ライフサイエンスコーパス: Eph receptor

1 rt through direct interaction with the VAB-1 Eph receptor.

2 lyses in situ confirmed expression of mutant EPH receptors.

3 igands bind weakly and promiscuously to many Eph receptors.

4 YK and is not dependent on activation of the Eph receptors.

5 he adult brain, regions enriched in Trks and Eph receptors.

6 emselves signal intracellularly upon binding Eph receptors.

7 hrins can also bind promiscuously to several Eph receptors.

8 nd the significance of structural domains in Eph receptors.

9 had previously been directly identified for Eph receptors.

10 in which ephrins act as in trans ligands of Eph receptors.

11 ubset of ephrin guidance ligands, as well as Eph receptors.

12 roteins are cleaved and secreted ligands for Eph receptors.

13 secreted and act as diffusible hormones for Eph receptors.

14 Here we show that an Eph receptor A (EphA) and ephrin A (Efna) signalling-dep

15 evated level of the receptor tyrosine kinase Eph receptor A2 (EphA2) is an important contributor to t

16 erexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressi

17 -EGF, CTGF, tenascin C, integrin alpha5, and Eph receptor A2.

18 Murine embryos lacking EPH receptor A4 (Epha4KO/KO), which is upstream of alpha

19 ormancy-specific biomarkers such as H2BK and Eph receptor A5 (EphA5) were discovered.

20 ocess including matrix metalloproteinase 16, eph receptor A7, angiopoetin 1, endothelial lipase, and

21 ector that mediates the neuron's response to Eph receptor activation.

22 t of Slap and NMDA receptors at the sites of Eph receptor activation.

23 Ephrin (Eph) signaling via Eph receptors affects neuronal structure and function.

24 mploys statistical resampling to measure the Eph receptor aggregation distribution within each pixel

25 In this way, Eph receptors allow cells to sense their immediate surro

26 e Eph/Ephrin family, Drosophila has a single Eph receptor and a single Ephrin ligand, both of which a

27 These distinct responses to Eph receptor and ephrin activation may in part be due to

28 cent work has revealed a role of overlapping Eph receptor and ephrin expression in modulating neurona

29 A promoter microarray, we identified several EPH receptor and EPHRIN genes as potential hypermethylat

30 n, a sperm-derived hormone that binds to the Eph receptor and induces oocyte maturation.

31 ilable that can selectively bind to a single Eph receptor and not other members of this large recepto

32 Our findings show that oocyte Eph receptor and somatic cell G protein signaling pathwa

33 he parallel function of the oocyte VAB-1 MSP/Eph receptor and somatic G protein signaling.

34 hat SAX-3/Robo acts in parallel to the VAB-1/Eph receptor and the UNC-6/netrin, UNC-40/DCC guidance s

35 Both Eph receptors and Abl are localized in the neuronal grow

36 bl have on neurite ougrowth and suggest that Eph receptors and Abl family kinases have shared signali

37 re consistent with the opposite effects that Eph receptors and Abl have on neurite ougrowth and sugge

38 ligand-binding domain of EphA2 but not other Eph receptors and could therefore be useful as selective

39 Eph receptors and ephrin ligands are key players in many

40 Both Eph receptors and ephrin ligands have been implicated in

41 g embryogenesis, bidirectional activation of Eph receptors and ephrin-B proteins could occur at inter

42 Previous work has implicated Eph receptors and ephrin-B proteins in the restriction o

43 dies in chick and mouse have shown that both Eph receptors and ephrins are also expressed within the

44 Interestingly, Eph receptors and ephrins are differentially distributed

45 ) or MsEphrin (ephrin-Fc), reveals that both Eph receptors and ephrins are expressed on axons of olfa

46 We propose a new role for Eph receptors and Ephrins as intercellular signaling mol

47 Eph receptors and ephrins can sharpen domains within dev

48 These results suggest that Eph receptors and ephrins constitute domain-specific pos

49 on and tyrosine phosphorylation suggest that Eph receptors and ephrins contribute to establishing top

50 progress has been made in understanding how Eph receptors and ephrins control cell adhesion.

51 New findings reveal that Eph receptors and ephrins coordinate not only developmen

52 Because Eph receptors and ephrins have complementary expression

53 These data implicate Eph receptors and ephrins in the segmental restriction o

54 stigated the tonotopic expression of several Eph receptors and ephrins in the VIIIth nerve during emb

55 nd in vitro experiments, we hypothesize that Eph receptors and ephrins mediate axon sorting and fasci

56 These results reveal that Eph receptors and ephrins regulate two aspects of cell b

57 Membrane-anchored Eph receptors and ephrins represent a ubiquitous interce

58 analysed whether complementary expression of Eph receptors and ephrins restricts cell intermingling,

59 Signaling of Eph receptors and ephrins underlies formation of a numbe

60 eemingly paradoxical signaling mechanisms of Eph receptors and ephrins, which will enable effective s

61 Here, we investigated the role of Eph receptors and ephrins-mediators of cell-contact-depe

62 ions and crosstalk between A- and B-subclass Eph receptors and ephrins.

63 of RNA, encoding dominant negative forms of Eph receptors and ephrins.

64 We show that multiple Eph receptors and ligands are expressed in the hippocamp

65 In addition, we find that Eph receptors and ligands colocalize with PDZ proteins a

66 ceptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a

67 of a bidirectional signal, in which both the Eph receptors and the ephrins activate downstream signal

68 arkers, or labels, are based on those of the Eph receptors and their associated ligands, the ephrins.

69 Eph receptors and their corresponding ephrin ligands hav

70 In developing brain, Eph receptors and their ephrin ligands (Ephs/ephrins) ar

71 Eph receptors and their ephrin ligands are involved in n

72 Eph receptors and their ephrin ligands are involved in v

73 Eph receptors and their ephrin ligands have been shown t

74 Signaling by Eph receptors and their ephrin ligands plays a key role

75 The conserved Eph receptors and their Ephrin ligands regulate a number

76 These results indicate that the Eph receptors and their ligands are critical regulators

77 In vivo, Eph receptors and their ligands distribute in complex pa

78 formation, we examined the expression of the Eph receptors and their ligands, the ephrins, during pri

79 Eph receptors and their ligands, the ephrins, mediate ce

80 Eph receptors and their membrane-bound ligands, ephrins,

81 The Eph receptors and their membrane-bound ligands, ephrins,

82 We report that Eph receptors and their membrane-linked ligands all cont

83 Eph receptors and their membrane-tethered ligands, the e

84 of EPHA7 (EPHA7(TR)) interferes with another Eph-receptor and blocks oncogenic signals in lymphoma ce

85 in ina-1 (alpha-integrin), as well as vab-1 (Eph receptor), and vab-2 (ephrin), display defects in em

86 The Eph receptors are a large family of receptor tyrosine ki

87 mpal neurons, we determined that ephrins and Eph receptors are also expressed on hippocampal astrocyt

88 Unexpectedly, we found that many Eph receptors are expressed not only in retinal ganglion

89 In contrast, B-class Eph receptors are expressed on decussated commissural ax

90 The ephrins and Eph receptors are implicated as positional labels that m

91 Ephrin ligands and their Eph receptors are key regulators of endothelial cell (EC

92 The Eph receptors are multitalented tyrosine kinases capable

93 post-synaptic membrane, while their cognate Eph receptors are presumed to be pre-synaptic.

94 The Eph receptors are the largest known family of receptor t

95 Eph receptors are unique among other RTKs in that they f

96 of protein receptor tyrosine kinases (RTKs), Eph receptors are unique in possessing a sterile alpha m

97 Ephrins and Eph receptors are well accepted as graded labels for map

98 Eph receptors are widely expressed during cerebral corti

99 Erythropoietin-producing hepatoma (Eph) receptors are critical for tissue organization.

100 tamembrane tyrosine (Y594), conserved in all Eph receptors, are both critical for NIK activation by E

101 ional differences between two highly similar Eph receptors at a decision point in vivo, with EphB1 di

102 region of EphB2, because they are conserved Eph receptor autophosphorylation sites and demonstrated

103 We show that multiple Eph receptors (B1, B2, B3, and A4) and B-class ephrins (

104 We further identified Eph receptor B2 (Ephb2) as a direct target of Ascl1.

105 itivity of growth cones to semaphorin 3F and Eph receptor B2, two repulsive guidance cues crucial for

106 ygous missense variants in the gene encoding Eph receptor B4 (EPHB4).

107 Eph receptors belong to a subfamily of receptor tyrosine

108 Eph receptor binding triggered ephrin-A2 cleavage in a l

109 s are promiscuous in their interactions with Eph receptors, binding studies with the five receptors k

110 g intermediate, SHEP1 (SH2 domain-containing Eph receptor-binding protein 1), which is expressed in t

111 Each Eph receptor binds an ephrin ligand through an expansive

112 In addition, SAX-3/Robo and the VAB-1/Eph receptor both function to prevent aberrant axon cros

113 ted neuronal cultures, activation of ephrin (Eph) receptors by chimeric preclustered eph-Fc ligands l

114 We previously found that the Eph receptor Cek5 is more highly expressed in the ventra

115 provide the first functional evidence of an Eph receptor-class-specific intracellular signaling prot

116 Eph receptors comprise the largest family of receptor ty

117 The association of ephexin with Eph receptors constitutes a molecular link between Eph r

118 Three new articles show that the Eph receptors continue to be important in modifying the

119 lated endocytic trafficking of the VAB-1 MSP/Eph receptor contributes to the control of oocyte meioti

120 For example, Eph receptors control whether two contacting cells are r

121 ceptor type O (PTPRO), which is required for Eph receptor-dependent retinotectal development in chick

122 d ephrins, which together with their cognate Eph receptors, direct axon navigation in a contact-media

123 y, we show that Ephexin binds the Drosophila Eph receptor (Eph) and Eph mutants disrupt synaptic home

124 Graded expression of the Eph receptor EphA3 in the retina and its two ligands, ep

125 n vivo tyrosine phosphorylation sites of the Eph receptors EphA3, EphA4, and EphB2 in embryonic retin

126 ing, so we hypothesized that deletion of the Eph receptor EphA4 would impair target selection in thes

127 a6A, and have helped re-evaluate that of the Eph receptor EphA4.

128 g somites and presomitic mesoderm, as is the Eph receptor EphA4.

129 We previously showed that the Eph receptor, EphA4, is expressed selectively in the dor

130 ental changes in the expression of two other Eph receptors, EphB2 and EphB5, and two ligands, ephrin-

131 y, we determined whether NIK is activated by Eph receptors (EphR).

132 at two members of the B-class of ephrins and Eph receptors, ephrin-B2 and EphB2, are expressed by ast

133 These data demonstrate that the Eph receptor-ephrin interface can be targeted by inhibit

134 The Eph receptor-ephrin system is an emerging target for the

135 n the development of compounds that modulate Eph receptor/ephrin interactions and biological activiti

136 ithelial somites is accompanied by a lack of Eph receptor/Ephrin signaling interfaces.

137 uld be used to selectively deliver agents to Eph receptor-expressing tissues and modify Eph signaling

138 gnalling occurs between adjacent ephrin- and Eph-receptor-expressing cells.

139 of KLFs in regulating neurite outgrowth and Eph receptor expression will be vital for successful res

140 We have isolated the genes for the eph receptor family ligands mouse LERK-3/Ephrin-A3 (Epl3

141 phrin binding triggers the clustering of the Eph receptor, fostering transphosphorylation and signal

142 applications of agents capable of modulating Eph receptor function, no small molecule inhibitors targ

143 dies shed light on which B-class ephrins and Eph receptors function to regulate CC midline growth and

144 d that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsynaptically as a receptor

145 An Eph receptor has now been shown also to regulate cell ad

146 One family, ephrins and Eph receptors, has been implicated in mediating midline

147 members of the ephrin family of ligands for Eph receptors have been identified in C. elegans.

148 Eph receptors have been known to be capable of respondin

149 1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundant function

150 ts involved in the signaling pathways of the Eph receptors, however, are incompletely characterized.

151 FN-4 may function independently of the VAB-1 Eph receptor in morphogenesis.

152 l septum, and that expression of a truncated Eph receptor in the mouse brain results in a pronounced

153 hway may explain the repulsive effect of the Eph receptors in axonal pathfinding and may facilitate t

154 s support a significant role for ephrins and Eph receptors in CC development and may provide insight

155 nt progress in understanding the function of Eph receptors in normal development and how disregulatio

156 These data support a role for ephrins and Eph receptors in regulating astrocyte gliotransmitters,

157 The functions of Eph receptors in the adult brain have only recently been

158 used in situ hybridization to localize nine Eph receptors in the chicken retina and optic tectum at

159 we provide the first comprehensive review of Eph receptors in the context of tumor immunity.

160 Our data provide new evidence that Eph receptors in the same subfamily are not simply inter

161 entions, further elucidation of the roles of Eph receptors in the tumor immune microenvironment will

162 y tumors and support the function of A class Eph receptors in tumor progression.

163 luate the function of the ephrin ligands and Eph receptors in vitro and in vivo in corneal angiogenes

164 data suggest an inhibitory role for midline Eph receptors, in which low levels permit axon growth an

165 We showed in this study that several Eph receptors, including EphA3, Eph A4, and Eph A5, are

166 secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, p

167 in the absence of the MSP ligand, the VAB-1 Eph receptor inhibits meiotic maturation while either in

168 ing and characterization of ephexin, a novel Eph receptor-interacting protein that is a member of the

169 knockout mice and chimeras revealed that Eph-Eph receptor-interacting proteins (ephrins) are expresse

170 The transmembrane ephrinB (Eph receptor interactor B) protein is a bidirectional si

171 e mechanism and regulation of ligand-induced Eph receptor internalization are not well understood.

172 Endocytosis of Eph receptors is critical for a number of biological pro

173 his phenomenon means that signalling through Eph receptors is largely dependent on cell-cell contact.

174 residue located in its effector domain by an Eph receptor kinase.

175 human platelets express on their surface the Eph receptor kinases EphA4 and EphB1 and the Eph kinase

176 Interaction of ephrinB molecules with Eph receptors leads to changes in long-term potentiation

177 We report here that mosaic activation of Eph receptors leads to sorting of cells to boundaries in

178 lation and characterisation of two zebrafish Eph receptor ligand cDNAs which we have called zfEphL3 a

179 We report that targeted inactivation of the Eph receptor ligand ephrinB1 in mouse caused perinatal l

180 antagonistic interactions with ephrinB1, an Eph receptor ligand that has a key role in regulating th

181 upport a possible role for repulsive B-class Eph receptor/ligand interactions in constraining the ori

182 The ephrins and Eph receptors make up two large families of bi-direction

183 Eph receptors mediate this response through interactions

184 The regulation of Eph receptor-mediated developmental processes by protein

185 dline during this growth, and the effects of Eph receptor misexpression on axonal growth across the m

186 The Manduca homologs of the Eph receptor (MsEph) and ephrin ligand (MsEphrin) are mo

187 hrin (MsEphrin; a GPI-linked ligand) and its Eph receptor (MsEph) might regulate the migration and ou

188 the midline cells express the corresponding Eph receptor (MsEph).

189 In contrast, neither Eph receptors nor ephrins are detectable in intrinsic co

190 This is the first evidence that Eph receptors play a physiological role in dendritic spi

191 of granuloma structure makes it likely that Eph receptors play a role in immunity to tuberculosis.

192 Eph receptors play critical roles in the establishment a

193 Eph receptors play important roles in axon guidance at t

194 Because Eph receptors play prominent roles in both the immune sy

195 in situ binding assay to identify the VAB-1 Eph receptor protein-tyrosine kinase as an MSP receptor.

196 s to multiple receptors, including the VAB-1 Eph receptor protein-tyrosine kinase on oocyte and ovari

197 We conclude that ephrinB1 and B class Eph receptors provide positional cues required for the n

198 w area of research, which has shown that the Eph receptors regulate the structure and physiological f

199 However, the functions of SAM domains in Eph receptors remain elusive.

200 or immune microenvironment, an area in which Eph receptors remain understudied.

201 Transmembrane B ephrins and their Eph receptors signal bidirectionally.

202 promotes meiotic maturation by antagonizing Eph receptor signaling and counteracting inhibitory inpu

203 r cellular contexts, thereby suggesting that Eph receptor signaling is mechanistically distinct in di

204 a, where they may regulate contact-dependent Eph receptor signaling pathways.

205 Eph receptor signaling plays key roles in vertebrate tis

206 Eph receptor signaling prevents intermingling at many bo

207 Little is known about whether the ephrin-Eph receptor signaling system is subject to such additio

208 tudy, we investigated whether the ability of Eph receptor signaling to mediate cell repulsion is anta

209 on, including potassium channel function and EPH receptor signaling.

210 These findings identify a novel Eph receptor signalling pathway with tumour-suppressor a

211 nce, including the involvement of the ephrin/Eph receptor system in contact repulsion.

212 eb-mTOR signaling cooperates with the ephrin-Eph receptor system to control axon guidance in the visu

213 s that WRK-1 functionally interacts with the Eph receptor system.

214 m, is that axons carrying similar amounts of Eph receptor terminate near to one another on the target

215 onist for EphA2 and EphA4, but not for other Eph receptors tested.

216 This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-p

217 4 and EphA2 from those of other co-expressed Eph receptors that are activated by the same ephrin liga

218 f transmembrane proteins called ephrinBs and Eph receptors that are expressed in the synapse and are

219 Eph receptors, the largest family of receptor tyrosine k

220 Eph receptors, the largest subfamily of receptor tyrosin

221 ach ephrin ligand to promiscuously bind many Eph receptors, the two compounds selectively target EphA

222 ar endothelial cell growth factor receptors, Eph receptors, Tie1, and Tie2, all of which are expresse

223 g a role for RCP-dependent trafficking of an Eph receptor to drive tumour dissemination in vivo.

224 tly links activated, tyrosine-phosphorylated Eph receptors to small Ras superfamily GTPases.

225 Eph receptor trafficking in other systems may be influen

226 Eph receptors transduce short-range repulsive signals fo

227 The Eph receptors transmit forward signals via their kinase

228 To dissect the mechanism by which Eph receptors transmit signals, we have developed an app

229 Here we describe a role for a Drosophila Eph receptor tyrosine kinase (EPH) in the control of pho

230 We have evaluated the role of an Eph receptor tyrosine kinase and an ephrin ligand in the

231 The Eph receptor tyrosine kinase EphA4 and the membrane-boun

232 The Eph receptor tyrosine kinase gene EphA4 (Sek-1) is expre

233 dermal development similar to those of VAB-1 Eph receptor tyrosine kinase mutants.

234 Roles for Eph receptor tyrosine kinase signaling in the formation

235 e have begun to examine the possibility that Eph receptor tyrosine kinase signaling is involved in es

236 ive interactions between cells expressing an Eph receptor tyrosine kinase, EphA4, and cells expressin

237 Here we show that the Eph receptor tyrosine kinase, EphB2, can control integri

238 crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large i

239 In adult animals lacking the VAB-1 Eph receptor tyrosine kinase, mechanosensory axon regrow

240 The C. elegans genome encodes a single Eph receptor tyrosine kinase, VAB-1, which functions in

241 Eph receptor tyrosine kinases and ephrins are required f

242 Eph receptor tyrosine kinases and ephrins mediate contac

243 incident rhombomere-restricted expression of Eph receptor tyrosine kinases and Hox homeobox genes, ra

244 Eph receptor tyrosine kinases and their ephrin ligands h

245 In this study, we tested the role of Eph receptor tyrosine kinases and their ephrin ligands i

246 Eph receptor tyrosine kinases and their ephrin ligands m

247 Eph receptor tyrosine kinases and their ephrin ligands p

248 The interactions between Eph receptor tyrosine kinases and their ephrin ligands r

249 The family of Eph receptor tyrosine kinases and their ephrin ligands r

250 Eph receptor tyrosine kinases and their ephrin ligands r

251 Recent evidence suggests that Eph receptor tyrosine kinases and their ligands provide

252 Eph receptor tyrosine kinases and their ligands, ephrins

253 Eph receptor tyrosine kinases and their ligands, the eph

254 y combinatorial expression of genes encoding Eph receptor tyrosine kinases and their ligands, the eph

255 Eph receptor tyrosine kinases and their ligands, the eph

256 Eph receptor tyrosine kinases and their membrane-anchore

257 Eph receptor tyrosine kinases and their membrane-associa

258 The Eph receptor tyrosine kinases and their membrane-tethere

259 Eph receptor tyrosine kinases and their membrane-tethere

260 Eph receptor tyrosine kinases are critical for cell-cell

261 The transmembrane ephrinB ligands and their Eph receptor tyrosine kinases are known to regulate exci

262 onents of the neuronal signaling pathways of Eph receptor tyrosine kinases are only beginning to be e

263 The Eph receptor tyrosine kinases are overexpressed in many

264 Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or

265 igands and receptors such as the ephrins and Eph receptor tyrosine kinases controls a wide range of d

266 t issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regu

267 Genetic studies have shown that Eph receptor tyrosine kinases have both kinase-dependent

268 ls mediated by membrane-anchored ephrins and Eph receptor tyrosine kinases have important functions i

269 Eph receptor tyrosine kinases mediate neurodevelopmental

270 At CNS targets, interactions between Eph receptor tyrosine kinases on RGC axons and ephrin li

271 Eph receptor tyrosine kinases play key roles in pattern

272 Eph receptor tyrosine kinases represent promising diseas

273 We conducted a comprehensive analysis of the Eph receptor tyrosine kinases to determine which members

274 mural cells require ephrin-B2, a ligand for Eph receptor tyrosine kinases, for normal association wi

275 Eph receptor tyrosine kinases, including EphA2, are expr

276 report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens

277 h that ephrin-B2, a transmembrane ligand for Eph receptor tyrosine kinases, promotes sprouting behavi

278 Ephrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal axons in v

279 ent and plasticity, are regulated in part by Eph receptor tyrosine kinases.

280 ily of non-receptor tyrosine kinases and the Eph receptor tyrosine kinases.

281 ephrin A1, a member of the ligand family for Eph receptor tyrosine kinases.

282 omologous to those in the C-terminal tail of Eph receptor tyrosine kinases.

283 in-producing human hepatocellular carcinoma (Eph) receptor tyrosine kinases (RTKs) regulate a variety

284 ietin-producing hepatoma-amplified sequence (Eph) receptor tyrosine kinases and their cell-surface-bo

285 However, blocking experiments suggest that Eph-receptor tyrosine kinases may be required for the se

286 What makes Eph receptors unique is that their cognate ligands, the

287 tify molecules that physically interact with Eph receptors using the cytoplasmic domain of EphA3 as "

288 Eph receptors usually guide migrations of cells by exclu

289 es phenotypes of mutations in the C. elegans Eph receptor VAB-1 and a subset of its ephrin ligands, b

290 We describe the function of the Eph receptor vab-1 and multiple ephrin ligands at the mi

291 The Eph receptor VAB-1 is required in neurons for epidermal

292 t, through HIF-1-dependent regulation of the Eph receptor VAB-1.

293 Phospho-Eph (p-Eph) receptor was evaluated during active EC proliferati

294 The Eph receptors, which bind a group of cell-membrane-ancho

295 phogenesis is triggered by the activation of Eph receptors, which causes tyrosine phosphorylation of

296 Indeed, all other Eph receptors, which promiscuously bind many ephrins, ha

297 butions of specific structural motifs within Eph receptors, wild-type or mutant forms of the EphA4 re

298 ance system that involves the interaction of Eph receptors with ephrin ligands.

299 rstanding how to modulate the interaction of Eph receptors with their ephrin ligands is therefore of

300 ythropoietin-producing human hepatocellular (Eph) receptors with their membrane-bound ephrin ligands