ライフサイエンスコーパス: F-box protein

1 arget described in any organism for the Fbh1 F box protein.

2 entified pallbearer (pall), which encodes an F box protein.

3 ing the host DDR by using a newly recognized F-box protein.

4 eats (LRRs) and regions with similarities to F-box proteins.

5 alpha/beta fold distinct from those of known F-box proteins.

6 n deneddylation and resulted in decreases in F-box proteins.

7 in Skp1 and aids in Skp1's association with F-box proteins.

8 arget proteins for degradation often contain F-box proteins.

9 B3 transcription factors, and genes encoding F-box proteins.

10 together with FLAVIN-BINDING, KELCH REPEAT, F BOX protein 1.

11 BCL6 protein stability is regulated by F-box protein 11 (FBXO11)-mediated ubiquitination and de

12 idues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase.

13 Transcriptional derepression of F-box protein 32 (FBXO32) (Atrogin1/MAFbx), a gene assoc

14 osing activated atrophic pathways, including F-box protein 32 (Fbxo32), which encodes atrogin-1.

15 issense mutation, c.616T>C (p.Cys206Arg), in F-box protein 38 (FBXO38).

16 TSEC treatment, ERalpha interacted with the F-box protein 45 (FBXO45) E3 ubiquitin ligase.

17 rmone is perceived by the TIR1/AFB family of F-box proteins acting in concert with the Aux/IAA transc

18 box proteins called the TIR1/auxin-signaling F box proteins (AFBs).

19 n to use the host UPS, the first prokaryotic F-box protein, an essential component of UPS, was identi

20 ans of regulating the interaction between an F box protein and its substrate.

21 indicating that the association between the F box protein and substrate is disrupted by stress-induc

22 RT INHIBITOR RESPONSE (TIR1)/AUXIN SIGNALING F-BOX protein and an AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA

23 OR OF drm1 drm2 cmt3 (SDC), which encodes an F-box protein and possesses seven promoter tandem repeat

24 e mechanism that competes with binding to an F-box protein and recognition by early modification enzy

25 Both activities depend on the F-box protein and SCF (Skp, Cullin, F-box) complex compo

26 F-box proteins and DCAF proteins are the substrate bindi

27 med an siRNA screen for all (about 70) human F-box proteins and found FBXW11 to be involved in PKR de

28 n variants bind at the interface of Skp1 and F-box proteins and inhibit ligase activity by preventing

29 ila exhibits molecular mimicry of eukaryotic F-box proteins and is essential for intracellular replic

30 ts its conformation and its interaction with F-box proteins and, ultimately, O2-sensing in the organi

31 oteasomal degradation mediated by FBXL20 (an F-box protein) and the associated Skp1 (S-phase kinase-a

32 2 binds Skp1, the common binding partner for F-box proteins, and is an unusually abundant inner ear p

33 etween ethylene, the regulation of ETP1/ETP2 F-box proteins, and subsequent targeting and degradation

34 leads to transcriptional upregulation of the F-box protein archipelago, the Fbxw7 homologue in flies.

35 F-box proteins are generally responsible for substrate r

36 F-box proteins are major subunits within the Skp1-Cul1-F

37 F-box proteins are the substrate binding subunits of SCF

38 The F-box proteins are the substrate recognition subunits of

39 Generally, F-box proteins are the substrate recognition subunits of

40 F-box proteins are the substrate-recognition components

41 of all SCF complexes, the 69 different human F-box proteins are variable substrate binding modules th

42 S-locus products (S-RNase and F-box proteins) are essential for the gametophytic self-

43 ppropriate context may be recognized by some F-box proteins as a unique inhibitory molecular signal f

44 Additionally, F-box proteins as clients may place HSP90 in a unique an

45 more, we identified Fbw7, a Csn5-interacting F-box protein, as the E3 ligase that targeted topoIIalph

46 p1-Cul1-F-box protein complex containing the F-box protein beta-TRCP (SCF(beta-TRCP)) as an E3 ubiqui

47 ed screen, that REST is an interactor of the F-box protein beta-TrCP.

48 or TAZ, that is, as a binding partner of the F-box protein beta-Trcp.

49 cifically associates with the SCF (Skp1-Cul1-F-box protein)-beta-TrCP complex.

50 lated isoforms via a mechanism involving the F-box protein, beta-TrCP (SLIMB in Drosophila).

51 cilitating binding and ubiquitylation by the F box protein betaTrCP, with consequent proteasomal degr

52 facilitating binding and degradation via the F box protein betaTrCP.

53 ulation triggers the binding of Tiam1 to the F-box protein betaTrCP via its degron sequence and subse

54 roteasome machinery via interaction with the F-box protein betaTrCP.

55 late DEPTOR, which is then recognized by the F box protein, betaTrCP, via its degron sequence for sub

56 Specifically, EF2K binds to the F-box proteins, betaTRCP1 and betaTRCP2, and betaTRCP re

57 rate receptor (SR) module comprising 1 of 69 F-box proteins bound to Skp1.

58 Mammalian genomes encode roughly 70 F-box proteins, but only a handful have established func

59 hin its substrate, which is typical of other F-box proteins, but uniquely targeted a calmodulin-bindi

60 nt hormone auxin is perceived by a family of F box proteins called the TIR1/auxin-signaling F box pro

61 Here we demonstrate that a family of F-box proteins, called the kiss me deadly (KMD) family,

62 We propose that most F-box proteins can be targeted by this approach for basi

63 Knockdown of Skp2, an F-box protein capable of regulating the normal turnover

64 g, we find that ubiquitin interaction by the F box protein Cdc4 promotes its autoubiquitination and t

65 h exhibit phosphodegron-dependent binding to F-box proteins, CDK-mediated phosphorylation of Thr464 p

66 Skp1 is a subunit of the SCF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin ligases that are im

67 ion, we identified a Kelch domain-containing F-box protein coding (CmKFB) gene that, when expressed,

68 linalool synthase in leaves depending on the F-box protein COI-1.

69 n S-phase kinase-associated protein1/Cullin1/F-box protein COI1 (SCF(COI1)) E3 ubiquitin ligase compl

70 ly of a coreceptor complex consisting of the F-box protein COI1 and JAZ transcriptional repressors.

71 The F-box protein COI1 functions both as a receptor for jasm

72 The perception of bioactive JAs by the F-box protein COI1 triggers the SCF(COI1)/ubiquitin-depe

73 ty binding of inositol pyrophosphates to the F-box protein COI1-JAZ jasmonate coreceptor complex and

74 n maintaining the steady state levels of the F-box proteins COI1 and TIR1, receptors for jasmonate an

75 form a cullin-RING ligase, or an SKP1-cullin-F box protein complex.

76 sed cullin 1 neddylation in the Skp1-cullin1-F-box protein complex and consequent Skp2 destabilizatio

77 erence (RNAi) screen to identify a Skp1-Cul1-F-box protein complex containing the F-box protein beta-

78 efore, these data suggest that the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondr

79 bunit of the E3 ubiquitin ligase Skp1-cullin-F-box protein complex, SCF(beta-TrCP).

80 ate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the G2 ubiquitin ligase for S

81 s been identified, the SCF(Cdc4) (Skp1/Cdc53/F-box protein) complex.

82 SCF (Skp1/Cul1/F-box protein) complexes are modular ubiquitin ligases.

83 The F-box protein Constitutive expressor of PR genes 1 (CPR1

84 en the pistil S-RNase and the pollen S-Locus F-box protein controls self-incompatibility (SI).

85 The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates j

86 Perception of bioactive JAs by the F-box protein CORONATINE INSENSITIVE1 (COI1) causes degr

87 teraction of JAZ repressor proteins with the F-box protein CORONATINE INSENSITIVE1 (COI1), part of an

88 SMONATE ZIM domain (JAZ) repressors with the F-box protein CORONATINE INSENSITIVE1 (COI1), which resu

89 oleucine (JA-Ile), stimulates binding of the F-box protein coronatine-insensitive 1 (COI1) to, and su

90 Here we report the identification of an F-box protein CPR1/CPR30 as a negative regulator of an R

91 We identified the F-box protein cyclin F, a substrate recognition subunit

92 ase family member 2) as an interactor of the F-box protein cyclin F.

93 Here we report an F-box protein, Dampened (Dmpd) as a nuclear cofactor of

94 Unlike the case for other F-box proteins, deletion of the F-box domain in Dia2 doe

95 ansport inhibitor response 1/auxin signaling F-box protein)]-dependent auxin signaling mechanism.

96 The F box protein Dia2 is an important determinant of genome

97 omponents required for Cdc6 degradation, the F-box protein Dia2 and the Hect domain E3 Tom1.

98 dy, we identify the Saccharomyces cerevisiae F-box protein Dia2 as a novel player in the S-phase chec

99 In budding yeast, the F-box protein Dia2 drives ubiquitylation of the CMG heli

100 The budding yeast F-box protein Dia2 is required for genomic stability and

101 In budding yeast, the chromatin-bound F-box protein Dia2 is required to maintain genomic stabi

102 ity in collaboration with either Rrm3 or the F-box protein Dia2.

103 for caspase activation in vivo involving the F-box protein DRE-1.

104 eta hydrolase protein DWARF 14 (D14) and the F-box protein DWARF 3 (D3), two previously identified si

105 dentified as a component of a Skp1, Cullin1, F-box protein E3 complex that targets NLRs, including Su

106 The SCF (Skip-Cullin1-F-box protein) E3 ligase family provides homeostatic fee

107 ed FBXL2, belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family.

108 and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tum

109 cognition subunit for the SCF (Skip1-Cullin1-F-box protein) E3 ubiquitin ligase complex.

110 ted by the SKP2-containing SCF (SKP1-cullin1-F-box protein) E3 ubiquitin ligase in the nucleus, but n

111 in-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protei

112 is a RING component of SCF (Skp-1, cullins, F-box proteins) E3 ubiquitin ligases, which regulate div

113 is the RING component of SCF (Skp1, Cullins, F-box proteins) E3 ubiquitin ligases, which regulate div

114 We show that COP1 directly targets the F box proteins EBF1 and EBF2 for ubiquitination and degr

115 triggering their degradation by bringing the F-box proteins EBF1 and 2 to the complex.

116 t manner and also physically associates with F box protein EBFs.

117 of phytochrome photoreceptors, EIN3-BINDING F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degra

118 We identified two F-box proteins, EIN2 TARGETING PROTEIN1 (ETP1) and EIN2

119 eas no specific binding was noted with other F-box proteins examined, including Skp2, Fbw7, Fbx4, and

120 The F-box protein family obtained its name from Cyclin F (al

121 ified FBXL19, a relatively new member of the F-box protein family that targets Rac1 for its polyubiqu

122 identify FBXO32 (ATROGIN 1), a member of the F-Box protein family, as a novel DCM-causing locus.

123 ure and status as the founding member of the F-box protein family, Cyclin F remains an orphan protein

124 Thus, unlike another Bcd-interacting F-box protein Fate-shifted (Fsd), which controls AP patt

125 pendent upon an SCF E3 ligase containing the F box protein Fbh1.

126 Altogether, these data indicate that the F-box protein FBL17 acts as a master cell cycle regulato

127 Our previous results showed that an F-box protein, Fbp1, is essential for Cryptococcus virul

128 ic destruction of substrate adapters such as F box proteins (FBPs).

129 Plant genomes encode large numbers of F-box proteins (FBPs), the substrate recognition subunit

130 The F-box protein Fbw7 (also known as Fbxw7, hCdc4 and Sel-1

131 The F-box protein Fbw7 (hAgo/hCdc4/FBXW7) functions as a spe

132 Remarkably, F-box protein FBW7, an E3-ubiquitin ligase, controlled s

133 is a short-lived protein that is targeted by F-box protein Fbw7, which is the substrate-specifying co

134 iew will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) a

135 cific ubiquitin-based inhibitors against two F-box proteins, Fbw7 and Fbw11.

136 eta, facilitating the binding of SOX9 to the F-box protein FBW7alpha, an E3 ligase that functions in

137 Here we show that dimerization of the F-box protein Fbx4 is essential for SCF(Fbx4) (the super

138 ation experiments, we identify the unstudied F-box protein FBXL17 as a regulator of the NFR2 oxidativ

139 Here we show that the F-box protein FBXL2 (the receptor subunit of one of 69 h

140 previously uncharacterized cardiac-specific F-box protein Fbxl22 as a component of a novel cardiac E

141 Notably, the F-box protein FBXL3 captures CRY2 by simultaneously occu

142 argets for the leucine-rich repeat family of F-box proteins (FBXLs) that function with SKP1-CUL1-F-bo

143 nd mass spectrometry, we determined that the F-box protein FBXO11 interacts with CDT2, a DCAF protein

144 itin ligase complex that contains the orphan F-box protein FBXO11.

145 in/proteasome system regulator NEDD8, or the F-box protein FBXO2 partially restored DeltaF508-CFTR-me

146 ed for ubiquitylation through actions of the F-box protein FBXO24.

147 derstanding the substrate specificity of the F-box protein FBXO31 and the mechanism of FBXO31-regulat

148 Here we show that the F-box protein FBXO31, a candidate tumor suppressor encod

149 One of these factors is an F-box protein, FBXO31, a candidate tumour suppressor enc

150 trate recognition subunits, and we found the F-box proteins FBXW11 and beta-TRCP1 to be relevant for

151 The gene encoding F-box protein FBXW7 is frequently mutated in many human

152 The F-box protein FBXW7 is the substrate-recruiting subunit

153 uitination and subsequent degradation by the F-box protein FBXW7.

154 tem (UPS) but that it is orchestrated by the F-Box protein, FBXW7.

155 Calmodulin competes with the F-box protein for access to this motif where it bound an

156 y direct intermolecular competition with the F-box protein for access within this motif.

157 have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate recognition.

158 tions in a ubiquitin ligase complex with the F-box protein FSN-1 and functions through the microtubul

159 n ubiquitin ligase complex that includes the F-box protein FSN-1 in C. elegans and Fbxo45 in mammals.

160 r trafficking, and another that involves the F-box protein FSN-1, which mediates RPM-1 ubiquitin liga

161 F-box proteins function as the substrate-recruiting subu

162 to glutamate missense mutation in Fbxl21, an F-box protein gene that is a paralog of Fbxl3 that targe

163 in-1-F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting M

164 Knockdown of each of the 25 putative F-box proteins identified by bioinformatics did not atte

165 namely, KFB(CHS), a Kelch domain-containing F-box protein in Arabidopsis thaliana KFB(CHS) physicall

166 ese results define an unexpected role for an F-box protein in functioning as a DNA-associated transcr

167 ial fusion, revealing a novel function of an F-box protein in mRNA export.

168 sstalk mechanism between these two important F-box proteins in cancer cells with aberrant Skp2 expres

169 how glycosylation enhances interactions with F-box proteins in cells.

170 as an adaptor protein that links Cullin-1 to F-box proteins in E3 Skp1/Cullin-1/F-box protein (SCF) u

171 Many F-box proteins in plants, yeast and mammals are unstable

172 The role of F-box proteins in regulating Rac1 stability has not been

173 1 is a conserved protein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box protein) E3 u

174 Collectively, the F-box proteins in the FBA family bind high mannose and s

175 lar to those found in other plant and animal F-box proteins, including cell cycle proteins and hormon

176 The STYX interactome contained several F-box proteins, including FBXW7.

177 8VirF, possesses the hallmarks of functional F-box proteins: it contains an active F-box domain and s

178 acterial virulence factor, VirF, which is an F-box protein known to target both VirE2 and VIP1 for pr

179 Screening of an F-box protein library and in vitro ubiquitination assays

180 SL perception and signaling involves the F-box protein MAX2 and the hydrolase DWARF14 (D14), prop

181 D14 acts with an F-box protein, MAX2, to target SMXL/D53 family proteins

182 roteins suggests that the stability of other F-box proteins may be controlled by similar mechanisms.

183 egulated through degradation of Fzo1p by the F-box protein Mdm30p.

184 at expression of a modified Arabidopsis TIR1 F-box protein mediates robust auxin-dependent depletion

185 We find that the mitochondrial F-box protein (Mfb1p) localizes to mitochondria in the m

186 est that the amino-terminal domains of other F box proteins might also play an analogous regulatory r

187 lecules in Arabidopsis thaliana requires the F-box protein MORE AXILLARY GROWTH2 (MAX2).

188 for S-Phase Kinase-Associated Protein2B), an F-box protein, negatively regulates cell cycle and later

189 dentified DmPI31 as a binding partner of the F box protein Nutcracker, a component of an SCF ubiquiti

190 targeted by the ubiquitin E3 ligase subunit F-box protein O10 (FBXO10), which associates with RAGE t

191 sely correlated with expression of SKP2, the F-box protein of SCF(SKP2) (SKP1/Cul1/F-box), the E3 ubi

192 structural data on Ctf13, defining it as an F-box protein of the leucine-rich-repeat family, and dem

193 Skp2B, an F-box protein of unknown function, is frequently overexp

194 Here we show that the F-box protein PALL interacts with phosphorylated ribosom

195 Previously, we have shown that MAX2, an F-box protein, positively regulates facets of photomorph

196 Moreover, of the 179 other F-box proteins predicted by S2 and S3 pollen transcripto

197 BL17 (F BOX-LIKE17), an Arabidopsis thaliana F-box protein previously shown to govern the progression

198 ant of such translocated factors is VirF, an F-box protein produced by octopine strains of Agrobacter

199 The ubiquitin ligase SCF(Cdc4) (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-depe

200 scued by overexpression of Jetlag (JET), the F-box protein required for light-mediated TIM degradatio

201 Mutations in Fbxl7, which encodes an F-box protein, result in tissue overgrowth and abnormali

202 receptor and intracellular protein kinases, F-box proteins, RNA-binding proteins, and proteins of un

203 dant candidate substrates identified for the F box protein Saf1 were all vacuolar/lysosomal proteins.

204 rate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases.

205 cruitment of PIF3-EBFs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitated by light sig

206 Using ligase traps of eight different F box proteins (SCF specificity factors) coupled with ma

207 d beta-catenin by the Skp1-cullin 1-betaTrCP F-box protein (SCF(betaTrCP)) E3 ubiquitin (Ub) ligase c

208 substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4)

209 arget of a beta-TrCP-containing Skp-Cullin 1-F-box protein (SCF) complex (SCF(beta-TrCP)) E3 ubiquiti

210 ase kinase-associated PROTEIN1 (SKP1)/Cullin/F-box protein (SCF) E3 ubiquitin ligase complex and dire

211 ene (SAG)/regulator of cullins-2-Skp1-cullin-F-box protein (SCF) E3 ubiquitin ligase regulates cellul

212 roteins (FBXLs) that function with SKP1-CUL1-F-box protein (SCF) E3s.

213 in-protein ligases such as the Skp1, cullin, F-box protein (SCF) have been implicated in many growth

214 ns as a specificity factor for the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex and targets

215 n and proteasomal degradation by a SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complex that contai

216 s substrate specificity for the Skp1-Cullin1-F-box protein (SCF) ubiquitin ligase complex that target

217 Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell surviv

218 llin-1 to F-box proteins in E3 Skp1/Cullin-1/F-box protein (SCF) ubiquitin ligases is well characteri

219 -154 of Skp1, a subunit of the Skp1/Cullin-1/F-box protein (SCF)-class of E3-ubiquitin ligases, is a

220 ligases composed of SKP1, Rbx1, Cullin1, and F-box protein (SCF1) that are involved in targeting prot

221 -box (SCF) complex composed of SKR-1 and the F-box protein SEL-10.

222 These three genes encoded an F-box protein similar to Hawaiian Skirt (PtaHWS) and two

223 t which Cul1-Rbx1 equilibrates with multiple F box protein-Skp1 modules.

224 The F box protein Skp2 is oncogenic, and its frequent amplif

225 Here, we demonstrate that the F-box protein SKP2 (S phase kinase-associated protein 2)

226 levels decrease after overexpression of the F-box protein Skp2.

227 compatibility predicts that multiple S-locus F-box proteins (SLFs) produced by pollen of a given S-ha

228 luding those required for recognition by the F box protein SLIMB/beta-TrCP and proteasomal degradatio

229 SCF E3 ubiquitin ligase in complex with the F-box protein Slimb mediates proteolytic degradation of

230 hosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set c

231 ubiquitin ligases feature a large family of F box protein substrate receptors that enable recognitio

232 Most F box protein-substrate interactions described to date a

233 hort peptides/degrons as often seen in other F-box protein-substrate complexes.

234 ode of substrate binding distinct from other F-box protein-substrate pairs, CP110 and Cyclin F physic

235 This novel F-box-protein-substrate bipartite interaction is suscept

236 SCF complexes have a variable F-box protein subunit that determines substrate specific

237 We have identified FBXO17 as an F-box protein subunit that recognizes and mediates GSK3b

238 ing many of the target proteins of these two F-box proteins (such as p27 and cyclin E).

239 Skp1, Cullin, and F-box proteins, such as SEL-10, are components of the SC

240 tween ARABIDILLOs and other plant and animal F-box proteins suggests that the stability of other F-bo

241 se findings provide the first evidence of an F-box protein targeting a small G protein for ubiquitina

242 The results raise opportunities for F-box protein targeting to preserve mitochondrial functi

243 ed and characterized the activity of a novel F-box protein, termed FBXL2, belonging to the SCF (Skip-

244 rmaphrodites require fog-2, which encodes an F box protein that regulates the translation of tra-2 mR

245 ach of which is distinguished by a different F box protein that uses a domain at the carboxyl terminu

246 lar cloning shows that she-1 encodes a novel F box protein that was created by a recent gene duplicat

247 ZEITLUPE (ZTL) is the F-box protein that associates with the SCF (Skp/Cullin/F

248 We show that FBXL4 is an F-box protein that colocalizes with mitochondria and tha

249 reased S-phase kinase-associated protein, an F-box protein that degrades p27(kip1) during G1.

250 results demonstrate that cyclin F is a novel F-box protein that functions as an intrinsic cellular re

251 1, also known as muscle atrophy F-box, is an F-box protein that inhibits pathologic cardiac hypertrop

252 studies reveal an unanticipated role for an F-box protein that inhibits proteolysis in the regulatio

253 FOF2 encodes a putative F-box protein that interacts specifically with ASK14, an

254 We determined that LEF-7 is a nuclear F-box protein that interacts with host S-phase kinase-as

255 se kinase-associated protein 2 (SKP-2) is an F-box protein that is part of the SKP-1/Cul1/F-box ubiqu

256 sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediate

257 , we identify FBXO41 as a novel CNS-specific F-box protein that localizes to the centrosome and the c

258 7 gene (FBXW7, FBW7, AGO, Cdc4), encoding an F-box protein that promotes degradation of the mammalian

259 ene family, including ZEITLUPE, that encodes F-Box proteins that regulate posttranslational protein s

260 FBXO25 is one of the 69 known human F-box proteins that serve as specificity factors for a f

261 Unlike other F-box proteins that target phosphodegrons within substra

262 e SKIP genes could encode the plant specific F-box proteins that target the T-complex associated prot

263 E3 ubiquitin ligase SCF (SKP1, Cullins, and F-box protein), that has been implicated recently in DNA

264 es a core pathway consisting of the TIR1/AFB F-box proteins, the Aux/IAA transcriptional repressors,

265 adation rates, and interact with the related F-box proteins TIR1 and AFB1-3, which indicates that the

266 RANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX PROTEIN (TIR1/AFB) family are known auxin receptor

267 Cand1 from cells impedes recruitment of new F box proteins to pre-existing Cul1 and profoundly alter

268 nate perception and highlight the ability of F-box proteins to evolve as multi-component signalling h

269 Skp1) binds one of many substrate recruiting F-box proteins to form an array of SCF ligases with dive

270 r else tethering SCF(Dia2) (SCF [Skp1/cullin/F-box protein]) to the replisome to increase its local c

271 Fbxl7, a component of the Skp1.Cul1.F-box protein type ubiquitin E3 ligase, regulates mitoti

272 tin ligase complexes of the SCF (Skp1, Cul1, F-box protein) type to destroy PKR.

273 mponent of an SCF (complex of SKP1, CUL1 and F-box protein)-type E3 ubiquitin ligase, is a key regula

274 d components of the modular SCF (Skp1, Cul1, F-box protein)-type E3 ubiquitin ligases as mediators of

275 strate-binding component of the Skp1/Cullin1/F-box protein ubiquitin ligase complex.

276 SKP1 is a component of SCF (for SKP1-Cullin-F box protein) ubiquitin ligase complexes that target pr

277 ognition subunits of the SCF (Skp1-Cul1-Rbx1-F- box protein) ubiquitin ligase complexes that control

278 subunit of one of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 a

279 trate recognition subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes, which mediate

280 substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes.

281 l for SCF(Fbx4) (the superscript denotes the F-box protein) ubiquitination activity toward the telome

282 rfering RNA screening that targets all human F-box proteins uncovered FBXO44 as an important protein

283 ts synthetic T-complexes via the Skp1/Cullin/F-box protein VBF pathway and exposes the T-DNA molecule

284 acterium have evolved to encode a functional F-box protein VirF.

285 rect physical interaction with the TIR1-like F box proteins, which in turn remove the Aux/IAA family

286 Mdm30p, a nucleus-encoded F-box protein, which binds to the substrate for ubiquiti

287 thogen Legionella pneumophila is a bona fide F-box protein, which is localized to the cytosolic side

288 tivation in this system, we isolated a novel F-box protein, which we termed Nutcracker, that is stric

289 beta-TrCP and SKP2 are two well-studied F-box proteins, which often act as oncogenes.

290 ion, a Cys(358)Ser substitution in Fbxl3, an F-box protein with leucine-rich repeats, results in long

291 Here we characterize MEC-15, an F-box protein with WD repeats, which is required for the

292 SCF (Skp1 x CUL1 x F-box protein x ROC1) E3 ubiquitin ligase and Cdc34 E2-c

293 ) domain of PRR5 interacts directly with the F box protein ZEITLUPE (ZTL) in vitro and in vivo.

294 Previous work has shown that the F-box protein ZEITLUPE (ZTL) and clock element GIGANTEA

295 t the Arabidopsis circadian clock-associated F-box protein ZEITLUPE (ZTL) is a unique client for cyto

296 thmic expression of the Arabidopsis thaliana F-box protein ZEITLUPE (ZTL) is necessary to sustain a n

297 lates the circadian clock by stabilizing the F-box protein ZEITLUPE via an unknown mechanism.

298 an unknown mechanism GIGANTEA stabilizes the F-box protein ZEITLUPE, a key regulator of the circadian

299 by stabilizing GI protein, dependent on the F-box protein ZEITLUPE, and implicate CONSTITUTIVE TRIPL

300 orms of PRR5 and TOC1 interact best with the F-box protein ZTL (ZEITLUPE), suggesting a mechanism to