ライフサイエンスコーパス: FD

1 FD hamsters and mice increased AgRP within the arcuate h

2 FD is a heterogeneous condition in children and adolesce

3 FD is caused by a point mutation in the gene IKBKAP/ELP1

4 FD is caused by an mRNA splicing mutation in intron 20 o

5 FD mice exhibited severe hearing loss measured by audito

6 FD soybean originated in China, although the details of

7 with a pharmacologic splicing modulator, 17S-FD-895, reversed pro-survival splice isoform switching a

8 for the adsorption of four dyes (FD&C red 2, FD&C yellow 5, FD&C blue 2, Acid Red 51) at different te

9 thin approximately 6% and approximately 30% (FD-SD1; patients) and approximately 4% and approximately

10 le; freeze-drying at -50 degrees C and 30Pa, FD sample; and convective drying at 60 degrees C and 2m/

11 ion of four dyes (FD&C red 2, FD&C yellow 5, FD&C blue 2, Acid Red 51) at different temperatures (298

12 and approximately 4% and approximately 75% (FD-SD2; animals).

13 for the GCL + IPL complex was obtained at a FD </= 1.66 (cut off point, asymptotic 95% Confidence In

14 imilar FRET efficiencies for FT-FD and AcMFT-FD heterodimer in nucleus were observed.

15 reduced due to the weakened ability of AcMFT-FD to activate the downstream gene AP1.

16 e whole group and for those fulfilling adult FD subtype criteria.

17 association between fibrosis score, BMI and FD CONCLUSION: FD is more prevalent in patients with chr

18 espectively), VLD (P < 0.0001 for both), and FD (P < 0.0001 for both) significantly decreased and VDI

19 The CDI and FD at the SVP and DVP for each severity level of DR and

20 tion of systemic risk factors vs the CDI and FD.

21 logical inhibitor, Hepc, in both control and FD cells.

22 using analysis, we show that both pro-FD and FD are present in the circulation of healthy donors.

23 IC50 values for ACE inhibition by OD-FPH and FD-FPH samples were found to be 1.15 and 1.53mg of prote

24 e molecular weight of peptides in OD-FPH and FD-FPH was in the range of 7030-339Da.

25 the critical amino acid residues in FT1 and FD-like proteins required for their interactions, and de

26 in early life increases the risk of IBS and FD throughout adulthood.

27 The association between OAB and FD was weak in both groups.

28 r depicted spherical shape without pores and FD encapsulated powder yielded larger particle sizes wit

29 tolerated volume in Nutrient Drink Test, and FD-related quality of life.

30 The SD, VD, and FD of the parafoveal capillaries were lower in uveitic e

31 BMI >/=30 kg/m(2)) to explore maximal apical FD (FDMaxApical).

32 Dried apples (FD and CD samples) were rehydrated prior to digestion.

33 pull-down assays indicated that Arabidopsis FD proteins interact with full-length FT and AcMFT, as w

34 Associations between FD and peak regional systolic circumferential strain (Ec

35 ion, strong correlation was detected between FD-OCT anterior angle measurements and ACV, ACD, spheric

36 ction fraction showed no differences between FD quartiles.

37 n models determined the relationship between FD and other parameters.

38 lly administered PPARgamma antagonism blocks FD-induced increases in AgRP and NPY; and finally, (5) w

39 In both FD and control fish, SMR was negatively correlated with

40 Individual symptoms were also compared by FD subtype.

41 y attributes) was found in fruits treated by FD and VMD 480-120 W.

42 Overlap syndromes/symptoms did not vary by FD subtype.

43 n pluripotent stem cells (PSCs) that capture FD severity.

44 were used to categorize p.D322E as a classic FD mutation and p.I232T as a later-onset FD mutation.

45 tween fibrosis score, BMI and FD CONCLUSION: FD is more prevalent in patients with chronic hepatitis

46 In the presence of craniofacial FD during CT or MRI imaging of the head, a detailed desc

47 ance, and sex of the cases with craniofacial FD.

48 ent reversible and selective human factor D (FD) inhibitors with drug-like properties.

49 t had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD l

50 highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the com

51 Factor D (FD), which is also known as adipsin, is regarded as the

52 performed using the foregoing full datasets (FD) and repeated for each of 2 shortened datasets corres

53 tions, including sitting, lateral decubitus, FD (with the CLS-instrumented eye toward the pillow), an

54 n = 65 each) that were fed folate-deficient (FD) or standard diets for 8 wk.

55 ing behaviors; (2) whether food deprivation (FD) co-increases agouti-related protein (AgRP) and PPARg

56 Individuals were either: 1) food deprived (FD) for 21 days, then fed ad libitum for the next 74 day

57 Food deserts (FD), neighborhoods defined as low-income areas with low

58 d residual alpha-GalA activity and developed FD manifestations in adulthood.

59 t FT1, other FT-like proteins, and different FD-like proteins, can interact with multiple wheat and b

60 isophorone (FD = 256) and dihydrooxophorone (FD = 128).

61 Key aroma compounds (flavor dilution (FD) factors >/=16) were beta-damascenone, furaneol, phen

62 On the basis of the flavour dilution (FD) factor, the most powerful aroma active compounds wer

63 y density index (CDI) and fractal dimension (FD) at the superficial vascular plexus (SVP) and deep re

64 ination were used for the fractal dimension (FD) calculations.

65 ring vessel density (VD), fractal dimension (FD), and foveal avascular zone (FAZ) of superficial and

66 SD), vessel density (VD), fractal dimension (FD), and vessel diameter index (VDI).

67 d with the maximal apical fractal dimension (FD), which is a marker of endocardial complexity.

68 ify LV trabeculation as a fractal dimension (FD).

69 diameter index (VDI), and fractal dimension (FD).

70 iac arrhythmias are common in Fabry disease (FD) and may occur in prehypertrophic cardiomyopathy sugg

71 from 2 families with X-linked Fabry disease (FD) caused by GLA(alpha-galactosidase A gene) mutations

72 Fabry disease (FD) is a progressive multisystemic disorder, treatable w

73 Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by mu

74 in the pathogenesis of ferroportin disease (FD), the disease attributed to lack-of-function FPN1 mut

75 molecular basis of facilitated dissociation (FD), we have used single-molecule imaging to measure dis

76 quantification method, using force-distance (FD) curve based atomic force microscopy (AFM) to detect

77 Recent developments in force-distance (FD) curve-based atomic force microscopy (FD-based AFM) e

78 reflected by numerical functional distance (FD) scores, assignable to all HLA-DPB1 alleles based on

79 ally defined using the functional diversity (FD) and functional identity (FI) of the community respec

80 Functional diversity (FD) and phylogenetic diversity (PD) are able to capture

81 degradation of extraneous long flanking DNA (FD) linked to Mu.

82 re the iridocorneal angle by Fourier domain (FD) OCT and to identify correlations between angle measu

83 s paper, we report a novel frequency-domain (FD) algorithm to enable robust and fast characterization

84 landraces (Glycine max, fully domesticated (FD)), annual wild type (Glycine soja, nondomesticated (N

85 ated with placing one side of the face down (FD) on a pillow in simulated sleep.

86 traditional stoves to improved forced draft (FD) stoves.

87 ies of oven-dried (OD-FPH) and freeze-dried (FD-FPH) protein hydrolysates derived from fresh water fi

88 Fruit Detachment Force (FDF) and Fruit Drop (FD) analyses combined with a metabolomic study carried o

89 vacuum oven drying (VOD) and freeze drying (FD) for tomatoes (Solanum lycopersicum) and ginger (Zing

90 ees C)-VMFD (480-120 W)], and freeze-drying (FD) on key quality parameters of dried jujube fruits (cv

91 The effect of freeze-drying (FD), vacuum drying (VD), convective drying (CD), microwa

92 such as spray drying (SD) and freeze-drying (FD).

93 re obtained for the adsorption of four dyes (FD&C red 2, FD&C yellow 5, FD&C blue 2, Acid Red 51) at

94 Familial dysautonomia (FD) is a debilitating disorder that affects derivatives

95 Familial dysautonomia (FD) is an autosomal recessive neurodegenerative disease

96 and purify iNCs from familial dysautonomia (FD) patient fibroblasts.

97 uropathy type III, or familial dysautonomia [FD; Online Mendelian Inheritance in Man (OMIM) 223900],

98 mine the prevalence of functional dyspepsia (FD) among patients with hepatitis C.

99 bowel syndrome (IBS), functional dyspepsia (FD) and chronic fatigue (CF).

100 reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functi

101 Functional dyspepsia (FD) is a functional gastrointestinal disorder diagnosed

102 Functional dyspepsia (FD) is a gastrointestinal disorder characterized by recu

103 Functional dyspepsia (FD) is associated with anxiety but it is not clear if on

104 ly prescribed to treat functional dyspepsia (FD), a common disorder characterized by upper abdominal

105 systemic symptoms, in functional dyspepsia (FD).

106 atients with craniofacial fibrous dysplasia (FD), the clinical and radiological findings of CT and MR

107 focusing technique that resolves endogenous FD variants in complex samples.

108 We describe procedures for experimental FD-based AFM setup, high-resolution imaging of proteins

109 he basic leucine-zipper transcription factor FD is proposed to form in the SAM, leading to activation

110 s a homolog of the bZIP transcription factor FD.

111 he fiber-degrading Ruminococcus flavefaciens FD-1 genome revealed a particularly elaborate cellulosom

112 tomography imaging of 6-[(18) F]fluorodopa (FD; reflects dopa decarboxylase) and [(11) C]dihydrotetr

113 United States Food Access Research Atlas for FD status.

114 several promising therapeutic candidates for FD have been identified that target the underlying mRNA

115 of patients who met the Rome II criteria for FD and did not have depression or use antidepressants.

116 se remarkable advances in drug discovery for FD, we lacked a phenotypic mouse model in which we could

117 ease AgRP/NPY, and possibly is necessary for FD-induced increases in feeding and AgRP/NPY.

118 differences between KRCs were found only for FD-SD2 correlations in patient studies.

119 KRCs deduced from both SD1 and SD2, and from FD.

120 nd SD2 were compared with those derived from FD by correlation (Pearson), regression (Passing-Bablok)

121 3/4/5) potentiate the FLOWERING LOCUS T (FT)-FD module in photoperiodic flowering.

122 urthermore, similar FRET efficiencies for FT-FD and AcMFT-FD heterodimer in nucleus were observed.

123 L, thus mediating their activation by the FT-FD complex.

124 hat SPL3/4/5 act synergistically with the FT-FD module to induce flowering under LDs, providing a lon

125 ndents meeting the criteria for either GERD, FD or IBS have significantly higher odds of reporting po

126 ity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet th

127 s experiencing overlapping symptoms of GERD, FD and IBS.

128 t individuals experiencing symptoms of GERD, FD or IBS report poor self-rated health as well as impai

129 The results show that grayscale FD values for diabetic cases are higher compared to cont

130 In a subgroup of 70 patients who had FD meeting the Rome III criteria a GIS(c) score reductio

131 estionnaires (79.3%); 110 were found to have FD at baseline (15.6%) and 93 at the follow-up examinati

132 gher fibrosis scores are more likely to have FD.

133 758 showed the highest FD factors in key aroma compounds and was correlated to

134 15 were evaluated for tocol contents by HPLC-FD.

135 temic AP activation in mice expressing human FD.

136 e sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes o

137 In FD macrophages, endogenous FPN1 showed a similar localiz

138 at mitochondrial function may be abnormal in FD.

139 late the stomach's proteolytic activities in FD.

140 in (relative to the mean) per unit change in FD (regression coefficient = 4.0%; P < .001).

141 We calculated the difference in FD scores (DeltaFD) of mismatched HLA-DPB1 alleles in pa

142 ain increase among patients with glaucoma in FD position was equivalent to strain expected for a mean

143 However, in FD, FPN1 fails to reach the cell surface when cells unde

144 CT infiltration in FD cardiomyopathy is constant in men and variable in wom

145 h those not living in FD, subjects living in FD (n=187, 13.2%) had a higher prevalence of hypertensio

146 Although living in FD is associated with a higher burden of cardiovascular

147 We evaluated the impact of living in FD on cardiovascular risk factors and subclinical cardio

148 D) with the hypothesis that people living in FD will have an unfavorable CVD risk profile.

149 Compared with those not living in FD, subjects living in FD (n=187, 13.2%) had a higher pr

150 t ganglia) and autonomic neurons observed in FD.

151 Contact with a pillow in FD position during simulated sleep produced a sustained

152 sidues in OD-FPH and hydrophilic residues in FD-FPH samples.

153 tissue-specific mis-splicing defect seen in FD patients.

154 m coil structure in OD-FPH and beta-sheet in FD-FPH samples.

155 but changes in TD were larger than those in FD and PD, suggesting increasing biotic homogenization o

156 he DNA specificity of the FACs, variation in FD-like gene expression can result in spatial and tempor

157 nferring floral meristem identity, including FD, SQUAMOSA PROMOTER-BINDING PROTEIN LIKE genes, LEAFY,

158 However, with increasing FD quartile, Ecc was greater (indicating worse average r

159 GW9662, and also prevented (intraperitoneal) FD-induced feeding.

160 were safranal (FD = 512), 4-ketoisophorone (FD = 256) and dihydrooxophorone (FD = 128).

161 to reference methods (MBA method 959.08, LC-FD method 2005.06).

162 correlation with reference methods (MBA, LC-FD).

163 , 75% were female, 70% with dysmotility-like FD, and 30% with ulcer-like FD) were randomly assigned t

164 Subjects with ulcer-like FD given amitriptyline were >3-fold more likely to repor

165 dysmotility-like FD, and 30% with ulcer-like FD) were randomly assigned to groups given placebo, 50 m

166 This ectopic expression lowers FD mRNA levels, reducing responsiveness to FT and impair

167 mplete human IKBKAP transgene with the major FD splice mutation (TgFD9) into a mouse that expresses e

168 However, unlike the case for male FD patients with the type 1 classic phenotype, GL-3 incl

169 hey also contain detectable levels of mature FD.

170 Mean FD was 1.2 +/- 0.07 in both groups, and mean Ecc was -18

171 n of the two ROIs was used to calculate mean FD by using the box-counting method.

172 The mean FD change in glaucoma eyes was equivalent to strain incr

173 The mean FD of patients with periodontitis was 0.83, whereas it w

174 nificant difference was obtained in the mean FD values of healthy individuals and patients with moder

175 ce (FD) curve-based atomic force microscopy (FD-based AFM) enable researchers to combine sub-nanomete

176 cells from individuals with severe and mild FD show defects in peripheral neuron survival, indicatin

177 ration is the main culprit for cases of mild FD.

178 We conclude that nonclassical FD is caused by Fpn mutations that decrease hepcidin bin

179 ation (13.3%); 48 of these were new cases of FD.

180 vasive techniques, supporting the concept of FD-NIRS/DCS as a promising technology to monitor cerebra

181 aging of the head, a detailed description of FD lesions may provide an important clinical benefit by

182 lgorithms, ASSP and SSPA, allow detection of FD sites likely to contribute to the broadening of the s

183 hod has been applied to the determination of FD&C dye Blue No.

184 ssion, increased the risk for development of FD by 7.6-fold in the next 10 years.

185 ents with endomyocardial biopsy diagnosis of FD cardiomyopathy, 13 (6 men; 7 women; mean age, 50.1+/-

186 y, patients with an established diagnosis of FD were treated with a fixed combination of pepsin and a

187 cies richness and testing for the effects of FD and community weighted means of traits (a proxy for F

188 enal and cardiac function, and evaluation of FD-related symptoms.

189 on in high-density plots along a gradient of FD, independent of species richness and testing for the

190 We further assessed whether the impact of FD on these measures is driven by area income, individua

191 , we show that relative transcript levels of FD-like and 14-3-3 genes vary among tissues and developm

192 anxiety and depression precede the onset of FD (based on the modified Rome III criteria) and gastroe

193 um play an important role in pathogenesis of FD.

194 tivation plays a role in the pathogenesis of FD.

195 asurements were compared across quartiles of FD.

196 ontrols were administered a questionnaire of FD according to Rome III criteria.

197 The primary end point was adequate relief of FD symptoms for >/=5 weeks of the last 10 weeks (of 12).

198 n, using pepsin and pancreatin) than that of FD-FPH sample.

199 s with GCC loss involving the foveal zone on FD-OCT imaging (n = 52) had lower MPOD at 0.25 degrees ,

200 activated at the site of synthesis, and only FD lacking a propeptide is present in blood.

201 Men with classic or later-onset FD caused by GLA missense mutations developed prominent

202 sic FD mutation and p.I232T as a later-onset FD mutation.

203 ty at baseline was associated with new-onset FD at the follow-up examination (OR, 7.61; 99% CI, 1.21-

204 particularly those with ulcer-like (painful) FD.

205 nd NPY similarly to FD, and GW9662 prevented FD-induced increases in AgRP and NPY in both species.

206 Pro-FD cleavage in serum or plasma was quantified by a novel

207 that MASP-1 and MASP-3 directly activate pro-FD; however, other experiments contradicted this view.

208 oteolytic activity capable of activating pro-FD exists in blood even in the absence of active coagula

209 ric focusing analysis, we show that both pro-FD and FD are present in the circulation of healthy dono

210 hough 3MC patients predominantly contain pro-FD, they also contain detectable levels of mature FD.

211 e protease (MASP)-1/3(-/-) mice contains pro-FD and has markedly reduced alternative pathway activity

212 -1 and MASP-2 can be ruled out as direct pro-FD activators in resting blood; however, active MASP-3 i

213 MASP-1) and MASP-3 contain zymogenic FD (pro-FD), and it is becoming evident that MASP-3 is implicate

214 However, the necessity of MASP-3 for pro-FD cleavage has been questioned, because AP activity is

215 Human pro-FD containing an APPRGR propeptide was produced in insec

216 d to clarify the involvement of MASPs in pro-FD activation in normal, as opposed to deficient, human

217 ing evident that MASP-3 is implicated in pro-FD maturation.

218 ing that there exists MASP-3-independent pro-FD maturation in 3MC patients.

219 Labeled pro-FD was processed with t1/2s of approximately 3 and 5 h i

220 novel assay using fluorescently labeled pro-FD.

221 eficiency, compromises the conversion of pro-FD to FD.

222 nly MASP-3 could reduce the half-life of pro-FD.

223 P-1 and MASP-2 inhibitors did not reduce pro-FD activation at reasonable concentration.

224 Questions regarding FD and IBS were extracted from the ROME III adult questi

225 Significant (P < .05, Cox regression) FD OCT risk factors included all GCC, NFL, and disc vari

226 By multivariable linear regression, FD position was associated with an increase in limbal st

227 We also report FD of NHP6A, a yeast TF with structure that differs sign

228 werful aroma active compounds were safranal (FD = 512), 4-ketoisophorone (FD = 256) and dihydrooxopho

229 The mean (SD) FD at the SVP increased from 1.53 (0.05) in patients wit

230 omatography with fluorescence detection (SEC-FD) for sEVs quantification.

231 edia, linear calibration curves based on SEC-FD peak height versus sEVs concentration were obtained w

232 Separation efficiency of the proposed SEC-FD method was evaluated by analyzing 100 nm liposomes an

233 e modifier genes for individuals with severe FD.

234 Since FD-like proteins determine the DNA specificity of the FA

235 frequency-domain near-infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS).

236 We observe a strong FD effect characterized by an exchange rate [Formula: se

237 In 54 eyes of 27 myopic subjects FD-OCT iridocorneal angle measurements were made before

238 temporal series revealed net increase in TD, FD, and PD, but changes in TD were larger than those in

239 a near half-century of changes in local TD, FD, and PD of breeding birds across much of North Americ

240 Our results clearly demonstrate that FD curve-based imaging is suitable for quantitative anal

241 rate [Formula: see text], establishing that FD of Fis occurs at the single-binding site level, and w

242 These findings provide initial evidence that FD-induced increases in AgRP/NPY may be a direct PPARgam

243 shows a strong salt dependence, we find that FD depends only weakly on salt.

244 ar dynamics simulations, which indicate that FD can occur for molecules that interact far more weakly

245 Taken together, our results indicate that FD is a general mechanism assisting in the local removal

246 These results indicated that FD could form the similar complex with FT and AcMFT.

247 It has been suggested that FD is secreted as a mature enzyme that does not require

248 hat the SD group is not a hybrid between the FD and ND groups.

249 Our findings provide a basis for the FD characterized by a preserved iron transfer in the ent

250 ttern, and 0.98 (95% CI: 0.95, 1.01) for the FD pattern.

251 the first event in repair is removal of the FD by the RecBCD exonuclease, whose entry past the N-pro

252 Overlap IBS was present in 33 % of the FD patients.

253 Although genetic repair of the FD-associated mutation reversed early developmental NC d

254 After en face images of the FD-OCT scan were aligned based on the blood vessels, cir

255 Using the FD as a marker to follow repair, we find that after tran

256 m from the scleral spur, were made using the FD-OCT RTVue(R).

257 arrives at the insertion site, whereupon the FD is rapidly degraded.

258 Therefore, FD X-linked and CT may be variously involved in male and

259 The performance of this FD algorithm was compared with traditional fitting metho

260 ncy, compromises the conversion of pro-FD to FD.

261 ate GL-3 in tissues and fluids, similarly to FD patients.

262 ROSI increased AgRP and NPY similarly to FD, and GW9662 prevented FD-induced increases in AgRP an

263 Fourier-domain optical coherence tomography (FD-OCT).

264 Fourier-domain optical coherence tomography (FD-OCT).

265 ing IKAP levels by correcting the underlying FD splicing defect.

266 ale; mean age, 67.1 years +/- 8.7) underwent FD and T1 measurement.

267 ears +/- 8.7 [standard deviation]) underwent FD and Ecc measurement, and 992 (521 [52.5%] female; mea

268 All patients underwent FD-OCT scans on at least 2 occasions separated by at lea

269 -18.3 +/- 2.27 in the subjects who underwent FD and Ecc measurement.

270 Mean VD, FD, and FAZ values between the instruments were compared

271 uments are not interchangeable regarding VD, FD, and FAZ for both the superficial and deep capillary

272 However, when FD macrophages were exposed to large amounts of heme iro

273 While FD, the increased CLS values in patients with glaucoma d

274 Major anxiety was associated with FD at the follow-up evaluation (odds ratio [OR], 6.30; 9

275 ric patients, age 8-17 years, diagnosed with FD.

276 ganglion cell complex (GCC) were imaged with FD OCT.

277 om a non-flowering plant could interact with FD to regulate the floral transition and that this funct

278 onal activators through the interaction with FD, a basic leucine zipper transcription factor which pl

279 bition status of 168 patients (68 male) with FD and compared outcomes of inhibition-positive patients

280 affected patients presented more often with FD-typical symptoms, such as diarrhea, fatigue, and neur

281 We enrolled 96 patients with FD and 24 healthy controls at Sir Run Run Shaw Hospital.

282 ochloride for the treatment of patients with FD and also suggest good to moderate treatment tolerabil

283 and duodenal bulb (D1) between patients with FD and healthy controls (all P > 0.05).

284 sinophil and mast cell between patients with FD and healthy subjects.

285 anted to determine if affected patients with FD benefit from acute reduction of anti-agalsidase antib

286 ly involved in male and female patients with FD cardiomyopathy, affecting CT function.

287 1 (P = 0.084) were observed in patients with FD compared with healthy controls.

288 T were significantly higher in patients with FD than in patients without FD (P < 0.001; P < 0.04; res

289 The percentage of patients with FD was significantly higher in patients with chronic HCV

290 er, degranulated mast cells in patients with FD were almost same with healthy controls.

291 nal degranulated eosinophil in patients with FD were significantly increased than healthy controls in

292 us inhibition of agalsidase in patients with FD, as reported for other lysosomal storage diseases.

293 opram, appears to benefit some patients with FD, particularly those with ulcer-like (painful) FD.

294 the efficacy of these drugs in patients with FD.

295 ), and meal-induced satiety in patients with FD.

296 For unknown reasons, people with FD show marked differences in disease severity despite c

297 s when traditional stoves were replaced with FD stoves.

298 analyzed in studies involving subjects with FD.

299 d by stereophotography were followed up with FD-OCT cube scans of the optic disc.

300 in patients with FD than in patients without FD (P < 0.001; P < 0.04; respectively).

301 ease-1 (MASP-1) and MASP-3 contain zymogenic FD (pro-FD), and it is becoming evident that MASP-3 is i