ライフサイエンスコーパス: ES cell

1 ntrol and L1CAM-deficient neurons from these ES cells.

2 ues the differentiation defects of aneuploid ES cells.

3 so contributes to the rapid proliferation of ES cells.

4 nt promoter genes were reduced in BAF250a KO ES cells.

5 3K79me2, H3K36me3, H3K9me3, and H4K20me3, in ES cells.

6 d promoters were bivalent in human and mouse ES cells.

7 omote de novo methylation in differentiating ES cells.

8 ocesses that establish healthy pregnancy and ES cells.

9 ongation, and alternative splicing events in ES cells.

10 essential for the proper differentiation of ES cells.

11 anisms in human prostate cancer versus mouse ES cells.

12 e of the most rapidly induced transcripts in ES cells.

13 h may support the diverse mRNA repertoire in ES cells.

14 l to the pluripotency and differentiation of ES cells.

15 rons derived from these conditionally mutant ES cells.

16 g wild-type Lsh but not the ATP mutant in KO ES cells.

17 hment XCI during in vitro differentiation of ES cells.

18 a genome-wide basis in differentiating mouse ES cells.

19 enes or more) after a single transfection of ES cells.

20 ased targeting vectors introduced into mouse ES cells.

21 ensable for global gene expression in murine ES cells.

22 restored SHF gene expression in Casp3 mutant ES cells.

23 ich is the preferred SOX2 binding partner in ES cells.

24 derepressed pluripotency-associated genes in ES cells.

25 dinate binding of SOX2 and p63 was absent in ES cells.

26 determining the developmental plasticity of ES cells.

27 regulated in Drosha- but not Dicer-deficient ES cells.

28 RNAPII elongation rates and RNA splicing in ES cells.

29 Tet triple KO fibroblast derived from mouse ES cells.

30 ns between LIF-independent iOCT4 and control ES cells.

31 ty as well as the developmental potential of ES cells.

32 GC-like cells (PGCLCs) in EpiLCs, but not in ES cells.

33 g the levels of expression driven by CREs in ES cells.

34 ssion in murine Mesp1(Cre/+); Rosa26(EYFP/+) ES cells.

35 s in early mouse embryos and embryonic stem (ES) cells.

36 critical for self-renewal in embryonic stem (ES) cells.

37 expression programs in mouse embryonic stem (ES) cells.

38 ogonia, growing oocytes, and embryonic stem (ES) cells.

39 1, at bivalent loci in human embryonic stem (ES) cells.

40 strongly suppressed in mouse embryonic stem (ES) cells.

41 hd9, Brg1 and Ep400 in mouse embryonic stem (ES) cells.

42 ed their expression in mouse embryonic stem (ES) cells.

43 s of the HH pathway in mouse embryonic stem (ES) cells.

44 We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at t

45 some occupancy in KO ES cells compared to WT ES cells after differentiation.

46 The mouse ES cells also differentiate into Pax7(+) cells with sate

47 osome inactivation and XIST transcription in ES cells, also plays a role in maintenance of the inacti

48 gene targeting in mice using embryonic stem (ES) cells, although suitable for generating sophisticate

49 ethodology that utilizes the differentiating ES cell and embryoid body system to define the modules a

50 analysis revealed that LIF-independent iOCT4 ES cells and control ES cells exhibit similar transcript

51 n, we purified native nucleosomes from mouse ES cells and detect that Suv39h1 and Suv39h2 exclusively

52 K27me3) of ChIP sequencing datasets in human ES cells and eight pairs in murine ES cells, and predict

53 de changes in NANOG-binding patterns between ES cells and EpiLCs, indicating epigenetic resetting of

54 otency-associated gene transcription both in ES cells and in differentiating embryoid bodies.

55 Both NT ES cells and iPS cells derived from the same somatic cel

56 (TRIM28; also known as TIF1beta and KAP1) in ES cells and orchestrates retroviral silencing activity

57 se phenotypes were mimicked by SHANK3-edited ES cells and rescued by transduction with a Shank3 expre

58 Pausing can be induced directly in cultured ES cells and sustained for weeks without appreciable cel

59 sing quantitative live-cell imaging in mouse ES cells and tumor cells, we demonstrate that, although

60 9 trimethylation (H3K9me3) profiles in mouse ES cells and uncovered two distinct classes of SETDB1 bi

61 s involved in maintenance of embryonic stem (ES) cells and early embryonic development of the mouse.

62 omatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we un

63 lentiviral vector in murine embryonic stem (ES) cells and human inducible pluripotent stem (iPS) cel

64 We show that in embryonic stem (ES) cells and in some tissues, the Stra6 gene encodes tw

65 mpetent-able to give rise to embryonic stem (ES) cells and live, fertile mice.

66 L4 enzyme-dead knock-in (KI) embryonic stem (ES) cells and mice, which carry Y5477A/Y5523A/Y5563A mut

67 is expressed in pluripotent embryonic stem (ES) cells and regulates ES cell differentiation.

68 re malignant counterparts of embryonic stem (ES) cells and serve as useful models for investigating c

69 activity in differentiating embryonic stem (ES) cells and that hearts from Wnt5a(-/-); Wnt11(-/-) em

70 Neurogenesis was reduced in BERKO ES cells, and oligodendrogliogenesis was enhanced.

71 in human ES cells and eight pairs in murine ES cells, and predicted high-confidence (HC) bivalent pr

72 tion: immature Xenopus laevis oocytes, mouse ES cells, and the transition state of proliferating mamm

73 precise control of the forces experienced by ES cells, and therefore provided at least one explanatio

74 promoter region are lost in embryonic stem (ES) cells, and ES-cloned embryos show RNF12-dependent Xi

75 o compare the gene expression profile of the ES cell- and adult progenitor-derived, GM-CSF-instructed

76 oduce the dramatic rearrangements underlying ES-cell- and PGC-specific transcriptional programs remai

77 In this protocol, mouse ES cells are aggregated in 96-well plates in medium cont

78 cated genome engineering in species in which ES cells are not available.

79 Mouse embryonic stem (ES) cells are a popular model system to study biological

80 Embryonic stem (ES) cells are in a dynamic equilibrium of distinct funct

81 Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from

82 mice as well as the differentiation of mouse ES cells as a model with which to address this issue.

83 gramming in which repression of pre-existing ES cell-associated gene expression program is followed b

84 we found thatGli1andNanogare co-expressed in ES cells at high levels.

85 of BAF250a, a key regulatory subunit of the ES cell ATP-dependent Brahma-associated factor (BAF) chr

86 In this setting, we inquired how ES cells avoid the potentially deleterious consequences

87 such models are generated by embryonic stem (ES) cell-based targeted insertion, or pronuclear injecti

88 combinations sufficient to explain observed ES cell behavior.

89 ly, we find the strongest gene clustering in ES cells between transcription factor genes that control

90 enes that are transcriptionally repressed in ES cells but ready to be activated in response to differ

91 ficient to support enhanced proliferation of ES cells, but not to maintain their undifferentiated phe

92 t characteristics similar to embryonic stem (ES) cells, but the genetic drivers underlying malignant

93 a disrupted the differentiation potential of ES cells by altering the expression timing of key develo

94 fects of aneuploidy on mouse embryonic stem (ES) cells by generating a series of cell lines that each

95 HDR-mediated events in mouse embryonic stem (ES) cells by more than 20-fold through the use of co-inc

96 Conventional ES cells can be derived and maintained in vitro with med

97 Nonetheless, ES cells can seemingly acquire TS-like characteristics u

98 Mouse pluripotent embryonic stem (ES) cells can exist in distinct yet interchangeable epig

99 rogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placenta

100 SCNT embryos developed into blastocysts and ES cells capable of contributing to traditional germline

101 Here we show that mouse ES cells carrying a hypomorphic Gpc4 allele, in a single

102 Here, we generated human embryonic stem (ES) cells carrying a conditional L1CAM loss-of-function

103 ry through which pluripotent embryonic stem (ES) cells choose between self-renewal and differentiatio

104 alyzing two independent conditionally mutant ES cell clones, we found that deletion of L1CAM dramatic

105 ndings highlight a unique mechanism by which ES cells communicate with trophoblasts within the blasto

106 we found distinct nucleosome occupancy in KO ES cells compared to WT ES cells after differentiation.

107 In vitro data from ES cells confirmed that bexarotene-activated RXR affecte

108 Despite this, ES cells consume high levels of exogenous glutamine when

109 Poised chromatin in ES cells contains both H3 Lys-4 trimethylation (H3K4me3)

110 Many of the transcription factors in ES cells control both host and retroviral genes coordina

111 methylation and transcriptome profiles of NT ES cells corresponded closely to those of IVF ES cells,

112 ly similar to those of their embryonic stem (ES) cell counterparts, and both are typical of aneural m

113 on of the Romk1-specific first exon using an ES cell Cre-LoxP strategy and examined the renal phenoty

114 ntional serum plus LIF medium phenocopy male ES cells cultured in 2i/L.

115 Furthermore, we find that female ES cells cultured in conventional serum plus LIF medium

116 ts long-term LIF-independent self-renewal of ES cells cultured in media containing fetal bovine serum

117 , in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bF

118 factor 4) plays an unappreciated role in the ES cell cycle by forming a complex with cyclin-Cdk1 and

119 educes endogenous H3K4 methylation levels in ES cells, decreases the protein stability of MLL3 and ML

120 RECQL5 and BLM has on mouse embryonic stem (ES) cells deleted for FANCB, a member of the FA core com

121 Map3k1(m) (PHD) ES cells demonstrate that the MEKK1 PHD controls p38 and

122 Here we demonstrate that embryonic stem (ES) cells derived from the ICM generate and shed microve

123 iPS cells and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear transfer (SCNT

124 s stably maintained in embryonic stem cells (ES cells) derived from most embryos.

125 to steer directional differentiation because ES cell-derived cells are typically immature with impair

126 istent with this notion, we found that mouse ES cell-derived DCs (ES-DCs) represented less mature cel

127 etry, microscopic imaging, and RNA-Seq, that ES cell-derived macrophages responded to S. Typhimurium,

128 eproducible strategy to exponentially expand ES cell-derived megakaryocyte-erythroid progenitors that

129 ously using fetus-derived NPCs, infection of ES cell-derived pNSCs with HCMV was nonprogressive.

130 Embryonic Stem (ES) cell-derived EphrinB2(+) cells are enriched with hem

131 Here, human embryonic stem (ES) cell-derived neural progenitor cells, endothelial ce

132 We used human embryonic stem (ES) cell-derived primitive prerosette neural stem cells

133 Using ES-cell-derived human neurons, we show that ApoE secrete

134 man embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chromatin

135 Here, we generated human ES cells designed to conditionally express heterozygous

136 In embryonic stem (ES) cells, developmental regulators have a characteristi

137 In ES cells, differentially expressed genes after perturbat

138 is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed

139 plays a critical role in the early stages of ES cell differentiation and the reprogramming of somatic

140 We showed that ES cell differentiation induces selective alteration of

141 oth the mRNA and protein levels during mouse ES cell differentiation into SMCs (ESC-SMC differentiati

142 y Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-ectoderm.

143 also improves, in addition to murine, human ES cell differentiation to blood cells.

144 t are recapitulated by existing protocols of ES cell differentiation, these data indicate that mouse

145 tent embryonic stem (ES) cells and regulates ES cell differentiation.

146 widely applied protocols of embryonic stem (ES) cell differentiation have been developed to enable i

147 Both the MEKK1 PHD and TAB1 are critical for ES-cell differentiation and tumourigenesis.

148 We show that paused ES cells display a remarkable global suppression of tran

149 Drosha-deficient embryonic stem (ES) cells display genomic hypomethylation that is not ac

150 renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory

151 Finally, in differentiating human ES cells, endodermal markers were more efficiently induc

152 nes based on their likelihood of determining ES cell (ESC) identity.

153 st cancer model, using our novel female GEMM ES cell (ESC) pipeline.

154 derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) a

155 from mutant p53-induced transformation using ES cells (ESCs) that express a conformational mutant of

156 Unlike in ES cells, Esrrb interacts in TS cells with the histone d

157 occupancy of pluripotency-associated loci in ES cells, Esrrb sustains the stemness of TS cells by dir

158 Consequently, naive ES cells exhibit an elevated alphaKG to succinate ratio

159 TGF-beta- or EGF-stimulated Map3k1(m) (PHD) ES cells exhibit defective non-canonical ubiquitination

160 Setdb1 ablated ES cells exhibit severe growth inhibition, which is not

161 t LIF-independent iOCT4 ES cells and control ES cells exhibit similar transcriptional programs relati

162 Haploid human ES cells exhibited typical pluripotent stem cell charact

163 Embryonic stem (ES) cells express pluripotency-associated genes and repr

164 eight genes including Braf, Mitf, and ERas (ES-cell expressed Ras) as candidate resistance genes.

165 ycle stage between the transplanted nucleus (ES cell, fetal fibroblast or terminally differentiated c

166 d using the data to deconvolute a mixture of ES cells, fibroblasts and hematopoietic progenitors into

167 uld aid efforts to generate autologous human ES cells for regenerative applications, as donated or di

168 Here, we engineered ES cells from WT mice to express a doxycycline-regulated

169 pulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but haploid hu

170 Although embryonic stem cells (ES cells) from in vitro fertilized embryos (IVF ES cells

171 Endogenous cyclin D1 enhanced Wnt and ES cell gene expression and expanded a prostate stem cel

172 gulates pivotal transcription factors in the ES cell gene regulatory network to sustain naive identit

173 Embryonic stem (ES) cells go though embryo-like cell cycles regulated by

174 Here we show that mouse embryonic stem (ES) cells grown under conditions that maintain naive plu

175 or expression of a functional RNAi-cassette, ES-cell handling, or screening for mice with the desired

176 several mammalian species, but haploid human ES cells have yet to be reported.

177 9(-/-) relative to Rad9(+/+) embryonic stem (ES) cells have reduced levels of Neil1 protein.

178 although short-term suppression of Mek1/2 in ES cells helps to maintain an ICM-like epigenetic state,

179 f a unique stem cell phenotype by both human ES cells (hESCs) and induced pluripotent stem cells (iPS

180 routes to generate nontransgenic naive human ES cells (hESCs).

181 he absence of proliferation (embryonic stem [ES] cell heterokaryons) or DNA replication (nuclear tran

182 Embryonic stem (ES) cells, however, characteristically suppress transcri

183 Extinction of ES cell identity in single cells is acute.

184 We propose that propagation of ES cell identity is not determined by a vast interactome

185 ed that Patz1 is required for maintenance of ES cell identity.

186 we show that prolonged culture of male mouse ES cells in 2i/L results in irreversible epigenetic and

187 19 is critical for proper differentiation of ES cells in collaboration with Rnf20.

188 Thus, even ES cells in ground-state pluripotency cannot fully overc

189 s unclear how sustained propagation of naive ES cells in vitro affects their stability and functional

190 irst' allele and identify essential genes in ES cells, including the histone methyltransferase Setdb1

191 ption factors in common with embryonic stem (ES) cells, including OCT4 (encoded by Pou5f1), SOX2, NAN

192 urther show that injecting MVs isolated from ES cells into blastocysts results in an increase in thei

193 Here we differentiated mouse ES cells into macrophages in vitro and showed, through a

194 e genetically modified mouse embryonic stem (ES) cells into functional macrophages provides a potenti

195 monolayer cultures of mouse embryonic stem (ES) cells into PSM-like cells without the introduction o

196 ethod, genetically matched sets of human IVF ES cells, iPS cells and nuclear transfer ES cells (NT ES

197 Our strategy to generate null mutant mouse ES cells is applicable to thousands of genes and repurpo

198 The unique chromatin signature of ES cells is fundamental to the pluripotency and differen

199 Interestingly, enzyme-dead MLL4 protein in ES cells is highly unstable.

200 that using engineered human embryonic stem (ES) cells is a viable approach to studying disease-assoc

201 ization both in the inducible Xist transgene ES cell line and in normal XX somatic cells.

202 cing of EC cell lines and their nonmalignant ES cell line counterparts.

203 We constructed a homozygous mutant mouse ES cell line in the Traf2 gene that is known to play a r

204 We have therefore generated an ES cell line in which Hdac1 and Hdac2 can be inactivated

205 Using this ES cell line, we observed that the first primitive eryth

206 operties, we used a modified embryonic stem (ES) cell line that emulates the early embryonic demethyl

207 engineered a new transgenic embryonic stem (ES) cell line, where eGFP expression is driven by the re

208 ndrial localization of MRP-1 was examined in ES cell lines by differential centrifugation and membran

209 However, some ES cell lines demonstrated gradual loss of donor mtDNA a

210 es in an allele-specific manner using hybrid ES cell lines from reciprocal crosses between C57BL/6J a

211 alysed a collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading

212 differentiation competence is more common in ES cell lines than in induced pluripotent stem cell line

213 uccessful isolation and maintenance of human ES cell lines with a normal haploid karyotype.

214 elf-renewal, but failed to expand as iPSC or ES cell lines.

215 n in conditional-ready IKMC 'knockout-first' ES cell lines.

216 ogenic SHANK3 knockout human embryonic stem (ES) cell lines.

217 ) drives TE-like transcriptional programs in ES cells, maintains trophoblast stem (TS) cell self-rene

218 ng key pluripotency pathways associated with ES cell maintenance and self-renewal.

219 phectoderm (TE) lineage by repression of the ES cell master regulator Oct4 or activation of the TE ma

220 Like Mll4 knockout ES cells, Mll4(KI/KI) ES cells show reduced levels of H3

221 ring the onset of Hox gene expression in the ES cell model and during body segment identity specifica

222 rrogated the progression of reprogramming in ES cell models with regulatable Oct4 and Cdx2 transgenes

223 IVF ES cells, iPS cells and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear t

224 Fibers derived from ES cells of mdx mice exhibit an abnormal branched phenot

225 dress this issue, we cultured Ewing sarcoma (ES) cells on electrospun poly(epsilon-caprolactone) 3D s

226 d that co-culture of wild-type and aneuploid ES cells or supplementation with extracellular BMP4 resc

227 ges but retain an epigenetic memory of their ES cell origin.

228 nscriptome upon conditional KAP1 knockout in ES cells overlapped with the changes during embryoid bod

229 IalphaI is not produced by the ES cells per se but is added to the cells via the cell c

230 nd PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

231 aling in a LIF-independent manner to promote ES cell pluripotency and self-renewal.

232 expression patterns can serve as markers of ES cell pluripotency.

233 Erk1/2 activation contributes to mouse ES cell pluripotency.

234 Embryonic stem (ES) cell pluripotency is governed by OCT4-centric transc

235 pose that after the dissolution of the naive ES-cell pluripotency network during establishment of Epi

236 The ES cell population behaves asynchronously.

237 ese functions, we used mouse embryonic stem (ES) cells, primary neurons, and APOE3 and APOE4 mice tre

238 gene profiles in multiple SCC cell lines to ES cell profiles and determined that SOX2 binds to disti

239 more, we found that a PKA inhibitor impaired ES cell proliferation, tumor growth and metastasis, whic

240 ly, Wnt5a/Wnt11 treatment of differentiating ES cells reduced both phosphorylated and total Akt throu

241 In contrast, pluripotent embryonic stem (ES) cells represent an inexhaustible source for DC produ

242 cells) from in vitro fertilized embryos (IVF ES cells) represent the 'gold standard', they are alloge

243 Although haploid human ES cells resembled their diploid counterparts, they also

244 on of Tet1 and Tet2 in mouse embryonic stem (ES) cells results in an apparent loss of H3K27me3 at biv

245 Moreover, LIF-independent iOCT4 ES cells retain the capacity to differentiate in vitro a

246 Transcriptome sequencing of the Ctcfl ES cells revealed 14 genes deregulated by Ctcfl expressi

247 In contrast to the in-depth studies of ES cell self-renewal and pluripotency, few TE-specific r

248 SALL4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47.7% o

249 critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency.

250 ription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauter

251 ith cell-permeable alphaKG directly supports ES-cell self-renewal while cell-permeable succinate prom

252 is study demonstrates shear stress-dependent ES cell sensitivity to dalotuzumab, highlighting the imp

253 Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature.

254 Like Mll4 knockout ES cells, Mll4(KI/KI) ES cells show reduced levels of H3K4me1/2.

255 changes using inducible CDX2 embryonic stem (ES) cells, so that we could predict which CDX2-bound gen

256 However, it is not known whether there are ES cell-specific mechanisms regulating mitotic fidelity.

257 enced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809.

258 Oct4) play a seminal role in embryonic stem (ES) cell-specific gene regulation.

259 Cells newly departed from the ES cell state display features of early post-implantatio

260 The human naive ES cell state has eluded derivation without the use of t

261 e Ctcfl transgene reproduce the phenotype in ES cell-tetraploid chimeras.

262 Embryonic stem (ES) cells that have the remarkable capability to differe

263 duces a naive state in mouse embryonic stem (ES) cells that resembles the inner cell mass (ICM) of th

264 se model cell line and mouse embryonic stem (ES) cells that this library can be used for genetic resc

265 e all-trans-retinoic acid (RA)-responsive in ES cells, the downstream promoter contains a half-site R

266 In differentiating ES cells, the presence of NANOG reduces the transcriptio

267 used successfully in murine embryonic stem (ES) cells, there remain a set of nearly two thousand gen

268 In ES cells, they are predicted to act as transcriptional a

269 2 and NANOG promote the pluripotent state in ES cells, they show contrasting roles in EpiLCs, as Sox2

270 extensive demethylation, we subjected mouse ES cells to chemically defined hypomethylating culture c

271 n a rate-dependent manner the sensitivity of ES cells to IGF-1R inhibitor dalotuzumab (MK-0646) and s

272 s, cohesin depletion enhanced the ability of ES cells to initiate somatic cell reprogramming in heter

273 states are vital for the differentiation of ES cells to multipotent stem cells, little is known rega

274 Neural differentiation of human ES cells to NPs is concurrent with a threefold elevation

275 the differentiation of mouse embryonic stem (ES) cells to both primitive and definitive haematopoieti

276 this link, we have used NOD embryonic stem (ES) cells to generate a novel NOD transgenic line with t

277 mes at the edge of NFRs, where they regulate ES cell transcriptional programs.

278 Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nanog promo

279 issue is produced from mouse embryonic stem (ES) cells under chemically defined conditions.

280 in from the inner cell mass, embryonic stem (ES) cells undergo differentiation to the trophectoderm (

281 We investigated whether mouse ES cells undergoing largely undirected neocortical diffe

282 mparison to more differentiated cells, naive ES cells utilize both glucose and glutamine catabolism t

283 isingly, inhibition of either Akt or PI3K in ES cells was an equally effective means of increasing SH

284 However, by assaying thousands of ES cells, we identify a spectrum of subpopulations defin

285 To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either in

286 In Oga KO mouse ES cells, we observed pronounced changes in expression o

287 ts, as well as 115 co-expression clusters in ES cells, we validate the utility of this approach.

288 e high in wild-type (WT) and Nf1 23aIN/23aIN ES cells, where the Nf1 exon 23a inclusion level is high

289 S cells corresponded closely to those of IVF ES cells, whereas iPS cells differed and retained residu

290 equired for Neil1 protein stability in mouse ES cells, whereas it regulates NEIL1 transcription in th

291 ablish the poised chromatin configuration in ES cells, which is essential for the proper differentiat

292 d c-Myc (Myc) expression in cohesin-depleted ES cells, which promoted DNA replication-dependent repro

293 that uses the immense regenerative power of ES cells while avoiding the risks associated with direct

294 ore, SHF markers are reduced in Casp3 mutant ES cells while the treatment of wild type ES cells with

295 ncreases the level of global H2Bub1 in mouse ES cells, while down-regulation of Fbxl19 reduces the le

296 We expect that haploid human ES cells will provide novel means for studying human fun

297 nt ES cells while the treatment of wild type ES cells with Caspase inhibitors blocked the ability of

298 Here we generated mouse embryonic stem (ES) cells with a constitutive endogenous Nf1 exon 23a in

299 datasets in murine and human embryonic stem (ES) cells with over 1000 mammalian TF sequence motifs.

300 Embryonic stem (ES) cells with the Ctcfl transgene reproduce the phenoty