ライフサイエンスコーパス: ErbB-4 receptor

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1 ddition, they are associated with erbB-1 and erbB-4 receptors.

2 ) associates physically with the full-length ErbB-4 receptor and functionally with the ErbB-4 cytopla

3 nd-dependent receptor trafficking, activated ErbB-4 receptors are subject to proteolytic cleavage inv

4 ctivity, however, does not act on the native ErbB-4 receptor before the metalloprotease-mediated clea

5 R analysis that expression of the ErbB-2 and ErbB-4 receptors, but not ErbB-1 or ErbB-3, is deregulat

6 ly regulates heregulin signaling through the ErbB-4 receptor by the activation of a selective proteol

7 els occurring in tumors with high ErbB-2 and ErbB-4 receptor coexpression.

8 Thus, activation of the erbB-2-erbB-4 receptor complex appears to be a critical compone

9 ced receptor trafficking between the EGF and ErbB-4 receptors, EGF and heregulin have equivalent capa

10 ErbB-4 receptor expression appeared to correlate with ER

11 erstanding of the biological significance of ErbB-4 receptor in breast cancer.

12 To delineate the biological function of ErbB-4 receptors in breast cancer, we used a hammerhead

13 se of ErbB-4 ribozymes to define the role of ErbB-4 receptors in human cancers.

14 ozyme strategy to achieve down-regulation of ErbB-4 receptors in various breast cancer cell lines.

15 ssays that intramembrane cleavage of APP and ErbB-4 receptor is not impaired by the Abeta42-lowering

16 binding to NIH 3T3 cells overexpressing the ErbB-4 receptor is rapidly decreased by 12-O-tetradecano

17 The ErbB-4 receptor is unique among the ErbB proteins becaus

18 Our data suggest that elevation of the ErbB-4 receptor plays a role in ER+ breast cancer cell p

19 we show that activation of astrocytic erbB-2/erbB-4 receptors plays a significant role in the process

20 The ErbB-4 receptor protein-tyrosine kinase is proteolytical

21 tutive activation of the erbB-2, erbB-3, and erbB-4 receptor signaling cascade.

22 In addition, YAP interacts with ErbB-4 receptor tyrosine kinase and acts as transcriptio

23 Ectodomain cleavage of the ErbB-4 receptor tyrosine kinase generates a membrane-ass

24 The ErbB-4 receptor tyrosine kinase has a PDZ domain recogni

25 The ErbB-4 receptor tyrosine kinase homo- and heterodimerize

26 er cells revealed that the expression of the ErbB-4 receptor was completely abrogated by ribozyme tre

27 analyzed the heregulin-responsive wild-type ErbB-4 receptor, which does not mediate the rapid intern

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