ライフサイエンスコーパス: F

1 F. tularensis DNA in buffer or CFU of F. tularensis was

2 forded the CAr -H bond activation product [1-F-2-IMe -C6 H4 ](+) I(-) (3).

3 de from bovine pericardial tissue that is 14-F compatible with a motorized delivery system allowing f

4 (18) F-flortaucipir standardized uptake value ratios were cal

5 gnificant aging effect was observed in [(18) F]Nifene binding over 5 decades.

6 ography for amyloid-beta ((11) C-PiB or (18) F-florbetapir) and tau ((18) F-flortaucipir).

7 ) C-PiB or (18) F-florbetapir) and tau ((18) F-flortaucipir).

8 (18)F-FDG PET identified intense inter-scapular BAT glucose

9 (18)F-FDG PET/CT can be considered a valuable tool for the w

10 (18)F-FDG PET/CT studies were analyzed both qualitatively an

11 (18)F-FET PET might provide additional information beyond th

12 (18)F-FHNP was obtained in 15%-40% radiochemical yield (deca

13 (18)F-florbetapir (Amyvid) is an amyloid-binding PET ligand

14 (18)F-FLT biodistribution over time revealed a previously un

15 (18)F-FLT imaging objectively identified subclinical bone-ma

16 (18)F-FLT uptake in these areas was much lower in patients w

17 (18)F-IRS accumulation was preferential in the tumor, which

18 (18)F-labeled fluoroazomycinarabinoside ((18)F-FAZA) is a PE

19 (18)F-T807 is a PET radiotracer developed for imaging tau pr

20 [(18)F]AV-1451 binds in vivo regions that are likely to conta

21 [(18)F]CPFPX positron emission tomography was used to quantif

22 1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG

23 f 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF

24 ro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2

25 Uptake of 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]flu

26 The final study population included 176 (18)F-FDG PET/CT studies in 153 patients (107 men, 46 women;

27 metabolism, exemplified by fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography

28 2-(18)F-FEtOH is a novel (18)F-based radiotracer for investiga

29 ics in these patients using dynamic O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET.

30 ), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]

31 dro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]

32 igate whether sex influences 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake and tissue distribu

33 irst (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p e

34 (4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-(18)F-fluoronicotinamid o)butanamido)butanamido)methyl)pheny

35 , 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-

36 nd 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studied in EMT6 cells, tumors, and muscle and

37 ro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]flu

38 d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studied in EMT6 ce

39 Moreover 7-[(18)F]FTrp accumulated in different tumor xenografts in a ch

40 In addition, (18)F-FDG images were obtained during the cold stress condit

41 roins at 3 h (delayed examination) after (18)F-FDG injection.

42 hly selective sigma-1 receptor PET agent (18)F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thi

43 , specifically for B-(18)F, Si-(18)F, Al-(18)F, and iodine (III)-mediated radiofluorination via the s

44 Although (18)F-FDG, (18)F-PBR111, and (18)F-AV45 all detected patholo

45 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly u

46 Although (18)F-FDG, (18)F-PBR111, and (18)F-AV45 all detected pathologic alterations between TG an

47 ncrease in uptake for both (18)F-FDS and (18)F-FDG (9.2 and 3.9).

48 BAT, cold stress reduces blood flow and (18)F-FDG uptake in subcutaneous WAT, indicating that the ph

49 es in caudate and putamen, p<0.0001) and (18)F-FDOPA uptake (in caudate: age </=50 years, p=0.0002; a

50 s the concordance between (18)F-FDHT and (18)F-FES PET and tumor AR and ER expression measured immuno

51 ere scanned with [(11)C]carfentanil and [(18)F]fluorodopa positron emission tomography using a high-r

52 When available,(18)F-FDG PET-CT may be preferred.

53 beling methodologies, specifically for B-(18)F, Si-(18)F, Al-(18)F, and iodine (III)-mediated radiofl

54 e of this study was to describe baseline (18)F-FDG PET voxel characteristics in pediatric diffuse int

55 im was to assess the concordance between (18)F-FDHT and (18)F-FES PET and tumor AR and ER expression

56 mine transporter binding, VMAT2 binding, (18)F-FDOPA uptake, and serotonin transporter binding in mul

57 ents underwent a preoperative whole-body (18)F-FDG PET/CT scan at 1 h (standard examination) and an a

58 Whole-body (18)F-FDG PET/MRI scans were obtained for 12 patients after

59 Whole-body (18)F-fluodeoxyglucose positron emission tomography ([(18)F]

60 th a drastic increase in uptake for both (18)F-FDS and (18)F-FDG (9.2 and 3.9).

61 based on early evaluation of response by (18)F-FDG PET in patients in the Dutch GIST registry treated

62 enty-three GBM patients were assessed by (18)F-fluoromisonidazole ((18)F-FMISO) PET and conventional

63 Conclusion:(18)F-FDG PET/CT is a valuable technique for early detection

64 95.2% and 77.8% on standard and delayed (18)F-FDG PET/CT for an SUVmax cutoff of greater than 1.32 a

65 We have developed (18)F-5-fluoroaminosuberic acid (FASu), a PET tracer that ta

66 When applied to the dynamic (18)F-FDG measurement of colon cancer, the proposed algorith

67 objective of this study was to evaluate (18)F-AV-1451 binding with full kinetic analysis using a met

68 ) The goal of this study was to evaluate (18)F-FASu as a specific gauge for system xC(-) activity in

69 This article reviews the data evaluating (18)F-FDG PET quantification approaches in lung diseases, fo

70 Although (18)F-FDG, (18)F-PBR111, and (18)F-AV45 all detected pathologic alterat

71 en (PSMA)-targeted PET/CT tracers, first (18)F-DCFPyL (2-(3-{1-carboxy-5-[(6-(18)F-fluoro-pyridine-3-

72 (18)F-labeled fluoroazomycinarabinoside ((18)F-FAZA) is a PET biomarker for noninvasive identificatio

73 re assessed by (18)F-fluoromisonidazole ((18)F-FMISO) PET and conventional and perfusion MRI before s

74 ences 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake and tissue distribution in mouse models of

75 ntly observed in nonspecific tissues for (18)F-4FMFES, notably a 4-fold decrease in blood-pool activi

76 A total of 13 articles (11 studies for (18)F-FDG PET-CT and 2 for LS), met the inclusion criteria.

77 (18)F-FPSCH (range, 1.41-2.62) than for (18)F-FESCH (range, 1.64-3.36).

78 rence region was significantly lower for (18)F-FPSCH (range, 1.41-2.62) than for (18)F-FESCH (range,

79 acteristic curve (AUC, in g/mL. min) for (18)F-FTT was assessed in normal mouse organs before and aft

80 by 40% for (11)C-raclopride, by 52% for (18)F-MNI-659, by 28% for (11)C-NNC, and by 11% for (11)C-MD

81 ficantly higher fluorescence signal from (18)F-FDG-treated than untreated cells.

82 alog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly used in PET/CT that is retained by m

83 iagnosing DLBCL in the clinic; however, [(18)F]FDG-PET often faces difficulty in differentiating mali

84 This review focuses on recent human (18)F-FDG PET studies in Parkinson disease.

85 Motion correction of hybrid (18)F-fluoride PET markedly improves SNR, resulting in impro

86 However, no significant differences in (18)F-FDG-derived SUVs were observed between different grade

87 control rats, while no focally increased (18)F-FDG uptake was detected in all ZDF-ND rats.

88 metastases predominantly show increased (18)F-FET uptake, and only a third of metastases < 1.0 cm we

89 nodes of nonsurvivors showed increased [(18)F]-FDG uptake by day 4 postinfection with minimal lymph

90 Moribund NHPs demonstrated increased [(18)F]-FDG uptake in bone marrow 4 days postinfection compar

91 ients who underwent clinically indicated (18)F-fluciclovine PET/CT prior to enrollment.

92 d urine stability analysis showed intact (18)F-FCP at 24 h after injection.

93 ) radioligands using the copper-mediated (18)F-fluorination of aryl boron reagents with (18)F-fluorid

94 In a rodent myositis model, [(18)F]FPTMP identified live bacterial infection without demo

95 2-(18)F-FEtOH is a novel (18)F-based radiotracer for investigating tumor perfusion wi

96 -fold increase in metabolic stability of (18)F-4FMFES over (18)F-FES.

97 There was rapid metabolization of (18)F-AV45, with only 35% of unchanged parent remaining at 1

98 The DRs of (18)F-choline PET/CT and multiparametric MRI were 56% and 74

99 The stability of (18)F-FCP was verified using high-performance liquid chromat

100 hed studies reporting the performance of (18)F-FDG PET or (18)F-FDG PET/CT in patients with suspected

101 we investigated the diagnostic value of (18)F-FDG PET/CT in chronic Q fever at diagnosis and during

102 encephalitides, comparing the utility of (18)F-FDG PET/CT versus conventional brain imaging with MRI.

103 ibution of (11)C-MET PET/CT with that of (18)F-FDG PET/CT.

104 ves, slope, and tumor-to-brain ratios of (18)F-FET uptake (18-61 min after injection) were evaluated

105 data, we evaluated the repeatability of (18)F-FLT PET as part of a multicenter trial involving patie

106 We derived average values of (18)F-FMISO kinetic parameters for NSCLC lesions as well as

107 The potential of (18)F-FTC-146 as an imaging agent for a variety of neuroinfl

108 Binding of (18)F-GP1 to GPIIb/IIIa receptors was investigated in compet

109 The introduction of (18)F-labeled prostate-specific membrane antigen (PSMA)-targ

110 However, the number of (18)F-labeled tracers addressing PSMA is still limited.

111 ytoma) received 148-444 MBq (4-12mCi) of (18)F-MFBG intravenously followed by serial whole-body imagi

112 r up to 120 min after bolus injection of (18)F-T807 with arterial blood sampling.

113 Additionally, the biodistribution of [(18)F]FPTMP in a nonhuman primate shows low background in ma

114 d the reproducibility of their impact on (18)F-FDG PET quantification in patients with non-small cell

115 lso evaluated the impact of succinate on (18)F-fluorocholine uptake and retention.

116 an-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ((18)F-FTC-146).

117 uded until March 2015, when at least one (18)F-FDG PET/CT scan was obtained.

118 alterations between TG and WT mice, only (18)F-AV45 could detect an effect of BACE inhibitor treatmen

119 ting the performance of (18)F-FDG PET or (18)F-FDG PET/CT in patients with suspected paraneoplastic s

120 metabolic stability of (18)F-4FMFES over (18)F-FES.

121 end clinical transfer of the radioligand (18)F-PSMA-1007 for use as a diagnostic PET tracer in presta

122 s article provides an overview of recent (18)F-labeling methodologies, specifically for B-(18)F, Si-(

123 o)-p entanedioic acid) and more recently (18)F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4

124 volunteers underwent a high-resolution [(18)F]FEPPA PET scan and MRI.

125 Results:(18)F-FDG uptake identified subjects with high and low level

126 Results:(18)F-PSMA-1007 PET/CT had an NPV of 68% and an accuracy of

127 hodologies, specifically for B-(18)F, Si-(18)F, Al-(18)F, and iodine (III)-mediated radiofluorination

128 e technique was assessed in simultaneous (18)F-FDG PET/MR scans of a canine model of myocardial infar

129 uman primate (NHP) PET imaging studies, [(18)F]8 showed rapid brain uptake and high target specificit

130 k versus low-risk coronary lesions than [(18)F]FDG.

131 igh target specificity, indicating that [(18)F]8 is a promising PDE4B-preferring radioligand for clin

132 We found that [(18)F]BF4(-) was superior due to better pharmacokinetics, i.

133 g hub between SDH-mutated tumors and the (18)F-FDG uptake profile.

134 sociated with DFS when adjusting for the (18)F-FMISO status.

135 Thus, (18)F-FLT PET may be a useful tool to measure the severity o

136 nation well, and no adverse reactions to (18)F-FTC-146 were reported.

137 xyglucose positron emission tomography ([(18)F]FDG-PET) imaging has an essential role in diagnosing D

138 udies using (18)F-fluoro-ethyl-tyrosine ((18)F-FET) (n = 31) and (68)Ga-DOTANOC (n = 7) and studies o

139 amic O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET.

140 LC, we recruited all those who underwent (18)F-FDG PET/CT for clinical reasons at our institution bef

141 tudy of all adult patients who underwent (18)F-FDG PET/CT in search of a focal source of infection wa

142 Overall, fourth and subsequent follow-up (18)F-FDG PET/CT scans resulted in change in management in 3

143 7) and studies of healthy subjects using (18)F-FDG (n = 11).

144 Positron lymphography using (18)F-FDG was successfully performed on tumor-bearing and no

145 ining quantitative imaging metrics using (18)F-FLT to assess tumor proliferation.

146 have previously reported that PET using (18)F-fluoride (NaF PET) for assessment of osseous metastati

147 were included: brain tumor studies using (18)F-fluoro-ethyl-tyrosine ((18)F-FET) (n = 31) and (68)Ga-

148 pecific biomarker for BAT imaging using [(18)F]-F-DPA, a TSPO-specific PET tracer.

149 This was achieved using [(18)F]fluoro-levo-dihydroxyphenylalanine dynamic positron em

150 ET/CT imaging was performed to visualize (18)F-FLT biodistribution and to determine pharmacokinetics.

151 only a third of metastases < 1.0 cm were (18)F-FET-negative, most likely because of scanner resolutio

152 This adnectin was labeled with (18)F to yield a PET radioligand for assessing PD-L1 express

153 PET with (18)F-FDG captures neuronal activity that is in steady state

154 observed with the control group or with (18)F-FDG PET/CT imaging.

155 ethod for early response evaluation with (18)F-FDG PET/CT performed most optimally for the prediction

156 associated with pTR, in 82 patients with (18)F-FDG-avid nodes before NAC we observed mNR in 10 (12.2%

157 in blood-pool activity as compared with (18)F-FES.

158 e have previously reported that PET with (18)F-fluoride (NaF PET) for assessment of osseous metastati

159 fluorination of aryl boron reagents with (18)F-fluoride as a model reaction.

160 llysine and lysine provide a degenerate (19) F NMR signal.

161 di-Zn(II) active site, were selectively (19) F-labeled using 3-bromo-1,1,1-trifluoroacetone.

162 ells detected by a clinically applicable (19)F MRI method correlated with the BLI findings, which poi

163 d with the BLI findings, which points to (19)F MRI as a reliable method with which to track ASCs afte

164 s to phenols has been investigated using (19)F NMR spectroscopy.

165 nonstereoselective approach starting from 2'-F U.

166 d seventy-eight consecutive CC patients (706 F) were enrolled (FC 62.5%, IBS-C 31.3%, NRC 6.2%).

167 85.5% versus 72.9%, AUC 0.854 versus 0.733, F 1 score 0.854 versus 0.725; P < e -90 ).

168 s. 0.05 +/- 9.57 mm shift; effect size: 2.9; F(1,39) = 88.33, P < 0.001].

169 f 2 or more subtypes, including subtypes A1, F, G, H, J, and K and unclassified fragments, including

170 is responsible for attaching the virus to an F-pilus and delivering the viral genome into the host du

171 id-beta insult caused cofilin activation and F-actin remodeling and decreased microtubule dynamics in

172 ively targeting mitochondria, lysosomes, and F-actin demonstrate low toxicity and enable stimulated e

173 microscopy to analyze nuclear morphology and F-actin rearrangements during the initiation, progressio

174 tput multi-task model we observed an average F-score improvement of 0.8% when compared to the single-

175 ntaining phosphate-rich bioactive glass (BAG-F).

176 in A, diphenyleneiodonium, DNase or blocking F(ab')2 fragments to CD16, CD18, CD32 and CD64.

177 ne candidate and that the expression of both F and G proteins of AMPV-C induces a protective response

178 selected for this study were fruit-to-bunch (F/B), shell-to-fruit (S/F), kernel-to-fruit (K/F), mesoc

179 These results suggest that the rLS/AMPV-C F&G recombinant virus is a safe and effective bivalent v

180 An unprecedented intermolecular aliphatic C-F...H-C interaction was observed in the X-ray crystal st

181 in's M44 and M47 residues to induce cellular F-actin disassembly.

182 previous observations, we suggest that CENP-F might act as a transporter of mitochondria and other c

183 Small-amplitude motions within contact F-Q pairs, which gate the electronic coupling, are sugge

184 he initiator caspase dronc triggers cortical F-actin dismantling, enabling the glands to stretch as t

185 ents TRF1 from binding to Fbx4, an Skp1-Cul1-F box E3 ligase subunit, thereby alleviating proteasomal

186 cruitment of PIF3-EBFs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitated by light sig

187 in-RING E3 ligases, such as SCF (Skp1-Cullin-F-box).

188 Mutational analysis of a cyclin F-specific amino acid motif in the C-terminal region of

189 indicated rescue of the protein from cyclin F-mediated down-regulation.

190 n of the TJ-associated ZO-1 and cytoskeletal-F-actin proteins, correlated with modulation of hepatic

191 ion repair (TC-NER) (category 1: XP-A, B, D, F, and G) and preserved TC-NER (category 2: XP-C, E, and

192 In the case-crossover analysis, a 5 degrees F increase during the week preceding delivery was associ

193 ipants compared with controls (group effect, F = 8.0; P = .006).

194 The three subjects exhibited [F-18]-AV-1451 in vivo retention predominantly in basal g

195 the parasite cytosol and labels an extensive F-actin network that connects parasites within the paras

196 ific biomarker for BAT imaging using [(18)F]-F-DPA, a TSPO-specific PET tracer.

197 Factor (F) Xa reactive IgG isolated from patients with antiphosp

198 des a 139-amino-acid protein containing five F-actin-binding sites and two G-actin-binding sites, and

199 Flortaucipir F 18 is one such tracer.

200 ed to TM-TM association and is important for F protein function and pre-fusion stability.

201 Electron transfer from F(-) anions to the pi-electron-deficient ClBDPPV through

202 ics (TPs), furan compounds (HMF and furfural F) and cytoprotective/cytotoxic effects upon Caco-2 cell

203 reviously as a vector expressing RSV fusion (F) protein to confer bivalent protection against RSV and

204 Gervais & Fessler's (G&F's) Attitude-Scenario-Emotion (ASE) model reduces senti

205 ector functions to proteolytically generated F(ab')2 fragments.

206 The fusion glycoprotein (F) of RSV in either its postfusion (post-F) or prefusion

207 endoglycosidase H and peptide:N-glycosidase-F digestions.

208 cluding use of either peptide:N-glycosidases F and A (PNGase F and A) or anhydrous hydrazine to cleav

209 The PR --> F transition is the first step in a catalytic cycle that

210 tuin-1 small interfering RNA prevented hnRNP F stimulation of Foxo3alpha and downregulation of acetyl

211 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3alpha wit

212 Here, we describe how F-specific antibodies protect against RSV and why specif

213 esigned and characterized a recombinant hRSV F protein, called Pre-F-GCN4t, stabilized in a pre-F con

214 HSP22E/F strongly accumulate during heat stress and form high m

215 with high confidence with chloroplast HSP22E/F under heat stress thus revealing chloroplast processes

216 One system (type I-F) targets DNA.

217 sted by a remarkable genomic conservation in F. acidiphilum Y(T) variants from geographically distant

218 alization of YAP which led to an increase in F-actin.

219 osing activated atrophic pathways, including F-box protein 32 (Fbxo32), which encodes atrogin-1.

220 (MMCs) and economic incentives may increase F&V consumption.

221 JNK activity was critical for ICAM-1-induced F-actin rearrangements.

222 ing the hMSC migration through mtROS-induced F-actin formation.

223 B), shell-to-fruit (S/F), kernel-to-fruit (K/F), mesocarp-to-fruit (M/F), oil per palm (O/P) and oil-

224 Encoded on CenA, C1-specific K44-KIR2DP1(F) were stronger receptors than the attenuated C2-specif

225 than the attenuated C2-specific T44-KIR2DP1(F) encoded on CenB The last common ancestor of humans an

226 Here we identified a Y/F-x-x-Y/L/F-x-Y/F motif, evolutionarily conserved from the first t

227 also increased circulating cortisol levels (F=12.78, P0.001).

228 kernel-to-fruit (K/F), mesocarp-to-fruit (M/F), oil per palm (O/P) and oil-to-dry mesocarp (O/DM).

229 s to combinatorially increase Mical-mediated F-actin disassembly, cellular remodeling, and repulsive

230 cal to directly amplify Mical Redox-mediated F-actin disassembly.

231 1.8Co5.8Ga0.6Al0.1B0.9 melt spun powder (MQU-F, neo Magnequench).

232 degrees C in the presence of (0.4 mM) NaBAr(F)4 as compared with a very slow reaction at 125 degrees

233 ion at 125 degrees C in the absence of NaBAr(F)4.

234 in 2015 would increase the average national F&V consumption by 7% for 1 y and prevent approximately

235 ed on the standard enthalpy change (DeltaH(o)F=-8.67kJ.mol(-1)), while microcalorimetry showed an ent

236 In the absence of F-actin, the sperm DNA, centrioles, and organelles were

237 F. tularensis DNA in buffer or CFU of F. tularensis was spiked into human or macaque blood.

238 The impact of F. johnsoniae on the tadpole surface microbiome was asse

239 ell morphology and disrupted organization of F-actin in Li1 plant cells by confocal microscopy.

240 We found stimulated polymerization of F-actin is not required for Syk recruitment but is progr

241 d activation of the PI3K, and recruitment of F-actin and of the actin-branching protein cortactin.

242 n maintaining the morphological structure of F-actin and in protein transport, loss of this function

243 model system towards better understanding of F. pseudograminearum-wheat interaction.

244 Energy landscapes based on F-actin-tropomyosin models show the mutation localizes t

245 The structure of cofilin on F-actin and the details of the intermolecular interface

246 Since PCDD/F congeners that are substituted in the lateral 2, 3, 7,

247 ggested that dechlorination proceeds to PCDD/F congeners with less than four chlorines.

248 Both PIV5/F and PIV5/G were also able to boost neutralization tite

249 ither peptide:N-glycosidases F and A (PNGase F and A) or anhydrous hydrazine to cleave the N-glycans

250 ecognizes site II on both the pre-F and post-F proteins, is restricted to prophylaxis in neonates at

251 in (F) of RSV in either its postfusion (post-F) or prefusion (pre-F) conformation is a target for neu

252 he prefusion (pre-F) to the postfusion (post-F) state at the time of virus-host cell membrane fusion.

253 ein, called Pre-F-GCN4t, stabilized in a pre-F conformation.

254 an attenuated rHPIV1 vector expressing a pre-F-stabilized form of RSV F demonstrated promising immuno

255 zed a recombinant hRSV F protein, called Pre-F-GCN4t, stabilized in a pre-F conformation.

256 Importantly, Pre-F-GCN4t was also shown to bind D25, a highly potent mono

257 er its postfusion (post-F) or prefusion (pre-F) conformation is a target for neutralizing antibodies

258 jor structural shift from the prefusion (pre-F) to the postfusion (post-F) state at the time of virus

259 Here, we further stabilized pre-F by adding both disulfide and cavity-filling mutations

260 ab, which recognizes site II on both the pre-F and post-F proteins, is restricted to prophylaxis in n

261 ent monoclonal antibody specific for the pre-F conformation.

262 izes antigenic site O at the apex of the pre-F protein trimer.

263 RSV and why specifically targeting prefusion F could have great clinical potential.

264 ed to express either the RSV fusion protein (F) or the RSV major attachment glycoprotein (G) between

265 Paramyxovirus viral fusion proteins (F) insert into the target cell membrane, and form a tran

266 or TIRF microscopy of in vitro reconstituted F-actin networks, we observed and characterized two dist

267 ivate Evaporative Cooling, which uses Relief-F feature selection and random forest classification.

268 utations (DS-Cav1), and we also modified RSV F codon usage to have a lower CpG content and a higher l

269 or expressing a pre-F-stabilized form of RSV F demonstrated promising immunogenicity and should be fu

270 PIV5-RSV F was equally protective when administered intranasally

271 The vectors exhibited stable RSV F expression in vitro and in vivo In conclusion, an atte

272 The RSV F protein and attachment (G) protein were found to be in

273 erase (L) genes of the PIV5 genome [PIV5-RSV-F (HN-L) and PIV5-RSV-G (HN-L), respectively].

274 were fruit-to-bunch (F/B), shell-to-fruit (S/F), kernel-to-fruit (K/F), mesocarp-to-fruit (M/F), oil

275 mation and exhibit increased levels of sigma(F) -directed gene transcription.

276 RANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX PROTEIN (TIR1/AFB) family are known auxin receptor

277 Similarly, F. graminearum affected fungal endophytes including Tric

278 ctase, alkyl hydroperoxide reductase subunit F (AhpF), catalyzes the rapid reduction of the redox-act

279 Measuring and targeting F. nucleatum and its associated pathway will yield valua

280 We demonstrate that F-actin automata implement OR, AND, XOR and AND-NOT gate

281 The F-box protein FBXW7 is the substrate-recruiting subunit

282 T-negative patients, 5-year PFS rates in the F group were 99.0% versus 87.1% (HR, 15.8; 95% CI, 3.8 t

283 quires septin-dependent reorientation of the F-actin cytoskeleton at the base of the infection cell,

284 Speed and space values of the F-actin molecular computers are discussed.

285 .1 mice to an I-Ab-associated epitope of the F-MuLV envelope protein is dominated by clones expressin

286 id at POmega, which enabled them to open the F pocket and expose their C-terminal extension into the

287 odium distachyon (Brachypodium hereafter) to F. pseudograminearum infection using RNA-seq to determin

288 t necessarily weak binding of tropomyosin to F-actin is required for effective thin filament function

289 extrahepatic tumour (E), multifocal tumour (F), and spontaneous rupture (R).

290 016, neurotoxigenic Clostridium baratii type F caused 18 (<0.5%) reported US infant botulism cases.

291 conformation is important for understanding F protein function.

292 myosin motor domain that are triggered upon F-actin binding and contribute critically to the mechano

293 Using F-PTS1 we are able to observe the pH conditions inside g

294 with the conformational change in the viral F protein that is required to elicit membrane fusion.

295 ate that isolated TM domains of Hendra virus F protein associate in a monomer-trimer equilibrium (Smi

296 VopL/F do not associate with the ends of preassembled filamen

297 nt nucleation by the bacterial proteins VopL/F.

298 e describe the interaction of myosin-5B with F-actin, nucleotides, and the pyrazolopyrimidine compoun

299 he relationship between Tau-PET imaging with F(18)-AV1451 and functional connectivity MRI (fcMRI) in

300 ivation in the back/side of the cell or with F-actin in the front of the cell.

301 Here we identified a Y/F-x-x-Y/L/F-x-Y/F motif, evolutionarily conserved from t

302 Here we identified a Y/F-x-x-Y/L/F-x-Y/F motif, evolutionarily conserved from the first tetrapo