ライフサイエンスコーパス: F344 rat

1 e in reversing age-dependent CKD in the male F344 rat.

2 om young (3-4 months) and old (22-24 months) F344 rats.

3 ale B6D23F1 mice and in most tissues of male F344 rats.

4 olved in modulating the severity of AA in CV-F344 rats.

5 e (AOM)-induced colon carcinogenesis in male F344 rats.

6 neic dipeptidyl peptidase IV (DPPIV-) mutant F344 rats.

7 using young (6 months) and aged (20 months) F344 rats.

8 iminished in aged coronary arteries from old F344 rats.

9 actin responses to morphine when compared to F344 rats.

10 ic dipeptidyl peptidase IV mutant (DPPIV(-)) F344 rats.

11 carcinogen treatment, was determined in male F344 rats.

12 porters in dipeptidyl peptidase IV-deficient F344 rats.

13 ession stage of colon carcinogenesis in male F344 rats.

14 ch disrupt PPI in Sprague-Dawley and Fischer F344 rats.

15 ages of azoxymethane-induced colon cancer in F344 rats.

16 xymethane (AOM)-induced colon tumors in male F344 rats.

17 ne (NNK), selectively induces lung tumors in F344 rats.

18 the colonic mucosa and colon tumors of male F344 rats.

19 accumulation of macrophages in the lungs of F344 rats.

20 e (AOM)-induced colon carcinogenesis in male F344 rats.

21 long-term bioassay for lung tumorigenesis in F344 rats.

22 4 d after viral inoculation as compared with F344 rats.

23 erent stages of colon carcinogenesis in male F344 rats.

24 xty-two units in those of old (24-26 months) F344 rats.

25 f oltipraz on PhIP-induced lymphomas in male F344 rats.

26 had higher breakpoints for cocaine than the F344 rats.

27 body weight and food intake in photoperiodic F344 rats.

28 rypt foci (ACF) and colon adenocarcinomas in F344 rats.

29 ritis-susceptible DA and arthritis-resistant F344 rats.

30 of both strains, but to a greater extent in F344 rats.

31 radiol modulates phrenic and XII LTF in male F344 rats.

32 y TCD bone marrow transplantation (BMT) from F344 rats.

33 methane-induced colon carcinogenesis in male F344 rats.

34 is was induced by azoxymethane (AOM) in male F344 rats.

35 locomotor activity in Lewis rats but not in F344 rats.

36 ferences in NAc DAT levels between Lewis and F344 rats.

37 vels in coronary myocytes from young and old F344 rats.

38 orsal region of control and protein-depleted F344 rats.

39 bt-AIA with the responses of parental DA and F344 rats.

40 al clusterin mRNA expression in Fischer 344 (F344) rats.

41 12-, 18- and 24-month old male Fischer 344 (F344) rats.

42 passive immunization studies in Fischer 344 (F344) rats.

43 nimal Care and Use Committee-approved study, F344 rats (150 gm, n = 96) with subcutaneous R3230 breas

44 ring of CIA-susceptible DA and CIA-resistant F344 rats, 5 quantitative trait loci (QTLs) for which F3

45 tiation period of colon carcinogenesis, male F344 rats 6 weeks of age were fed the high-fat diet, and

46 In S-D but not in F344 rats, a significant (P < 0.05) age-linked 24% nephr

47 -dG adducts was observed in the liver DNA of F344 rats after treatment with CCl4, suggesting that tis

48 Immunization of F344 rats against ovalbumin followed by intranasal chall

49 vaccination may contribute to the defense of F344 rats against respiratory infection by type A strain

50 mal age affects bladder regeneration, female F344 rats aged 12 weeks (young) and 12 months (old) unde

51 rogenic chemicals (e.g., zearalenone) in the F344 rat and B6C3F1 mouse have not shown the same spectr

52 e brown Norway (BN) rats and virus-resistant F344 rats and to determine which of several virus-induce

53 yme expression, the drug was administered to F344 rats, and hepatic glutathione S-transferase (GST),

54 k tea protects against lung tumorigenesis in F344 rats, and this effect appears to be attributed, to

55 Inbred Lewis (LEW) and Fischer 344 (F344) rats are differentially sensitive to drugs of abus

56 xtent than F344 rats, while LEW (compared to F344) rats are more sensitive to the aversive effects of

57 Fischer 344 (F344) rats are relatively resistant to hypoxia-induced r

58 a, we used dipeptidyl peptidase IV-deficient F344 rats as hosts.

59 ofenin in syngeneic recipients of liver from F344 rats, as well as secretion of albumin in allografte

60 ered continuously in the feed for 2 years to F344 rats at doses of 0, 12,500, 25,000, and 50,000 ppm

61 patial maze learning were used to study male F344 rats at five age points.

62 ution and PET studies were performed on male F344 rats bearing 9L tumor xenografts.

63 The -labeled cells were then transferred to F344 rats bearing Lewis (LEW) cardiac allografts to meas

64 Alternatively, the F344 rats began sessions with lower intake and increased

65 Strikingly, naive unimmunized CV-F344 rats but not BF-F344 rats raised T cell responses t

66 and systemic inflammation in B27 transgenic F344 rats, but all bacterial species do not have equal a

67 TC), an inhibitor of lung tumor induction in F344 rats by NNK, on O6-methyldeoxyguanosine (O6-mG) and

68 d in 2 animal models: xenografts produced in F344 rats by subcutaneous injection of 9L tumor cells an

69 t of graft arteriosclerosis, in the LEW into F344 rat cardiac transplant model.

70 ss, we produced congenitally athymic rnu/rnu F344 rats carrying the disease-prone B27 transgenic locu

71 F344 rats chronically infected with Ureaplasma parvum de

72 oronary arteries, old coronary arteries from F344 rats contract less effectively ( approximately 70%

73 We have reported previously that F344 rats develop a spontaneous tolerance to WKY lung al

74 Lewis and Fischer 344 (F344) rats differ in responses to cocaine and characteri

75 he three major subdivisions of the IC in the F344 rat: dorsal cortex (DCIC), external cortex (ECIC),

76 hippocampus of old (n = 5) and young (n = 6) F344 rats during periods of rest preceding and following

77 MBA)-induced esophageal tumorigenesis in the F344 rat, during initiation and postinitiation phases of

78 er novelty- and AMPH-induced locomotion, but F344 rats exhibited greater AMPH-induced rearing and ste

79 After chronic TAA administration, DPPIV(-) F344 rats exhibited progressive fibrosis, cirrhosis, and

80 o saline injection (i.e., mild stress), with F344 rats exhibiting sustained elevations in corticoster

81 ll response and bile duct carcinomas of male F344 rats exposed to a cyclic choline deficiency-ethioni

82 these adducts in tissues of B6C3F1 mice and F344 rats exposed to a range of BD concentrations (0-625

83 ) inflammatory proteins in the blood of male F344 rats exposed to an acute tail shock stressor.

84 With aging, male F344 rats exposed to cyclic CDE diet display a diminishe

85 erflow may not differ between young and aged F344 rats, extracellular regulation of striatal DA (as m

86 evaluated Sprague-Dawley (SD) or Fisher 344 (F344) rats following intratracheal instillation (IT).

87 lved feeding to the male and female parental F344 rats for 4 weeks before mating, feeding the dams du

88 ely protected the highly susceptible Fischer F344 rats from lethal toxin.

89 ion in Mat2A promoter of fast-growing HCC of F344 rats, genetically susceptible to hepatocarcinogenes

90 Male Fisher F344 rats given 3-chloropropanediol showed astrocyte los

91 ixture of host and donor marrow (B10 mouse + F344 rat --> B10 mouse) results in donor-specific cross-

92 Fisher 344 (F344) rat heart or SB grafts were transplanted into F344

93 Male Fisher F344 rat hearts were heterotopically transplanted into L

94 Intrasplenic transplantation of F344 rat hepatocytes followed by their localization with

95 F344 rat hepatocytes were transplanted intrasplenically

96 We transplanted primary F344 rat hepatocytes with or without DAR in dipeptidyl p

97 by intrasplenic transplantation of syngeneic F344 rat hepatocytes.

98 BAA receptor picrotoxin site in the Fischer (F344) rat IC.

99 -AIA of relatively greater severity than did F344 rats, implying that in DA and F344 rats, there coul

100 D of perillyl alcohol was determined in male F344 rats in a 6-week subchronic toxicity study and foun

101 Two groups of male F344 rats in late middle-age having similar learning and

102 ons and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mi

103 IQ) produces tumors at multiple sites in the F344 rat, including adenocarcinomas of the colon.

104 ck tea and caffeine on lung tumorigenesis in F344 rats induced by the nicotine-derived carcinogen 4-(

105 ministration of estrogen to the Fischer 344 (F344) rat induces growth of large, hemorrhagic pituitary

106 liver cells were transplanted from DPPIV(+) F344 rats into DPPIV(-) rats of different ages (2, 6, 14

107 tes were transplanted via spleen from either F344 rats into syngeneic recipients deficient in dipepti

108 reater inhibition of DA clearance by AMPH in F344 rats is consistent with their marked AMPH-induced r

109 get genes in the aged cortex of 24-month-old F344 rats is significantly attenuated during acute hypox

110 the obese Zucker rat kidney and in 24-mo-old F344 rat kidney as assessed by in situ hybridization.

111 calcineurin inhibitor on IRI in a syngeneic F344 rat kidney transplant model.

112 transplanted cells, we treated Fischer 344 (F344) rats lacking dipeptidyl peptidase IV (DPPIV) activ

113 Compared to F344 rats, Lewis rats have lower D2 receptor and dopamin

114 Northern analysis of RNA from female F344 rat liver and LCS-3 cells revealed over a 40-fold a

115 The genomic evolution of a cohort of WB-F344 rat liver epithelial cell lineages undergoing spont

116 ipeptidyl peptidase IV (DPP-IV), cultured WB-F344 rat liver epithelial cells (without exogenous marke

117 the molecular changes that take place in WB-F344 rat liver epithelial cells during neoplastic transf

118 ocytes and strengthen the suggestion that WB-F344 rat liver epithelial cells represent the cultured c

119 tiple independent lineages of low-passage WB-F344 rat liver epithelial stem-like cells were initiated

120 In cells isolated from the normal F344 rat liver, cytochrome P450 inducibility was origina

121 IMP-2) were overexpressed by gene therapy in F344 rat lung allografts prior to transplantation into W

122 ity (BF-F344) are susceptible to AA, whereas F344 rats maintained in a conventional facility (CV-F344

123 n DNA isolated from tissues of rodents (male F344 rats, male B6D2F1 mice, male C57BL/6 mice, and fema

124 genesis of pneumonic tularemia in the female F344 rat model appears to replicate the disease in human

125 complete remission in the syngeneic Fischer F344 rat model of aggressive NK-LGL leukemia.

126 28-B7 costimulation, was studied in a LEW to F344 rat model of chronic cardiac rejection.

127 dy was performed in C57BL6 mice (n = 20) and F344 rats (n = 124).

128 In aged Fischer 344 (F344) rats, noradrenergic (NA) nerve density in secondar

129 Furthermore, adoptive transfer into naive BF-F344 rats of splenic cells of naive CV-F344 rats (restim

130 (across 4-, 10-, 12-, 14-, and 23-month-old F344 rats) of several established biomarkers, including

131 alpha protein compared with virus-inoculated F344 rats (P < 0.05).

132 at the more frequent AMPH-induced rearing in F344 rats persisted.

133 hylstilbestrol (DES) treatment caused female F344 rat pituitaries to grow to an average of 109.2 +/-

134 tive bronchiolitis (OB) in orthotopic WKY-to-F344 rat pulmonary transplants that have been subjected

135 y, naive unimmunized CV-F344 rats but not BF-F344 rats raised T cell responses to Bhsp65 C-terminal d

136 We observed that Fischer 344 (F344) rats raised in a barrier facility (BF-F344) are su

137 ek acclimatization period, groups of 30 male F344 rats received s.c. injections of NMBA (0.5 mg/kg b.

138 Fischer (F344) rats resembled Lewis rats in being similarly affec

139 ve BF-F344 rats of splenic cells of naive CV-F344 rats (restimulated with BCTD in vitro) before induc

140 Results show that F344 rats self-administer more cocaine than Lewis or Spr

141 tor response to colorectal distention in the F344 rat strain.

142 Lewis (LEW) and Fischer 344 (F344) rat strains have been reported to differ in their

143 ) in male Lewis, Sprague-Dawley, and Fischer F344 rats tested as adults.

144 mino)-1-(3-pyridyl)-1-butanone (NNK) in male F344 rats that had been fed either a semipurified AIN-76

145 erance group, the skin grafts were placed on F344 rats that had received a WKY lung transplant 35 day

146 of the nine HIV-1 toxic proteins) and non-Tg F344 rats that self-administered cocaine for 14 days (CO

147 ible (Lewis; LEW) or resistant (Fischer 344; F344) rats that have identical MHC class II haplotype.

148 e a strikingly different immune profile than F344 rats, the traditional animal model for aging resear

149 than did F344 rats, implying that in DA and F344 rats, there could be other Mbt-AIA loci in addition

150 derwent transplantation into DPPIV(-) mutant F344 rats to follow the fate and differentiation of tran

151 We subjected F344 rats to hepatic RT and partial hepatectomy with/wit

152 erential behavioral sensitivities of LEW and F344 rats to these drugs within CTA learning.

153 adducts in whole lung and pulmonary cells of F344 rats treated with different doses of NNK (0.3, 1.0,

154 DNA adducts in whole lung and lung cells of F344 rats treated with NNK.

155 female Sprague-Dawley (S-D) and Fischer 344 (F344) rats treated with AG (0.1% in drinking water) for

156 Young male and female F344 rats underwent sham surgery (SHAM), gonadectomy (GX

157 The behavior of male LEW and F344 rats was assessed in an open-field arena during hab

158 omparison, renal clusterin mRNA in 12-mo-old F344 rats was twofold higher than in 3-mo-old animals an

159 njection of the WBras cells into a syngeneic F344 rat, WBrasIIa, contained additional chromosomal cha

160 In an intercross between F1(BBDP x F344) rats, we identified a rat with a recombination eve

161 Heat-inactivated sera from skin grafted F344 rats were assayed against BN and F344 lymphoid cell

162 Splenic lymphoid cells from skin grafted F344 rats were assayed for cytotoxicity against BN and F

163 At 5 weeks of age, groups of male F344 rats were assigned to one of six diets: a high-fat

164 rom the cortex of embryonic day (E)14 Fisher F344 rats were cocultured with different concentrations

165 Young adult and aged F344 rats were compared on a silent gap variant of the p

166 Intact and sham operated male F344 rats were compared to gonadectomized rats implanted

167 At 5 weeks of age, groups of male F344 rats were fed a 5% corn oil diet (LFCO).

168 At 5 weeks of age, groups of male F344 rats were fed a control diet containing no curcumin

169 At 5 weeks of age, groups of male F344 rats were fed control (AIN-76A) diet or a diet cont

170 At 5 weeks of age, groups of male F344 rats were fed control (AIN-76A) diet or diets conta

171 F344 rats were fed control or PEITC-containing diets (3

172 At 5 weeks of age, groups of male F344 rats were fed diets containing 0%, 0.06%, and 0.12%

173 For 5-6 mo, middle-aged F344 rats were fed diets containing low, medium (typical

174 Groups of 5-week-old male F344 rats were fed either a control diet or experimental

175 F344 rats were fed experimental diets containing one of

176 Five-week-old male F344 rats were fed the control diet (modified AIN-76A) o

177 Five-week-old male F344 rats were fed the control diet (modified AIN-76A) o

178 Male F344 rats were fed the semipurified AIN-76A diet contain

179 Male F344 rats were fed the semipurified American Institute o

180 To explore this relationship, LEW and F344 rats were injected with saline or doses of morphine

181 F344 rats were injected with syngeneic labeled red blood

182 Kidneys of Lewis (LEW) and F344 rats were orthotopically transplanted into bilatera

183 Dipeptidyl peptidase-deficient F344 rats were preconditioned with whole liver radiation

184 Young and middle-aged male F344 rats were provided 1 d of training on the spatial v

185 s old) and senescent (22-24 months old) male F344 rats were repeatedly exposed to a given spatial con

186 F344 rats were resistant to significant virus-induced al

187 on with the uveitogenic peptide R16, whereas F344 rats were resistant.

188 endpoints, young (2-4 mo) and old (24-28 mo) F344 rats were supplemented for up to 1 mo before death

189 l livers or mature hepatocytes from DPPIV(+) F344 rats were transplanted into DPPIV(-) rats with thio

190 ctive effects in aging, aged (29 months old) F344 rats were treated with etanercept (1 mg/kg/week for

191 Male F344 rats were treated with the tobacco-specific nitrosa

192 ts for the NNK-induced lung tumorigenesis in F344 rats, whereas NAC was not active at all.

193 group, WKY skin grafts were placed on normal F344 rats, whereas, in the tolerance group, the skin gra

194 s (PN) from adult male HIV-1 transgenic (Tg) F344 rats (which express seven of the nine HIV-1 toxic p

195 induced autoimmunity, but not in WF, DA, or F344 rats, which are resistant.

196 orphine and cocaine to a greater extent than F344 rats, while LEW (compared to F344) rats are more se

197 336 increased cocaine self-administration in F344 rats, while Lewis rats showed reduced intake under

198 f most rat strains, we included Fischer 344 (F344) rats whose CT responses to sodium chloride (NaCl)

199 ls (Mat B III) orthotopically into syngeneic F344 rats with an intact immune system.

200 F344 rats with struvite uroliths had the highest urinary

201 In the present study, we treated F344 rats with the esophageal carcinogen, N-nitrosomethy

202 Intraperitoneal injection of F344 rats with zymosan led to a marked elevation in prot

203 F344 rats without struvite stones at necropsy had milder