ライフサイエンスコーパス: EphB receptor

1 ction being selectively inhibited by soluble EphB receptor.

2 ty peptides antagonize ephrin binding to the EphB receptors.

3 mediates high-affinity interaction with the EphB receptors.

4 nd NMDA receptors as prolonged activation of EphB receptors.

5 embrane-anchored presynaptic ligands for the EphB receptors.

6 emonstrate that melanoblasts express several EphB receptors.

7 und to be remarkably conserved between these EphB receptors.

8 In mice lacking ephrin-B3 or multiple EphB receptors, a significant number of axons followed a

9 nd that ephrin-B2-mediated activation of the EphB receptors accelerates dendritic spine development.

10 g within the retina is partially mediated by EphB receptors acting in a kinase-independent manner.

11 Recombinant ephrinB1-Fc, which induces EphB receptor activation, enhanced bFGF-induced tube for

12 Dominant-negative inhibition of endogenous EphB receptor activities blocks clustering of endogenous

13 B localized to the midline, together with an EphB receptor and a zinc-finger transcription factor exp

14 inhibitors of the pathological activities of EphB receptors and as targeting agents for imaging probe

15 more fully document the presence of specific EphB receptors and B-ephrins in embryonic mouse retina a

16 Contact-dependent interactions between EphB receptors and ephrin-B ligands mediate a variety of

17 be the spatiotemporal expression patterns of EphB receptors and ephrin-B1 in the vertebrate spinal co

18 At this age, ephrin-B2, a ligand for EphB receptors and for EphA4, is expressed in NL cell bo

19 through an association between postsynaptic EphB receptors and presynaptic B-ephrins are necessary f

20 s-synaptic interactions between postsynaptic EphB receptors and presynaptic B-ephrins are necessary f

21 These functions require processing of EphB receptors and removal of EphB-ephrinB complexes fro

22 EphB receptors and their ephrin-B ligands are required f

23 These observations indicate that the EphB receptors and their ligand regulate hippocampal axo

24 are phosphorylated upon interaction with an EphB receptor, and may transduce signals that regulate a

25 Here we show that EphB receptors, and especially EphB4, regulate the migra

26 At this age, EphB receptors are expressed at the ventral floor plate.

27 EphB receptors are expressed in a low to high DV gradien

28 The EphB receptors are expressed in the hippocampus, and the

29 yonic mouse retina and provide evidence that EphB receptors are involved in RGC axon pathfinding to t

30 on of the embryonic mouse spinal cord, while EphB receptors are present on decussated segments of com

31 as RGC axons begin this pathfinding process, EphB receptors are uniformly expressed along the dorsal-

32 These data suggest that EphB receptors are upstream regulators of FAK in dendrit

33 ed in the dorsal spinal cord, and decussated EphB receptor-bearing commissural axons navigate between

34 however, are significantly inhibited by the EphB receptor blocker.

35 Spinal administration of an EphB receptor blocking reagent EphB2-Fc prevents and/or

36 the retina to the optic disc is dependent on EphB receptors, but independent of their kinase activity

37 We show that the expression of EphB receptors by motor axons, and ephrin-B ligands by l

38 Overexpression of dominant-negative EphB receptor, catalytically inactive kalirin, or domina

39 These results indicate EphB receptor cell autonomous forward signaling is respo

40 We report that EphB receptors direct unique axonal behaviors required f

41 There are 10 EphA receptors, and six EphB receptors, distinguished on sequence difference and

42 role of Eph proteins signaling as receptors, EphB receptor ECDs can also function in the opposite rol

43 proteins including cadherins, integrins, and EphB receptor/ephrinB significantly reduced the presynap

44 ll-to-cell contact, engagement of EphrinB by EphB receptors expressed on another cell, and Src-depend

45 thus grow across the midline at a time when EphB receptor expression levels are low.

46 on and post-transcriptional up-regulation of EphB receptor expression through relief of endocytosis a

47 ritic spines, and is accomplished through an EphB receptor-focal adhesion kinase (FAK) pathway.

48 jor recent advance is the demonstration that EphB receptor forward signaling and ephrin-B reverse sig

49 We show in vivo that EphB receptor forward signaling and the ephrinB1 ligand

50 Furthermore, inhibition of EphB receptor forward signaling by overexpression of a f

51 increases RhoA activity, whereas inhibiting EphB receptor forward signaling decreases RhoA activity.

52 llowing ephrinB(+) cells to trans-endocytose EphB receptors from opposing cells.

53 idirectional signaling between ephrin-B2 and EphB receptors impairs morphogenetic cell-cell septation

54 te the well-established roles of ephrins and EphB receptors in axon pathfinding, expression of these

55 dies demonstrate that FAK acts downstream of EphB receptors in hippocampal neurons and EphB2-FAK sign

56 that signaling occurs between B-ephrins and EphB receptors in the adult CNS in response to injury.

57 ults indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS)

58 on assays, engagement of ephrin-B ligands to EphB receptors increases melanoblast attachment to fibro

59 with Connector Enhancer of KSR1 (CNK1) in an EphB receptor-independent manner.

60 of ephrinB2 to EphB4, these data suggest an EphB-receptor-independent blocking mechanism.

61 Activation of the EphB receptor induces translocation of the Rho-GEF kalir

62 e activated by ephrin-A ligands, whereas the EphB receptors interact with ephrin-B ligands.

63 reported high ventral-low dorsal gradient of EphB receptors later in development when RGC axons map t

64 We report that the EphB receptor ligand, ephrin-B1, may act bifunctionally

65 ervations provide a mechanistic link between EPHB receptor mutations and metastasis in colorectal can

66 EphB receptors provide crucial adhesive and repulsive si

67 in is specifically required for EphA and not EphB receptor signaling in mouse and chick spinal motor

68 Alternatively, EphB receptor signaling may act as a 'ligand-density sen

69 This novel role for EphB receptor signaling suggests that these molecules ma

70 These findings indicate that EphB receptor signaling, probably by interacting with NR

71 Peptides with the same EphB receptor specificity compete with each other for bi

72 that dorsal retinal axons prefer to grow on EphB receptor stripes supporting an attractive guidance

73 hosphorylation sites identified here for the EphB receptors suggest a complex regulation of their fun

74 wever, because VT RGCs express more than one EphB receptor, the sufficiency and specificity of the Ep

75 r protein for kinesin-dependent transport of EphB receptors to dendrites.

76 Binding of EphB receptors to ephrinB ligands on the surface of adja

77 Signaling is initiated by binding of EphB receptors to ephrinB ligands, stimulating their tyr

78 The ability of the EphB receptors to regulate cell migration and promote an

79 We have identified an ephrinB-EphB receptor trans-synaptic signaling pathway which reg

80 EphB receptor tyrosine kinase signaling has been implica

81 pse development until EphrinB binding to the EphB receptor tyrosine kinase triggers Ephexin5 phosphor

82 nd antibodies that interfere with binding of EphB receptor tyrosine kinases (EphRs) to the PDZ protei

83 EphB receptor tyrosine kinases are enriched at synapses,

84 The EphB receptor tyrosine kinases are localized at excitato

85 Recent evidence supports a role for EphB receptor tyrosine kinases as tumour suppressors in

86 EphB receptor tyrosine kinases control multiple steps in

87 Here we show that activation of the EphB receptor tyrosine kinases in cultured hippocampal n

88 a genetic approach, we dissect the roles of EphB receptor tyrosine kinases in dendritic spine develo

89 In neurons, EphB receptor tyrosine kinases mediate excitatory synapt

90 rinB transmembrane ligands and their cognate EphB receptor tyrosine kinases regulate vascular develop

91 EphrinB2, a transmembrane ligand of EphB receptor tyrosine kinases, is specifically expresse

92 We investigated roles of EphB receptor tyrosine kinases--which play important rol

93 l studies have reported the up-regulation of EphB receptor-tyrosine kinases and ephrin-B ligands in a

94 Notably, EphB receptors utilize the Tiam1-Bcr complex to control