ライフサイエンスコーパス: ErbB4 receptor

1 g the C-terminal 20 amino acids of the mouse ErbB4 receptor.

2 oligodendrocytes expressed erbB2, erbB3, and erbB4 receptors.

3 by neuregulin-2 is mediated by ErbB3 and/or ErbB4 receptors.

4 ivation of the BACE1 beta-secretase, and (3) ErbB4 receptor activation.

5 -activated protein kinase activation through ErbB4 receptors and were able to modulate a transphospho

6 Importantly, D4 and ErbB4 receptors are coexpressed in parvalbumin-positive

7 However, ErbB4 receptors are expressed in subpopulations of GABAe

8 Here, we show that the erbB4 receptor, as a postsynaptic target of NRG1, plays

9 tential signaling partner of the full-length ErbB4 receptor at the membrane and of the COOH-terminal

10 d ErbB4 receptor levels, (b) solubilized the ErbB4 receptor cognate ligand heparin-bound epidermal gr

11 actor heregulin (HRG), a ligand of ErbB3 and ErbB4 receptors, contributes to breast cancer developmen

12 olving increased expression of a PI3K-linked ErbB4 receptor (CYT-1) and the phosphoinositide 3-kinase

13 ansgenic mice expressing a dominant-negative erbB4 receptor (DN-erbB4) under the control of the GFAP

14 at preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of s

15 signaling in the nucleus by an intracellular ErbB4 receptor fragment that is released upon receptor a

16 like growth factors on signaling through the ErbB4 receptor homodimer in CEM/HER4 cells, a transfecte

17 lates GABAergic transmission via presynaptic ErbB4 receptors, identifying a novel function of NRG1.

18 s evidenced by its ability to bind ErbB3 and ErbB4 receptor-IgG fusion proteins with affinities close

19 resence of mRNA for all four variants of the erbB4 receptor in a single CNS cell type.

20 etermined the expression of neuregulin 1 and ErbB4 receptors in AS mice and wild-type littermates (ag

21 Overexpression of ErbB2 and ErbB4 receptors in breast cancers may be accompanied by

22 iated by NRG1/ErbB signaling, which requires ErbB4 receptors in PV interneurons, is impaired.

23 Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possib

24 nts and induces the suppression of ErbB3 and ErbB4 receptor levels but not epidermal growth factor re

25 estigation showed that MMP7 (a) up-regulated ErbB4 receptor levels, (b) solubilized the ErbB4 recepto

26 The erbB4 receptor ligand neuregulin-1beta (NRG1beta) promot

27 puberty, the physiological contribution that erbB4 receptors may make to this process has not been es

28 nd widespread expression of ErbB2, ErbB3 and ErbB4 receptor mRNAs throughout the telencephalon of juv

29 Conversely, in mice which lack the erbB4 receptor (normally expressed in r3), trigeminal an

30 epidermal growth factor receptor (EGFR), and ErbB4 receptors or blocking antibodies directed to plate

31 Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cle

32 erbB3 and erbB4 receptors showed the highest expression in tumor s

33 gulins are a family of ligands for the ErbB3/ErbB4 receptors that play important roles in breast canc

34 2 are both binding ligands for the ErbB3 and ErbB4 receptors, they exhibit distinct biological activi

35 ected E-cadherin-dependent activation of the ErbB4 receptor tyrosine kinase but not of other ErbB fam

36 ErbB4 receptor tyrosine kinase contributes to the develo

37 The ErbB4 receptor tyrosine kinase regulates cell growth, su

38 family of EGF proteins and a ligand for the ErbB4 receptor tyrosine kinase that plays pleotropic rol

39 llustrate that PIAS3 is a novel regulator of ErbB4 receptor tyrosine kinase, controlling its nuclear

40 lear localization and function of the ICD of ErbB4 receptor tyrosine kinase.

41 ophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase.

42 teady-state cellular levels of the ErbB3 and ErbB4 receptor tyrosine kinases and has been implicated

43 the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases.

44 he ligand specificity and function(s) of the erbB4 receptor variants.

45 Binding to ErbB3 and ErbB4 receptors was affected by mutation of residues thr

46 Both ErbB2 and ErbB4 receptors were found to be expressed by neonatal a

47 in-1 (type I) are mediated by a homo-dimeric ErbB4 receptor, which can interact with the PSD-95 prote

48 strocytes, SynCAM1 is functionally linked to erbB4 receptors, which are involved in the control of bo