ライフサイエンスコーパス: ERK MAP kinase

1 ses, namely Raf, MEK (MAP kinase kinase) and ERK (MAP kinase).

2 L-4 and IL-13 also caused phosphorylation of ERK MAP kinase.

3 ETS proteins that are also phosphorylated by ERK MAP kinase.

4 ggesting that LIN-1 is directly regulated by ERK MAP kinase.

5 he interaction of betaarrs with clathrin and ERK MAP kinase.

6 cated in Wnt signalling and in activation of Erk MAP kinase.

7 independent of the activation of the bulk of ERK MAP kinase.

8 be associated with an increase in activated ERK-MAP kinase.

9 sis of docking interactions in a full-length ERK/MAP kinase.

10 ch is a protein kinase directly activated by Erk MAP kinases.

11 d for LPA-induced stimulation of the p38 and ERK MAP kinases.

12 ced phosphorylation of Smad1/5/8 and p38/Jnk/Erk MAP kinases.

13 here it mainly facilitates the activation of ERK MAP kinases.

14 thway linking receptor tyrosine kinases with Erk MAP kinases.

15 e induction is preceded by the activation of ERK MAP kinases.

16 dispersion, transiently activate the p42/p44 ERK/MAP kinases.

17 to play a key role in signal transduction by ERK/MAP kinases.

18 tions despite constitutive activation of the Erk/MAP kinases.

19 ctivation of extracellular signal regulated (Erk) MAP kinases.

20 results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct ph

21 previously undescribed signaling pathway of ERK/MAP kinases activating calpain to destabilize cell-s

22 utocrine mediator of growth factor-dependent ERK MAP kinase activation and cell cycle progression.

23 l Gab2 as a limiting signaling component for Erk MAP kinase activation and terminal differentiation o

24 tributes strongly to phorbol ester (TPA) and Erk MAP kinase activation of the c-fos enhancer and that

25 When ERK MAP kinase activation was analyzed in hepatocytes at

26 induced RhoA/ROCK activation, but not p42/44 ERK MAP kinase activation, suggesting that Lbc is an int

27 is of a broad set of GPCRs without affecting ERK MAP kinase activation.

28 s shedding in response to growth factors and Erk MAP kinase activation.

29 of apoptosis protein 2) gene expression, and ERK/MAP kinase activation are all inhibited in TNF-treat

30 Inhibiting BDNF's receptor, TrkB, ERK/MAP kinase activation, or NMDA receptors blocks this

31 nt overall EGFR tyrosine phosphorylation and ERK/MAP kinase activation; however, phosphorylation of T

32 -regulated kinase/mitogen-activated protein (ERK/MAP) kinase activation, both of which have been impl

33 f focal adhesion kinase (FAK) and consequent ERK MAP kinase activity leading to Smad3 linker region p

34 f SDF-1alpha on T cells, including prolonged ERK MAP kinase activity, increased intracellular calcium

35 By increasing ERK MAP kinase activity, Nef is functionally associated

36 fficient for the inhibitory effect of KSR on ERK MAP kinase activity.

37 hed from blast crisis were found to have low Erk MAP kinase activity.

38 of PI3K signaling also blocked increases in ERK/MAP kinase activity associated with memory retrieval

39 By contrast, Erk/MAP kinase activity is weak in tumors initiated by T

40 scribe a versatile intracellular reporter of ERK/MAP kinase activity: a cDNA construct, pGFP.MBP, enc

41 d HMGB-1 and analyzing for activation of the ERK MAP kinase and NF-kappaB.

42 tion by zebrafish PEA3 is potentiated by the ERK MAP kinase and protein kinase A pathways.

43 B or HMGB-1 increased phosphorylation of the ERK MAP kinase and the p65 subunit of NF-kappaB and incr

44 -1(4H)-benzopyran-4-one], demonstrating that ERK MAP kinases and Akt are both required for EPO-induce

45 hways leading to activation of p38, JNK, and ERK MAP kinases and to generate reactive oxygen species.

46 ity phosphatase and a specific antagonist of ERK MAP kinases and we demonstrate that in somites Mkp3

47 Rapid activation of both ERK/MAP kinase and phosphatidylinositol 3-kinase activit

48 on by Notch requires active signals from the Erk/MAP kinase and PI-3 kinase pathways downstream of Ra

49 ane-bound proteins in the dmPFC that include ERK/MAP kinase and the NMDA receptor subunits, GluN1 and

50 -Ha-ras and c-myc have high levels of active Erk/MAP kinase and their anchorage independent growth is

51 -regulated kinase/mitogen-activated protein (ERK/MAP) kinase and calpain (EC 3.4.22.17) in these proc

52 on and survival, including activation of the ERK/MAP kinases, and immediate-early induction of c-Jun

53 These findings demonstrate that ERK-MAP kinases are directly involved in activating Cdc2

54 onarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein

55 This expression is mediated by ERK MAP kinase but not PI3K signalling.

56 xpression of KSR inhibited the activation of ERK MAP kinase by insulin, phorbol ester, or activated a

57 Shc and subsequent activation of the Raf-MEK-ERK (MAP) kinase cascade.

58 ticular, PEA-15 regulates the actions of the ERK MAP kinase cascade by binding to ERK and altering it

59 BDNF-induced alterations in the ERK-MAP kinase cascade and in prefronto-accumbens glutam

60 and inhibits Ras-dependent activation of the Erk/MAP kinase cascade in 293T cells.

61 The ERK/MAP kinase cascade is important for long-term memory

62 e Rap1A, but activates H-Ras, R-Ras, and the Erk/MAP kinase cascade under Ca2+ and DAG modulation.

63 that it can assemble modules of the JNK and ERK MAP kinase cascades.

64 Ras acting via Erk MAP kinases causes phosphorylation of Smad2 and Smad

65 Therefore, MKP3 and ERK MAP kinase constitute a negative feedback loop activ

66 Because mpk-1 ERK MAP kinase controls at least one cell-fate decision

67 ites in the hTERT promoter or suppression of ERK MAP kinase-dependent phosphorylation of ER81 rendere

68 retrieval and is required for activation of ERK/MAP kinase during retrieval.

69 CHO-K1) cells, uPA-binding to uPAR activates ERK/MAP kinase, even though these cells do not express t

70 expression can be mediated by SMAD, p38, and ERK/MAP kinase (extracellular signal-regulated kinase/mi

71 Inhibition of ERK/MAP kinase fails to affect p21 up-regulation.

72 uishes it from MEKs that phosphorylate other ERK/MAP kinase family members.

73 es, indicating that LIN-45, MEK-2, and MPK-1 ERK MAP kinase function in a predominantly linear signal

74 veral signal transduction pathways including ERK/MAP kinase have been implicated in memory retrieval,

75 ted forms of Mek (MAP kinase/Erk kinase) and Erk (MAP kinase) have been previously shown capable of i

76 olding complex is required for signaling via ERK MAP kinase in an efficient and specific manner upon

77 he Gab2 docking protein in regulation of the Erk MAP kinase in Bcr-Abl(+) K562 human CML cells.

78 The differential contribution of p38 and ERK MAP kinases in mediating MKP-1 induction by differen

79 FP3 blocked activation of Akt and ERK/MAP kinase in response to nerve growth factor-beta (

80 FP6 rapidly and robustly activated Akt and ERK/MAP kinase in Schwann cells and PC12 cells.

81 rc, Ras, Raf-1, Mek (MAP kinase kinase), and Erk (MAP kinase) in baculovirus-infected Sf9 insect cell

82 We find that Erk MAP kinase is normally active in ureteric bud, and t

83 Activation of ERK MAP kinase is required for both RSV-induced inflamma

84 a molecular and pharmacologic assessment of Erk/MAP kinase, Jnk/SAP kinase, PI 3-kinase, protein kin

85 strointestinal smooth muscle which activates ERK MAP kinases leading to phosphorylation of caldesmon.

86 ERK MAP kinase (MAPK) activity in neural progenitor cell

87 SHP2 is required for RAS-ERK MAP kinase (MAPK) cascade activation, and Noonan syn

88 Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural inductio

89 MSP binding stimulates oocyte MPK-1 ERK MAP Kinase (MAPK) phosphorylation, but the function

90 enetic proteins (BMPs) and activation of the ERK/MAP kinase (MAPK) pathway by growth factors have bee

91 The cAMP and ERK/MAP kinase (MAPK) signal transduction pathways are c

92 ent, highlighting the importance of the MKP3-ERK-MAP kinase mediated feedback loop for cell specifica

93 ERK/MAP kinase-mediated activation of the protease Calpa

94 Rapid activation of the ERK MAP kinase occurred when articular cartilage was loa

95 Activation of ERK MAP kinases occurred in these cells by 30 min postch

96 ine, was strongly inhibited by inhibitors of Erk MAP kinase or p38 MAP kinase signaling.

97 not result in the activation of the p42/p44 ERK MAP kinases or the c-jun N-terminal kinases.

98 fect on the ability of VHR to inactivate the ERK MAP kinases or to hydrolyze artificial substrates.

99 itors of these kinases but not inhibitors of ERK/MAP kinase or protein kinase C reduced heregulin-med

100 proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both

101 eta signaling through TACE activation by the Erk MAP kinase pathway and a strategy for evasion of tum

102 We report that activation of the Erk MAP kinase pathway decreases the TGF-beta-induced Sm

103 EK kinase is essential for activation of the Erk MAP kinase pathway during innate immune responses.

104 To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen-induced arthri

105 The activity of the Erk MAP kinase pathway is dependent on at least two know

106 study suggest that targeting the RAGE or the ERK MAP kinase pathway may provide new therapeutic strat

107 The RAS RAF MEK ERK MAP kinase pathway mediates cellular responses to gr

108 In the Erk MAP kinase pathway, activation of MAP kinases takes

109 TCR-induced calcium flux, activation of the ERK MAP kinase pathway, activation of the NF-kappaB tran

110 tein kinase Ctheta (PKCtheta) turning on the Erk MAP kinase pathway, but the biochemical mechanism re

111 uppression correlated with activation of the ERK MAP kinase pathway.

112 ound protein 2, as well as activation of the Erk MAP kinase pathway.

113 l outcome from activation of the multipotent ERK MAP kinase pathway.

114 s) inhibit chondrocyte proliferation via the Erk MAP kinase pathway.

115 Elk-1 in response to signalling through the ERK MAP kinase pathway.

116 signal-regulated kinase (ERK) kinase [MEK]-->ERK MAP kinase pathway.

117 on of Ser(791), depends on activation of the Erk MAP kinase pathway.

118 ated independently of bulk activation of the ERK MAP-kinase pathway.

119 The RAS-RAF-MEK-ERK-MAP kinase pathway mediates the cellular response to

120 ore regulated by both the mitogen-stimulated ERK/MAP kinase pathway and a PDK1-dependent pathway.

121 To examine the role of the ERK/MAP kinase pathway in megakaryocytic differentiation

122 ach to improve the efficacy of targeting the ERK/MAP kinase pathway in melanoma.

123 It is thought that stimulation of the ERK/MAP kinase pathway is sufficient for RSK1 activation

124 a suggested that sustained activation of the ERK/MAP kinase pathway promoted the autocrine secretion

125 n of both STAT transcription factors and the ERK/MAP kinase pathway, suggesting a mechanism for the o

126 ng the intracellular signaling involving the Erk/MAP kinase pathway, T cells with specificity for MHC

127 y of T-cell-tropic HIV-1, activates also the ERK/MAP kinase pathway.

128 activation of the EGFR and activation of the ERK/MAP kinase pathway.

129 e data confirm the importance of the p38 and ERK MAP kinase pathways in macrophage activation by bact

130 sustained and enhanced activation of p38 and ERK MAP kinase pathways.

131 e progression, and the activation of p38 and ERK MAP kinase pathways.

132 in basic protein contains a single consensus ERK/MAP kinase phosphorylation motif (PRTP, where the th

133 on was associated with activation of p38 and ERK MAP kinases, phosphorylation of histone H3, and incr

134 by sequence-specific down-regulation of the ERK-MAP kinase phosphosignaling cascade in KRAS-driven c

135 vates extracellular signal-regulated kinase (ERK)-MAP kinases, reduced MAF mRNA in cells representing

136 striatum-enriched regulators of the Ras/Rap/ERK MAP kinase signal transduction cascade, matrix-enric

137 have described an important link between the ERK MAP kinase signaling cascade and the translational m

138 The ERK MAP kinase signaling cascade plays critical roles in

139 membrane TGF-alpha through activation of the Erk MAP kinase signaling cascade without the need for ne

140 imal activation of the canonical Ras/Raf/MEK/ERK Map kinase signaling cascade, likely because of PAK

141 Here, we investigate the role of ERK MAP kinase signaling in this process.

142 , ECT-2, functions through the conserved RAS/ERK MAP kinase signaling pathway in the C. elegans germl

143 We now demonstrate that the Akt and Erk MAP kinase signaling pathways are activated in andro

144 6 protein family, operates downstream of FGF/Erk MAP kinase signaling to regulate pluripotency and ce

145 FGF/Erk MAP kinase signaling up-regulates Brf1, which disrup

146 resses EGF receptor signaling and downstream Erk MAP kinase signaling, as well as autocrine EGF recep

147 The link between ERK/MAP kinase signaling and cell motility required the

148 family GTPase with a well documented role in ERK/MAP kinase signaling and integrin activation.

149 eration of undifferentiated ES cells via the ERK/MAP kinase signaling pathway.

150 itor blocked this LTP, suggesting a role for ERK/MAP kinase signaling pathways in this process.

151 protein that integrates G protein and H-Ras/ERK/MAP kinase signaling pathways, thereby making it wel

152 quires activation of M-calpain downstream of ERK/MAP kinase signaling.

153 -regulated kinase/mitogen-activated protein (ERK/MAP) kinase signaling but not on the immediate early

154 Since growth factor-dependent ERK MAP kinase signalling plays an important role in reg

155 of Rho- dependent stress fibre formation by ERK-MAP kinase signalling contributes to the increased m

156 We show that the sustained ERK-MAP kinase signalling resulting from transformation

157 ut are selected for in response to sustained ERK-MAP kinase signalling.

158 ay causes the phosphorylation of TGIF at two Erk MAP kinase sites, leading to TGIF stabilization and

159 However, TGF-beta stimulation also activates Erk MAP kinases through an undefined mechanism, albeit t

160 s driven in part by cAMP, which acts through Erk MAP kinase to initiate a cascade leading to modulati

161 Smad3 is phosphorylated by ERK MAP kinase upon EGF treatment.

162 However, induction of ERK MAP kinase was reduced and the chimera was incapable

163 role of beta-arrestins in the regulation of ERK MAP kinases, we examined the effect of beta-arrestin

164 via activation of p38 MAP kinase rather than ERK MAP kinase, which has more frequently been linked to

165 Ser(676) is also targeted by the ERK MAP kinase, which interacts with NFAT at a distinct