).

112 RNAs in enterohemorrhagic Escherichia coli (EHEC).

113 tant for enterohemorrhagic Escherichia coli (EHEC).

114 (ImmunoCard STAT! enterohemorrhagic E. coli [EHEC]; Meridian Bioscience) and cultured in attempts to

115 present in nonpathogenic strains of E. coli, EHEC exploits these kinases for virulence regulation.

116 In conclusion, EHEC and WEM have the potential to be used as natural an

117 have previously reported that the conserved EHEC and EPEC effector EspG disrupts recycling endosome

118 In contrast, EHEC adherence to polarized T84 cells occurred independe

119 ated adfO here), a gene located in a cryptic EHEC prophage, exhibits similarity to adherence and/or c

120 Actin-dependent EHEC attachment also requires the outer membrane protein

121 he Stx-encoding bacteriophages differentiate EHEC O157 isolates into genogroups commonly isolated fro

122 strointestinal (GI) tract and cause disease, EHEC must be able to sense the host environment and prom

123 e patients show complement activation during EHEC infection, raising the possibility of therapeutic t

124 e cellular immune responses of cattle during EHEC O157:H7 colonization.

125 ndent regulation was necessary for efficient EHEC colonization of cattle fed a grain diet.

126 ess colonization at this site, we engineered EHEC to express the Yersinia enterocolitica AHL synthase

127 We show that Bt enhances EHEC virulence gene expression through the transcription

128 analysis suggests that C. rodentium and EPEC/EHEC have converged on a common host infection strategy

129 nd enterohaemorrhagic Escherichia coli (EPEC/EHEC) manipulate a plethora of host cell processes to es

130 Upon attachment to intestinal epithelium, EHEC generates "attaching and effacing" (AE) lesions cha

131 nduced Th2 cytokines and production of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonizati

132 5 localized to the actin pedestals following EHEC infection.

133 port that DHMA is also a chemoattractant for EHEC.

134 rated between strains, with implications for EHEC epidemiology and strain evolution.

135 comprise a regulatory circuit important for EHEC colonization of the gastrointestinal tract.

136 nolamine (EA) is an important metabolite for EHEC in the GI tract, and EA is also a signal that EHEC

137 or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microor

138 Host actin rearrangement necessary for EHEC attachment to enterocytes is mediated by the type 3

139 Here, we show that SdiA is necessary for EHEC colonization of cattle and that AHLs are prominent

140 is different from what has been reported for EHEC strain EDL933 and that the role of Hfq in EHEC viru

141 hing and effacing (AE) lesions requisite for EHEC colonization.

142 The main reservoirs for EHEC are healthy ruminants.

143 Enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) is an important cause of food and waterborne

144 Enterohemorrhagic Escherichia coli O157:H7 (EHEC) causes bloody diarrhea and hemolytic-uremic syndro

145 Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a foodborne pathogen that causes bloody diarrhe

146 ype I locus within Escherichia coli O157:H7 (EHEC), which we have named the gene pairs zorO-orzO and

147 enterohemorrhagic Escherichia coli O157:H7 (EHEC).

148 EspF sequences differ between EHEC O157:H7, EHEC O26:H11, and EPEC O127:H6 in terms of the number of

149 ted approximately 50% of all stx2a-harboring EHEC O26 strains isolated between 1996 and 2012.

150 tion and disease are well characterized, how EHEC regulates its expression in response to a host enco

151 nvestigate outbreak-derived animal and human EHEC isolates.

152 rovide a new platform upon which to identify EHEC alterations of host epithelium that contribute to s

153 genomics analysis was performed to identify EHEC-specific antigens useful as potential vaccines.

154 In EHEC strain EDL933, Hfq acts as a negative regulator of

155 In EHEC the NPY(458) actin polymerization pathway is amplif

156 mine synthase (GlmS) in E. coli K-12, and in EHEC they destabilize the 3' fragments of the LEE4 and L

157 ly, we mapped the EtrB regulatory circuit in EHEC to determine a global role for EtrB.

158 S) excision enhancer (IEE) was discovered in EHEC O157:H7 that promoted the excision of IS3 family me

159 er, as well as promoters of genes encoded in EHEC-specific O-islands.

160 gulation and reveal a novel role for EutR in EHEC pathogenesis.

161 ract and induce virulence gene expression in EHEC, we propose that DHMA acts as a molecular beacon to

162 holine activated fimbrial gene expression in EHEC.

163 6-24 to investigate the role of this gene in EHEC adhesion to tissue-cultured monolayers, global gene

164 known to occur, a regulatory role of Hfq in EHEC virulence gene expression has yet to be defined.

165 EC strain EDL933 and that the role of Hfq in EHEC virulence regulation extends beyond the LEE.

166 We compared these TIR interactions in EHEC and enteropathogenic E. coli (EPEC) and found that

167 two interacting regulators, Cra and KdpE, in EHEC pathogenesis and global gene regulation.

168 ription of several putative fimbrial loci in EHEC.

169 within O-islands (genomic islands present in EHEC but absent from E. coli K-12), such as Z0639, Z0640

170 629, actively transposes and proliferates in EHEC O157:H7 and enterotoxigenic E. coli (ETEC) O139 and

171 The loss of qseD in EHEC does not affect motility, but the K-12 Delta qseD m

172 m signaling and virulence gene regulation in EHEC, as well as an increase in expression of stx(2AB),

173 owledge of posttranscriptional regulation in EHEC.

174 cate that QseA acts as a global regulator in EHEC, co-ordinating expression of virulence genes.

175 indicate that Hfq plays a regulatory role in EHEC 86-24 that is different from what has been reported

176 Here, we compared the SdiA role in EHEC colonization of cattle fed a forage hay diet.

177 ein renamed EtrB, plays an important role in EHEC pathogenesis.

178 Comparable metabolic changes are seen in EHEC DeltaqseC, suggesting that deletion of qseC confers

179 ur understanding of the regulation of T3S in EHEC, focusing on the induction and assembly of the T3S

180 We showed that in EHEC, epinephrine sensing seems to occur primarily throu

181 k grazing, we found no evidence of increased EHEC, generic E. coli, or Salmonella near nongrazed, sem

182 ion of HeLa cells with epinephrine increases EHEC infectivity in a QseC- and QseE-dependent manner.

183 Here, we report that EA influenced EHEC adherence to epithelial cells and fimbrial gene exp

184 In this study, we investigated EHEC adherence to the human colon by using in vitro orga

185 al colicins are highly effective against key EHEC strains.

186 Shiga toxins (Stx) are the key EHEC virulence determinant contributing to severe diseas

187 tegories, the ethanol extract of curry leaf (EHEC) and the water extract of mint leaf (WEM) showed hi

188 the outer membrane protein intimin, a major EHEC adhesin.

189 showed very high activity against all major EHEC strains, as defined by the US Department of Agricul

190 ade available by the microbiota, to modulate EHEC pathogenicity and metabolism.

191 lved in the development of disease in murine EHEC infection.

192 C. rodentium NleB, EHEC NleB1, and SseK1 glycosylated host GAPDH.

193 C. rodentium NleB, EHEC NleB1, EPEC NleB1, and SseK2 glycosylated the FADD

194 55:H7 (SOR(+) GUD(+)) strains, two nonmotile EHEC O157:H(-) strains (SOR(+) GUD(+)) containing plasmi

195 In addition, seven novel EHEC-specific sRNAs were identified using RNA sequencing

196 d espW in the sequenced O157:H7 and non-O157 EHEC strains as well as in Shigella boydii Furthermore,

197 Most EPEC and non-O157 EHEC strains express lymphostatin (also known as LifA),

198 was no difference between O157 and non-O157 EHEC.

199 Five years after diagnosis, 70% of EHEC-infected patients (95% confidence interval [CI], .6

200 Further analysis of EHEC secreted proteins shows that a serine protease EspP

201 In the case of EHEC strains, CadA modulates expression of the intimin,

202 We investigated the global changes of EHEC gene expression governed by GlmY and GlmZ using RNA

203 A new highly virulent clone of EHEC O26 has emerged in Europe.

204 y plasmid genes to the new virulent clone of EHEC O26 that emerged in Germany in the 1990s.

205 RAJ is the prominent site of colonization of EHEC in cattle.

206 nces in the pathogenesis and epidemiology of EHEC strains.

207 e to cultured cells as well as expression of EHEC secreted protein A (EspA).

208 In addition, DHMA induces the expression of EHEC virulence genes and increases attachment to intesti

209 modulating the virulence gene expression of EHEC.

210 d CG share the cardinal virulence factors of EHEC O157 and are carried by cattle at similar prevalenc

211 A defining feature of EHEC pathogenesis is the formation of attaching and effa

212 Cattle are a reservoir host of EHEC O157 and a major source of human exposure through c

213 espite the magnitude of the social impact of EHEC infections, no licensed vaccine or effective therap

214 Toxin macropinocytosis is independent of EHEC type 3 secretion and intimin attachment.

215 orphism (SNP) is observed in the majority of EHEC O157:H7 isolates and correlates with a negative ure

216 ntact ure locus, ureDABCEFG, the majority of EHEC strains are phenotypically urease negative under te

217 protects mice from disease manifestations of EHEC.

218 P3) inflammasome as an essential mediator of EHEC-induced IL-1beta.

219 Models of EHEC infection in conventional mice do not manifest key

220 -56.2), was able to induce the production of EHEC IgG and sIgA in sera and feces.

221 Although post-transcriptional regulation of EHEC virulence genes is known to occur, a regulatory rol

222 phenotype including the global regulator of EHEC virulence gene expression, Ler.

223 The virulence repertoire of EHEC includes the genes within the locus of enterocyte e

224 rectum, the predominant colonization site of EHEC O157 in cattle and a site containing M-like cells.

225 esults is that a single successful strain of EHEC spread from a single introduction through the farm

226 A number of other strains of EHEC in addition to O157:H7 are emerging as serious thre

227 showed that LPF is present on the surface of EHEC lpfA(+) strains.

228 that block the functionality of the T3SS of EHEC.

229 txs) are an important pathogenicity trait of EHEC O157.

230 mediates to positively regulate virulence of EHEC.

231 ffacing (A/E) lesions which are dependent on EHEC type III secretion (T3S) and binding of the outer m

232 nt of epinephrine and its sensors' impact on EHEC virulence, we performed transcriptomic and phenotyp

233 , but the influence of the gut microbiota on EHEC infection is largely unknown.

234 R(+) GUD(+)) containing plasmid pSFO157, one EHEC O157:H7 (SOR(-) GUD(+)) strain, and one O157:H7 str

235 ium-specific (without orthologues in EPEC or EHEC) coding sequences, 10 prophage-like regions, and 17

236 Risk estimates for Salmonella or EHEC-related AGI were most sensitive to the assumed leve

237 4:H4 outbreak and 32 'negative' non-outbreak EHEC isolates indicated that individual primer sets exhi

238 was proposed in which the highly pathogenic EHEC O157:H7 serotype arose from its ancestor, enteropat

239 The Premier EHEC assay and SMAC culture detected 96.0% and 58.0% of

240 tested by both SMAC culture and the Premier EHEC assay at Children's Hospital Boston.

241 The Premier EHEC assay was significantly more sensitive than SMAC cu

242 ostic utility of SMAC to that of the Premier EHEC enzyme immunoassay (Meridian Diagnostics) for detec

243 candidates potentially useful for preventing EHEC O157:H7 infections.

244 lutamate acid resistance (gad) genes priming EHEC's acid resistance before they pass into the acidic

245 s bacteriophage-encoded "anti-sRNA" provided EHEC with a growth advantage specifically in bovine rect

246 of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization.

247 complicated by other, potentially redundant EHEC-encoded binding pathways, so we utilized cell bindi

248 fucose-sensing system is required for robust EHEC colonization of the mammalian intestine.

249 ensitivity and reliably detected Salmonella, EHEC O157, Shigella, and Campylobacter at concentrations

250 there is no direct clinical evidence showing EHEC binding to the colonic epithelium in patients.

251 o a range of chemical environmental signals, EHEC is capable of sensing and responding to mechanical

252 SseK1, SseK3, EHEC NleB1, EPEC NleB1, and Crodentium NleB blocked TNF-

253 stinct from previously reported O157:H7 ST11 EHEC and was not a member of the hypervirulent clade 8.

254 flammasome activation, delivery of synthetic EHEC RNA:DNA hybrids into the cytosol triggered NLRP3-de

255 We have recently demonstrated that EHEC infection of intestinal epithelial cells stimulates

256 We previously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by

257 to other bacteria and viruses we found that EHEC effectors bind more frequently to hub proteins as w

258 We found that EHEC in fresh produce increased by more than an order of

259 We also found that EHEC NleB1 glycosylated two GAPDH arginine residues, Arg

260 Here, we report that EHEC perceives attachment to host cells as a mechanical

261 n the GI tract, and EA is also a signal that EHEC uses to activate virulence traits.

262 Our findings suggest that EHEC uses fucose, a host-derived signal made available b

263 Our study suggests that EHEC colonizes and forms stable A/E lesions on the human

264 We show for the first time that EHEC colonizes human colonic biopsy samples by forming t

265 The EHEC Delta qseD mutant exhibits increased expression of

266 The EHEC hns ler mutant constitutively expressed the lpf gen

267 Disruption of lpfA in the EHEC hns and hns ler mutants or the addition of anti-Lpf

268 Previously, in the EHEC O157:H7 Sakai strain, a point mutation in ureD, enc

269 Here, we deleted hfq in the EHEC strain 86-24 and compared global transcription prof

270 within bacteriophage-derived regions of the EHEC genome, including some of the most abundant Hfq-int

271 proteins, was found to be a substrate of the EHEC pO157-encoded type 2 secretion system (T2SS).

272 We show that the EHEC and EPEC NleH effectors are functionally equivalent

273 acteria to mammalian cells by binding to the EHEC outer surface protein Intimin.

274 EC challenge and every other day thereafter, EHEC colonization was suppressed and mice were significa

275 Comparative analysis of the three EHEC plasmids shows that pO157-2 is highly related to pO

276 ay multiple functions that may contribute to EHEC colonization of different hosts and to virulence, s

277 ion to suggesting that Lpf can contribute to EHEC intestinal colonization, our observations indicate

278 in mucin, B. thetaiotaomicron contributes to EHEC virulence by cleaving fucose from mucin, thereby ac

279 se model of renal and enteric disease due to EHEC to determine if probiotic Lactobacillus reuteri ATC

280 tx2), and bacterial strain in disease due to EHEC.

281 tium, a natural mouse pathogen homologous to EHEC, in Bt-reconstituted mice results in increased gut

282 n L. reuteri was administered 1 day prior to EHEC challenge and every other day thereafter, EHEC colo

283 the two adrenergic sensors QseC and QseE to EHEC pathogenesis.

284 Comparative studies performed with wild-type EHEC EDL933 and an isogenic hcpA mutant revealed that HC

285 Whereas EHEC-specific virulence factors were dispensable for NLR

286 retion systems (T6SS) (CTS1 and CTS2), while EHEC contains only one T6SS (EHS).

287 ssembly or by infecting mammalian cells with EHEC mutants that translocate Tir but are specifically d

288 weaned mice receiving an oral challenge with EHEC were completely protected by the transference of im

289 fed either grain or hay and challenged with EHEC orally carried the bacteria similarly.

290 deposits in the renal biopsy of a child with EHEC-associated hemolytic uremic syndrome.

291 ar immune responses during colonization with EHEC O157:H7, the temporality of which is strain depende

292 after infection of human ileal explants with EHEC.

293 ee Swiss Webster mice are monocolonized with EHEC, they develop disease characterized by weight loss,

294 The pork meat samples treated with EHEC and WEM showed a decrease in the Hunter L- and a-va

295 nscriptome analyses comparing wild-type (WT) EHEC and the qseA mutant to elucidate QseA's role in gen

296 ere challenged at the RAJ with WT or yenI(+) EHEC.

297 The yenI(+) EHEC also activated expression of the gad genes.

298 Although the yenI(+) EHEC colonized the RAJ with efficiency equal to that of

299 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and

300 o shed the WT strain longer than the yenI(+) EHEC.