ライフサイエンスコーパス: EphA receptor

1 tion through tonic stimulation of alpha-cell EphA receptors.

2 ligands, to retinal growth cones, expressing EphA receptors.

3 We also found that EphA receptor activation by ephrin-A ligands in neurons

4 Ephrin-A3-dependent EphA receptor activation is reduced in mutant cells that

5 ntagonist) or the ligand binding site of the EphA receptor (agonist) and thus target EphA function.

6 The induced association of EphA receptor and Vav proteins modulates the activity of

7 n between complementary gradients of retinal EphA receptors and collicular ephrin-A ligands.

8 , through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and

9 eved to involve graded repulsion mediated by EphA receptors and ephrin-A ligands.

10 that in the chicken olivocerebellar system, EphA receptors and ephrin-As are expressed with distinct

11 Here we review recent data indicating that EphA receptors and glycosylphosphatidylinositol (GPI)-an

12 signaling activities exerted by coexpressed EphA receptors and GPI-linked ephrin-A ligands in spinal

13 Thus, EphA receptors and their ligands are implicated as media

14 There are 10 EphA receptors, and six EphB receptors, distinguished on

15 al to low nasal gradient in RGCs, similar to EphA receptors, and that balanced FAK activation is nece

16 In addition, multiple EphA receptors are expressed in callosal neurons and eph

17 We show that multiple EphA receptors are expressed in DRGs when limb innervati

18 LMC axons also express ephrinAs, while their EphA receptors are expressed in the limb mesenchyme.

19 In the embryonic visual system, EphA receptors are expressed on both temporal and nasal

20 The EphA receptors are generally thought to become activated

21 n limb innervation is being established, and EphA receptors are present on growth cones of both NGF-d

22 A6 binds with high affinity to several other EphA receptors as well and causes growth cone collapse i

23 niculate projections that suggest defects in EphA receptor-dependent axon guidance.

24 hemistry revealed the expression of multiple EphA receptors (EphARs) in astrocytes.

25 ypothesis by using gene targeting to elevate EphA receptor expression in a subset of mouse ganglion c

26 g paradigm to a transgenic mouse lacking the EphA receptor family ligands ephrin-A2 and ephrin-A5 res

27 is well established that EphA7, a member of EphA receptor family, is involved in the topographic map

28 glion cell populations that express distinct EphA receptor gradients.

29 observations suggest critical functions for EphA receptor in establishing callosal connections durin

30 ow the functional requirement for endogenous EphA receptors in retinotectal mapping, show that the re

31 , we describe a loss-of-function analysis of EphA receptors in retinotectal mapping.

32 ur data suggest that prolonged activation of EphA receptors is as efficient in recruiting Slap and NM

33 but that in cell culture, expression of the EphA receptors is predominant.

34 iments, exploiting a combinatorial series of EphA receptor knock-in and knockout mice, confirm the sa

35 Of the eight EphA receptors known to be expressed in mice (A1-A8), RT

36 ch can be predicted as a function of the net EphA receptor level that a given ganglion cell expresses

37 tition is not based on comparisons of axonal EphA receptor levels but rather relies on the optimizati

38 The EphA receptor-mediated angiogenic response is dependent

39 Ephrin-A stimulation of EphA receptors modulates the activity of ephexin leading

40 Ephrin-A1 and ephrin-A4 selectively bind to EphA receptors on neurons restricted to the matrix compa

41 ar maps in mice in which the distribution of EphA receptors over the retina has been modified by knoc

42 branching is mediated by relative levels of EphA receptor repellent signaling.

43 Here we show that EphA receptor signaling remodels spines by triggering a

44 ls (HUVECs), demonstrating a requirement for EphA receptor signaling.

45 mpetition that is governed by comparisons of EphA receptor signalling intensity, which are made using

46 the individual roles played by the multiple EphA receptors that make up the retinal EphA gradient.

47 ciation of ephrin-A cell surface ligands and EphA receptor tyrosine kinases (RTKs) with the organizat

48 expression of members of the EphA family-the EphA receptor tyrosine kinases and the ephrin-A ligands-

49 this map requires complementary gradients of EphA receptor tyrosine kinases and their ephrin-A ligand

50 Ephrin-A1, the prototypic ligand for EphA receptor tyrosine kinases, is overexpressed in vasc

51 Thus, EphA receptors utilize discrete cellular and molecular p

52 are no pharmacological agents available for EphA receptors, we designed recombinant immunoadhesins t