ライフサイエンスコーパス: ERG1

1 Finally using erg1-1 and erg7-1 mutant strains, we demonstrate that th

2 We have mapped mutations within the erg1-1/ets1-1 (G247D) and erg7-1/ets2-1 (D530N, V615E) a

3 ith known Id2 promoter (ETS) binding factors Erg1/2 and Fli1, but not with c-Myc; and this interactio

4 This study aimed to assess the expression of ERG1-3 (KCNH1-3) genes in the murine myometrium (smooth

5 urtle CD afferents express KCNQ3, KCNQ4, and ERG1-3 potassium channel subunits.

6 Quantitative RT-PCR showed that ERG1 and ERG3 were the predominant mRNAs and immunohisto

7 tely transcriptionally regulated, along with ERG1 and ERG7, in response to blocks in sterol biosynthe

8 Thus, ETS1 and ETS2 are allelic to ERG1 and ERG7, respectively.

9 ssion of the ETS family transcription factor ERG1, and constitutive activation of PI3K signaling were

10 fied as antifungal drug targets (i.e., FKS1, ERG1, and ERG11), verifying that this methodology can be

11 Using isoform-specific ERG1 antibodies, we have new evidence that subunits enco

12 x endings were strongly labeled by KCNQ4 and erg1 antisera.

13 leotide sequence analysis of the full-length ERG1 cDNA indicates that it has an open reading frame of

14 Two isoforms of mammalian ERG1 channel subunits, ERG1a and ERG1b, are the principa

15 This is exemplified by the mammalian Erg1 channel, which is responsible for IKr, a current th

16 ryonic kidney tsA-201 cells coexpressing rat erg1 channels with M(1) muscarinic receptors.

17 required for slow deactivation in mammalian Erg1 channels, and thus its loss may partially explain t

18 ediated by heteromeric erg1/erg3 or modified erg1 channels.

19 ssion the ETS transcription factors FLI1 and ERG1, concomitant with TGF-beta inhibition for 3 weeks,

20 pendent activation of currents by -14 mV for ERG1 (EC50 = 414 nM), -20 mV for ERG3 (EC50 = 374 nM), -

21 Although the precise function of ERG1 eludes us presently, its unique pattern of expressi

22 ure rAC-VECs, whereas coexpression with FLI1/ERG1 endows rAC-VECs with a vascular repertoire and morp

23 nt for activation by -6, -18, and -11 mV for ERG1, ERG2, and ERG3 channels, respectively.

24 Rg3 also induced slowing of ERG1, ERG3, and ELK1 channel deactivation and accelerate

25 cells are presumably mediated by heteromeric erg1/erg3 or modified erg1 channels.

26 Chromosomal integration of ERG1 ERG7 at their loci in erg26-1ts ets1-1 and erg26-1t

27 icopathological features also suggested that ERG1 expression level in prostate tumor cells relative t

28 Comprehensive evaluation of quantitative ERG1 expression with clinicopathological features also s

29 ion and TGFbeta inhibition with constitutive ERG1/FLI1 coexpression reprogram mature ACs into durable

30 Expression of the erg1 gene in the sympathetic nervous system has potentia

31 techniques, we have recently shown that the Erg1 gene is a target for ETS proteins.

32 s encoded solely by the 1a transcript of the ERG1 gene.

33 ll gene family with the previously described erg1 (HERG) gene.

34 N-terminal alternatively spliced variants of ERG1 (i.e. ERG1b) are not expressed at the protein level

35 ew bands at 175 and 130 kDa, suggesting that ERG1 is differentially glycosylated in rat/mouse brain a

36 Spatio-temporal analyses reveal that ERG1 mRNA is expressed in a highly stage-specific manner

37 forms of SE by complementation of the yeast erg1 mutant, and beta-AS by expression in yeast.

38 N. vectensis Erg1 (NvErg1) is highly conserved with respect to bilate

39 cells expressing HERG1, MERG1, or RERG1 (rat ERG1) probed with antibodies targeted against the C term

40 In rats, ERG1 protein (and I(Kr)) expression is higher in atria t

41 generated against HERG1 were used to examine ERG1 protein expression in heart and in brain.

42 al splice variants of HERG1 and MERG1 (mouse ERG1) referred to as HERG1b and MERG1b have been cloned

43 sis of alanine to valine in the S4 region of erg1-sm converted many of the properties to that of the

44 When expressed in Xenopus oocytes, erg1-sm currents had much faster activation and deactiva

45 erg1-sm is truncated by 101 amino acids in the C terminu

46 The threshold for activation of erg1-sm was -60 mV and steady-state conductance was appr

47 he smooth muscle isoform of HERG, denoted as erg1-sm, from human and rabbit colon.

48 ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascula

49 Introduction of the erg26 mutation into an erg1 (squalene epoxidase) strain also was viable in ergo

50 Here we report the cloning of a novel gene (ERG1) that is tightly regulated by estrogen in two key r

51 in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural t