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1 l proteins and a singly spliced mRNA encodes Env protein.
2 ous neutralization determinants on the HIV-1 Env protein.
3 d on the surface of the gp120 subunit of the Env protein.
4 icular stomatitis virus (VSV) expressing HIV Env protein.
5 ch region in the surface (SU) subunit of the Env protein.
6 binant expressing a secreted form of the HIV Env protein.
7 levels of antibody responses against the HIV Env protein.
8 boosted (week 8) with the DNA or recombinant Env protein.
9 he induction of XC cell syncytia by the R(+) Env protein.
10 Env protein but not that induced by the R(-) Env protein.
11 ell-specific syncytium formation by the R(+) Env protein.
12 mic domain of gp41 and the ectodomain of the Env protein.
13 ntical or chemically conserved in the HTLV-1 Env protein.
14 diversity and poor immunogenicity of the HIV Env protein.
15 rize the phenotypic features of the M-tropic Env protein.
16 ts a need for broad antibodies targeting the Env protein.
17 with about 500 glycoforms characterized per Env protein.
18 ved Gag and the cytoplasmic tail (CT) of the Env protein.
19 usion-inducing conformational changes in the Env protein.
20 ents of HTLV-3 using independently expressed Env proteins.
21 uld confer this property on two heterologous Env proteins.
22 tness similar to those carrying the mothers' Env proteins.
23 h MA facilitates the virion incorporation of Env proteins.
24 tance mutations into phenotypically distinct Env proteins.
25 e leukemia virus (MLV), bearing heterologous Env proteins.
26 rotocol with their homologous vaccine native Env proteins.
27 endent virus, and with subgroups A or B ASLV Env proteins.
28 ls that were transformed by the JSRV or ENTV Env proteins.
29 ke particles (VLPs), both FV and HBV require Env proteins.
30 cted an enhanced fusogenicity of the mutated Env proteins.
31 proliferative responses to both SIV gag and env proteins.
32 ning technique of obtaining novel retargeted Env proteins.
33 properties have been described for subtype C Env proteins.
34 ) that are buried in the parental, unadapted Env proteins.
35 r the 17b antibody than are IFITM3-resistant Env proteins.
36 rains LAI and NL4.3 lack wild-type levels of Env proteins.
37 HERV-K(HML-2)] and the expression of Gag and Env proteins.
38 ons in the HR1 region of the viral envelope (Env) protein.
39 e V3 glycan supersite on the HIV-1 envelope (Env) protein.
40 he sequence of the capsid (CA) and envelope (Env) proteins.
42 -displayed human antibody library; these two Env proteins (89.6 and IIIB gp140s), and one additional
43 ccine will include a recombinant form of the Env protein, a trimer located on the virion surface.
45 bsets prior to immunization with recombinant Env protein affects the vaccine-induced Ab response in m
48 e show that expression of the JSRV envelope (Env) protein alone in lungs of mice, by using a replicat
49 anding of the humoral responses to the HIV-1 Env protein and provide insights regarding the most rele
52 ximately normal amounts of Gag, Gag-Pol, and Env proteins and genomic viral RNA (vRNA), but several m
53 ortant influences on the quality of trimeric Env proteins and hence their suitability as vaccine comp
54 tivated in cells transformed by JSRV or ENTV Env proteins and in cells transformed by the proteins wi
55 reflect different interactions between their Env proteins and molecules on CD4(+) and CD8(+) T cells
57 human immunodeficiency virus type 1 (HIV-1) Env proteins and possess broad neutralizing activities.
58 enome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at
59 l conformational heterogeneity of some HIV-1 Env proteins and, by extrapolation, also vaccine immunog
60 obe interactions between the viral envelope (Env) protein and CXCR4 and to identify pathways by which
61 ) in the gp41 subunit of the viral envelope (Env) protein and prevents conformational changes require
62 ns within the V3 loop of the viral envelope (Env) protein and was modulated by additional mutations i
63 ined viral sequences in their DNA, expressed Env protein, and showed retroviral particles by electron
64 ular protein, Zfp111, that binds to the JSRV Env protein, and this binding plays a role in Env transf
65 ssing the human immunodeficiency virus (HIV) Env protein are nonpathogenic in mice, even when given b
68 These data suggest that VIR165-dependent Env proteins are kinetically trapped in the unliganded s
69 To increase yield and simplify purification, Env proteins are often made in truncated, soluble forms.
73 f trimer spokes have been observed to impair Env protein assembly into virus particles, and several o
74 to HIV-1 gp120, suppress interactions of the Env protein at host cell receptor binding sites, inhibit
75 recombinant expressing the membrane-anchored Env protein at producing CD8 T cells and antibody respon
76 nstrated to contain high levels of the viral env proteins, averaged 70-79 trimers per virion in tomog
78 ncept that a distally related retroviral SIV Env protein boost can increase pre-existing NAb response
79 v and monovalent gag) followed by a 5-valent Env protein boost for seronegative adults was previously
80 These data demonstrate that the adjuvanted Env protein boost is critical for protecting against hig
82 vs) DNA prime, followed by a SIVmac239 gp140 Env protein boost that aimed to focus the immune respons
84 of the alphavirus replicon vector prime plus Env protein boost vaccine approach for the induction of
90 e characteristics and immunogenicity of this Env protein, both alone and mixed together with a clade
91 ediate entry of virions bearing JSRV or ENTV Env proteins, bound JSRV SU poorly if at all, and did no
92 tion of XC cell syncytia induced by the R(+) Env protein but not that induced by the R(-) Env protein
94 g antibodies (nAbs) to some cloned SIVsmE660 Env proteins, but antibodies able to neutralize the chal
96 man immunoglobulin G that reacted with HIV-1 Env proteins by enzyme-linked immunosorbent assay and ne
97 ild-type and palmitoylation-deficient mutant Env proteins by using extraction with the mild detergent
100 sformation of mouse fibroblasts and that the Env proteins can transform at least some cells by a Hyal
101 These results show that the JSRV and ENTV Env proteins can transform epithelial cells besides BEAS
102 gested the hypothesis that the JSRV and ENTV Env proteins cause cancer by inhibiting the tumor suppre
103 s so they may not accurately represent HIV-1 Env proteins circulating in humans, potentially limiting
107 r proteins may influence surface exposure of Env protein complexes in virus-infected cells, assisting
108 n overlapping peptide pools from three HIV-1 Env proteins, CON6, MN (subtype B), and Chn19 (subtype C
110 NLHX; however, all of the PFI-insusceptible Env proteins conserved the sequence of a critical enfuvi
111 us type 1) uses its trimeric gp160 envelope (Env) protein consisting of non-covalently associated gp1
113 es syncytium formation with cells expressing Env protein containing R peptide (R(+) Env), which is kn
115 unodeficiency virus type 1 (HIV-1) envelope (Env) protein contains numerous N-linked carbohydrates th
116 Among HIV-1 gene products, the envelope (Env) protein contains variable as well as conserved regi
118 fected by ENTV vectors, even though the ENTV Env protein could bind well to human Hyal2 expressed on
119 humoral and cellular immune responses to the Env protein could reveal potential determinants of vacci
120 possibility that these endogenous retroviral Env proteins could directly influence HIV-1 replication.
123 the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-direct
124 irus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated durin
125 en soluble gp140 and virion-associated gp160 Env proteins derived from SF162 may be the basis for the
126 tion sensitivities of HIV-1 pseudotyped with Env proteins derived from two prototypic clade B primary
127 ay measurable binding to a recombinant gp140 Env protein (derived from the dual-tropic 89.6 virus), w
128 protein in the boosting phase along with the Env protein did not contribute further to the preservati
129 The results demonstrated that ancestral Env proteins did not impart broad levels of protection a
130 S mutation into heterologous R5, X4, or R5X4 Env proteins did not impart CD4 independence, it did aff
131 rsions of CZA97.012 and 92UG037.8 oligomeric Env proteins do not resemble the trimeric Env glycoprote
133 candidate HIV-1 vaccine vectors and purified Env proteins elicited potent and durable humoral immune
135 possessed long env open reading frames, the Env proteins encoded by these loci were nonfunctional ac
136 e localized the transforming activity to the Env proteins encoded by these viruses, which require the
140 ine leukemia virus retroviral Envelope (FeLV Env) protein for productive infection of feline AH927 ce
142 ne (expressing clade B Gag, Pol, and Nef and Env proteins from clades A, B, and C) was administered a
145 ggest that a multicomponent vaccine encoding Env proteins from multiple clades of HIV-1 can generate
149 n for their ability to incorporate envelope (Env) proteins from other retroviral strains and genera,
150 odies, soluble HIV-1 envelope glycoproteins (Envs proteins) from two isolates complexed with two-doma
151 However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of t
155 ults indicate that the R peptide of the MuLV Env protein has a sequence-dependent inhibitory effect o
156 mmunodeficiency virus type 1 (HIV-1) surface Env protein has been implicated in the development of HI
157 roid plexus cells stably expressing the JSRV Env protein, human 293T cells, mouse NIH 3T3 cells, or N
160 ble of lysing target cells expressing HERV-K env protein in BC patients but not in normal female cont
161 s were primed with VRP and then boosted with Env protein in MF59 adjuvant, or they were given VRP int
165 domain (CTD) of murine leukemia virus (MuLV) Env protein in viral fusion was indicated by the potent
167 d characterized viruses pseudotyped with the Env proteins in a single-round drug sensitivity assay.
168 the virus ensures the production of Gag and Env proteins in an appropriate ratio remains unknown.
170 between T cell-tropic and macrophage-tropic Env proteins, including functional differences with host
172 suppress transformation by the JSRV or ENTV Env proteins, indicating that mouse Hyal2 plays no role
173 activity with both the wild-type and mutant Env proteins, indicating that palmitoylation or raft ass
176 litates the incorporation of HIV-1 envelope (Env) proteins into virions by virtue of an interaction w
177 he human immunodeficiency virus type 1 gp120 Env protein is a key domain in Env due to its role in in
181 h lipid rafts and that palmitoylation of the Env protein is critical for lipid raft association.
183 at the more promiscuous use of CCR5 by these Env proteins is selected against at the level of virus t
184 The gp120 subunit of the HIV-1 envelope (Env) protein is heavily glycosylated at approximately 25
185 human immunodeficiency virus (HIV) envelope (Env) protein is incorporated into HIV virions or virus-l
186 f the murine leukemia virus (MuLV) envelope (Env) protein is known to play an important role in regul
190 ported on a panel of HIV-1 clade B envelope (Env) proteins isolated from a patient treated with the C
193 essing JSRV Env caused a marked reduction in Env protein levels, indicating that human Hyal2 suppress
195 These results suggest that some engineered Env proteins may more efficiently direct responses towar
197 gths of the individual Env-receptor bonds of Env proteins obtained from a HIV-1 infected patient prio
198 rs target in some manner the highly variable Env protein of HIV-1, there are likely to be challenges
204 ically evaluated the differences between the Env proteins of simian immunodeficiency virus/simian HIV
205 characteristics of the binding of V3 MAbs to Env proteins of the subtype B virus JR-FL and the subtyp
206 ere we show that as with JSRV, the envelope (Env) protein of ENTV can transform cultured cells and th
213 t peptide in the Vr1 region of the envelope (Env) proteins of feline leukemia virus (FeLV) subgroups
215 aced by that of the wild-type or mutant MuLV Env protein or in which the cytoplasmic tail sequence of
216 y of SU for appropriate configuration of the Env protein or independent activation by SU of a signali
217 ect tyrosine phosphorylation of JSRV or ENTV Env proteins or an interaction between the Env proteins
218 gether, these studies indicate that the MMTV Env protein participates in mammary epithelial cell tran
219 erate in culture; express Tax, Rex, Gag, and Env proteins persistently; and transmit HTLV-1 to naive
221 method could influence the proportion of an Env protein population that contained aberrant disulfide
223 eneral, the alanine mutations did not affect Env protein production or its localization to the plasma
224 fficiency and fusion competency of the viral Env proteins relate to infection during this transition
225 erior envelope glycoprotein (Env), nonnative Env protein released from cells, and the glycan shieldin
227 ous data have shown that the HIV-1 Envelope (Env) protein requires an interaction with MA for assembl
228 and that at least two of the most expressed Env proteins retain their ability to make a protein.
229 e always replaced, both coding for envelope (Env) protein segments: the N terminus of the surface sub
230 unodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated ne
231 accines and therapeutics targeting the HIV-1 Env protein should consider virus variation within indiv
233 ans when using the SHIV/macaque model, HIV-1 Env proteins should be identified that use mCD4 as a fun
234 ion to the V5 variable loop of the envelope (Env) protein showed that viruses bearing HI insertions r
235 ncreased breadth of recognition of different Env proteins, suggesting anti-V regions 1 and 2 Abs may
238 iciency virus type 1 (HIV-1) HXBc2 envelope (Env) protein, termed 8x, mediates infection of CD4-negat
239 the marked neutralization sensitivity of all Env proteins tested to human immunodeficiency virus-posi
241 HIV-1 B/C recombinant, native-like trimeric Env protein that is highly resistant to CD4-induced conf
243 Here, we identified several soluble gp140 Env proteins that are recognized by PG9 and PG16, and we
244 trimer adds to the repertoire of native-like Env proteins that are suitable for immunogenicity and st
246 neutralization determinants in heterologous Env proteins that may prove useful for vaccine developme
247 bored genetically and phenotypically diverse Env proteins that used CCR5 and/or CXCR4 to elicit membr
249 ansmitted to infants IP, but not IU, encoded Env proteins that were shorter and had fewer putative N-
251 unodeficiency virus type-1 (HIV-1) envelope (Env) proteins that mediate membrane fusion represent a m
252 perties of the viral envelope glycoproteins (Env proteins) that influence the ability of HIV-1 to ind
253 T cell responses engendered was against the Env protein, the Mamu-A*02-restricted epitope, Env(788-7
254 nclude that for both X4-tropic and R5-tropic Env proteins, the CT facilitates conformational changes
256 ate the cell surface expression of envelope (Env) proteins through peptide sequences located in the c
257 roglial precursor cells were stimulated with ENV protein to determine the effects of this ligand/rece
258 not significantly alter the capacity of the Env protein to mediate fusion, so they have not radicall
259 9E), giving rise to a reduced ability of the Env proteins to both induce fusion and to establish prod
261 of anti-Env Abs can be improved by coupling Env proteins to costimulatory molecules such as a prolif
262 MAbs, C108g did not block binding of soluble Env proteins to either the CD4 or the CCR5 receptor, but
263 ining synthetic Galcer and recombinant HIV-1 Env proteins to identify antibodies that would block the
264 which multivalent binding of trimeric HIV-1 Env proteins to MA trimers contributes to the process of
265 t that multivalent binding of trimeric HIV-1 Env proteins to MA trimers contributes to the process of
269 eceptor responses to SHIV(AD8) infection and Env protein vaccination with eight different adjuvants.
272 idual represents a source of closely related Env protein variants that can be used to explore various
275 ch the cytoplasmic tail sequence of the MuLV Env protein was added to the HA cytoplasmic domain.
276 ved that the palmitoylation-deficient mutant Env protein was mostly soluble when extracted by ice-col
277 lated on serine residues, but the native BLV Env protein was not phosphorylated either in transfected
280 t to the plasma membrane of selected deleted Env proteins was confirmed by confocal immunofluorescenc
281 among targeting peptides of library-selected Env proteins was greater than that found in parental FeL
283 he NXT/S N-linked glycosylation motif of the Env protein, we created 27 mutants lacking 1 to 5 of 14
285 xplore whether Tier-2 nAbs can be induced by Env proteins, we immunized conventional mice with solubl
286 st, viruses pseudotyped with subtype A and C Env proteins were able to use the recently described alt
291 simian immunodeficiency virus (SIV) Gag and Env proteins were used to vaccinate rhesus macaques with
292 ave created a RV containing a chimeric HIV-1 Env protein, which contains introduced cysteine residues
293 ociation of the murine leukemia virus (MuLV) Env protein with lipid rafts, we compared wild-type and
294 ergent in sequence, the two viruses share an Env protein with similarly curtailed VRA and VRB regions
295 protein, show that interaction of the viral Env protein with the virus entry receptor Hyal2 is not r
297 d the disulfide bond profiles of two soluble Env proteins with different designs that are being asses
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