ライフサイエンスコーパス: FDR

1 FDRs had an increased risk of CRC (hazard rate ratio [HR

2 FDRs, second-degree relatives, and first cousins of pati

3 promising genes from 10 QTLs (P </= 0.0001; FDR </= 0.10) that exhibited reproducible associations w

4 th participants with lower HbA1c (P < 0.001, FDR = 0.00016).

5 rate (FDR) correction (empirical P < 0.001, FDR = 0.008, family-wise error rate = 0.008).

6 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.0

7 e risk (OR=1.828, 95% CI=1.25-2.68, P=0.002, FDR=0.04, conditional logistic regression).

8 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02).

9 ely, compared with untreated cells (P<0.005; FDR=0), using Affymetrix microarrays.

10 peptides, and 20% more proteins at the 0.01 FDR level.

11 of TB (OR=0.502, 95% CI=0.29-0.86, P=0.013, FDR=0.14).

12 ior cingulate and the basal ganglia (p<0.05, FDR-corrected).

13 y different EMT protein expression (P < .05, FDR < 0.20), cell migration, glucose uptake, and hexokin

14 EMT cell line gene expression data (P < .05, FDR < 0.20).

15 adjusted survival (p= 1.12e-07 and 1.80e-07, FDR q= 1.2e-04 and 2.4e-04, respectively).

16 After 55 years of age, subjects with 1 FDR with CRC had only a modest increase in risk for CRC

17 However, among individuals with 1 FDR with CRC, there were no differences in risk based on

18 l dysfunction and apoptosis, increased at 1% FDR.

19 n groups from 4030 unique peptides (with <1% FDR for both peptides and proteins).

20 Application of a 10% FDR revealed an additional 57 metabolites that were diff

21 We identified 1,119 (FDR = 5%) interactions that appear to regulate gene expr

22 ant druggable genes outside the MHC, and 128 FDR-significant biological pathways related to neurons,

23 leotide polymorphism (SNP) (P<3.2 x 10(-13); FDR<5%).

24 genes upon viral stimulation (p<1.00E(-15), FDR<1.00E(-14)), including various immune function and i

25 = 238; HR, 1.23; 95% CI, 1.07-1.42) or >/=2 FDRs with CRC (n = 35; HR, 2.04; 95% CI, 1.44-2.86) were

26 Individuals with >/=2 FDRs with CRC had continued increased risk in older age.

27 three cis-eQTL associations (P<1.4 x 10(-3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9)

28 knockout screens in human cell lines at 5 % FDR, a major advance over competing platforms.

29 he 304 independent variants associated at 5% FDR in this study explain 21.2% of CAD heritability and

30 At 5% FDR, 11.8% skin and 10.4% blood DEGs in our study mapped

31 1534 in the MRCA data set to 4452 (with <5% FDR).

32 ng increased the number of residue pairs (5% FDR) by 33% (n = 108 to n = 144).

33 Eleven of them replicate (5% FDR) in five independent longevity studies combined; all

34 to be altered in the postprandial state (5% FDR).

35 on our previous list of loci meeting the 5% FDR threshold, thus providing strong support that the re

36 Using stringent criteria (Fold change > 1.5; FDR < 0.05), three genes were found to be significantly

37 RCC1 rs1799782 (OR, 1.57; 95% CI, 1.27-1.94; FDR-P = 0.0007).

38 licated by the ICSNPathway method, yielded a FDR = 0.002.

39 n was shown between Lachnospira and acetate (FDR-corrected P = 0.002) or butyrate (FDR-corrected P =

40 have decomposed various factors that affect FDR estimation, and illustrated the direction and extent

41 For people with 1 affected FDR (92% of those with a family history), screening ever

42 perspective, individuals with more affected FDRs should start screening earlier and at shorter inter

43 For each number of affected FDRs, we used the Microsimulation Screening Analysis mod

44 DR at any given level, we further develop an FDR-controlled MSC procedure, which combines a local FDR

45 ith suggestive literature evidences, with an FDR of 0.01.

46 evotella (FDR p-value = 0.03), Anaerococcus (FDR p-value = 0.07), and Dialister (FDR p-value = 0.09)

47 n status identified 27 genes (p</=0.0006 and FDR</=0.30) that responded differently to viral stimulat

48 al rare variants, whereas the Bonferroni and FDR are exceedingly over-conservative for rare variants

49 ompetitive performance in terms of power and FDR control for RNA-seq differential expression analysis

50 Sensitivity and FDR are similar to that of the BCFtools and Beagle metho

51 and bump hunting methods showed appropriate FDR control and the highest power when methylation level

52 y the bump hunting method showed appropriate FDR control and the highest power when methylation level

53 We discovered 1455 genes with ASE (FDR < 10%) and 215 genes with GxE interactions.

54 genes and 12 and eight TFs were associated (FDR-adjusted P-value <0.05) with ovarian cancer survival

55 Among the top replicated associations (FDR < 0.05) were eSNPs for four known (IL18R1, IL18RAP,

56 At FDR adjusted p-value < 0.05, 29 genes were differentiall

57 anscript expression of seven nearby genes at FDR < 0.05 (BABAM1, DCLRE1B/PHTF1, PEX14, RAD51L1, SRGAP

58 in transcription with immune stimulation at FDR < 0.05.

59 es P-values and optionally permutation-based FDR estimates (q-values) for potential mediators.

60 Also, the permutation-based FDR option provides a non-parametric implementation.

61 a substantial advantage of permutation-based FDR over other common multiple testing strategies.

62 pressed between XX and XY eNSCs at baseline (FDR = 0.10).

63 q-value procedure and also result in better FDR control and higher stability than Storey's q-value p

64 del assessment-insulin resistance, and BMI) (FDR <5%; P = 1.34 x 10(-4)).

65 prostate cancer and show that the bootstrap FDRs are highly useful in selecting the most robust patt

66 etate (FDR-corrected P = 0.002) or butyrate (FDR-corrected P = 0.005).

67 upport that the remaining loci identified by FDR represent genuine signals.

68 A common approach to calculate FDRs for glycopeptide analysis, adopted from the target-

69 s associated with different types of cancer (FDR < 0.05).

70 ed transcripts with at least twofold change (FDR corrected p < 0.05) in needle tissues in response to

71 s of 3,423 genes were significantly changed (FDR </= 0.01).

72 h using a combination of RES and conditional FDR improved power of traditional GWAS for gene discover

73 evaluate genetic pleiotropy and conditional FDR to identify novel FTD-associated SNPs.

74 the five SNPs, all identified by conditional FDR, were replicated (P < 0.05) in an independent sample

75 notably four additional SNPs by conditional FDR.

76 ignificant SNPs were identified (conditional FDR < 0.05).

77 Here, SNP's conditional FDR was estimated given its RES based on SNP prior infor

78 ns could be identified with high confidence (FDR < 1%) in human retina samples.

79 th C > 1.22, the procedures strongly control FDR.

80 To control FDR at any given level, we further develop an FDR-contro

81 to be DE, while still adequately controlling FDR.

82 rolled MSC procedure is valid in controlling FDR at a prespecified level and is more powerful than th

83 d generates procedures of weakly controlling FDR, and with C > 1.22, the procedures strongly control

84 or sample size calculation while controlling FDR for RNA-seq experimental design.

85 m to calculate sample size while controlling FDR for RNA-seq experimental design.

86 ve a desired average power while controlling FDR.

87 failed to pass the multiple test correction (FDR = 0.11).

88 G sites (22,272 out of studied 437,022 CpGs, FDR < 0.05).

89 ar and luteal phases of the menstrual cycle (FDR-adjusted p-value <0.05).

90 health protections were removed in 2006, DC FDR spiked in 2007-2009 versus 2004-2006 (p < 0.05), in

91 rtial lead service line replacements, and DC FDR dropped to historically low levels in 2010-2011 afte

92 Changes in the DC FDR vs neighboring Baltimore City were correlated to DC

93 s alpha4 and alpha2, nidogen 1, and decorin (FDR-adjusted P value < 10(-7)) and minor enrichment of l

94 bolite-signal match score and a target-decoy FDR estimate for spatial metabolomics.

95 ximize discoveries satisfying a user-defined FDR.

96 ern mass spectrometers, target-decoy derived FDRs can diminish.

97 To address the need to accurately determine FDRs for automated glycopeptide assignments, we develope

98 ococcus (FDR p-value = 0.07), and Dialister (FDR p-value = 0.09) were detected at higher relative abu

99 In addition, significantly different (FDR corrected P value < 0.05) lipids within the 600 to 1

100 At an empirical FDR of 5%, 48 genes were associated with asthma risk.

101 f the accuracy of TDA estimates of empirical FDR.

102 and reproducible TDA estimation of empirical FDR.

103 ementary approaches for estimating empirical FDRs in this context.

104 ro entries, and KEGG pathways were enriched (FDR <0.05) with differentially expressed genes involved

105 creased pro-inflammatory Enterobacteriaceae (FDR-corrected P = 0.25).

106 ion, the MSC procedure exhibits an estimated FDR of 0.1426 and an estimated FNDR of 0.0067.

107 We estimated FDR using a beta-uniform mixture (BUM) model, and examin

108 chromosome 8p was excluded before estimating FDR due to long-range LD structure.

109 Among transcripts differentially expressed (FDR < 0.05) between muscle or adipose cells of insulin-s

110 We develop the first FDR-estimating algorithms for domain prediction, and eva

111 ound to be overabundant by more than 2-fold (FDR corrected p-value </=0.032, fold change (log2) >/= 1

112 ound to be overabundant by more than 2-fold (FDR corrected p-value </=0.032, fold change (log2) >/= 1

113 cript in WD-fed rats (approximately 30-fold, FDR = 0.01) which supports previous literature underscor

114 lyzed using Partek Genomics Suite (1.4-fold, FDR adjusted p0.05) and Ingenuity Pathway Analysis Softw

115 19 phosphatases were upregulated (0.66-fold; FDR = 0.05) in TNBC compared with ER-positive breast can

116 ars of age: HR, 1.33; 95% CI, 1.06-1.62; for FDR >70 years of age: HR, 1.14; 95% CI, 0.93-1.45; P tre

117 ars of age: HR, 1.27; 95% CI, 0.97-1.63; for FDR 60-70 years of age: HR, 1.33; 95% CI, 1.06-1.62; for

118 power improved when gene expression data for FDR-controlled informative weighting of association test

119 sk based on age at diagnosis in the FDR (for FDR <60 years of age: HR, 1.27; 95% CI, 0.97-1.63; for F

120 This risk was greater for FDRs when index patients developed CRC at younger than a

121 The expression of 571 genes (FDR<10%) changed between pre- and post-MMF treatment bio

122 late the 748 differentially expressed genes (FDR < 0.01) that were mainly enriched into mitochondrial

123 cognized 241 differentially expressed genes (FDR < 0.1).

124 CNV regions (noted above) and 65 risk genes (FDR </= 0.1).

125 e identified both gene (99 individual genes, FDR < 0.05) and gene set (four of the six reported multi

126 e clinical setting one could permit a higher FDR and lower specificity to maximise sensitivity.

127 in patients with MDD and suicidal ideation (FDR-adjusted p < 0.05).

128 ple sizes, the Bon-EV procedure has improved FDR control and stability compared with the Storey's q-v

129 e (BUM) model, and examined the variation in FDR estimation.

130 Three percent of CRCs in FDRs would have been missed if the current guidelines, w

131 3; 95% CI, 1.96-3.01) also were increased in FDRs.

132 boost in power with the annotation-informed FDR method, and provide insight into the genetic archite

133 nymous variants associated with QT interval (FDR 5%), 22 of which were in TTN.

134 cantly associated with interleukin-6 levels (FDR<0.05) after adjusting for age, sex and blood cell co

135 down-regulated in MR-treated IWAT and liver (FDR</=0.07-0.3).

136 c up-regulation of ribosomal genes in liver (FDR</=0.001).

137 rolled MSC procedure, which combines a local FDR-based adaptive procedure with the MSC procedure.

138 pecificity of 99.2%, while maintaining a low FDR of 5%.

139 ROCker typically showed 60-fold lower FDR when compared to the common practice of using fixed

140 ly expressed in well-fed and underfed males (FDR < 0.05).

141 ifferential exon skipping events with a MATS FDR of <10%.

142 e full list of RT-PCR tested exons, the MATS FDR estimates matched well with the experimental validat

143 d IL-6 pathways (upregulated in current MDD, FDR=3.2 x 10(-3)).

144 ll activation (downregulated in current MDD, FDR=5.8 x 10(-5)) and IL-6 pathways (upregulated in curr

145 valuator (GPE), a tool that helps to measure FDRs in identifying glycopeptides without using a decoy

146 ssociated with purine nucleotide metabolism (FDR < 0.01), indicating an adaptation to the limited ava

147 ytomegalovirus (CMV; >4 log10 DNA copies/mL; FDR-adjusted P = .08), and presence of Epstein-Barr viru

148 We propose a new FDR control procedure that incorporates the prior struct

149 h Ghanaian RVV responders and nonresponders (FDR, 0.008 vs 0.003) and Dutch infants and Ghanaian nonr

150 nt between RVV responders and nonresponders (FDR, 0.12), and Ghanaian responders were more similar to

151 nd Dutch infants and Ghanaian nonresponders (FDR, 0.002 vs 0.009).

152 erebellar cortex and deep cerebellar nuclei (FDR q < 0.05).

153 nce of PBC could imply screening with AMA of FDR with at least another autoimmune disease.

154 n our simulation study that the estimates of FDR and FNDR of the MSC procedure are appropriate.

155 hod works well for an accurate estimation of FDR in various scenarios, and we illustrate the applicat

156 has accurate and conservative estimation of FDR profile.

157 DEGs affect both magnitude and precision of FDR estimation, while the correlation structure mainly a

158 ression of 12 miRNAs in office workers only (FDR < 20%).

159 s method against other SNP callers using our FDR method with three fungal genomes, finding that it wa

160 anscripts (expression difference >2-fold, p [FDR] < 0.01) after a seven-day treatment with nZnO (aver

161 group testing and regression, Porphyromonas (FDR p-value = 0.02), Prevotella (FDR p-value = 0.03), An

162 stically significantly improved predictions (FDR < 0.05) for three cancers but those quantitative gai

163 l blood of women who developed preeclampsia (FDR <0.05 in the Vitamin D Antenatal Asthma Reduction Tr

164 phyromonas (FDR p-value = 0.02), Prevotella (FDR p-value = 0.03), Anaerococcus (FDR p-value = 0.07),

165 ompared to trypsin (8363 vs 6807; 1% protein FDR).

166 ificity of 97% and low false detection rate (FDR) of 3%.

167 y controls and LC at a False Discovery Rate (FDR) < 0.01.

168 nces between LCLs at a false discovery rate (FDR) < 0.05, which accounted for ~ 37% of the gene expre

169 cant pathways for BMD [false discovery rate (FDR) < 0.05], such as KEGG FOCAL ADHESION and KEGG AXON

170 e changing at weaning [false discovery rate (FDR) < 0.05].

171 n breast tumors with a false discovery rate (FDR) < 1% in the discovery dataset.

172 rgets (eGenes), with a false discovery rate (FDR) < 5%.

173 t cis-regulated genes (false discovery rate (FDR) </= 0.05), 2,743 (12%) showed context-dependent eQT

174 significant SNPs with false discovery rate (FDR) </=0.05 were mapped to one novel gene PRPF6 and two

175 At a false discovery rate (FDR) <0.1, we identified 1270 differentially expressed g

176 erythritol [P < 0.001, false discovery rate (FDR) = 0.0435], and the targeted assay revealed 15-fold

177 cantly across strains [false discovery rate (FDR) = 5%].

178 adjustment and (iii) a false discovery rate (FDR) adjustment which is widely used in transcriptome st

179 her methods in scaling False Discovery Rate (FDR) analysis.

180 ROC) curve to minimize false discovery rate (FDR) and calculate the best thresholds based on how simu

181 location rate, and the false discovery rate (FDR) and false non-discovery rate (FNDR) of MSC can be e

182 f controlling both the false discovery rate (FDR) and the false negative rate (FNR).

183 Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy in SNPs associate

184 e both can control the false discovery rate (FDR) at a similar level.

185 med Bon-EV, to control false discovery rate (FDR) based on Bonferroni's approach.

186 matches with a peptide false discovery rate (FDR) below 1%.

187 False discovery rate (FDR) control is an important tool of statistical inferen

188 ing procedures such as false discovery rate (FDR) control, methods that take into account the phyloge

189 Crucial steps such as false discovery rate (FDR) control, retention time normalization and handling

190 asma adiponectin after false-discovery rate (FDR) correction (empirical P < 0.001, FDR = 0.008, famil

191 After false discovery rate (FDR) correction, a total of 8 CNVs on 6 chromosomes were

192 The results, at a false discovery rate (FDR) cutoff of 0.1, consisted of 44 769 and 50 792 SNP-c

193 ethods to estimate the false discovery rate (FDR) for 70 public metabolomics data sets.

194 ment while controlling false discovery rate (FDR) is Storey's q-value method.

195 me with spectrum-level false discovery rate (FDR) less than 1%.

196 tatus at a genome-wide false discovery rate (FDR) of 0.05, while simultaneously controlling for confo

197 th personal PM2.5 at a false discovery rate (FDR) of 20%.

198 evel QTLs (pQTLs) at a false discovery rate (FDR) of 20%.

199 nsitivity of 90% and a false discovery rate (FDR) of 3%, surpassing the performance of expression-bas

200 of putative loci at a false discovery rate (FDR) of 5% (refs.

201 At a false discovery rate (FDR) of 5%, we had identified 28 such ID protein-encodin

202 culate the P-value and false discovery rate (FDR) of differential alternative splicing.

203 P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly assoc

204 Fs while requiring the false discovery rate (FDR) to be lower than a cut-off.

205 We used conjunction false discovery rate (FDR) to evaluate genetic pleiotropy and conditional FDR

206 rms of sensitivity and false discovery rate (FDR) using real data and simulated data.

207 ts (fold change>/=1.5, false discovery rate (FDR)</=0.3; p<0.05) compared with controls including a c

208 significant frequency (false discovery rate (FDR)<0.05) of non-silent mutations include TP53 (47.1%),

209 de significance level [false discovery rate (FDR)<0.05].

210 A total of 321 genes (false discovery rate (FDR)<5%) were differentially expressed at baseline betwe

211 ,002 proteins (at a 1% false discovery rate (FDR)) in yeast (Saccharomyces cerevisiae strain BY4741)

212 of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction

213 as the Bonferroni and false discovery rate (FDR), are often impractical to apply, as a majority of t

214 In addition, false discovery rate (FDR), instead of family-wise type I error rate, is contr

215 ating stratum-specific false discovery rate (FDR), where strata are classified according to enrichmen

216 method for estimating false discovery rate (FDR), which is a conventional significance measure in th

217 pySM, a framework for false discovery rate (FDR)-controlled metabolite annotation at the level of th

218 producer Lachnospira [false-discovery rate (FDR)-corrected P = 0.25] but decreased pro-inflammatory

219 lues while controlling false discovery rate (FDR).

220 ng cross-links at 0.5% false discovery rate (FDR).

221 07 CpG probes) at a 5% false discovery rate (FDR).

222 (RES) and conditional false discovery rate (FDR).

223 t Bayes factor at a 5% false discovery rate (FDR).

224 dentifications at a 1% false discovery rate (FDR).

225 and the others control false discovery rate (FDR).

226 ols and/or provide the false discovery rate (FDR).

227 significance, such as False Discovery Rate (FDR).

228 ated miRNAs (P < 0.05, false discovery rate (FDR): 10%) were then validated in a second blinded "test

229 rotransmission system (false discovery rate (FDR)=0.0097) and the serotonergic system (FDR=0.0213).

230 ; P value adjusted for false discovery rate [FDR-P] = 0.017) and XRCC1 rs1799782 (OR, 1.57; 95% CI, 1

231 plicated 16 CpG-sites (false discovery rate [FDR] < 0.05), at 11 independent loci including MIR21.

232 ith transcript levels (false discovery rate [FDR] < 0.1).

233 ic signature (P < .05, false discovery rate [FDR] < 0.20), which was confirmed to have differences in

234 with cis-acting eQTLs (false discovery rate [FDR] <5%; P < 1.96 x 10(-5)) and 49 expression-insulin s

235 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months.

236 (P values adjusted for false discovery rate [FDR] = 0.08).

237 provement index (>30%; false discovery rate [FDR] corrected p < 0.0008) and nontrained WM tests after

238 nd beta-casein (P<.01, false discovery rate [FDR]<.1).

239 nificant associations (false discovery rate [FDR]) < 0.05).

240 l groups (129 genes at false-discovery rate, FDR<0.1).

241 ecologic study notes that fetal death rates (FDR) during the Washington DC drinking water "lead crisi

242 ds for estimating the false discovery rates (FDR) of these annotations.

243 is tool for comparing False Discovery Rates (FDR), we include a method for determining homozygous and

244 to unacceptably high false discovery rates (FDR).

245 tstrapping determines false discovery rates (FDRs) associated with each pattern.

246 er by WD feeding (46 up-, 48 down-regulated, FDR < 0.05).

247 Subjects with 1 first degree relative (FDR) with CRC (n = 238; HR, 1.23; 95% CI, 1.07-1.42) or

248 CRC and adenomas in first-degree relatives (FDRs) and second-degree relatives and first cousins of i

249 of autoantibody-free first-degree relatives (FDRs) in the abundance of four taxa.

250 cluding or excluding first-degree relatives (FDRs) or different conditional likelihoods.

251 d number of affected first-degree relatives (FDRs) using data from publications.

252 in either 1 or >/= 2 first-degree relatives (FDRs).

253 Over 90% of these pairs are replicated (FDR<5%) in at least one of two independent data sets.

254 154 and 2863 genes that were TH-responsive (FDR < 0.05) in the tilapia cerebellum, thalamus-pituitar

255 tibody-positive individuals and seronegative FDRs clustered together but separate from those of new-o

256 , subjects with autoantibodies, seronegative FDRs, and new-onset patients had different levels of the

257 evident in seropositive versus seronegative FDRs.

258 is-surgery interval (48 up, 2 down; Siggenes FDR 0.05) in a manner independent of both subtype and sa

259 hway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enr

260 RNA sequencing identified five significant (FDR<0.01) and seven trending (0.01FDR<0.02) gene sets re

261 nt (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our

262 Twenty-one polymorphisms were significantly (FDR-adjusted P < 0.05) associated with mRNA expression a

263 hose from Mascot and SEQUEST using a similar FDR.

264 methods have better sensitivity and similar FDR in calling heterozygous SNPs than the VarScan method

265 with significantly and consistently smaller FDR than any other available method.

266 e (FDR)=0.0097) and the serotonergic system (FDR=0.0213).

267 significantly enriched for microRNA targets (FDR < 5%).

268 diagnosed with MI and 14 enriched GO terms (FDR < 0.05, enrichment > 2) were identified, including '

269 nt AF after correction for multiple testing (FDR < 0.05).

270 cer and apoptosis, was associated with TGCT (FDR < 0.1).

271 The FDR estimation methods presented will enable a user to a

272 ated bacterial species while controlling the FDR at desired levels.

273 ces in risk based on age at diagnosis in the FDR (for FDR <60 years of age: HR, 1.27; 95% CI, 0.97-1.

274 CRC incidence and death; age of onset in the FDR was not significantly associated with risk.

275 sensitivity of 90.4% without increasing the FDR.

276 l validation is not possible, minimising the FDR and improving specificity may be a preferable trade-

277 (UKBB) data to evaluate the validity of the FDR approach.

278 cross the data at any given threshold on the FDR or E-value over all strata combined.

279 Simulation study also demonstrates that the FDR-controlled MSC procedure is valid in controlling FDR

280 ly in patients as expected but also in their FDR.

281 by the global false discovery rate threshold FDR < 0.3.

282 vements after adaptive WMT (Global: training FDR corrected, p = 0.004), and only HIV participants imp

283 differential expression between treatments (FDR <0.10).

284 NP was detected by analyses of unconditional FDR and traditional GWAS in the discovery sample (N = 59

285 s a random variable and it may underestimate FDR in practice.

286 An underestimated FDR can lead to unexpected false discoveries in the foll

287 ith inclusion of index patients and untested FDRs gave the smallest bias: +2% (SD, 2%) in BRCA1 and +

288 index patients and a proportion of untested FDRs provide suitable CLTRs for carriers counseled in th

289 remained significant after correction using FDR.

290 ) performs the simpler MTA of P-values using FDR and (ii) obtains noncentralities by back-transformin

291 = .08), and presence of Epstein-Barr virus (FDR-adjusted P = .06) in semen to be associated with det

292 n practice, we develop an algorithm by which FDR can be correctly and reliably estimated.

293 are scored against the ETD data, from which FDRs can be calculated accurately based on the number of

294 predicting glucocorticoid dose of >0.9 with FDR adjusted P values in the range 3.3 E-04 -1.9 E-10.

295 cific analyses, we identified more CpGs with FDR<0.05 among female infants (n=38) than among male inf

296 ted by DAVID, a gene ontology database, with FDR < 0.05.

297 ctions independently validated by DAVID with FDR < 0.05.

298 ere 19 significant pathways, which withstood FDR correction for multiple testing that were identified

299 groups at 1 and 6 months after adaptive WMT (FDR corrected, p < 0.0001), with normalization of brain

300 and nontrained WM tests after adaptive WMT (FDR corrected, p </= 0.001), but not after nonadaptive W