ライフサイエンスコーパス: ExPEC

1 ExPEC causes the vast majority of urinary tract infectio

2 ExPEC harboring a deletion of the gene encoding the mann

3 ExPEC strains are extracellular bacterial pathogens; the

4 of survival was used, four of six additional ExPEC strains, but not an E. coli laboratory strain, wer

5 An effective vaccine against ExPEC infection is urgently needed.

6 trace the fate of PAC after they agglutinate ExPEC and follow PAC-ExPEC complexes in cell culture ass

7 Increasing multidrug resistance among ExPEC strains constitutes a major obstacle to treatment

8 An ExPEC vaccine effective against strains that are associa

9 Here, we report that FimX, an ExPEC-associated DNA invertase that regulates the major

10 nd 94% of samples, respectively; P<.001) and ExPEC contamination (4%, 19%, and 46%, respectively; P<.

11 ation of antimicrobial-resistant E. coli and ExPEC, which may represent a newly recognized group of m

12 O1 genomic islands among 828 human and avian ExPEC and commensal E. coli isolates was determined.

13 evidence that at least some human and avian ExPEC strains are highly similar to one another, and it

14 dherence phenotype resembling that of canine ExPEC prompted the present reevaluation of the canine-hu

15 These data demonstrate that canine ExPEC strains are similar to, and in some instances esse

16 used to compare the virulence of a clinical ExPEC isolate with its isogenic mutant impaired for the

17 bored by extraintestinal pathogenic E. coli (ExPEC) and encodes the genotoxin colibactin, is epidemio

18 known as extraintestinal pathogenic E. coli (ExPEC) and include human uropathogenic E. coli (UPEC) an

19 known as extraintestinal pathogenic E. coli (ExPEC) and include pathogens of humans and animals.

20 eages of extraintestinal pathogenic E. coli (ExPEC) and superseded serotyping for certain isolates wi

21 olate of extraintestinal pathogenic E. coli (ExPEC) leads to stable and long-term colonization of the

22 classic extraintestinal pathogenic E. coli (ExPEC) sequence types (STs) and case report ST131 househ

23 utant of extraintestinal pathogenic E. coli (ExPEC) strain CFT073 that could not synthesize the K2 ca

24 cialized extraintestinal pathogenic E. coli (ExPEC) strains and, increasingly, with antimicrobial res

25 tions of extraintestinal pathogenic E. coli (ExPEC) was assessed.

26 ified as extraintestinal pathogenic E. coli (ExPEC), and even these isolates exhibited significantly

27 , termed extraintestinal pathogenic E. coli (ExPEC), that have a special ability to cause disease at

28 lones of extraintestinal pathogenic E. coli (ExPEC), which traditionally have been regarded primarily

29 known as extraintestinal pathogenic E. coli (ExPEC).

30 of human extraintestinal pathogenic E. coli (ExPEC).

31 extraintestinal pathogenic Escherichia coli (ExPEC) encode a variety of fitness and virulence factors

32 Extraintestinal pathogenic Escherichia coli (ExPEC) is the most common gram-negative bacterial pathog

33 Extraintestinal pathogenic Escherichia coli (ExPEC) reside in the enteric tract as a commensal reserv

34 Extracellular pathogenic Escherichia coli (ExPEC) strains are common causes of a variety of clinica

35 Extraintestinal pathogenic Escherichia coli (ExPEC) strains are typically benign within the mammalian

36 extraintestinal pathogenic Escherichia coli (ExPEC) strains, referred to as uropathogenic E. coli (UP

37 extraintestinal pathogenic Escherichia coli (ExPEC) with infectious potential for humans, presumed ho

38 extraintestinal pathogenic Escherichia coli (ExPEC), 63 environmental canine fecal deposits were eval

39 Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses

40 Extraintestinal pathogenic Escherichia coli (ExPEC), so named because this pathotype infects tissues

41 extraintestinal pathogenic Escherichia coli (ExPEC), such as avian pathogenic E. coli (APEC), and des

42 extraintestinal pathogenic Escherichia coli (ExPEC), which encodes the genotoxin colibactin, are inco

43 xtra-intestinal pathogenic Escherichia coli (ExPEC).

44 the chemotherapeutic drug cyclophosphamide, ExPEC translocates from the intestine to the lungs, live

45 tion-based assays and O serotyping to define ExPEC-associated traits were performed.

46 ibactin synthesis), plus molecularly defined ExPEC status, were significantly associated with virulen

47 for further discrimination of the different ExPEC subpathotypes, serogroups, phylogenetic types, and

48 The food supply may disseminate ExPEC and antimicrobial-resistant E. coli.

49 roles in pathogenesis are well described for ExPEC strains that cause urinary tract infections and me

50 s study indicates that FimH is important for ExPEC translocation, suggesting that the type 1 pilus is

51 intestinal tract is often a prerequisite for ExPEC-mediated pathogenesis, we set out to understand ho

52 Macrophages are required for ExPEC dissemination, suggesting the pathogen has develop

53 d pathogenesis, we set out to understand how ExPEC colonizes this niche.

54 Commonality between canine and human ExPEC has potentially important implications for disease

55 pecific differences between canine and human ExPEC strains have cast doubt on this hypothesis.

56 city-associated island from archetypal human ExPEC strain CFT073.

57 a, or meningitis, including archetypal human ExPEC strains 536, CP9, and RS218.

58 d human isolates, including archetypal human ExPEC strains CFT073 (O6:K2:H1), 536 (O6:K15:H31), and J

59 arison of this genome to all available human ExPEC genomic sequences.

60 the present reevaluation of the canine-human ExPEC connection.

61 es essentially indistinguishable from, human ExPEC strains, which implicates dogs and their feces as

62 re analyzed and compared with those of human ExPEC controls.

63 virulence-associated genes typical of human ExPEC were prevalent among the canine fecal isolates.

64 similarities between APEC O1 and other human ExPEC strains belonging to the ST95 phylogenetic lineage

65 ains were more like APEC O1 than other human ExPEC strains.

66 In addition to pap, human ExPEC-associated virulence genes detected among the cani

67 ping showed that some of the sequenced human ExPEC strains were more like APEC O1 than other human Ex

68 Mutation of either glpG or glpR impaired ExPEC growth in mucus and on plates containing the long-

69 asmids are found significantly more often in ExPEC, including ExPEC associated with human neonatal me

70 significantly more often in ExPEC, including ExPEC associated with human neonatal meningitis and avia

71 PAC inhibit ExPEC invasion of epithelial cells and, therefore, may p

72 Studies using the model ExPEC strain CP9 demonstrated that it is relatively resi

73 icantly associated with bacteremia, multiple ExPEC-associated virulence genes, and group B2, and with

74 lectively, we have shown that the ability of ExPEC to survive in macrophages is contingent upon the p

75 Characterization of ExPEC strains using various typing techniques has shown

76 rulence in E. coli and that the evolution of ExPEC, which involves extensive horizontal transmission

77 ay for diverse virulence-associated genes of ExPEC.

78 port of a chemotherapy-based animal model of ExPEC translocation in cancerous mice, a system that can

79 deposits were evaluated for the presence of ExPEC by a combination of selective culturing, extended

80 hich consequently may provide a reservoir of ExPEC for acquisition by humans.

81 The present study examined a subset of ExPEC strains: neonatal meningitis E. coli (NMEC) strain

82 These findings suggest that survival of ExPEC within neutrophils may be an important virulence m

83 Translocation of ExPEC is also associated with an increase of the diversi

84 he extraintestinal pathogenic versatility of ExPEC clones, which supports the use of an inclusive des

85 flicting results related to the virulence of ExPEC strains.

86 Regardless of host of origin, ExPEC strains share many traits.

87 ld help us understand the virulence of other ExPEC strains and design more efficient infection contro

88 after they agglutinate ExPEC and follow PAC-ExPEC complexes in cell culture assays.

89 ived isolates of extraintestinal pathogenic (ExPEC) Escherichia coli, a common agent of sepsis and co

90 Fluorescent labeled PAC were able to promote ExPEC agglutination when observed with fluorescence micr

91 l pks island markers), and 12 other putative ExPEC virulence genes were newly sought by PCR among 131

92 n of glpG but not glpR significantly reduced ExPEC survival.

93 PEC O1's genome not found in other sequenced ExPEC genomes.

94 mechanisms underlie host specificity in some ExPEC strains.

95 that might contribute to the ability of some ExPEC strains to cause high-level bacteremia and meningi

96 Four food-source ExPEC isolates (from pea pods, turkey parts, ground pork

97 lower virulence scores than did susceptible ExPEC (7.25 vs. 9.0; P=.001).

98 In contrast, multiple known or suspected ExPEC virulence genes, including pap (P fimbriae), vat (

99 These data confirm that ExPEC representing known virulent clones are highly prev

100 We find that ExPEC E. coli are highly genomically heterogeneous, cons

101 host species, leading to the hypothesis that ExPEC may have zoonotic potential.

102 and transformed Caco-2 cells, we report that ExPEC strain CP9 binds to and invades the intestinal epi

103 e lines of evidence suggest that many of the ExPEC strains encountered in humans with urinary tract i

104 Multiple genes that contribute to ExPEC fitness in mucus broth were identified, with genes

105 model of chemotherapy-induced translocation, ExPEC lacking fimH colonized at levels comparable to tha

106 rther challenges for preventing and treating ExPEC infections.

107 mutant, and oxyRS mutants of other wild-type ExPEC strains, exhibited significantly increased in vitr

108 rred either in APEC O1 or in highly virulent ExPEC isolates, resulting in differences in pathogenicit

109 new avenues for defining mechanisms by which ExPEC strains colonize the mammalian gastrointestinal tr

110 oxidative burst is not a mechanism by which ExPEC survives within neutrophils.

111 increasing healthcare costs associated with ExPEC infections.

112 everal virulence factors are associated with ExPEC, there is no core set of virulence factors that ca

113 eq) was performed to search for genes within ExPEC isolate F11 that are important for growth in intes