ライフサイエンスコーパス: EMC

1 EMC and Notch were both required in the main body cells

2 EMC expression in the main body cells is Notch dependent

3 EMC expression is reduced in the precursors of the polar

4 EMC is expressed in proliferating cells in the germarium

5 EMC mutants have a significant reduction in the amount o

6 EMC-6 is ubiquitously expressed and localizes to the ER.

7 demonstrated that inactivation of additional EMC members in C. elegans also impaired AChR synthesis a

8 ls derived from RXRalpha(-/-) embryos and an EMC subline constitutively expressing a dominant negativ

9 n ER-shaping protein localized to EMCs as an EMC promoter.

10 ated their strong cross-reactivity with anti-EMC-RBD antibodies.

11 t heterochromatin domain (HOOD) formation at EMC-target loci.

12 The underlying causes of endometrial cancer (EMC) are poorly understood, and treatment options for pa

13 Etiology of endometrial cancer (EMC) is not fully understood.

14 recurrent or persistent endometrial cancer (EMC).

15 en EC is paired with ethyl methyl carbonate (EMC), poly(ethylene glycol) dimethyl ether, poly(ethylen

16 Expanded monocyte cells (EMC), the immature (ER-MP12(+)) and more mature (ER-MP20

17 ion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocat

18 nd includes enzymes of the ethylmalonyl-CoA (EMC) pathway that were recently shown to operate during

19 the recently identified ER membrane complex (EMC).

20 etric complex, called the Erh1-Mmi1 complex (EMC), to promote meiotic mRNA decay and facultative hete

21 a member of the ER membrane protein complex (EMC) called EMC1 promotes SV40 ER membrane transport and

22 f the conserved ER membrane protein complex (EMC) has decreased phosphatidylserine (PS) transfer from

23 e the conserved ER membrane protein complex (EMC) was shown to be essential for efficient insertion i

24 mic reticulum (ER)-membrane protein complex (EMC), an evolutionarily conserved complex that has been

25 asmic reticulum (ER)-mitochondrial contacts (EMC) regulate diverse cellular activities such as metabo

26 -2)) and lower equilibrium moisture content (EMC), thus showing potential for active food packaging m

27 new method called expected Markov counting (EMC) that produces maximum-likelihood estimates of subst

28 and Riyadh were not different from MERS-CoV EMC/2012 in replication, escape of interferon response,

29 ients with essential mixed cryoglobulinemia (EMC; all with type II), 50 hospital control patients, an

30 In response to LPS, LTA, and Pam(3)Cys (EMC Microcollection GmbH, Tubingen, Germany), CCL20 leve

31 ls with rapidly and spontaneously developing EMC will help explore mechanisms of cancer initiation an

32 Like the RBD of prototype EMC2012 (EMC-RBD), all five RBDs maintained good antigenicity and

33 cross-regulated and cooperatively exacerbate EMC.

34 slocation appears to be largely specific for EMC, but has not been detected in all such tumours.

35 To perform these functions, EMC associates with two distinct complexes, Mtl1-Red1 co

36 hCoV-EMC/2012 was sensitive to both interferon-alpha2b and ri

37 The virus (called HCoV-EMC) replicated readily in cell culture, producing cytop

38 n-alpha2b and ribavirin on nCoV isolate hCoV-EMC/2012 replication in Vero and LLC-MK2 cells was evalu

39 infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower re

40 n coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula.

41 pamycin, in mouse models of EMC and in human EMC cell lines to explore the interactive roles of Cox2

42 because they mimic several features of human EMC.

43 in homologue gene are frequently detected in EMC.

44 in, and their activities are up-regulated in EMC.

45 onal deletion of endometrial Pten results in EMC in all female mice as early as age 1 month with myom

46 Cells lacking EMC proteins and the ER-mitochondria tethering complex c

47 ls, and an established epicardial cell line (EMC cells), secrete trophic protein factors into conditi

48 s transplanted with ER-MP20(+) (more mature) EMC than in animals transplanted with unseparated EMC or

49 lanted animals and confirmed that ER-MP20(+) EMC preferentially engrafted.

50 We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abn

51 Such rapid development of EMC from homozygous loss of endometrial Pten suggests th

52 Partial inhibition of EMC-6 caused decreased expression of heteromeric levamis

53 RC1 inhibitor, rapamycin, in mouse models of EMC and in human EMC cell lines to explore the interacti

54 polar and stalk cells, and overexpression of EMC caused dramatic egg chamber fusions, indicating that

55 in detail the initiation and progression of EMC.

56 ime reversible (GTR) model, used with AWP or EMC, accurately recovered the substitution counts, even

57 lonyl coenzyme A (ethylmalonyl-CoA) pathway (EMC pathway).

58 n PFS at 6 months in recurrent or persistent EMC and warrants further investigation.

59 Purified EMC in synthetic liposomes catalyzed the insertion of it

60 ith celecoxib and rapamycin markedly reduces EMC progression.

61 the use of this model to specifically study EMC.

62 are currently being used as a model to study EMC.

63 been highlighted by reports indicating that EMC dysregulation is linked to neurodegenerative disease

64 ramatic egg chamber fusions, indicating that EMC is a negative regulator of polar and/or stalk cells.

65 We propose that EMC functions downstream of Notch and upstream of EYA to

66 ce of distinct entry points for acetate: the EMC pathway and the TCA cycle.

67 During growth on ethylamine, the EMC pathway operates as a linear pathway carrying the fu

68 A mutase is a metabolic control point in the EMC pathway, expanding our understanding of its regulati

69 luable proxy to decipher the function of the EMC further.

70 ful condition to study the regulation of the EMC pathway.

71 structure) are inviable, suggesting that the EMC also functions as a tether.

72 ransfer and cell growth, suggesting that the EMC forms a tether by associating with the TOM complex.

73 These results suggest that the EMC is a component of the ER folding machinery.

74 intact in these mutants, suggesting that the EMC performs an additional tethering function to ERMES.

75 Together, our findings support that the EMC tethers ER to mitochondria, which is required for ph

76 A cycle and that assimilation occurs via the EMC pathway.

77 Furthermore, acetyl-CoA condenses with the EMC pathway product glyoxylate, resulting in malate form

78 Thus, EMC is a transmembrane domain insertase, a function that

79 sia of which approximately 20% progresses to EMC.

80 han in animals transplanted with unseparated EMC or fresh marrow mononuclear cells, a pattern that pe

81 ryoglobulinemia, and none of 6 patients with EMC were positive for HGV RNA, for an overall prevalence