ライフサイエンスコーパス: EMMPRIN

1 EMMPRIN (extracellular matrix metalloproteinase inducer)

2 EMMPRIN and MIF were up-regulated in cocultured tumor ce

3 EMMPRIN expression in cultures of mouse splenocytes or h

4 EMMPRIN increased by >250% and MT1-MMP increased by >100

5 EMMPRIN is a transmembrane glycoprotein expressed at hig

6 EMMPRIN, which is expressed by human cancer cells and ma

7 eractions, VEGF expression was induced in an EMMPRIN- and MMP-dependent fashion, and was further enha

8 001), tissue factor (2.5-fold, P<0.001), and EMMPRIN (1.9-fold, P=0.01).

9 genes such as RhoA, CDK5, TIMP-1, MMP-7, and EMMPRIN; and MIC-1.

10 ly with the expressions of MMP-2, MMP-9, and EMMPRIN in gingiva.

11 ace protein basigin (also known as CD147 and EMMPRIN).

12 found for the expressions of gelatinases and EMMPRIN among the groups demonstrating that the Lig + Cs

13 ature-induced expressions of gelatinases and EMMPRIN in gingival tissues were examined with Western b

14 ngival protein expression of gelatinases and EMMPRIN than the Lig group.

15 lpha, via NF-kappaB, and JNK induces MIF and EMMPRIN in macrophage to tumor cell cocultures and this

16 bited the expressions of gelatinase MMPs and EMMPRIN and partially prevented the periodontal breakdow

17 rivascular cuffs, inflammatory molecules and EMMPRIN, and these were abrogated by minocycline.

18 Administration of anti-EMMPRIN Abs reduces the severity of EAE.

19 at the membrane protein CD147 (also known as EMMPRIN or basigin) forms a specific heterodimeric compl

20 ogenesis mechanism in which tumor-associated EMMPRIN functionally mediates tumor-stroma interactions

21 immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein expressed

22 and rapidly break down to release bioactive EMMPRIN.

23 Both EMMPRIN and MT-MMP expression and total MMP activity wer

24 d host cells, respectively, was regulated by EMMPRIN.

25 nt study examined whether and to what degree EMMPRIN and MT1-MMP were expressed in human left ventric

26 hed MS medication, IFN-beta, also diminished EMMPRIN levels on human cells whereas this was not readi

27 derstanding the molecular mechanisms driving EMMPRIN-induced lung tumorigenesis will provide enormous

28 a1 and induce the secretion of extracellular EMMPRIN, which all play a role in driving immune evasion

29 hat encode the entire open reading frame for EMMPRIN from a human keratinocyte library.

30 or Sp1, AP1TFII and EGR-2, was important for EMMPRIN transcription in both THP-1 and Raw264.7 macroph

31 least one signalling cascade responsible for EMMPRIN release.

32 this report we have demonstrated a role for EMMPRIN in cancer progression.

33 lated a cosmid clone that contains the human EMMPRIN gene.

34 In this study, we identify EMMPRIN as a novel regulator of the canonical Wnt/beta-c

35 Importantly, EMMPRIN-alpha3beta1 complexes appear not to contain TM4S

36 In human breast cancer cells, changes in EMMPRIN expression influenced vascular endothelial growt

37 in substrate zymography) was demonstrated in EMMPRIN-enhanced tumors.

38 roapoptotic BH3-only protein, was reduced in EMMPRIN-expressing cells and that silencing of EMMPRIN e

39 Increasing EMMPRIN expression levels in lung cancer epithelial cell

40 racellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family

41 racellular matrix metalloproteinase inducer (EMMPRIN) and cytokine stimulatory mechanisms; and (3) MM

42 racellular matrix metalloproteinase inducer (EMMPRIN) has been reported to increase MMP expression, a

43 racellular matrix metalloproteinase inducer (EMMPRIN), a glycoprotein present on the cancer cell plas

44 racellular matrix metalloproteinase inducer (EMMPRIN), a transmembrane glycoprotein that is attached

45 racellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprot

46 racellular matrix metalloproteinase inducer (EMMPRIN), with the cognate apical marker, p75-neurotroph

47 racellular matrix metalloproteinase inducer (EMMPRIN).

48 racellular matrix metalloproteinase inducer (EMMPRIN).

49 racellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a transmembrane glycoprotein that is

50 racellular matrix metalloproteinase inducer (EMMPRIN; CD147) is a heavily glycosylated protein contai

51 issue factor, and extracellular MMP inducer (EMMPRIN).

52 Recent studies have shown that full-length EMMPRIN is released by tumor cells, but the mechanism of

53 of a protein family that includes mammalian EMMPRIN/CD147/basigin, neuroplastin, and embigin.

54 enesis and growth was explored by modulating EMMPRIN expression and activity using recombinant DNA en

55 w that it is highly conserved with the mouse EMMPRIN/basigin gene.

56 Native EMMPRIN isolated directly from extracts of keratinocytes

57 N expression in tumor cells, by neutralizing EMMPRIN activity, or by inhibiting MMPs.

58 lecular mechanisms underlying the actions of EMMPRIN are not fully understood.

59 tenuated the activation-induced elevation of EMMPRIN on T cells in culture and in EAE mice, correspon

60 nd how minocycline affects the expression of EMMPRIN on T cells in culture and in mice afflicted with

61 These results indicated that expression of EMMPRIN protects cancer cells from anoikis and that this

62 cate that they express very similar forms of EMMPRIN.

63 n this study we report immunolocalization of EMMPRIN around the surface of human keratinocytes in vit

64 Knockdown of EMMPRIN expression by RNA interference (small interferin

65 High levels of EMMPRIN expression have been shown to correlate with poo

66 st carcinoma cells expressing high levels of EMMPRIN formed less compact aggregates with larger surfa

67 data demonstrate that the apical polarity of EMMPRIN and N-CAM in mature RPE results from suppressed

68 hanism involved underscores the potential of EMMPRIN expression as a prognostic marker and novel targ

69 These results establish the presence of EMMPRIN in the normal epidermis and raise the possibilit

70 promoter and cooperate in the regulation of EMMPRIN gene expression in macrophages.

71 rolled through the microvesicular release of EMMPRIN from tumor cells.

72 The role of EMMPRIN during tumor angiogenesis and growth was explore

73 elial cancer cells, our study on the role of EMMPRIN in anoikis resistance and the mechanism involved

74 emselves has ignited interest in the role of EMMPRIN in tumor dissemination.

75 MPRIN-expressing cells and that silencing of EMMPRIN expression elevated Bim protein levels and enhan

76 cantly inhibited by antisense suppression of EMMPRIN.

77 sting with a basolateral to apical switch of EMMPRIN in developing postnatal rat RPE.

78 Knocking down either MIF or EMMPRIN by RNAi in the tumor cells significantly reduced

79 Using our EMMPRIN cDNA, we have isolated a cosmid clone that conta

80 , and was further enhanced by overexpressing EMMPRIN.

81 We confirmed that the transmembrane protein EMMPRIN, postulated to be a marker of EVs, was indeed se

82 ECM inducer protein (EMMPRIN); membrane-type MMP (MT-MMP); and MMP-1, -2, and

83 d and purified a tumor cell surface protein, EMMPRIN (extracellular matrix metalloproteinase inducer)

84 ncluded 15 monoclonal antibodies recognizing EMMPRIN/basigin/OX-47/M6, a 45-55-kDa transmembrane prot

85 -translationally processed; this recombinant EMMPRIN stimulates human fibroblast production of inters

86 minocycline treatment significantly reduced EMMPRIN levels on splenic lymphocytes at the presymptoma

87 beta-catenin signaling pathway and silencing EMMPRIN inhibited beta-catenin signaling, cell migration

88 lture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibro

89 sults suggest that the production of soluble EMMPRIN, phospholipase A(2) and 5-lipoxygenase activitie

90 family of transcription factors, stimulated EMMPRIN promoter activity in a synergistic manner.

91 VEGF expression was inhibited by suppressing EMMPRIN expression in tumor cells, by neutralizing EMMPR

92 show that these transfected cells synthesize EMMPRIN that is extensively post-translationally process

93 provide a compelling rationale for targeting EMMPRIN for anticancer therapies.

94 studies and our previous demonstration that EMMPRIN is prominently displayed in human cancer tissue,

95 In this study, we have found that EMMPRIN not only stimulates the production of interstiti

96 ayed in human cancer tissue, we propose that EMMPRIN plays an important role in cancer progression by

97 We propose that EMMPRIN regulates matrix metalloproteinase production du

98 Here, we show that EMMPRIN is released from the surface of NCI-H460 cells v

99 delivery in MDCK and RPE-J cells showed that EMMPRIN has a basolateral signal in its cytoplasmic tail

100 The EMMPRIN protein associated with alpha3beta1 and alpha6be

101 we have obtained cDNA clones that encode the EMMPRIN protein from LX-1 human lung carcinoma cells.

102 Comparison of the EMMPRIN cDNAs from normal human keratinocytes and LX-1 h

103 A fragment 471 bp upstream of the EMMPRIN coding region was sufficient to promote transcri

104 agment containing 1797 bp 5' upstream of the EMMPRIN gene and the transcription start site was genera

105 of the Sp1 element at -122 to -116 bp of the EMMPRIN promoter significantly diminished promoter activ

106 ciate with the functional Sp1 element on the EMMPRIN promoter and cooperate in the regulation of EMMP

107 ugh a variety of functions are attributed to EMMPRIN in tumorigenesis, the specific mechanism(s) thro

108 Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in mo

109 In vivo, EMMPRIN overexpression stimulated tumor angiogenesis and

110 In this study we sought to determine whether EMMPRIN contributes to the malignant phenotype of breast

111 T-1 and CD98 levels, factors associated with EMMPRIN function.

112 slow growing in vivo, were transfected with EMMPRIN cDNA and injected orthotopically into mammary ti

113 , breast cancer cell clones transfected with EMMPRIN cDNA were considerably more tumorigenic and inva