ライフサイエンスコーパス: Ehrlichia

1 enus Anaplasma and the closely related genus Ehrlichia.

2 , lipopolysaccharide-lacking, monocytotropic Ehrlichia.

3 o a low dose but succumbed to a high dose of Ehrlichia.

4 otropic ehrlichiosis caused by Ixodes ovatus ehrlichia.

5 le targeted knockouts may become feasible in Ehrlichia.

6 l revealed key themes in the pathogenesis of Ehrlichia.

7 unopathology during infection with monocytic Ehrlichia.

8 ) had increased resistance to infection with Ehrlichia.

9 2), IL-15, and IL-18 genes, which might make Ehrlichia a stealth organism for the macrophage.

10 tive obligate intracellular bacteria such as Ehrlichia and Anaplasma phagocytophilum, as well as obli

11 say that detects known pathogenic species of Ehrlichia and ANAPLASMA: The species was determined by u

12 omology to outer membrane protein genes from Ehrlichia and Cowdria spp.: p30 of Ehrlichia canis (< or

13 cytokine associated with protection against ehrlichia and needed for rapid generation of variant-spe

14 Also of note was that Ehrlichia and Rickettsia bacteria were detected in each

15 ecent findings include descriptions of novel Ehrlichia and Rickettsia species, recognition of the occ

16 of CD4(+) and CD8(+) T cells in immunity to Ehrlichia and the pathogenesis of fatal ehrlichiosis cau

17 cellular organisms in the genera Rickettsia, Ehrlichia, and Anaplasma, persists in ticks and mammalia

18 Ehrlichia antibody testing was performed by using an ind

19 fatal monocytotropic ehrlichiosis caused by Ehrlichia bacteria from Ixodes ovatus (IOE) to determine

20 Our studies of highly pathogenic Ehrlichia bacteria isolated from Ixodes ovatus (IOE) rev

21 The 38 specimens that were positive for Ehrlichia by both PCR/ESI-MS and the PCR-EIA were furthe

22 adaptive pathogenic immune responses against Ehrlichia by influencing T cell priming functions of den

23 tA genes revealed the presence of Anaplasma, Ehrlichia, Candidatus Neoehrlichia, and Rickettsia bacte

24 enes from Ehrlichia and Cowdria spp.: p30 of Ehrlichia canis (< or =71.3%), p28 of E. chaffeensis (<

25 Ehrlichia canis and E. chaffeensis are tick-borne obliga

26 Immunoreactive proteins of Ehrlichia canis and Ehrlichia chaffeensis that have been

27 phagocytophilum antibodies but negative for Ehrlichia canis antibodies.

28 Ehrlichia canis causes a potentially fatal rickettsial d

29 n designated MmpA was cloned by screening an Ehrlichia canis expression library with convalescent dog

30 on oligonucleotide sequences from the unique Ehrlichia canis gene, p30, to facilitate studies that re

31 Ehrlichia canis has a small subset of major immunoreacti

32 Ehrlichia canis major immunoreactive proteins of 36 and

33 m MSP2 (p44), Ehrlichia chaffeensis p28-OMP, Ehrlichia canis p30, and Ehrlichia ruminantium MAP1, and

34 .3 kDa with 26.3% identity to a hypothetical Ehrlichia canis protein with no known function.

35 ehrlichiosis were examined for infection of Ehrlichia canis using PCR, multiplex real-time PCR, and

36 Ehrlichia canis virB9 was cloned and expressed.

37 The major antigenic protein 2 (MAP2) of Ehrlichia canis was cloned and expressed.

38 reactive ferric ion-binding protein (Fbp) of Ehrlichia canis was identified and its iron-binding capa

39 -kDa major immunoreactive protein (gp200) of Ehrlichia canis were defined.

40 (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA acti

41 Ehrlichia canis, a small obligately intracellular, tick-

42 Ehrlichia canis, an obligatory intracellular bacterium o

43 pathogens tested (Anaplasma phagocytophilum, Ehrlichia canis, and Rickettsia rickettsii), but the sam

44 siales, including Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeensis, E. ewingii, Rickettsia

45 ndicated that both dogs were coinfected with Ehrlichia canis, E. platys, and E. equi.

46 nst Ehrlichia phagocytophila but not against Ehrlichia canis, Ehrlichia ewingii, B. burgdorferi, or C

47 been identified in Ehrlichia chaffeensis and Ehrlichia canis, including three molecularly and immunol

48 sociated with exposure to canine parvovirus, Ehrlichia canis, Neospora caninum and perhaps rabies vir

49 We previously culture isolated a strain of Ehrlichia canis, the causative agent of canine ehrlichio

50 Rhipicephalus sanguineus ticks transmit Ehrlichia canis, the etiologic agent of canine ehrlichio

51 phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia canis.

52 ttsial pathogens in the genera Anaplasma and Ehrlichia cause acute infection in immunologically naive

53 000 and 2001 were positive by PCR assays for Ehrlichia chaffeensis (50 of 217; 23%), Ehrlichia ewingi

54 Whereas Ehrlichia chaffeensis (HME) often causes meningoencephal

55 coinfections with nonviral pathogens (2 with Ehrlichia chaffeensis and 1 with Mycoplasma pneumoniae).

56 Ehrlichia chaffeensis and Anaplasma phagocytophilum are

57 y both a polymerase chain reaction assay for Ehrlichia chaffeensis and by the demonstration of morula

58 Ehrlichia chaffeensis and E. canis have a small subset o

59 Only Ehrlichia chaffeensis and E. ewingii have been thought t

60 e disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identifie

61 unoreactive proteins have been identified in Ehrlichia chaffeensis and Ehrlichia canis, including thr

62 locus is conserved in the omp1 gene locus of Ehrlichia chaffeensis and p30 gene locus of E. canis des

63 basis of serologic cross-reactivity between Ehrlichia chaffeensis and the agent of HGE.

64 Ehrlichia chaffeensis AnkA was recently reported to be t

65 minant outer membrane proteins (P28 OMPs) of Ehrlichia chaffeensis are encoded by a multigene family.

66 ng an indirect immunofluorescence assay with Ehrlichia chaffeensis as the antigenic substrate.

67 single copy of the mmpA gene in E. canis and Ehrlichia chaffeensis but not in the human granulocytic

68 lasm of the reticulate forms of E. canis and Ehrlichia chaffeensis but was notably found on extracell

69 Ehrlichia chaffeensis components that induce inflammatio

70 g ubiquitous transcription across the entire Ehrlichia chaffeensis genome.

71 n the closely related A. phagocytophilum and Ehrlichia chaffeensis have been shown to localize to the

72 sive myocarditis and multiorgan failure from Ehrlichia chaffeensis in a previously healthy adolescent

73 Previous studies of Ehrlichia chaffeensis infection in the mouse have demons

74 can protect susceptible SCID mice from fatal Ehrlichia chaffeensis infection, an observation that has

75 Ehrlichia chaffeensis invades and survives in phagocytes

76 Human monocytotropic ehrlichiosis caused by Ehrlichia chaffeensis is a life-threatening, tick-borne,

77 Ehrlichia chaffeensis is an obligate intracellular bacte

78 Ehrlichia chaffeensis is an obligate intracellular bacte

79 Ehrlichia chaffeensis is an obligate intracellular bacte

80 Ehrlichia chaffeensis is an obligate, intracellular bact

81 Ehrlichia chaffeensis is an obligately intracellular bac

82 Ehrlichia chaffeensis is an obligately intracellular bac

83 Ehrlichia chaffeensis is an obligately intracellular bac

84 Ehrlichia chaffeensis is an obligately intracellular bac

85 Ehrlichia chaffeensis is an obligately intracellular gra

86 Ehrlichia chaffeensis is an obligately intracellular Gra

87 Ehrlichia chaffeensis is an obligatory intracellular and

88 Ehrlichia chaffeensis is an obligatory intracellular bac

89 Ehrlichia chaffeensis is an obligatory intracellular bac

90 -copy gene and was located downstream of two Ehrlichia chaffeensis omp-1 homologs and a decarboxylase

91 were similar to those of human infection by Ehrlichia chaffeensis or EMLA.

92 ation (ChIP) with DNA sequencing revealed an Ehrlichia chaffeensis p200 interaction located within ho

93 Homologous sequences for Ehrlichia chaffeensis p28 were compared to sequences of

94 ovis, Anaplasma phagocytophilum MSP2 (p44), Ehrlichia chaffeensis p28-OMP, Ehrlichia canis p30, and

95 The surface proteins of Ehrlichia chaffeensis provide an important interface for

96 otably, the obligate intracellular bacterium Ehrlichia chaffeensis resides in early endosome-like vac

97 Ehrlichia chaffeensis secretes tandem repeat protein (TR

98 munoreactive proteins of Ehrlichia canis and Ehrlichia chaffeensis that have been characterized inclu

99 hreatening tick-borne zoonoses, is caused by Ehrlichia chaffeensis that lacks endotoxin and peptidogl

100 reactive glycoprotein (gp19) ortholog of the Ehrlichia chaffeensis variable-length PCR target (VLPT)

101 Human monocytotropic ehrlichiosis caused by Ehrlichia chaffeensis was reported in 1987.

102 Ehrlichia chaffeensis was suspected as the causal agent

103 28-kDa outer membrane protein gene (p28) of Ehrlichia chaffeensis were analyzed to determine the mec

104 ge immunodominant outer membrane proteins of Ehrlichia chaffeensis were transcribed in blood monocyte

105 ed by 1) polymerase chain reaction (PCR) for Ehrlichia chaffeensis, 2) acute and convalescent serum t

106 Ehrlichia chaffeensis, a bacterium that cannot survive o

107 man monocytotropic ehrlichiosis is caused by Ehrlichia chaffeensis, a Gram-negative bacterium lacking

108 Ehrlichia chaffeensis, a tick-borne rickettsial organism

109 Ehrlichia chaffeensis, a tick-transmitted rickettsial ag

110 Ehrlichia chaffeensis, a tick-transmitted rickettsial ag

111 Ehrlichia chaffeensis, a tick-transmitted rickettsial, i

112 fe-threatening, infectious disease caused by Ehrlichia chaffeensis, an obligate intracellular bacteri

113 e, we examined immunity against infection by Ehrlichia chaffeensis, an obligate intracellular bacteri

114 le targeted mutations by allelic exchange in Ehrlichia chaffeensis, an obligate intracellular tick-bo

115 Ehrlichia chaffeensis, an obligate intracellular, tick-t

116 The genome of Ehrlichia chaffeensis, an obligatory intracellular bacte

117 Ehrlichia chaffeensis, an obligatory intracellular gram-

118 ogous proteins in Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia canis.

119 ane protein (p120) is a potential adhesin of Ehrlichia chaffeensis, and recombinant p120 is very usef

120 With the recent discoveries of Ehrlichia chaffeensis, Ehrlichia ewingii, and "Borrelia

121 tick-transmitted infectious agents, such as Ehrlichia chaffeensis, Ehrlichia ewingll, the Ehrlichia

122 tion by the obligate intracellular bacterium Ehrlichia chaffeensis, even when administered well after

123 ion of an obligatory intracellular pathogen, Ehrlichia chaffeensis, is characterized by formation of

124 ed by the use of template DNA extracted from Ehrlichia chaffeensis, Rickettsia rickettsii, and Barton

125 Ehrlichia chaffeensis, the etiologic agent of human mono

126 Infection of humans with Ehrlichia chaffeensis, the etiologic agent of human mono

127 Ehrlichia chaffeensis, the etiologic agent of human mono

128 Anaplasma (Ehrlichia) phagocytophila and Ehrlichia chaffeensis, the etiologic agents of granulocy

129 ciens are found in an intravacuolar pathogen Ehrlichia chaffeensis, the tick-borne causative agent of

130 s encoding two surface-expressed antigens of Ehrlichia chaffeensis, the variable-length PCR target (V

131 In the rickettsial pathogen Ehrlichia chaffeensis, the virBD genes are split into tw

132 sma (formerly Ehrlichia) phagocytophilum and Ehrlichia chaffeensis, upon infection of humans, replica

133 osis (HME) is a tick-borne disease caused by Ehrlichia chaffeensis.

134 is caused by a tick-transmitted rickettsia, Ehrlichia chaffeensis.

135 tick-borne disease caused by the rickettsia Ehrlichia chaffeensis.

136 PCR assay was developed for the detection of Ehrlichia chaffeensis.

137 the 28-kDa major antigenic protein (P28) of Ehrlichia chaffeensis.

138 tick-borne disease caused by the rickettsia Ehrlichia chaffeensis.

139 tick-borne zoonoses caused by infection with Ehrlichia chaffeensis.

140 th a lipopolysaccharide-deficient bacterium, Ehrlichia chaffeensis.

141 ed by the obligately intracellular bacterium Ehrlichia chaffeensis.

142 resistance of IL-18Ralpha(-/-) mice against Ehrlichia correlated with increased proinflammatory cyto

143 Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera fr

144 ion with a closely related weakly pathogenic ehrlichia, Ehrlichia muris.

145 terial pathogens in the genera Anaplasma and Ehrlichia encode a protein superfamily, pfam01617, which

146 recommended for use in the identification of Ehrlichia equi in clinical samples.

147 examined 11 naturally occurring isolates of Ehrlichia equi in horses and two human granulocytic ehrl

148 for Ehrlichia chaffeensis (50 of 217; 23%), Ehrlichia ewingii (44 of 217; 20%), and Anaplasma specie

149 e marrow biopsy specimens, and PCR amplified Ehrlichia ewingii DNA from both specimens.

150 CR was used to amplify a 537-bp region of an Ehrlichia ewingii gene encoding a homologue of the 28-kD

151 A case of Ehrlichia ewingii infection likely transmitted by transf

152 recent discoveries of Ehrlichia chaffeensis, Ehrlichia ewingii, and "Borrelia lonestari," the public

153 gocytophila but not against Ehrlichia canis, Ehrlichia ewingii, B. burgdorferi, or Coxiella burnetii.

154 ncultivable obligate intracellular bacterium Ehrlichia ewingii, previously known only as a canine pat

155 tious agents, such as Ehrlichia chaffeensis, Ehrlichia ewingll, the Ehrlichia phagocytophila group an

156 This report reveals Ehrlichia exploitation of the evolutionarily conserved W

157 f dense-cored ehrlichiae and detected in the Ehrlichia-free supernatants, indicating that these prote

158 rlichiosis during infection with a strain of Ehrlichia from Ixodes ovatus (IOE) were evaluated using

159 chia-infected canine cells covers 93% of the Ehrlichia genome, suggesting ubiquitous transcription ac

160 evidence of infection using PCR targeting an Ehrlichia genus-wide 16S rDNA target.

161 emory T cells in protection against virulent Ehrlichia have not been completely investigated.

162 ype I secretion proteins are secreted at the Ehrlichia-host interface.

163 models for persistent infection in the genus Ehrlichia in immunocompetent mice have not been characte

164 Genogroup II ehrlichia, including the agent of human granulocytic ehr

165 y to fatal ehrlichiosis, because it mediates ehrlichia-induced immunopathology and supports bacterial

166 nic versus protective immunity in a model of Ehrlichia-induced immunopathology.

167 that TNFR I/II and TNF-alpha participate in Ehrlichia-induced shock and host defense by regulating l

168 ion, our data suggest that NKT cells mediate Ehrlichia-induced T-cell-mediated toxic shock-like syndr

169 unopathology in which CD8(+) T cells mediate Ehrlichia-induced toxic shock, which is associated with

170 g a pathogenic role for IL-18/IL-18Ralpha in Ehrlichia-induced toxic shock.

171 ions of natural killer (NK) and NKT cells in Ehrlichia-induced toxic shock.

172 racellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes by hijacking host-cell compo

173 cterial mRNA-enriched samples generated from Ehrlichia-infected canine cells covers 93% of the Ehrlic

174 Ehrlichia-infected flies showed decreased survival compa

175 Polyclonal sera generated in I. ovatus ehrlichia-infected mice recognized a conserved ehrlichia

176 rotein p200 is translocated to the nuclei of Ehrlichia-infected monocytes.

177 ture of memory CD8 T cells and Ixodes ovatus ehrlichia-infected peritoneal exudate cells resulted in

178 ibit cytotoxic T-lymphocyte activity against Ehrlichia-infected target cells.

179 mmunofluorescence assay (IFA) using cultured ehrlichia-infected whole cells as antigen.

180 oles that Msp2 proteins play in granulocytic ehrlichia infection and evolution of the polymorphic maj

181 oral immunity plays an essential role during ehrlichia infection in immunocompetent mice, we utilized

182 Omental plasmablasts elicited during Ehrlichia infection lacked expression of CD138 but expre

183 ypothesize that inflammation associated with ehrlichia infection suppresses bone marrow function, ind

184 s were demonstrated for the first time in an Ehrlichia infection to exhibit cytotoxic T-lymphocyte ac

185 a primary low-dose (nonfatal) Ixodes ovatus ehrlichia infection, a secondary low-dose challenge infe

186 were also susceptible to sublethal I. ovatus ehrlichia infection, as were mice that lacked the phox91

187 address the role of cellular immunity during ehrlichia infection, we have used a newly described mode

188 to resolve a low-dose (sublethal) I. ovatus ehrlichia infection, which suggested that humoral immuni

189 are expressed concurrently during persistent Ehrlichia infection.

190 aluable dogs had evidence of past or current Ehrlichia infection.

191 d by interleukin (IL)-10 after initiation by ehrlichia infection.

192 paired bacterial clearance during persistent Ehrlichia infection.

193 Ehrlichia infections activated both the cellular and hum

194 infection with highly virulent Ixodes ovatus ehrlichia (IOE), an obligate intracellular bacterium tha

195 uses persistent infection, and Ixodes ovatus Ehrlichia (IOE), which is either acutely lethal or suble

196 f fatal ehrlichiosis caused by Ixodes ovatus Ehrlichia (IOE).

197 mice with virulent Ehrlichia (Ixodes ovatus Ehrlichia [IOE]) results in CD8+ T-cell-mediated fatal t

198 ed from an Ixodes ovatus tick (Ixodes ovatus ehrlichia, IOE).

199 of the previously reported Venezuelan human Ehrlichia isolate (VHE) and was closely related (99.9%)

200 animal model of severe HME using a strain of Ehrlichia isolated from Ixodes ovatus ticks (IOE).

201 fection of wild-type (WT) mice with virulent Ehrlichia (Ixodes ovatus Ehrlichia [IOE]) results in CD8

202 e HGE murine model do not result from direct ehrlichia-mediated injury but from immunopathological me

203 (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata.

204 he human granulocytic ehrlichiosis agent, or Ehrlichia muris DNA.

205 Infection of mice with the bacterium Ehrlichia muris elicits a protective T cell-independent

206 c infection with the intracellular bacterium Ehrlichia muris elicits a protective, long-term IgM resp

207 ent of WT mice infected with mildly virulent Ehrlichia muris impaired bacterial clearance and enhance

208 Although Ehrlichia muris infection elicits a robust expansion of

209 report the histopathological progression of Ehrlichia muris infection in immunocompetent mice (AKR a

210 en-specific CD4(+) T cells during persistent Ehrlichia muris infection in wild-type and interleukin-1

211 During Ehrlichia muris infection, TI IgM secretion in the splee

212 s of protective immunity were examined in an Ehrlichia muris mouse model of monocytotropic ehrlichios

213 Mice were primed with either Ehrlichia muris or closely related virulent ehrlichiae t

214 ly virulent IOE strain and the less virulent Ehrlichia muris strain that are closely related to E. ch

215 vivo during acute and chronic infection with Ehrlichia muris, a bacterium that establishes persistent

216 Infection with Ehrlichia muris, a pathogen closely related to E. chaffe

217 also generated during infection of mice with Ehrlichia muris, a tick-borne intracellular bacterial pa

218 Our previous study demonstrated that Ehrlichia muris, an obligate intracellular tick-borne pa

219 HME is modeled in C57BL/6 mice using Ehrlichia muris, which causes persistent infection, and

220 Within the bone marrow of Ehrlichia muris-infected C57BL/6 mice, we observed a red

221 is with the newly discovered human pathogen, Ehrlichia muris-like agent (EMLA).

222 ehrlichial infection using a human pathogen, Ehrlichia muris-like agent (EMLA).

223 closely related weakly pathogenic ehrlichia, Ehrlichia muris.

224 OE or intraperitoneally with mildly virulent Ehrlichia muris.

225 e for generating plasmablasts in response to Ehrlichia muris.

226 t not in response to a less virulent strain, Ehrlichia muris.

227 The broad-range assay detected Ehrlichia or Anaplasma DNA in 20 (26%) of the symptomati

228 rlichia-infected mice recognized a conserved ehrlichia outer membrane protein and, when administered

229 of seven recombinant antigens, derived from Ehrlichia phagocytophila (the agent of human granulocyti

230 r B. clarridgeiae and had antibodies against Ehrlichia phagocytophila but not against Ehrlichia canis

231 ction of ticks with Borrelia burgdorferi and Ehrlichia phagocytophila did not appear to affect the tr

232 hrlichia chaffeensis, Ehrlichia ewingll, the Ehrlichia phagocytophila group and Rickettsia conorii.

233 te Borrelia burgdorferi and field strains of Ehrlichia phagocytophila, an agent of human granulocytic

234 he agent of human granulocytic ehrlichiosis, Ehrlichia phagocytophila, and the bovine pathogen Anapla

235 Anaplasma (Ehrlichia) phagocytophila and Ehrlichia chaffeensis, the

236 Anaplasma (Ehrlichia) phagocytophila's major immunodominant surface

237 Anaplasma (formerly Ehrlichia) phagocytophilum and Ehrlichia chaffeensis, up

238 To investigate the species distribution of Ehrlichia present in Missouri dogs, we tested 78 dogs su

239 able to bacteria in the genera Anaplasma and Ehrlichia, removing a major technical impediment to the

240 permissive" genes for the ability to support Ehrlichia replication.

241 expressed from the map1 multigene family of Ehrlichia ruminantium are strongly recognized by immune

242 haffeensis p28-OMP, Ehrlichia canis p30, and Ehrlichia ruminantium MAP1, and has been shown to be inv

243 loci were examined between three genomes of Ehrlichia ruminantium, the causative agent of heartwater

244 No Borrelia burgdorferi or Ehrlichia sp. DNA could be identified.

245 Human neutrophils migrate towards Ehrlichia sp.-infected cells in a chemotaxis chamber ass

246 Ehrlichia species are intracellular bacteria that cause

247 35 homologs are found in other Anaplasma and Ehrlichia species but not in other bacteria.

248 University Hospital, 40 were positive for an Ehrlichia species by PCR/ESI-MS, giving a positive rate

249 Ehrlichia species can cause life-threatening infections

250 trometry (PCR/ESI-MS) to detect and identify Ehrlichia species directly from blood specimens.

251 al major immunoreactive protein orthologs of Ehrlichia species have recently been identified and mole

252 , but not Toll-like receptors, suggests that Ehrlichia species have unique inflammatory molecules.

253 Rapid detection and identification of Ehrlichia species improves clinical outcome for patients

254 We report a new ehrlichia species in Minnesota and Wisconsin and provide

255 ela, documentation of coinfection with three Ehrlichia species in two dogs, one from each country, be

256 ccines to protect animals and people against Ehrlichia species infections.

257 Genetic analyses revealed that this new ehrlichia species is closely related to E. muris.

258 E. ewingii is the only Ehrlichia species known to infect neutrophils.

259 sota or Wisconsin were positive for the same ehrlichia species on polymerase-chain-reaction testing.

260 specimens were Anaplasma phagocytophilum; no Ehrlichia species were identified.

261 urve analysis to differentiate Anaplasma and Ehrlichia species with blood smear and serologic methods

262 f the 27-kb locus or the 28-kb locus of each Ehrlichia species, 14 paralogs were linked by short inte

263 athogen interactions have been identified in Ehrlichia species, but their roles in pathobiology are u

264 ests that dogs could be a reservoir for this Ehrlichia species.

265 s and is conserved among other Anaplasma and Ehrlichia species.

266 d instead to be caused by a newly discovered ehrlichia species.

267 ludes a 19-kDa protein that elicits an early Ehrlichia-specific antibody response in infected dogs.

268 cific polyclonal Abs and IFN-gamma-producing Ehrlichia-specific CD4(+) and CD8(+) type 1 cells protec

269 cell numbers, and increased the frequency of Ehrlichia-specific CD4(+) Th1 cells in comparison to inf

270 drome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tu

271 imed mice correlated with (i) decline in the Ehrlichia-specific CD4+ and CD8+ type 1 responses, (ii)

272 D4+ and CD8+ memory type 1 T-cell responses, Ehrlichia-specific immunoglobulin G (IgG) antibodies, an

273 ing this intracellular infection, a panel of Ehrlichia-specific mAbs was generated and analyzed.

274 essing B cells nearly eliminated the omental Ehrlichia-specific plasmablasts and reduced antigen-spec

275 Moreover, we found a high frequency of Ehrlichia-specific plasmablasts in the omentum of both c

276 Transfer of Ehrlichia-specific polyclonal Abs and IFN-gamma-producin

277 ection against lethal infection, (ii) strong Ehrlichia-specific secondary gamma interferon (IFN-gamma

278 of TNF-alpha in the serum, high frequency of Ehrlichia-specific, TNF-alpha-producing CD8(+) T cells i

279 ured from the study sites were infected with Ehrlichia spp.

280 mproved molecular diagnostic assay to detect Ehrlichia spp.

281 sodB-based quantitative PCR assay to detect Ehrlichia spp.

282 Anaplasma and related Ehrlichia spp. are important tick-borne, Gram-negative b

283 ar survival and replication of Anaplasma and Ehrlichia spp. in granulocytes or monocytes.

284 three virB genes in these two Anaplasma and Ehrlichia spp. is regulated by factors that influence th

285 vergence in Ank function among Anaplasma and Ehrlichia spp. is supported by both locus and allelic an

286 The spectrum of disease caused by Ehrlichia spp. ranges from asymptomatic to fatal.

287 eria, the absence of an intact fbp operon in Ehrlichia spp. suggests that genes involved in ehrlichia

288 The ability to detect Ehrlichia spp. within individual experimentally infected

289 e basic developmental cycle of Anaplasma and Ehrlichia spp. within the tick has been delineated, ther

290 ection with a high dose of a highly virulent Ehrlichia strain (IOE) results in a toxic shock-like syn

291 Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like sy

292 hrlichiosis caused by related monocytotropic Ehrlichia strains.

293 to develop a tick transmission model with an Ehrlichia that is pathogenic for humans.

294 is that results from infection of mice by an ehrlichia that was isolated from an Ixodes ovatus tick (

295 e locus are conserved between two species of Ehrlichia to maintain a unique transcriptional mechanism

296 r processes and molecular cross talk between Ehrlichia TRPs and host targets.

297 ing that molecular cross talk occurs between Ehrlichia TRPs and host targets.

298 An ehrlichial agent (Venezuelan dog Ehrlichia [VDE]) was isolated and propagated in cell cul

299 he novel exploitation of the SUMO pathway by Ehrlichia, which facilitates effector-eukaryote interact

300 ovel host response to obligate intracellular Ehrlichia, whose survival depends entirely on a long evo