ライフサイエンスコーパス: ETEC

1 ETEC adheres to host epithelial cells in the small intes

2 ETEC adhesion is mediated by lectins (adhesins) that bin

3 ETEC causes disease by colonizing the small intestine an

4 ETEC infection also caused a drastic inhibition of host

5 ETEC seedlings revealed increased photosynthesis and imp

6 ETEC strains expressing F4 fimbriae are associated with

7 ETEC strains that express the heat-stable toxin (ST), wi

8 ETEC was significantly associated with diarrhea (crude o

9 ETEC-associated diarrhea remains common among children l

10 ETEC-mediated diarrhea is orchestrated by heat-labile to

11 as defined by the reference method was 1.2% ETEC, 0.1% Vibrio, 0% Y. enterocolitica, and 0% P. shige

12 Of the strains examined, 21 of 94 ETEC isolates lacked any previously identified CF.

13 related to EPEC, but appear to have acquired ETEC virulence genes.

14 ts showed that high pup survival rates after ETEC challenge were associated with suckling but not bir

15 vine colostral IgG (bIgG) antibodies against ETEC challenge in volunteers.

16 nisms by which intestinal antibodies against ETEC fimbriae function to prevent disease.

17 ecombinant EtpA conferred protection against ETEC H10407 in this model.

18 ies conferred significant protection against ETEC, providing the first clinical evidence that fimbria

19 providing broad-spectrum protection against ETEC-induced diarrhoeal disease.

20 subunit and live-attenuated vaccines against ETEC and other enteric pathogens, including Shigella fle

21 n antigen in development of vaccines against ETEC diarrhea because of its poor immunogenicity.

22 ave been used in developing vaccines against ETEC diarrhea.

23 to develop effective toxoid vaccines against ETEC-associated diarrhea in animals and humans.

24 a heavy chain-only antibodies (VHHs) against ETEC to the Fc part of a porcine immunoglobulin (IgG or

25 ic regions were conserved exclusively in all ETEC genomes; however, we identified more genomic conten

26 ntified more genomic content conserved among ETEC genomes than among non-ETEC E. coli genomes, sugges

27 ggesting that it is widely distributed among ETEC strains.

28 This makes ST an attractive target for an ETEC vaccine.

29 One clone, derived from an ETEC 1766a genomic library (clone G10), did not produce

30 sites in the genome of H10407 (O78:H11), an ETEC strain that was originally isolated from the stool

31 We elucidate atomic structures of an ETEC major pilin subunit, CfaB, from colonization factor

32 Entamoeba histolytica, Cryptosporidium, and ETEC infections and more severe diarrhea.

33 Incidence of diarrhea and ETEC-associated diarrhea was 7.8 and 1.48 per child-year

34 e efficacy against travellers' diarrhoea and ETEC.

35 trobacter rodentium, Salmonella enterica and ETEC were capable of complementing Aar activity by repre

36 A sequencing, demonstrated that the EPEC and ETEC virulence genes of these hybrid isolates were diffe

37 t contain virulence factors of both EPEC and ETEC.

38 association between H. pylori infection and ETEC diarrhea was similar, albeit not statistically sign

39 As a proof of principle, we designed anti-ETEC antibodies by fusing variable domains of llama heav

40 ed virulence factors or have the appropriate ETEC core genome required for virulence.

41 yl cyclase toxin-producing bacteria, such as ETEC.

42 in complex and dynamic interactions between ETEC and the gastrointestinal mucosae in which host glyc

43 were accompanied by visible changes in both ETEC architecture and the expression of surface antigens

44 ls in a 24 h period) in which either or both ETEC enterotoxins (LT and heat-stable toxin [ST]) were d

45 ying that each fimbrial type was acquired by ETEC strains very recently, consistent with a recent ori

46 compound for treatment of diarrhea caused by ETEC and other adenylyl cyclase toxin-producing bacteria

47 otect travellers against diarrhoea caused by ETEC or other organisms.

48 ith the CFA/I and CS20 fimbriae expressed by ETEC strains.

49 The three fimbriae are expressed by ETEC, colonize in similar gut environments, and exhibit

50 cal characteristics of fimbriae expressed by ETEC.

51 fferences in host gene expression induced by ETEC infection.

52 , potentially, secretory outcomes induced by ETEC strains expressing LT+ST compared with strains that

53 host interactions are finely orchestrated by ETEC and are characterized by coordinated responses invo

54 identified a number of molecules produced by ETEC that contribute to its virulence and are novel anti

55 y and temporally diverse set of 192 clinical ETEC strains and identified 12 novel LT variants.

56 aracterized in ETEC at least 30% of clinical ETEC isolates lack known CFs.

57 ETAC), or elevated temperature/elevated CO2 (ETEC).

58 nd pathogenicity by enterotoxigenic E. coli (ETEC) and other organisms.

59 in EHEC O157:H7 and enterotoxigenic E. coli (ETEC) O139 and O149.

60 HLT encoded from an enterotoxigenic E. coli (ETEC) strain isolated from an avian host.

61 o sequenced a human enterotoxigenic E. coli (ETEC) strain of the same ST23 serogroup O78 lineage.

62 richia coli (EAEC), enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), Shigella spp., C

63 E. coli (EPEC) and enterotoxigenic E. coli (ETEC).

64 on factors (CFs) of enterotoxigenic E. coli (ETEC).

65 (n = 66), enterotoxigenic Escherichia coli (ETEC) (n = 31) or negative for bacterial pathogens (n =

66 (LT) from enterotoxigenic Escherichia coli (ETEC) and cholera toxin (CT) from Vibrio cholerae.

67 termine if enterotoxigenic Escherichia coli (ETEC) and enteroaggregative E. coli (EAEC) DNA could be

68 Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrhea worldwide, and infec

69 es against enterotoxigenic Escherichia coli (ETEC) are being developed, many of which target common f

70 Enterotoxigenic Escherichia coli (ETEC) cause more than 500,000 deaths each year in the de

71 Enterotoxigenic Escherichia coli (ETEC) causes approximately 20% of the acute infectious d

72 Enterotoxigenic Escherichia coli (ETEC) causes considerable morbidity and mortality due to

73 Enterotoxigenic Escherichia coli (ETEC) causes diarrheal disease and significant morbidity

74 chetype of enterotoxigenic Escherichia coli (ETEC) Class 5 fimbriae.

75 Enterotoxigenic Escherichia coli (ETEC) commonly elaborate colonization factors comprising

76 imbriae of enterotoxigenic Escherichia coli (ETEC) comprise eight serologically discrete colonization

77 Porcine enterotoxigenic Escherichia coli (ETEC) continues to result in major morbidity and mortali

78 Enterotoxigenic Escherichia coli (ETEC) has consistently been the predominant bacterial ca

79 enges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important

80 antage for enterotoxigenic Escherichia coli (ETEC) in vivo, we hypothesized that LT preconditions the

81 and severe enterotoxigenic Escherichia coli (ETEC) infections are caused by strains that express K88

82 Enterotoxigenic Escherichia coli (ETEC) is a bacterial pathogen that causes diarrhea in ch

83 Enterotoxigenic Escherichia coli (ETEC) is a common cause of travelers' and postweaning di

84 Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea.

85 Enterotoxigenic Escherichia coli (ETEC) is a Gram-negative enteric pathogen that causes pr

86 Globally, enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' dia

87 Enterotoxigenic Escherichia coli (ETEC) is a leading cause of death due to diarrheal illne

88 Enterotoxigenic Escherichia coli (ETEC) is a leading cause of traveler's diarrhea worldwid

89 Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal illness in children

90 Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to

91 Enterotoxigenic Escherichia coli (ETEC) is a major cause of travellers' diarrhoea.

92 Enterotoxigenic Escherichia coli (ETEC) is a major cause of travellers' diarrhoea.

93 Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease and de

94 Enterotoxigenic Escherichia coli (ETEC) is a significant cause of morbidity and mortality

95 Enterotoxigenic Escherichia coli (ETEC) is an important pathogenic variant (pathovar) of E

96 Enterotoxigenic Escherichia coli (ETEC) is commonly associated with diarrhea in Egyptian c

97 Enterotoxigenic Escherichia coli (ETEC) is the leading cause of traveler's diarrhea and ch

98 Enterotoxigenic Escherichia coli (ETEC) produces both heat-labile (LT) and heat-stable (ST

99 Enterotoxigenic Escherichia coli (ETEC) produces the ADP-ribosyltransferase toxin known as

100 Enterotoxigenic Escherichia coli (ETEC) strains are a leading cause of morbidity and morta

101 Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal disease in

102 Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal disease in

103 Enterotoxigenic Escherichia coli (ETEC) strains are among the most common causes of diarrh

104 Enterotoxigenic Escherichia coli (ETEC) strains are important causes of intestinal disease

105 Enterotoxigenic Escherichia coli (ETEC) strains are important pathogens in developing coun

106 The enterotoxigenic Escherichia coli (ETEC) strains are major causes of morbidity and mortalit

107 Enterotoxigenic Escherichia coli (ETEC) strains expressing K88 (F4) fimbriae are the major

108 strain of enterotoxigenic Escherichia coli (ETEC) that utilizes CFA/I pili to adhere to surfaces of

109 ential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea.

110 Enterotoxigenic Escherichia coli (ETEC), a leading cause of acute diarrhea, colonizes the

111 including enterotoxigenic Escherichia coli (ETEC), a major cause of diarrhoea in travellers and chil

112 Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce hea

113 disease by enterotoxigenic Escherichia coli (ETEC), an E. coli pathotype that inflicts an enormous gl

114 accine for enterotoxigenic Escherichia coli (ETEC), an important cause of diarrheal illness.

115 olerae O1, enterotoxigenic Escherichia coli (ETEC), enteropathogenic E. coli, Campylobacter jejuni, a

116 r included enterotoxigenic Escherichia coli (ETEC), enteropathogenic E.coli (EPEC), Listeria monocyto

117 including enterotoxigenic Escherichia coli (ETEC), produce one or more serine proteases that are sec

118 es against enterotoxigenic Escherichia coli (ETEC), the most common bacteria causing diarrhea in chil

119 ocolitica, enterotoxigenic Escherichia coli (ETEC), Vibrio, and Plesiomonas shigelloides The study in

120 Enterotoxigenic Escherichia coli (ETEC)-caused postweaning diarrhea in piglets is one such

121 virus, and enterotoxigenic Escherichia coli (ETEC).

122 ive E. coli [EAEC], enterotoxigenic E. coli [ETEC], enteropathogenic E. coli [EPEC], and Shiga-toxige

123 ella spp., enterotoxigenic Escherichia coli [ETEC], Shiga toxin-producing E. coli [STEC], E. coli O15

124 Enterotoxigenic Escherichia coli(ETEC) is an important cause of diarrheal disease and dea

125 onpermeabilized bacteria, while, conversely, ETEC 1766a seems to secrete most of the produced autotra

126 briae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials.

127 tes represent distinct and globally dominant ETEC clonal groups.

128 vided long-awaited information for effective ETEC vaccine development.

129 Enterotoxigenic (ETEC) Escherichia coli (E. coli) causes traveller's diar

130 i O148 is a nonencapsulated enterotoxigenic (ETEC) Gram negative bacterium that can cause diarrhea, h

131 nia spp., Citrobacter spp., enterotoxigenic (ETEC) and enteroaggregative E. coli (EAEC), and members

132 ulture methods detected Shigella spp., EPEC, ETEC, and EAEC in smaller proportions of the samples tha

133 itial exposure, only ST and LT/ST-expressing ETEC isolates (P < 0.0001) were associated with disease

134 ntributor than STb to the virulence of F4(+) ETEC infections in young F4ac receptor-positive pigs les

135 sion of LT enhanced the ability of the F4(+) ETEC strain to colonize the small intestine.

136 Among its virulence factors, ETEC produces heat-labile enterotoxin (LT).

137 dress this, we sequenced the genomes of five ETEC isolates obtained from children in Guinea-Bissau wi

138 f host phosphatidylserine exposure following ETEC infection suggested that ETEC induced changes in pl

139 for all specimens combined were as follows: ETEC, 97.6% (87.4 to 99.6), 99.8% (99.5 to 99.9), and 0.

140 li O157:H7; 95% for Giardia lamblia; 94% for ETEC and STEC; 93% for Shigella spp.; 92% for Salmonella

141 onditions the host intestinal epithelium for ETEC adherence.

142 ith alternate PCR and sequencing, except for ETEC, for which the reference method was two alternate P

143 l molecular signaling events responsible for ETEC-induced diarrhea, including cyclic GMP (cGMP) produ

144 five E. coli-like colonies were screened for ETEC enterotoxins using a GM1 enzyme-linked immunosorben

145 he availability of genomic DNA sequences for ETEC strains coupled with proteomics technology affords

146 other TPS proteins may be viable targets for ETEC vaccine development.

147 and 63%, respectively, compared to those for ETEC.

148 The adhesion of four ETEC strains (E. coli H10407, CFA(+), K99 and K88) to PS

149 containing heat-labile enterotoxin (LT) from ETEC delivered to the skin by patch in travellers to Mex

150 ies have focused on soluble LT purified from ETEC periplasm.

151 subunit (LTB) that reduce its secretion from ETEC without global effects on the toxin.

152 in addition to the two previously generated ETEC genomes, highlights the genomic diversity of ETEC.

153 cipients had diarrhoea, of whom 11 (10%) had ETEC diarrhoea.

154 for developing toxoid vaccines against human ETEC diarrhea.

155 were generally distinct from existing human ETEC database isolates.

156 rming units of colonization factor I (CFA/I)-ETEC strain H10407 with buffer.

157 For CFA/I-ETEC strain H10407, which has been extensively studied i

158 Fecal PCR was performed to identify ETEC and EAEC in DNA extracted from stools and from occu

159 SR) analysis was further applied to identify ETEC-specific genomic regions when compared to non-ETEC

160 against the passenger domain of EatA impair ETEC delivery of labile toxin to epithelial cells sugges

161 A range of fimbrial adhesins in ETEC strains determines host and tissue tropism.

162 A central challenge in ETEC vaccinology has been the identification of conserve

163 cted promoters were used to study changes in ETEC transcriptomes.

164 s) have been identified and characterized in ETEC at least 30% of clinical ETEC isolates lack known C

165 ch also secretes LT, are highly conserved in ETEC and exist in other enteric pathogens, including oth

166 ile toxin (LT) are virulence determinants in ETEC diarrhea.

167 oxins (ST), are the key virulence factors in ETEC diarrhea.

168 ion of virulence and colonization factors in ETEC.

169 The EtpA protein, identified in ETEC H10407 in a recent search for candidate immunogens,

170 an autotransporter previously identified in ETEC, possesses a functional serine protease motif withi

171 xpressed and secreted at wild-type levels in ETEC.

172 ave examined specific regulatory networks in ETEC, although little is known about the global effects

173 versely affecting expression or secretion in ETEC.

174 An isogenic ETEC 1766a strain with a tleA mutation showed an adhesio

175 Isolated ETEC expresses a plethora of colonization factors (fimbr

176 ls of porcine diarrhea disease caused by K88 ETEC strains.

177 coverage) and that is called TleA (Tsh-like ETEC autotransporter) herein.

178 tedly broad protective effects against LT(+) ETEC and mixed infections when using a toxin-based enter

179 Given the common exposure to LT(+) ETEC by humans visiting or residing in regions of endemi

180 1 allele variants were correlated with major ETEC lineages expressing CS1 + CS3 or CS2 + CS3, and the

181 2 allele variants were correlated with major ETEC lineages expressing CS5 + CS6 or CFA/I.

182 Although this protein is expressed by many ETEC strains and is highly immunogenic, its precise func

183 ericidal, upregulates the expression of many ETEC virulence factors, including heat-stable (estA) and

184 urface antigen 20 (CS20) fimbriae as a model ETEC colonization factor, we show using force spectrosco

185 Similarly, more ETEC cases were detected from card DNA (38%) than from f

186 r immunogenic peptide, is necessary, as most ETEC strains can produce both toxins.

187 ctive antigen, using a lethal neonatal mouse ETEC challenge model and passive dam vaccination.

188 escent human sera obtained following natural ETEC infections demonstrated multiple immunoreactive mol

189 ion of 136 human CF-positive and CF-negative ETEC strains of different geographic origins.

190 conserved among ETEC genomes than among non-ETEC E. coli genomes, suggesting that ETEC isolates shar

191 pecific genomic regions when compared to non-ETEC genomes, as well as genes that are more associated

192 ese studies suggest that CexE may be a novel ETEC virulence factor because its expression is controll

193 CS20 fimbriae impedes sustained adhesion of ETEC to the intestinal mucosal surface.

194 Particularly, passive oral administration of ETEC anti-fimbrial antibodies prevent ETEC diarrhea.

195 th of toxin-induced cAMP accumulation and of ETEC adherence to epithelial cells.

196 an important role for ECP in the biology of ETEC, particularly in CF-negative strains, and in human

197 sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally

198 e that influences intestinal colonization of ETEC by degrading the major mucins in the small intestin

199 le is known about the genomic composition of ETEC.

200 he conventional methods for the detection of ETEC, Vibrio, Y. enterocolitica, and P. shigelloides in

201 The distribution of ETEC enterotoxins varied between the symptomatic childre

202 genomes, highlights the genomic diversity of ETEC.

203 Many elements of ETEC pathogenesis are still poorly defined.

204 The epidemiology of ETEC diarrhea among children living in a rural Egyptian

205 tness have persisted during the evolution of ETEC and have spread globally.

206 ation between initial or repeat excretion of ETEC and the occurrences of diarrhea.

207 seq), was used to quantify the expression of ETEC virulence and colonization factors.

208 The key virulence factors of ETEC strains, their serotypes, and their fimbrial compon

209 attributed to this biomechanical feature of ETEC fimbriae.

210 ANR homologs of ETEC and Vibrio cholerae bound to AggR as well as to oth

211 Incidence of ETEC infection was estimated among children with diarrhe

212 The majority of ETEC strains produce both ST and LT.

213 his hypothesis, we used an in vitro model of ETEC adherence to examine the role of LT in promoting ba

214 ere use a recently developed murine model of ETEC intestinal colonization to examine the immunogenici

215 , we found that a major effector molecule of ETEC, the heat-labile enterotoxin (LT), may enhance thes

216 in gene expression and surface morphology of ETEC upon interaction with intestinal epithelial cells i

217 nisation with a patch containing 37.5 mug of ETEC LT or a placebo patch.

218 itional insight into the intricate nature of ETEC interactions with the intestinal epithelium that ha

219 dies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suita

220 We evaluated the pathogenicity of ETEC isolates in a birth cohort of children living in a

221 The pathogenicity of ETEC was estimated in symptomatic children compared to t

222 es of a geographically diverse population of ETEC elaborating CFA/I (n = 31), CS17 (n = 20), and CS2

223 ard reaction may serve in the prophylaxis of ETEC K88 diarrhoea.

224 , an immunogenic secreted serine protease of ETEC, contributes to virulence by degrading MUC2, the ma

225 points were to investigate the field rate of ETEC diarrhoea, and to assess the safety of heat-labile

226 PCR screening of ETEC isolates revealed that 8.6% (n = 13) of "CF negativ

227 A study of ETEC isolates from humans in Brazil reported the existen

228 EtpA interacts with the tips of ETEC flagella to promote bacterial adhesion, toxin deliv

229 ector EspB of EPEC, and heat-labile toxin of ETEC were secreted.

230 These studies increase our understanding of ETEC evolution, as well as provide insight into virulenc

231 d pili, including the CFA/I pili, present on ETEC and other Gram-negative bacterial pathogens.

232 Pig ETEC strain was unable to ferment galactooligosaccharide

233 nd K88ad) have been identified among porcine ETEC strains.

234 hylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic conten

235 Overall, most porcine ETEC strains appear to have emerged from a limited subse

236 presented that probe the ability of porcine ETEC isolates to induce apoptosis and cell death in porc

237 ea revealed that a limited subset of porcine ETEC lineages exist that generally contain common toxin

238 The genomes of porcine ETEC strains UMNK88 and UMNF18 were both found to contai

239 r of animal pathogens (eg, bovine or porcine ETEC) that do not cause human illness.

240 ces of K88-positive and F18-positive porcine ETEC strains and examined the phylogenetic distribution

241 otected when challenged with an STa-positive ETEC strain.

242 ion of ETEC anti-fimbrial antibodies prevent ETEC diarrhea.

243 erstanding, tracking and possibly preventing ETEC disease.

244 livery of the heat-labile toxin, a principal ETEC virulence determinant.

245 in scores of enteroid lumens, recapitulating ETEC-induced intestinal secretion.

246 enterotoxins and pathogenicity during repeat ETEC infections appears to be variable and dependent on

247 e breast-feeding was protective for repeated ETEC infection.

248 High risk of repeated ETEC diarrhea was associated with being over 6 months of

249 Here we demonstrate that YghJ, a secreted ETEC antigen identified in immunoproteomic studies using

250 unction blocked the activity of the secreted ETEC factor, suggesting that this yet-uncharacterized ac

251 lonization factor genes across all sequenced ETEC genomes not only identified variability but also in

252 alignment method demonstrated that sequenced ETEC strains share approximately 2.7 million bases of ge

253 in the placebo group had moderate or severe ETEC diarrhoea (vaccine efficacy 34.6%, -2.2 to 58.9; p=

254 higella spp, rotavirus, adenovirus 40/41, ST-ETEC, Cryptosporidium spp, and Campylobacter spp.

255 eat-stable enterotoxin-producing E coli ([ST-ETEC] around 1.5 times).

256 Norovirus GII, Cryptosporidium, Shigella, ST-ETEC, and adenovirus 40/41 were also important.

257 ting five pathogens (rotavirus, Shigella, ST-ETEC, Cryptosporidium, typical enteropathogenic E coli)

258 erichia coli producing heat-stable toxin (ST-ETEC; with or without co-expression of heat-labile enter

259 ed with increased risk of case death were ST-ETEC (hazard ratio [HR] 1.9; 0.99-3.5) and typical enter

260 ains were more closely related to human ST23 ETEC than to APEC O1, indicating that separation of path

261 uced apoptosis markedly increased subsequent ETEC adherence.

262 A sustained ETEC infection, under adverse conditions of dynamic shea

263 Here we report that ETEC secretes a heat-stable, proteinaceous factor that b

264 These data suggest that ETEC evades the host innate immune response by directly

265 Emerging data suggest that ETEC undergoes considerable changes in its surface archi

266 sure following ETEC infection suggested that ETEC induced changes in plasma membrane asymmetry, indep

267 ng non-ETEC E. coli genomes, suggesting that ETEC isolates share a genomic core.

268 The ETEC strain 1766a, obtained from a child with watery dia

269 In contrast, the ETEC colonization factors CS1 and CS3 were downregulated

270 lusion, naturally occurring mutations in the ETEC adhesive and non-adhesive subunits altered function

271 In corroboration, preincubation of the ETEC inoculum with antiadhesin and antifimbrial bovine c

272 genome" confirmed the diverse history of the ETEC pathovar and provides a finer resolution of the E.

273 toxin would have a suppressive effect on the ETEC colonization capabilities.

274 noprecipitation experiments suggest that the ETEC factor functions by preventing IkappaBalpha polyubi

275 ponses corroborating reduced exposure to the ETEC pathogen, and a significantly higher weight gain co

276 ted that some antigens are restricted to the ETEC pathovar.

277 partner adhesin that is conserved within the ETEC pathovar.

278 Therefore, ETEC's T2S system seems to accommodate mutations in CTB

279 a useful complement to ongoing approaches to ETEC vaccine development.

280 nd at least one of these episodes was due to ETEC.

281 We report that mice repeatedly exposed to ETEC are protected from subsequent colonization and that

282 al function may provide insights relevant to ETEC vaccine development.

283 CfaD, and its distribution is restricted to ETEC.

284 ould frequently render the gut vulnerable to ETEC and other enteric infections.

285 protects against LT and LT/heat-stable toxin ETEC disease in the field, was 6,741 EU (a 3.3-fold incr

286 dentify novel compounds to prevent and treat ETEC diarrheal disease.

287 enged 30 healthy adults with an unattenuated ETEC strain, and collected serial blood samples shortly

288 ic analyses of 94 previously uncharacterized ETEC isolates demonstrated remarkable genomic diversity,

289 ave important implications for understanding ETEC pathogenesis, unraveling immunologic responses indu

290 n, 31 volunteers received product, underwent ETEC challenge, and were included in the per protocol ef

291 dings from the first challenge studies using ETEC-expressing colonization factor fimbria CS17 and CS1

292 The extent to which ETEC damages host cells is unclear.

293 While ETEC infection resulted in activation of host caspase 3,

294 vellers' diarrhoea is a common ailment, with ETEC diarrhoea illness occurring in 10% of cases.

295 ve" LT + STp isolates and is associated with ETEC that cause diarrhea.

296 Pretreating intestinal epithelial cells with ETEC supernatant significantly blocked the degradation o

297 host response to experimental challenge with ETEC.

298 relevant chemical signals were combined with ETEC isolate E24377A during growth in either Luria broth

299 roteomics approach to antigen discovery with ETEC strain H10407.

300 protective against intestinal infection with ETEC.