ライフサイエンスコーパス: Ets transcription factor

1 ein with the DNA binding domain of FLI-1, an ETS transcription factor.

2 encompasses multiple binding motifs for the ETS transcription factor.

3 thway regulates G-CSF expression through the Ets transcription factor.

4 33, Ccl20, and SAM pointed domain-containing Ets transcription factor.

5 nd synergistically activated by Forkhead and Ets transcription factors.

6 ulation by the absence of a binding site for Ets transcription factors.

7 sors, including a core component of PRC1 and ETS transcription factors.

8 E-3), a novel member of the ESE subfamily of Ets transcription factors.

9 s may function as dominant negative forms of ets transcription factors.

10 s of Ras1 and two Ras1/MAP kinase-responsive ETS transcription factors.

11 rol the activity of this subset of oncogenic Ets transcription factors.

12 canonical ETS motifs by displacing wild-type ETS transcription factors.

13 result in overexpression of any one of four ETS transcription factors.

14 des an erythroblast transformation-specific (ETS) transcription factor.

15 ccurred via the E26 transformation-specific (ETS) transcription factor.

16 L sequences, an E26-transformation-specific (ETS) transcription factor.

17 alysis revealed that the epithelium-specific ETS transcription factor-1 (ESE-1 or ELF3), known to reg

18 ers of EHF and the 5' adjacent gene E47 like ETS transcription factor 5 (ELF5) in reporter gene assay

19 SAP-1 is a member of the Ets transcription factors and cooperates with SRF protei

20 e precise spatial relationship between these Ets transcription factors and the FGF signal originating

21 nscriptional control of Bcl-xl that involves ETS transcription factors and the HGF/Met axis.

22 the anterior one producing the Pointed (Pnt) ETS transcription factors and the posterior one the Odd-

23 Here we report that beta-catenin, Lef-1, Ets transcription factors, and the AP-1 protein c-Jun ea

24 o consensus binding motifs for E-twenty-six (ETS) transcription factors, and in reporter assays, the

25 ETS transcription factors are commonly deregulated in ca

26 cations leading to deregulated expression of ETS transcription factors are frequent in prostate tumor

27 ETS transcription factors are hypothesized to play a sim

28 Ets transcription factors are important downstream targe

29 Ets transcription factors are known to be important medi

30 Here, members of two groups of ETS transcription factors are shown to act directly at t

31 The DA motif is activated by the ETS transcription factor AST-1.

32 eal disparate, but overlapping, functions of Ets transcription factors at distinct stages of megakary

33 ted transcription and activate expression of ETS transcription factors at the early stages of more th

34 assays demonstrated that IRF-8 and the PU.1 Ets transcription factor bind to this element in vivo.

35 This region contains an Ets transcription factor binding motif, and a 2-base pai

36 scription initiation site and includes three Ets transcription factor binding sequences.

37 n by deltaRaf-1:ER required a composite AP-1/Ets transcription factor binding site located between bp

38 -responsive element (HRE) in proximity to an ETS transcription factor binding site.

39 appaB consensus site, it does contain tandem Ets transcription factor binding sites previously shown

40 ell enhancer contains four perfect consensus Ets transcription factor binding sites that are efficien

41 omoters show significant enrichment for NRF2/ETS transcription factor binding sites.

42 Consistent with the predicted loss of ETS transcription factor binding, we observed that recur

43 mutations are predicted to disrupt consensus ETS transcription factor-binding sites and are correlate

44 ndrogen-stimulated overexpression of ERG, an ETS transcription factor, but critical downstream effect

45 We further demonstrate that Ets transcription factors, but not Nrf2, are regulated d

46 pecific transcription factors, including the ETS transcription factors, C/EBP, GATA, and CREB.

47 Ets transcription factors control multiple biological pr

48 Transcriptional analysis revealed that Ets transcription factors controlled VEGFR2 expression i

49 with a key role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression i

50 d dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 (refs.

51 this study, we report that the E-twenty six (ETS) transcription factor E74-like factor 4 (ELF4) suppr

52 ction studies and ChIP-seq, we show that the Ets transcription factor EHF promotes cornea epithelial

53 The ETS transcription factor Elf-4 is an important regulator

54 wth factor family members), induction of the ETS transcription factor Elf3, which transactivates gene

55 During pregnancy, the ETS transcription factor ELF5 establishes the milk-secre

56 Additional experiments indicate that the ETS transcription factor ELK is required for HIF-2alpha

57 e mitogen-activated protein kinase-regulated ETS transcription factor Elk-1, but not by multiple othe

58 cancer-associated E26 transformed specific (ETS) transcription factor ELK4, and comprises numerous g

59 f, stimulate hTERT promoter activity via the ETS transcription factor ER81 and ERK mitogen-activated

60 In this study, we show that the ETS transcription factor ER81 directly binds to and acti

61 The regulated expression of the ETS transcription factor ER81 is a prerequisite for norm

62 The ETS transcription factor ER81 is activated in response t

63 The ETS transcription factor ER81 is expressed in sensory ne

64 ied a novel interaction partner of ACTR, the ETS transcription factor ER81 that is also heavily impli

65 ein HER2/Neu is able to collaborate with the ETS transcription factor ER81 to activate Smad7 transcri

66 in, however, contains cells that express the ETS transcription factor Er81, which is also expressed i

67 is similar to the defect in mice lacking the ETS transcription factor ER81.

68 cluding the subpopulation that expresses the ETS transcription factor ER81.

69 Two ETS transcription factors, ER81 and PEA3, are expressed

70 In previous studies we found that the ets transcription factor ERG and its alternatively-splic

71 To examine the hypothesis that the Hsa21 ETS transcription factor ERG cooperates with GATA1s in t

72 ow that mice with homozygous deletion of the Ets transcription factor Erg die between embryonic day 1

73 The ETS transcription factor ERG drives expression of VE-cad

74 251-262) show an essential role for the ETS transcription factor ERG in the self-renewal of embr

75 The ETS transcription factor Erg is required for endothelial

76 Overexpression of KLF2 or the ETS transcription factor ERG is sufficient to induce ect

77 The ETS transcription factor ERG plays a central role in def

78 The endothelial ETS transcription factor Erg plays an important role in

79 nduces phosphorylation and activation of the ETS transcription factor ERG, a prerequisite for DLL4 in

80 s in transcriptional activation of truncated ETS transcription factors ERG and ETV1, the first candid

81 normally silent E26 transformation-specific (ETS) transcription factor ERG in prostate cells.

82 sions involving E26 transformation-specific (ETS) transcription factors ERG, ETV1, ETV4, or ETV5 have

83 ement resulting in the overexpression of the ETS transcription factor, ERG; however, the functional s

84 Two ETS transcription factors, ERG and ETV1, were identified

85 The newly identified epithelium-specific ets transcription factor ERT/ESX/ELF-3/ESE-1/jen binds t

86 ently isolated the first epithelium-specific Ets transcription factor (ESE-1).

87 ort the involvement of a novel member of the ETS transcription factor, ESE-1, in mediating vascular i

88 ere, we show that the endogenously expressed ETS transcription factor ESE3/EHF controls prostate epit

89 cer, we investigated connections between the ETS transcription factor ESE3/EHF, the Lin28/let-7 micro

90 sent study, we investigated whether ER71, an Ets transcription factor essential for hematopoietic and

91 utant lung, two E26 transformation-specific (ETS) transcription factors essential for normal lung bra

92 The Ets transcription factor, ESX, exhibits a unique pattern

93 In this report, we demonstrate that the ETS transcription factor ETS variant 5 (ETV5) promotes I

94 The genes encoding the E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Et

95 ting IL-2 production as proposed for another ETS transcription factor, ETS1.

96 DA motifs that can be activated by the mouse ETS transcription factor Etv1 (also known as ER81), and

97 al muscles differ in their dependence on the ETS transcription factor Etv1 for their survival and dif

98 r, combined overexpression of JMJD2A and the ETS transcription factor ETV1, a JMJD2A-binding protein,

99 cular basis of DNA-binding autoinhibition of ETS transcription factors ETV1, ETV4 and ETV5, which are

100 The ETS-transcription factor ETV1 is involved in epithelial-

101 By transient expression of the ETS transcription factor ETV2 for 2 weeks and constituti

102 The ETS transcription factor Etv2 is necessary and sufficien

103 e for Forkhead transcription factors and the Ets transcription factor Etv2, for activity in vivo.

104 ETS transcription factors ETV2, FLI1, and ERG1 specify p

105 Although the ETS transcription factors Etv4 and Etv5 are known to be

106 Here we show that the ETS transcription factors Etv4 and Etv5 are positively r

107 we show that FGF-dependent activation of the ETS transcription factors Etv4 and Etv5 contributes to p

108 Prostate-derived Ets factor (PDEF) is an ETS transcription factor expressed in normal tissues wit

109 ty are unclear, the STAT, Rel/NF-kappaB, and Ets transcription factor families have recently been rep

110 Fli-1 belongs to the Ets transcription factor family and is expressed primari

111 The ER71 protein belongs to the ETS transcription factor family and is testis-specifical

112 of BLCA-4 reveals that it is a member of the ETS transcription factor family and that it seems to ass

113 Members of the Ets transcription factor family are widely expressed in

114 First, by screening the entire ETS transcription factor family for rearrangements, we f

115 defining a role for selected members of the ETS transcription factor family in the regulation of vas

116 The ETS transcription factor family is characterized by a co

117 The Ets transcription factor family is involved in a variety

118 novel target of MK2 has been identified, the ETS transcription factor family member ER81, whose dysre

119 cbp-1 may function in concert with LIN-1, an Ets transcription factor family member that is one of th

120 iend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acu

121 viously isolated different isoforms of a new Ets transcription factor family member, NERF/ELF-2, NERF

122 the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and E

123 of androgen-regulated TMPRSS2 promoter with ETS transcription factor family members is found frequen

124 nslocations fuse the EWS gene to a subset of ets transcription factor family members, most commonly t

125 ibody disruption assays demonstrated that an Ets transcription factor family protein, GA-binding prot

126 ERG is a member of the ETS transcription factor family that is highly enriched

127 a prototypic member of a novel subset of the ETS transcription factor family that is predominantly ex

128 hermore, we found that PU.1 (a member of the Ets transcription factor family that plays a crucial rol

129 fies ETS-related gene (ERG), a member of the ETS transcription factor family, as the most frequently

130 PU.1, a member of the ets transcription factor family, has been previously sho

131 integration factor 1 (Fli1), a member of the Ets transcription factor family, has been shown to play

132 ERG, a member of the ETS transcription factor family, is frequently overexpre

133 PU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expres

134 egulated TMPRSS2 promoter to a member of the ETS transcription factor family, most commonly ERG.

135 is an epithelially restricted member of the ETS transcription factor family, which is involved in a

136 he isolation of Tel-2, a novel member of the Ets transcription factor family, with high homology to T

137 uggest two distinct roles for members of the ETS transcription factor family.

138 Ets1 is a member of the Ets transcription factor family.

139 strongly stimulated by Elf3, a member of the Ets transcription factor family.

140 e consensus-binding site for a member of the ets transcription factor family.

141 comprise the most divergent subfamily of the Ets transcription factor family.

142 POU domain protein Pit-1 and members of the ETS transcription factor family.

143 ETS-related gene (ERG) is a member of the ETS transcription factor family.

144 e fusions between TMPRSS2 and members of the ETS transcription factor family.

145 erythroblast transformation-specific domain (Ets) transcription factor family member Spi-C, and oncog

146 ne megakaryoblastic cells and identified the ets transcription factor FLI-1 as a novel in vivo-associ

147 DNA-binding and COOH-terminal regions of the Ets transcription factor FLI-1.

148 rminal EWS with the DNA binding moiety of an ETS transcription factor (FLI-1 in 90% of cases).

149 chanism whereby the fusion of EWSR1 with the ETS transcription factor FLI1 contributes to malignant t

150 for 2 weeks and constitutive expression the ETS transcription factors FLI1 and ERG1, concomitant wit

151 actor 1, Fli-1 proto-oncogene, E-twenty-six (ETS) transcription factor (friend leukemia integration 1

152 Interfering with Ets transcription factor function reverses multiple aspe

153 Here we show that ETS transcription factor fusions resulting from disease

154 The E-twenty six (ets) transcription factor GA binding protein (GABP) is a

155 Binding sites for the ets transcription factor, GA-binding protein (GABP), and

156 include interactions of the widely expressed ETS transcription factor, GA-binding protein (GABP), wit

157 us and that this activity is mediated by the ets transcription factor, GABPalpha.

158 eobox transcription factor gene DUX4 and the ETS transcription factor gene ERG is a hallmark of a sub

159 ssion of the human FEV (fifth Ewing variant) ETS transcription factor gene impacts the level of CNS s

160 The current paradigm of ETS transcription factors holds that their DNA-binding (

161 Here we report that transcripts of PEA3, an ETS transcription factor implicated in oncogenesis, were

162 are activated by the combination of ZicL and ETS transcription factors in Ciona embryos.

163 tween the EWS gene and one of five different ETS transcription factors in Ewing's family tumors (EFTs

164 n pattern, we analyzed the roles of Runx and ETS transcription factors in the laminar targeting of se

165 get of AR action in TMPRSS2, a gene fused to ETS transcription factors in the majority of prostate ca

166 ion of PARP expression levels, and implicate ETS transcription factors in the radiation response of E

167 he Raf kinase, suggesting the involvement of Ets transcription factors in the regulation of GlcNAc-T

168 In this study, we investigated the role of Ets transcription factors in the regulation of NOS2 by L

169 thus implicating a novel function for these ETS transcription factors in the regulation of the Egr1

170 further implicate a novel function for these ETS transcription factors in the regulation of the Egr1

171 dentified highly conserved binding sites for Ets transcription factors in the Tie2 promoter.

172 tal lineage dependency mediated by oncogenic ETS transcription factors in this malignancy.

173 K homolog) and upstream of lin-1 (encodes an Ets transcription factor) in the anchor cell signaling p

174 Lef-1, however, was considerably enhanced by Ets transcription factors including Ets-1, Ets-2, ERM, a

175 Recurrent gene fusions involving oncogenic ETS transcription factors (including ERG, ETV1, and ETV4

176 Several ETS transcription factors, including ELF4/MEF, can funct

177 Motifs for several ETS transcription factors, including GABPA and ELF1, are

178 protein interaction domain, found in several ETS transcription factors, including TEL (translocation

179 The LIN-1 ETS transcription factor inhibits vulval cell fates duri

180 The aberrant expression of an oncogenic ETS transcription factor is implicated in the progressio

181 Fli-1 (friend leukemia integration 1), an Ets transcription factor, is required for the normal mat

182 We show here that Pointed, an ETS transcription factor, is required in dorsal follicle

183 -9 expression is regulated by AP-1, Sp1, and Ets transcription factors, KiSS-1 did not alter the bind

184 Recent evidence suggests that Ets transcription factors may contribute to NOS2 inducti

185 Thus, downstream targets of Neu, including Ets transcription factors, may be useful points for ther

186 ETS transcription factors mediate a wide array of cellul

187 To identify which ETS transcription factors might be involved in Gata4 reg

188 the RNA binding protein EWS and one of five ETS transcription factors, most commonly FLI1.

189 e that 1 of 3 distinct isoforms of the novel Ets transcription factor NERF, NERF2, is expressed in en

190 d lipid signaling pathways and activation of ETS transcription factors occur in oligodendrocytes only

191 itical AR-tethering proteins led to ELK1, an ETS transcription factor of the ternary complex factor s

192 ovel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epi

193 We recently isolated a novel member of the Ets transcription factor/oncogene family, ESE-1/ESX/ELF3

194 with an expression vector encoding the PEA3 Ets transcription factor, or its close relatives ER81 an

195 Pdef is an Ets transcription factor originally identified in prosta

196 a correlated with the expression of multiple ETS transcription factors, particularly in SDHD promoter

197 ion of a novel, prostate epithelium-specific Ets transcription factor, PDEF (prostate-derived Ets fac

198 The epithelium-specific Ets transcription factor, PDEF, plays a role in prostate

199 skeletal muscle, triggers expression of the ETS transcription factor Pea3 in a subset of motor neuro

200 essential for interaction of SRC-3 with the ETS transcription factor PEA3, which promotes upregulati

201 Of particular interest were the Ets transcription factors Pea3 and Erm, which function a

202 motor neuron survival factor, GDNF, and the ETS transcription factor, PEA3, as key components of a s

203 The ETS transcription factors perform distinct biological fu

204 Ets transcription factors play important roles during th

205 ETS transcription factors play important roles in hemato

206 Here we show that one isoform of the Ets transcription factor Pointed (Pnt), PntP1, is specif

207 ow that Btd functions cooperatively with the Ets transcription factor Pointed P1 to promote the gener

208 ing a genetic screen, we have identified the ETS-transcription factor pointed as a key regulator of c

209 target of Spi/DER signaling mediated by the ETS transcription factor PointedP1 (PntP1).

210 at, contrary to ETS1, EWS/FLI-1, an aberrant ETS transcription factor present in most EWS cells, is a

211 The ETS transcription factor PU.1 has a potent ability to co

212 The Ets transcription factor PU.1 is a master regulator for

213 The ets transcription factor PU.1 is an important regulator

214 of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreas

215 pression through heterodimerization with the ETS transcription factor PU.1.

216 interference experiments, we found that the Ets transcription factors PU.1 and GA-binding protein (G

217 Although the ets transcription factor, PU.1, bound to this ets site,

218 Because ETS transcription factors regulate expression of TGFBR2

219 emonstrate that at subthreshold levels, this Ets transcription factor regulates a mixed pattern (macr

220 he ternary complex factor (TCF) subfamily of ETS-transcription factors represent key nuclear targets

221 (HMG-I(Y)) is a proposed co-activator of the ETS transcription factors required for mu enhancer activ

222 expression and suggest the participation of Ets transcription factor(s) in this control.

223 and Ets-2 proteins, thus confirming that an ETS transcription factor(s) recognizes the -12 motif.

224 ression of the SAM pointed domain containing ETS transcription factor (SPDEF or prostate-derived ETS

225 expression of SAM-pointed domain containing ETS transcription factor (SPDEF) in stratified conjuncti

226 monstrate that SAM pointed domain-containing ETS transcription factor (SPDEF) inhibited prostate canc

227 nt work, mouse SAM pointed domain-containing ETS transcription factor (SPDEF) mRNA and protein were d

228 gests that the SAM pointed domain containing ETS transcription factor (SPDEF) plays a significant rol

229 The SAM pointed domain containing ETS transcription factor (SPDEF) suppresses formation of

230 Furthermore, we isolated spib, an ETS transcription factor, specifically expressed in prim

231 Thus, Ets transcription factors specify non-vascular, amniotic

232 The DNA-binding ETS transcription factor Spi-1/PU.1 is of central import

233 inal deoxynucleotidyl transferase (TdT), the ETS transcription factor Spi-B, the nuclear factor-kappa

234 The Ets transcription factor Spi-C, expressed in B cells and

235 y, we report our analysis of the role of the Ets transcription factor, Spi-B, in this process.

236 ogram, including the sustained expression of Ets transcription factors such as ETV1 Together, our dat

237 Chromosomal rearrangements involving ETS transcription factors, such as ERG and ETV1, occur f

238 TEL2/ETV7 is highly homologous to the ETS transcription factor TEL/ETV6, a frequent target of

239 We show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first

240 ETS1 is the archetype of the ETS transcription factor (TF) family.

241 ESE-1 is an epithelium-specific ETS transcription factor that contains two distinguishin

242 ERG (Ets-related gene) is an ETS transcription factor that has recently been shown to

243 etv2 is an endothelial-specific ETS transcription factor that is essential for vascular

244 ER71, also known as ETV2, is an ETS transcription factor that is expressed during embryo

245 SPIB is an Ets transcription factor that is expressed exclusively i

246 Moreover, we found that PU.1, an Ets transcription factor that is oncogenic in erythroid

247 ified prostate derived Ets factor (PDEF), an Ets transcription factor that is overexpressed in both p

248 GABP is an ets transcription factor that regulates genes that are r

249 SPI-B is a B lymphocyte-specific Ets transcription factor that shares a high degree of si

250 ESE-1 is an epithelium-specific ETS transcription factor that transforms human breast ep

251 polyoma enhancing activity-3/E26 virus (PEA3/ETS) transcription factors through consensus binding sit

252 s both the LIN-31 winged-helix and the LIN-1 Ets transcription factors to specify the vulval cell fat

253 g subtractive cloning, we identified ERM, an Ets transcription factor, to be a Th1-specific, IL-12-in

254 Ha-ras promoter resembles a binding site for Ets transcription factors, we did not detect the binding

255 ontaining the binding sites for the AP-1 and Ets transcription factors, we observed that IGF-I stimul

256 ctions of PU.1 and Spi-B, two highly related Ets transcription factors, we previously generated PU.

257 The GATA and Ets transcription factors were shown to function as acti

258 wing Family Tumors (EFT) harbor chimeric EWS/ETS transcription factors which are thought to aberrantl

259 from 22q-12 to FLI1 and genes encoding other ETS transcription factors (which bind DNA through the co

260 ression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet ce

261 Ets transcription factors, which share the conserved Ets

262 Among these is a novel ets transcription factor with a dual DNA-binding specifi

263 We find that the ETS transcription factor Yan is required for border cell