ライフサイエンスコーパス: ET

1 ET of spleen revealed thousands of virions released by i

2 ET patients demonstrated increases in MD in the bilatera

3 ET processes that are still not fully understood such as

4 ET uses evolutionary distances to estimate functional di

5 ET-1 inhibited single BK channels and transient BK curre

6 ET-1 production was readily detectable in the culture su

7 ET-1 stimulated Rab11A phosphorylation, which reduced Ra

8 ET-1 stimulates PKC-mediated phosphorylation of Rab11A a

9 ET-1-treated PbN-infected mice displayed leukocyte adhes

10 Endothelin 1 (ET-1), mainly produced from vascular endothelial cells,

11 lator reactivity and increased endothelin 1 (ET-1)-mediated vasoconstriction, two abnormalities contr

12 Endothelin-1 (ET-1) antagonists are a possibility because elevated ET-

13 Previous studies suggest that endothelin-1 (ET-1) contributes to the pathogenesis of ECM.

14 Endothelin-1 (ET-1) dose and time-dependently up-regulated TRPC6 expre

15 injury molecule-1 (KIM-1) and endothelin-1 (ET-1) during EVKP in a series of discarded human kidneys

16 Endothelin-1 (ET-1) is a potent endothelial-derived vasoconstrictor th

17 Since endothelin-1 (ET-1) is implicated in blood pressure (BP) regulation, w

18 ng the vasodilatory effects of endothelin-1 (ET-1) is induced by OA-NO2 Inasmuch as ET-1 is one of th

19 Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac and ren

20 Endothelin-1 (ET-1) promotes renal damage during cardiovascular diseas

21 ith increased plasma levels of endothelin-1 (ET-1), a potent vasoconstrictor, in sickle cell disease

22 Vasoconstrictors, including endothelin-1 (ET-1), inhibit myocyte BK channels, leading to contracti

23 ere, we studied the mutational profile of 17 ET patients negative for JAK2V617F, MPLW515K/L, and CALR

24 e isolates belonged to the cc11 lineage 11.2/ET-15 with fine type of PorA P1.5-1, 10-8; FetA F3-6; Po

25 iffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched

26 These findings indicate that dual ET-A/ET-B receptor inhibition improves HFpEF by abrogating ad

27 These results suggest that an active ET signaling pathway reduces root attractiveness to SCN

28 zymes can modulate their substrate affinity, ET rate and enzymatic activity.

29 Although ET tended to be higher in PM than in the other treatment

30 JA regulate each other's concentration in an ET-dependent manner.

31 Urinary levels of NGAL, KIM-1, and ET-1 were measured after EVKP.

32 M1, 41.5% of patients treated with T-DM1 and ET, and 15.1% with trastuzumab and ET ( P < .001).

33 , tissue damage, fibrosis, inflammation, and ET system activation.

34 METHODS AND ET-1, through activation of PKC (protein kinase C), redu

35 um creatinine, and higher levels of NGAL and ET-1 were associated with a higher EVKP score (P < 0.05)

36 The progress made on integrating QDs and ET in biological configurations and applications is revi

37 elevated renal GPCR-Gbetagamma signaling and ET system expression.

38 T-DM1 and ET, and 15.1% with trastuzumab and ET ( P < .001).

39 l ACC and JA concentrations in wild-type and ET-insensitive plants treated simultaneously with these

40 creased as much as 41% and 23% for yield and ET, respectively, as temperature (T) or rainfall (W) mov

41 but consistently underestimated mean annual ET by 50%.

42 an energy balance model, to partition annual ET into green (rainfall-based) and blue (surface water/g

43 Moreover, Arabidopsis ET insensitive mutants (ein2, ein2-1, ein2-5, ein3-1, ei

44 in-1 (ET-1) is induced by OA-NO2 Inasmuch as ET-1 is one of the key regulators of vascular tone, we c

45 ailed to properly deposit the pollen coat at ET, which made pollen grains clump and prevented their n

46 ribute to disease pathogenesis by augmenting ET-1 responses.

47 lly mechanical control method for automating ET data acquisition without using beam tilt/shift proces

48 We observed that endothelin receptor B [ET-B (gene name EDNRB)], the receptor mediating the vaso

49 ty, and suggest that the origin of DNA-based ETs as an innate immune defence predates the emergence o

50 gher degree, the pathway model of biological ET partly capture the predicted rate enhancements, our s

51 d4 with NSD3, and that substitutions of Brd4 ET residues essential for binding MLV IN also impair int

52 strate that the association between the BRD4 ET domain and JMJD6 likely requires a protein conformati

53 e NMR-derived solution structure of the Brd4 ET domain bound to a conserved peptide sequence from the

54 nfected cells were not readily detectable by ET at 5-days post-infection, whereas HIV-1-infected cell

55 the protein ET dynamics onto the calibrated ET catalogue shows that SCPZnI3 undergoes a switch in th

56 The new algorithm, called ET-MIp, identifies evolutionarily relevant patterns of a

57 e nongroupable, ST-11 clonal complex (cc11), ET-15, and clustered together phylogenetically.

58 ur results suggest that increases in central ET-1 activity could possibly play a role in chronic E2-i

59 effects on MAP are mediated through central ET-1.

60 In contrast, ET-1 did not alter surface BKalpha, total beta1, or tota

61 These findings show that RNR controls ET by lowering lambda, raising HDA, and directing PT bot

62 cryo-electron microscopy (cryo-EM), and cryo-ET (i.e., cryo-CLEM) of virus-infected or transfected ma

63 fied before acquisition of cryo-fLM and cryo-ET images, which is followed by data processing.

64 nd subtomogram averaging refinement for cryo-ET data of purified hepatitis B capsid particles and Sac

65 is possible from individual incomplete cryo-ET reconstructions.

66 employed to navigate the acquisition of cryo-ET data within FIB-lamellas at specific locations, unamb

67 We provided a sequence-specific cryo-ET tomogram fitting of DNA minicircles, registering the

68 Electron cryo-tomography (cryo-ET) is a technique that is used to produce 3D pictures (

69 TEM) and cryogenic electron tomography (cryo-ET) results indicate that the single helices have a peri

70 Here we used cryo-electron tomography (cryo-ET) to image the interplay between influenza virus and v

71 ngle particle cryo-electron tomography (cryo-ET) to investigate cyanophage-host interactions in this

72 bserved using cryo-electron tomography (cryo-ET).

73 s observed by cryo-electron tomography (cryo-ET).

74 ral data from cryo-electron tomography (cryo-ET).

75 two 1 km actual evapotranspiration datasets (ET), one obtained from a root zone water balance model a

76 ympathetic nervous system and the downstream ET system, respectively.

77 udies are needed to explore the role of dual ET-1 receptor antagonists in patients with HFpEF.

78 These findings indicate that dual ET-A/ET-B receptor inhibition improves HFpEF by abrogati

79 f the two ATP to two ADP and two Pi for each ET, Pi release, and dissociation of oxidized Fe protein-

80 tagonists are a possibility because elevated ET-1 levels are associated with adverse cardiovascular e

81 vailability and metabolism of ellagitannins (ETs) in healthy volunteers.

82 GPCRs), including adrenergic and endothelin (ET) receptors, after elevated neurohormonal signaling of

83 iation-induced lung injury via endotracheal (ET) or intravascular (IV) administration.

84 However, it enhanced ET-1 vasoconstriction and prolonged the increase in bloo

85 ocesses in photosynthesis, that is, LH, EnT, ET, and CAT, define the structure of this review with th

86 ficant correction in the angle of esotropia (ET) from 39+/-17Delta (14-55Delta) to 12 +/- 9.8Delta (0

87 or exciton coupling was employed to estimate ET rate and efficiency in the prepared material.

88 acid (SA), jasmonic acid (JA), and ethylene (ET) pathways suggest the involvement of a complex hormon

89 involved in jasmonic acid (JA) and ethylene (ET) signaling pathways were also accumulated and may par

90 ense signaling, jasmonic acid (JA)/ethylene (ET) and sialic acid (SA)-involved signaling, the MAPK si

91 when combined with JA depended on ethylene (ET) signaling, as shown by a decrease in the response in

92 -host Arabidopsis treated with the ethylene (ET)-synthesis inhibitor aminoethoxyvinylglycine (AVG) we

93 P to anomalies in annual evapotranspiration (ET), used here as a proxy for annually available water a

94 differences observed for evapotranspiration (ET), nitrogen uptake, and water use efficiency as compar

95 w soil moisture and high evapotranspiration (ET), occurred frequently around the world, and caused de

96 nd strongly coupled with evapotranspiration (ET).

97 , average temperature and evapotranspiration(ET).

98 turn mediates the decrease in extracellular ET-1 concentration.

99 The change in the extracellular ET-1 concentration was dependent on ET-B receptor expres

100 BAF, via its bromodomain and extraterminal (ET) domain, and this isoform was necessary for BRG1 recr

101 R of JMJD6 recognition by the extraterminal (ET) domain of BRD4 in that a JMJD6 peptide (Lys84-Asn96)

102 -sized electrode and its application to fast ET kinetic study with simple instrumentation should be u

103 For ET the targeted region is the ventralis intermedius (Vim

104 l, while the color only increased by 22% for ET.

105 respectively for PEF and TV, and only 3% for ET comparing to the control.

106 97% was noted respectively, and only 4% for ET.

107 from nearly 1 for ESPT to 10(-4)-10(-6) for ET.

108 ndamental properties, the rate constants for ET between the constituent heme groups, have so far evad

109 utation are the main diagnostic criteria for ET.

110 ents as well as healthy subjects at risk for ET.

111 more, in vitro studies showed a key role for ET receptor-Gbetagamma signaling in pathologic fibroblas

112 perior to current second-line treatments for ET.

113 required for protecting male fertility from ET.

114 Furthermore, monocytes purified from ET(flox/flox);Tie2-Cre( + ) mice, which conditionally la

115 ractiveness between another gain-of-function ET receptor mutant, etr1-3, or the loss-of-function muta

116 GeneMark-ET is a gene prediction tool that incorporates RNA-Seq d

117 barriers depend on covalency (which governs ET from Fe), and therefore vary with DFT functional.

118 recipitation)-induced ET variability and GPP-ET coupling strength.

119 In ET-challenged kidneys, compared to placebo treatment, ad

120 The SPN activity in ET was very low (2.1 +/- 0.1 Hz) and reminiscent of that

121 nhibitor) vs best available therapy (BAT) in ET and polycythemia vera patients resistant or intoleran

122 ificantly higher number of detected cells in ET injection compared to IV and a slight increase in the

123 -level sensitivity to interannual changes in ET among the 21 ecosystems.

124 ave identified brain morphometric changes in ET, but these changes remain poorly understood.

125 sing questions about the relevance of CMR in ET patients.

126 in the pathogenesis of cognitive deficits in ET.

127 itive deficits, which have been described in ET patients.

128 F) whereas CALR and MPL mutants are found in ET and PMF.

129 Cultivating RS-hAFSCs in ET conditions with TGFbeta may therefore increase their

130 ansion of hAFSCs and that TGFbeta present in ET conditions causes the phenotype of RS-hAFSCs to rever

131 ranscription with a concomitant reduction in ET-1 levels in cultured endothelial cells.

132 g, as shown by a decrease in the response in ET-insensitive plants.

133 siform areas was shown to play a key role in ET characterization.

134 co-limited by supply (precipitation)-induced ET variability and GPP-ET coupling strength.

135 Two-thirds of the 186 women initiated ET, which was evenly split between AI and tamoxifen, and

136 eate intrinsically inhomogeneous interfacial ET dynamics associated with both static and dynamic diso

137 n binding; and (vi) the rates of interflavin ET and the FMN domain conformational dynamics.

138 Tie2-Cre( + ) mice, which conditionally lack ET-1 in hematopoietic stem cells and vascular endothelia

139 The ligand-to-ligand ET rate calculated using two models is comparable with t

140 Here, findings of MAJIC-ET are reported, where the modified intention-to-treat p

141 The MAJIC-ET trial suggests that ruxolitinib is not superior to cu

142 from an asymptomatic Ethiopian rodent (MARV/ET/75/HO174) and verified it as L. adleri by comparison

143 Here, we studied whether T cell-mediated ET-1 production system exists and operates independent o

144 nstrates the existence of an immune-mediated ET-1 production induced by T cells upon activation throu

145 um)ethyl] methane thiosulfonate bromide (MTS-ET) increased Cx30-mediated currents with unperturbed et

146 such as incorporation of QDs into multistep ET processes or use of initial chemical and bioluminesce

147 r dissecting the pathogenesis of CALR-mutant ET and PMF.

148 We calibrated PZn-Ph-NDI ET dynamics as a function of solvent dielectric, and com

149 rk typically activated by both necrotrophic (ET/JA) and biotrophic (SA) pathogens supporting that S.

150 NGS on 26 additional triple-negative ETs detected only 1 MPLY591N mutation.

151 antly blunted after administration of 400 nm ET-1 (P < 0.05).

152 a NOS inhibitor) or a combination of 400 nm ET-1 and 10 mm l-NNA; in Protocol 3 (n = 8), only two si

153 (n = 8), only two sites (Control and 400 nm ET-1) were utilized to assess the influence of ET-1 on t

154 h lactated Ringer solution (Control), 400 nm ET-1, 10 mm N(G) -nitro-l-arginine (l-NNA; a NOS inhibit

155 er solution (Control), 40 pm, 4 nm or 400 nm ET-1; in Protocol 2 (n = 11) sites were perfused with la

156 The no-ET group showed either stable or declining symptom sever

157 e follow-up time points compared with the no-ET group.

158 , and bladder problems (P = .02) than the no-ET group.

159 Heightened activity of ET-1 in the neonatal endothelium might contribute to ina

160 for gene expression and protein analysis of ET-1 and its receptors.

161 The appearance of ET-induced nanosecond-scale kinetics in TA features is c

162 cal basis for it being a better biomarker of ET-1 synthesis.

163 esults suggest that triple-negative cases of ET and PMF do not represent a homogenous disease entity.

164 K2 in 49 additional triple-negative cases of ET or PMF.

165 The precise cause of ET is unknown, however pathological oscillations of a ne

166 to completely understand the contribution of ET-1 in this phenomenon.

167 trategy (i.e., calculation and disruption of ET pathways by mutations) may represent a new approach t

168 A high dose of ET-1 (400 nm) co-infused with l-NNA further attenuated C

169 ay alleviate the vasoconstrictive effects of ET-1 by removing it from the circulation.

170 Gene expression of ET-1 and ETA but not ETB receptors were upregulated in t

171 -1) were utilized to assess the influence of ET-1 on the dilatation capacity of vascular smooth muscl

172 ux into the monolayer MoS2 in the process of ET from photoexcited CdSe/ZnS nanocrystals.

173 uring cortical thickness for the purposes of ET diagnosis, applying feature selection and machine lea

174 rapidly increased the endothelial release of ET-1 from P1 but not P21 aortas.

175 lation with molecular dynamics simulation of ET free energies.

176 ttle is known about the production source of ET-1 in inflammation and immunity.

177 features allowed us to identify subgroups of ET patients as well as healthy subjects at risk for ET.

178 ligand recognition is different from that of ET domain recognition of NSD3, LANA of herpesvirus, and

179 regulate the OA-NO2-induced transcription of ET-B in human and mouse endothelial cells.

180 e our approach to diagnosis and treatment of ET.

181 ults expand the fundamental understanding of ET transfer processes in SWNT and allow for an accurate

182 cellular ET-1 concentration was dependent on ET-B receptor expression.

183 obese subjects and assessed its influence on ET-1-dependent vasoconstrictor tone in obesity.

184 ion step that could also be applied to other ET reactions performed in DMSO.

185 In properly selected patients, ET appears to benefit patients with large core and large

186 e dielectric constant following photoinduced ET, from epsilon(S) approximately 8 to epsilon(S) approx

187 o BK-SS mice significantly attenuated plasma ET-1 and PlGF levels.

188 dverse events (T-DM1 arms v trastuzumab plus ET; 5.3% v 3.1%, respectively) were reported.

189 vascular endothelial cells, did not produce ET-1 even when stimulated by antigen-specific T cell act

190 gocytes of mammals and invertebrates produce ETs, however, the evolutionary history of this DNA-based

191 magnetic beads in the inner chamber produced ET-1 when T cells were activated with antigen or anti-CD

192 Mapping the protein ET dynamics onto the calibrated ET catalogue shows that

193 tion of an Fe protein with the MoFe protein, ET from the Fe protein to the MoFe protein, hydrolysis o

194 oupled proton transfer-electron transfer (PT/ET) schemes involving negatively charged oxygenate ligan

195 For each QD-ET mechanism, a working explanation of the appropriate b

196 , nonprotonated oxygen; and (iii) long-range ET can only occur at a late step with a large driving fo

197 curs by an electron transfer-oxygen rebound (ET-OT) mechanism leading to aryl 1-methyl-1-phenylethyl

198 Patients receiving ET and controls receiving medical treatment alone were m

199 n of PCR products in bacteria expressing Red/ET recombineering proteins.

200 obesity, where it is accompanied by reduced ET-1-mediated vasoconstriction.

201 efore examining their biosensing and related ET utility.

202 llenge (n = 14 or 15 kidneys, respectively), ET (13 or 15 kidneys, respectively) progressively increa

203 A web interface retrieves ET rankings of sequence positions and maps results to a

204 The energy loss in the second ET step also was small, only 20 mV, and the potential fo

205 potential for the EC involved in the second ET was -0.15 V, a value documenting that >99% of the EC

206 tes of the essential electron-transfer step (ET) of this reaction in order to identify a possible pat

207 in the QDs ability to succeed in subsequent ET applications.

208 SEE SUN ET AL DOI101093/AWW306 FOR A SCIENTIFIC COMMENTARY ON TH

209 FATc4 using small interfering RNA suppressed ET-1-induced TRPC6 up-regulation.

210 Inhibition of PDE5 by sildenafil suppressed ET-1-induced activation of calcineurin/NFATc4 signaling

211 Our simulations confirm that ET in (6-4) photolyase proceeds out of equilibrium.

212 Test the hypothesis that ET-1 inhibits BK channels by altering BKalpha and beta1

213 Taken together, our study indicates that ET-1 stimulates TRPC6 expression by activation of calcin

214 early as 6 h post infection, indicating that ET signaling was activated in Arabidopsis early by SCN i

215 Molecular dynamics studies revealed that ET between Trp(233) and Cys(222) is possible and likely

216 Our findings show that ET-1 attenuates methacholine-induced cutaneous vasodilat

217 We show that ET-1 does not modulate methacholine-induced sweating at

218 Immunocytostaining showed that ET-1-producing cells emerged only in PBMCs stimulated wi

219 The ET in the eastern US arises mostly from GWET, and in the

220 Rab11A construct (Rab11A S177A) blocked the ET-1-induced Rab11A phosphorylation, reduction in Rab11A

221 ition, we show that a peptide comprising the ET binding motif (EBM) of MLV IN can disrupt the cognate

222 In conclusion, the ET-1 system is important for the development of tunicamy

223 d the LUMO of acceptor molecules dictate the ET process.

224 This approach was used to re-evaluate the ET rate constants measured for several electroactive spe

225 ubular cell cAMP levels, we hypothesized the ET would also do so.

226 reased and that Nrf2 silencing increased the ET-1 concentration in the culture media of endothelial c

227 lytic longevity, and (iii) insights into the ET mechanism at the biofilm interface.

228 s with the conserved hydrophobic core of the ET domain, and reinforced by electrostatic interactions

229 the inter-helical alpha1-alpha2 loop of the ET domain.

230 This study shows that the dynamics of the ET network support oscillations at the tremor frequency

231 increasing Nrf2-dependent expression of the ET-B receptor in endothelial cells, which in turn mediat

232 nteractions between MB and DNA, and then the ET in duplexes is limited by the diffusion of the MB-con

233 n96) adapts an alpha-helix when bound to the ET domain.

234 nd 100 mm MCh administration relative to the ET-1 site (all P < 0.05).

235 When the ET rate constants and the maximum VOC are plotted versus

236 This observation, where the ET driving force exceeds reorganization energies, allows

237 e or declining symptom severity, whereas the ET groups often showed increased severity over time, and

238 These studies aimed to determine whether the ET-1 system promotes renal ER stress development in resp

239 e we report the set of heme-heme theoretical ET rate constants that define electron flow in the tetra

240 acy of the combination of endocrine therapy (ET) with trastuzumab or with the potent antibody-cytotox

241 Endovascular therapy (ET) is typically not considered for patients with large

242 This ET-1 production was inhibited by anti-IFN-gamma and/or T

243 If this ET did not occur temperatures would be higher, so unders

244 nts for high-risk essential thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as

245 of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF).

246 Patients with essential thrombocythemia (ET) are at high risk for both thrombosis and hemorrhage.

247 olycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis (PMF) whereas CALR and MP

248 themia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).

249 Electron tomography (ET) provides a tool for imaging a single and unique biol

250 immunofluorescence, and electron tomography (ET) to longitudinally assess early HIV-1 spread in lymph

251 three-dimensional (3D) electron tomography (ET), determined that desmotubule structures found in the

252 accounts for nearly 70% and 30% of the total ET, respectively.

253 Bacillus anthracis edema toxin (ET) consists of protective antigen (PA), necessary for h

254 oparticle (AuNP)-mediated electron transfer (ET) across a self-assembled monolayer (SAM) was the deve

255 oceeded by intramolecular electron transfer (ET) between the triplet excited saccharin moiety and sul

256 In both mechanisms, electron transfer (ET) from phenol occurs after the PT (and after the barri

257 tive measurements of fast electron transfer (ET) kinetics when coupled with modeling predictions from

258 supporting an alternative electron transfer (ET) pathway from the heme.

259 occur due to inefficient electron transfer (ET) processes.

260 The electron transfer (ET) rate constants driving the VOC generation are shown

261 V results in increases in electron transfer (ET) rates by 30-fold, rate of O2 binding by 12-fold, O2

262 t to be essential for the electron transfer (ET) reactions in NOSs.

263 rmations are initiated by electron transfer (ET).

264 They also demonstrate energy transfer (ET) acceptor/sensitization properties which have been as

265 r growing role as versatile energy transfer (ET) donors and acceptors within a similar biological con

266 with rapid ligand-to-ligand energy transfer (ET).

267 ive structural analysis and energy-transfer (ET) studies of the fulleretic donor-acceptor scaffold.

268 urs by an electron transfer-oxygen transfer (ET-OT) mechanism as supported by the observation of prod

269 CALR(del/+) mice develop a transplantable ET-like disease with marked thrombocytosis, which is ass

270 mediating extracellular electron transport (ET), but one of their key fundamental properties, the ra

271 Extracellular traps (ETs) from neutrophils are reticulated nets of DNA decora

272 Though DBS is effective for treating ET, the mechanism through which the therapeutic effect i

273 ompared with patients with essential tremor (ET) and isolated dystonia (ID).

274 Essential tremor (ET) is one of the most prevalent movement disorders.

275 Essential tremor (ET), a movement disorder characterised by an uncontrolla

276 microstructural changes in essential tremor (ET).

277 in treating patients with essential tremor (ET).

278 ckness features alone distinguished the two, ET from controls, with 81% diagnostic accuracy.

279 otential when cultured under embryonic-type (ET) conditions.

280 Here, we show that culturing RS-hAFSCs under ET conditions confers faster proliferation and enhances

281 ge baseline ischemic cores on CTP undergoing ET with the outcomes of matched controls who had medical

282 odelled the network hypothesised to underlie ET using the Wilson-Cowan approach.

283 mperatures would be higher, so understanding ET trends is crucial to predict future temperatures.

284 maps of green water ET (GWET) and blue water ET (BWET) are produced for the conterminous United State

285 Time series maps of green water ET (GWET) and blue water ET (BWET) are produced for the

286 While ET receptor gain-of-function mutant ein4-1 attracted mor

287 ratio of antiplatelet therapy in adults with ET is highly uncertain.

288 its of antithrombotic therapy in adults with ET.

289 ng the apical membrane of tubular cells with ET but not PA, and urine aquaporin 2 levels were higher

290 Synthesis of these peptides correlated with ET-1, and plasma ELDP and CT-proET-1 were elevated in pa

291 nd urine aquaporin 2 levels were higher with ET (5.52 +/- 1.06 ng/ml versus 1.51 +/- 0.44 ng/ml [mean

292 ethods to a study sample of 18 patients with ET and 18 age- and sex-matched healthy control subjects.

293 rated dose (MTD) of oral OA in patients with ET and assess the pharmacokinetics (PK) and pharmacodyna

294 important in the management of patients with ET.

295 reated patients by 98% relative to that with ET.

296 (pCR) rates of T-DM1 versus trastuzumab with ET in early HER2-positive/HR-positive breast cancer.

297 M1 with or without ET or to trastuzumab with ET.

298 rastuzumab emtansine (T-DM1) with or without ET for this subgroup.

299 ssigned to 12 weeks of T-DM1 with or without ET or to trastuzumab with ET.

300 ates that neoadjuvant T-DM1 (with or without ET) given for only 12 weeks results in a clinically mean