ライフサイエンスコーパス: Encephalitozoon

1 f human microsporidia belonging to the genus Encephalitozoon.

2 Microsporidian organisms within the genus Encephalitozoon are the cause of nephrologic, ophthalmic

3 Microsporidia of the genus Encephalitozoon are widespread pathogens of animals that

4 m Encephalitozoon intestinalis (2.3 Mbp) and Encephalitozoon cuniculi (2.9 Mbp) revealed massive gene

5 In this study, we show that both Encephalitozoon cuniculi and Encephalitozoon intestinali

6 e genomes are strikingly similar to those of Encephalitozoon cuniculi and Encephalitozoon intestinali

7 assembly components for the microsporidians Encephalitozoon cuniculi and Trachipleistophora hominis.

8 c acid, a TrpRS from the eukaryotic pathogen Encephalitozoon cuniculi bound to tryptophan, a HisRS fr

9 rystal structure of the N-terminal domain of Encephalitozoon cuniculi Cdc27 (Cdc27(Nterm)), revealing

10 The CTD of the microsporidian parasite Encephalitozoon cuniculi consists of 15 heptad repeats,

11 Encephalitozoon cuniculi continues to pose a problem for

12 evious mutational and structural analyses of Encephalitozoon cuniculi Ecm1, a prototypal cellular cap

13 Here we show that the intracellular parasite Encephalitozoon cuniculi encodes a complete mRNA capping

14 Notably the genome of the microsporidian Encephalitozoon cuniculi has lost all of its genes for M

15 eir ability to prime an IEL response against Encephalitozoon cuniculi in vitro.

16 er animals exhibit greater susceptibility to Encephalitozoon cuniculi infection, and their ability to

17 Effectively, after Encephalitozoon cuniculi infection, CD11b(-) CD8(+) DC w

18 response is critical for protection against Encephalitozoon cuniculi infection.

19 to play an important role in defense against Encephalitozoon cuniculi infection.

20 Encephalitozoon cuniculi infects a wide range of mammali

21 Encephalitozoon cuniculi is a protozoan parasite that ha

22 Encephalitozoon cuniculi is commonly found in domestic r

23 Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied m

24 er (ITS) region of a recently cultured human Encephalitozoon cuniculi isolate was analyzed by gene am

25 The Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltr

26 primary human macrophages were infected with Encephalitozoon cuniculi or Encephalitozoon intestinalis

27 n to examine the protein interactions of the Encephalitozoon cuniculi polar tube proteins (EcPTPs).

28 rformed a bioinformatic investigation of the Encephalitozoon cuniculi proteome.

29 n live (freshly harvested) and dead (boiled) Encephalitozoon cuniculi spores.

30 testinalis but not Encephalitozoon hellem or Encephalitozoon cuniculi was confirmed in 6 of 8 mammali

31 Encephalitozoon cuniculi was detected in three patients:

32 Encephalitozoon cuniculi, a microsporidial species most

33 (delta) T cells during murine infection with Encephalitozoon cuniculi, an intracellular parasite, was

34 al antibody, termed 3B6, strongly recognized Encephalitozoon cuniculi, E. hellem, and E. intestinalis

35 sis with oligonucleotide probes specific for Encephalitozoon cuniculi, E. hellem, and Encephalitozoon

36 MicrosporidiaDB contains the genomes of Encephalitozoon cuniculi, E. intestinalis and E. bieneus

37 In aged animals challenged with the parasite Encephalitozoon cuniculi, effector CD8+ T cell survival

38 osporidian species: Enterocytozoon bieneusi, Encephalitozoon cuniculi, Encephalitozoon hellem, and En

39 t with culture-grown Encephalitozoon hellem, Encephalitozoon cuniculi, or Vittaforma corneae or with

40 , E. intestinalis, and E. hellem, as well as Encephalitozoon cuniculi, spores in fecal samples and is

41 0 also demonstrated in vivo activity against Encephalitozoon cuniculi, with prolonged survival and th

42 structural components of these organelles in Encephalitozoon cuniculi.

43 le in the protective immune response against Encephalitozoon cuniculi.

44 2-7 complex from the microsporidian parasite Encephalitozoon cuniculi.

45 o intermediate-sized genomes (2.5 Mbp), from Encephalitozoon hellem and Encephalitozoon romaleae.

46 The presence of E. intestinalis but not Encephalitozoon hellem or Encephalitozoon cuniculi was c

47 Analysis of the glycosylation of Encephalitozoon hellem PTP1 suggested that it is modifie

48 Encephalitozoon hellem was detected in one patient, and

49 ve genotyping tool, the genetic diversity of Encephalitozoon hellem was examined at the polar tube pr

50 oon intestinalis, 2 (2.1%) were positive for Encephalitozoon hellem, and 9 samples (9.6%) contained b

51 cytozoon bieneusi, Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis

52 Microsporidian spores of Encephalitozoon hellem, E. cuniculi, and E. intestinalis

53 this serum does not react with culture-grown Encephalitozoon hellem, Encephalitozoon cuniculi, or Vit

54 so present in the parasitophorous vacuole of Encephalitozoon hellem.

55 h murine polyclonal antiserum raised against Encephalitozoon hellem.

56 Complete sequences from Encephalitozoon intestinalis (2.3 Mbp) and Encephalitozo

57 Encephalitozoon intestinalis (Septata intestinalis) is t

58 show that both Encephalitozoon cuniculi and Encephalitozoon intestinalis are preferentially recogniz

59 to cause a gastrointestinal disease whereas Encephalitozoon intestinalis causes both a disseminated

60 Our data show that Encephalitozoon intestinalis exploits sulfated glycans s

61 lar to those of Encephalitozoon cuniculi and Encephalitozoon intestinalis in both form and content.

62 Encephalitozoon intestinalis is a microsporidian species

63 In studies, as few 10 to 50 Encephalitozoon intestinalis spores could be detected wh

64 ment (Roche) and fecal specimens spiked with Encephalitozoon intestinalis spores.

65 e in size from 2.3 Mb for the microsporidian Encephalitozoon intestinalis up to 8000 Mb for Entomopha

66 re wall constituents from the microsporidian Encephalitozoon intestinalis were characterized.

67 ozoon bieneusi, 43 (45.8%) were positive for Encephalitozoon intestinalis, 2 (2.1%) were positive for

68 re infected with Encephalitozoon cuniculi or Encephalitozoon intestinalis, and the recruitment of nai

69 The higher prevalence of Encephalitozoon intestinalis, in 21 (12.8%) patients, th

70 tozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis.

71 microsporidians, Enterocytozoon bieneusi and Encephalitozoon intestinalis.

72 isseminated microsporidial infection with an Encephalitozoon-like species was diagnosed by electron m

73 2 avian) containing spores detected by anti-Encephalitozoon monoclonal antibody immunofluorescence (

74 The G distribution in the Encephalitozoon (parasite) genome was not protective rel

75 microsporidia were amplified by PCR with pan-Encephalitozoon primers, and the PCR DNA products were s

76 microsporidian ribosomal DNA (rDNA) with pan-Encephalitozoon primers.

77 s (2.5 Mbp), from Encephalitozoon hellem and Encephalitozoon romaleae.

78 Encephalitozoon (Septata) intestinalis, the agent that c

79 for Encephalitozoon cuniculi, E. hellem, and Encephalitozoon (Septata) intestinalis.

80 ons allowed for the differentiation of three Encephalitozoon species (E. intestinalis, E. cuniculi, a

81 rn blot, and immunoelectron microscopy using Encephalitozoon species from fresh and fixed samples fro

82 s DNA extraction methods and to detect three Encephalitozoon species in feces.

83 We have developed an anti-Encephalitozoon species monoclonal antibody-based immuno

84 cteristics compared with the slightly larger Encephalitozoon species spores.

85 This antiserum cross-reacted with other Encephalitozoon species, so PCR was performed to amplify

86 clonal antibody 3B6 bound to the exospore of Encephalitozoon species, while in Western blot assays, i

87 first real-time PCR assay designed to detect Encephalitozoon species.

88 microsporidian infections, particularly with Encephalitozoon species.

89 cognition by immunofluorescence of all known Encephalitozoon spores affecting humans.

90 rocedure is established for the isolation of Encephalitozoon spores from clinical specimens, identifi

91 Encephalitozoon spp. induced an average threefold increa

92 the initial inflammatory response induced by Encephalitozoon spp. to TLR2 stimulation in human macrop

93 nofluorescence with E. bieneusi but not with Encephalitozoon spp., Candida albicans, Staphylococcus a

94 y, formalin-treated and nontreated spores of Encephalitozoon were identified to the species level by