ライフサイエンスコーパス: FGF receptor

1 inity signaling complexes with their cognate FGF receptor.

2 action between different FGF ligands and the FGF receptor.

3 aling through this pathway downstream of the FGF receptor.

4 dependent expression of the breathless (btl) FGF receptor.

5 ltikinase inhibitor that targets BCR-ABL and FGF receptor.

6 that Cubn is a novel, interspecies-conserved Fgf receptor.

7 e to their different binding affinities with FGF receptors.

8 ly sensitive to small molecule inhibitors of FGF receptors.

9 ble FGF traps or a dominant inhibitor of all FGF receptors.

10 d ability of FGF23 to signal via its cognate FGF receptors.

11 nductive activity due to higher affinity for Fgf receptors.

12 ished binding of a subset of FGF proteins to FGF receptors.

13 forms of the mutant but not of the wild-type FGF receptors.

14 at BMP signaling is required at the level of FGF receptors.

15 sine-kinase inhibitor that inhibits VEGF and FGF receptors.

16 We created two lines of mice lacking both FGF receptor 1 (Fgfr1) and Fgfr2 in oligodendrocyte-line

17 NgR1 and FGF receptor 1 (FGFR1) are colocalized to synapses, and

18 While loss-of-function mutations in FGF receptor 1 (FGFR1) cause human GnRH deficiency, to d

19 we show using signal transduction mutants of FGF receptor 1 (FGFR1) expressed in rat VSMC that the ad

20 Here we examined FGF receptor 1 (FGFR1) expression and investigated its i

21 FGF receptor 1 (FGFR1) expression is restricted to MMCm

22 mal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis.

23 Morpholino knockdown of FGF receptor 1 (Fgfr1) in zebrafish cell-autonomously re

24 e defect had been identified: a heterozygous FGF receptor 1 (FGFR1) mutation in pedigree 1 and a comp

25 nce suggests that bFGF selectively activates FGF receptor 1 (FGFR1) to exert degradative effects in b

26 ctive factors include FGFs via activation of FGF receptor 1 (FGFR1).

27 nase (ERK)-cFos pathway after binding to the FGF receptor 1 (FGFR1).

28 tified SK1 as a target of the canonical FGF2/FGF receptor 1 activation pathway in endothelial cells a

29 Moreover, a differential expression of Fgf Receptor 1 and 2 resembling that previously found in

30 functions by blocking FGF2 signaling through FGF receptor 1 and syndecan-4 and downstream effectors p

31 r, rPAI-1(23) blocked FGF2 signaling through FGF receptor 1 and syndecan-4, inhibiting cell migration

32 signaling in animal caps, did interact with Fgf receptor 1 in cultured cells and, according to conte

33 c activity and is mediated predominantly via FGF receptor 1 signalling.

34 lt, 12 hits were identified including FGFR1 (FGF receptor 1), TrkB, and TrkC as well as components of

35 sumably mediated by activation of the FGFR1 (FGF receptor 1), which is expressed in mammalian brain m

36 s specifically express high levels of FGFR1 (FGF receptor 1).

37 mice had significantly reduced expression of FGF receptor 1, hypoxia-inducible factor-1alpha, vascula

38 FGF receptors 1 and 2 (Fgfr1 and Fgfr2) are both express

39 llar development are primarily transduced by FGF receptors 1 and 2.

40 FGF receptors 1, 2, and 3 (Fgfrs) are expressed in the e

41 activation of the fibroblast growth factor (FGF) receptor 1 (FGFR1) are a feature of stem cell leuke

42 (BMP) receptor or fibroblast growth factor (FGF) receptor 1, we demonstrate that the BMP and FGF sig

43 growth factor (bFGF) and its major receptor FGF receptor-1 (FGFR-1) play an important role in the de

44 th factor (bFGF), causing phosphorylation of FGF receptor-1 (FGFR-1).

45 nity heparan sulfate co-receptor and blocked FGF receptor-1 autophosphorylation and p42/44 MAP kinase

46 antithrombin blocked the formation of FGF-2-FGF receptor-1 ectodomain-heparin ternary complexes, and

47 in (FN), activates fibroblast growth factor (FGF) receptor-1 (FGFR1) independent of FGF ligand in liv

48 n of the catalytic tyrosine kinase domain of FGF-receptor-1 (FGFR1) is mediated by a sequential and p

49 r 2 (FGF-2) and its receptor tyrosine kinase FGF receptor 1c.

50 BetaKlotho physically interacts with FGF receptors 1c and 4, thereby increasing the ability o

51 on Cre-mediated recombination to investigate FGF receptor 2 (Fgfr2) function in the postnatal mammary

52 FGF receptor 2 (FGFR2) has a significant role in the pro

53 Conditionally deleting one copy of FGF receptor 2 (FGFR2) in adult mouse airway basal cells

54 n fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome.

55 mb development, we conditionally inactivated fgf receptor 2 (Fgfr2) in the mouse AER to terminate all

56 st on the endothelium, and downregulation of FGF receptor 2 (FGFR2) on PMNs rescued host defense in t

57 Aberrant activation of FGF receptor 2 (FGFR2) signaling, through overexpression

58 BSS is caused by mutations in the FGF receptor 2 (FGFR2), but the molecular mechanisms tha

59 8b in complex with the "c" splice isoform of FGF receptor 2 (FGFR2c).

60 ere, we present the crystal structure of the FGF receptor 2 kinases caught in the act of trans-phosph

61 fgf8 (fibroblast growth factor 8) and fgfr2 (fgf receptor 2) transcripts.

62 dy brings up the intriguing possibility that FGF receptor 2, in the oligodendrocyte/myelin compartmen

63 utation (S252W) in fibroblast growth factor (FGF) receptor 2 (FGFR2), which leads to abnormal FGF/FGF

64 nockdown changes the alternative splicing of FGF receptor-2 (FGFR2) transcripts, altering the incorpo

65 hed, and fibroblast growth factor 10 (FGF10)/FGF receptor 2b (FGFR2b) signaling directly regulates th

66 ion and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by s

67 revealed that the proximal tubule expresses FGF receptor 3 (FGFR3) but not FGFR1, FGFR2, or FGFR4.

68 Gain-of-function mutations in FGF receptor 3 (FGFR3) have been implicated in severe sk

69 FGF receptor 3 (FGFR3) is activated by mutation or over-

70 Overexpression of FGF receptor 3 (FGFR3) is implicated in the development

71 verexpression, or intensified signaling from FGF receptor 3, occurs in 70%-90% of these tumors in hum

72 on Sulf 1 and Sulf 2 expression, to control FGF receptor 3-IIIb-mediated astrocytic responses.

73 sed in tissues lacking a receptor for FGF18, FGF receptor 3.

74 both short- and long-term assays through the FGF receptor 3/RAS/c-RAF/mitogen-activated protein kinas

75 ating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 g

76 the expression of Fibroblast Growth Factor (FGF) Receptor 3 and responsiveness of progenitors to FGF

77 In contrast, the tyrosine kinase receptor FGF receptor-3 (FGFR3) and the transcription factor fork

78 lkaline phosphatase (Tnap) transcription via FGF receptor-3 (FGFR3) signaling, leading to inhibition

79 e report that FGF19 and its cognate receptor FGF receptor 4 (FGFR4) are coexpressed in primary human

80 A stimulated tyrosine phosphorylation of the FGF receptor 4 (FGFR4) in hepatocytes.

81 nd gall bladder filling; FGF19 binds only to FGF receptor 4 (FGFR4), but its liver-specific activity

82 studies demonstrate that FGF signalling, via FGF receptor 4 (Fgfr4), mediates a signal-transduction p

83 FGF19 uniquely binds to FGF receptor 4 (FGFR4).

84 kdown of SCUBE3 in C2C12 myoblasts inhibited FGF receptor 4 expression and FGF signaling, thus result

85 Protein levels of FGF19, FGF receptor 4, FXR and short heterodimer partner were i

86 antagonizes transcription of the breathless FGF receptor, a known target of Trh in the tracheal syst

87 FGF receptor activation upregulates expression of these

88 ion as a co-factor permitting FGF21 mediated FGF receptor activation.

89 ha), a key link in fibroblast growth factor (FGF) receptor activation of ERK1/2.

90 ting up a gradient of CXCL12a, and trailing (FGF receptor active) cells moving actively by chemotaxis

91 the lead positions, whereas those with less FGF receptor activity assume subsidiary positions and fo

92 , we have generated transgenic fish in which Fgf receptor activity can be experimentally manipulated.

93 nd link tissue subdivision (Wnt receptor and FGF receptor activity domains) to receptor-ligand parame

94 tween cells such that those with the highest FGF receptor activity take the lead positions, whereas t

95 The Heartless FGF receptor acts cell-autonomously in ensheathing glia

96 Activating FGF receptors acutely had an antidepressant-like effect

97 data that show that an SMC deletion of a pan-FGF receptor adaptor Frs2alpha (fibroblast growth factor

98 e demonstrate that skin hyperplasia requires FGF receptor adaptor protein Frs2alpha and tyrosine phos

99 a region on FGF2 that binds heparin and the FGF receptor and is important in FGF2 central cavity for

100 t2 interacts specifically with the activated FGF receptor and is required for a rapid phase of recept

101 from fibroblast growth factor (FGF) via the FGF receptor and its effectors in the Ras-MAPK pathway.

102 led to autocrine activation of Stat3 via the FGF receptor and JAK kinases, and pharmacological inhibi

103 the ability of VE-cadherin to associate with FGF receptor and the density-enhanced phosphatase-1 (Dep

104 ERK, which is sensitive to dominant-negative FGF receptor and to the inhibitors SU5402 and U0126, and

105 We immunolocalized FGF receptors and analyzed changes in FGFR, FGF and MMP

106 isolated lamprey homologs of FGF3, FGF8 and FGF receptors and asked whether these functions are ance

107 The FGF receptors and co-receptors for these three FGF molec

108 Using mice with tissue-specific ablation of FGF receptors and FGF receptor substrate 2alpha (Frs2alp

109 ressed in response to Wnt signaling activate FGF receptors and initiate proto-neuromast formation.

110 , which, respectively, activate cell surface FGF receptors and intranuclear FGFR1, to determine the r

111 This response is mediated by FGF receptors and involves the activation of IkappaBalph

112 expressed in thymic stromal cells along with FGF receptors and its obligate coreceptor, betaKlotho.

113 tion of Shh responses requires activation of FGF receptors and of ERK and JNK kinases, because it can

114 lying the control of transphosphorylation of FGF receptors and other receptor tyrosine kinases.

115 t physical interaction between the A(2A) and FGF receptors and the robust physiological consequences

116 r IHH-associated genes, including kal-1, the FGF receptor, and FGF.

117 tor cooperation between integrin beta(3) and FGF receptor, and triggered a downstream cascade includi

118 cient zebrafish embryos can be rescued by an FGF receptor antagonist SU5402.

119 The action of FGF receptors appears to be through increasing self-rene

120 at some of the FGF ligands together with the FGF receptors are altered in individuals with affective

121 rs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling i

122 g several FGF ligands and the four classical FGF receptors are detectable in the lens-forming ectoder

123 to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for

124 We find that FGF receptors are required for neural stem-cell maintena

125 inases and nonraft fibroblast growth factor (FGF) receptors are implicated in cell adhesion molecule-

126 road evidence that fibroblast growth factor (FGF) receptors are important in prostate cancer initiati

127 Mutations in fibroblast growth factor (FGF) receptors are responsible for a variety of skeletal

128 Because small molecule inhibitors of Fgf-receptors are in human clinical trials, this suggest

129 receptor substrate 2alpha (FRS2alpha) is an FGF receptor-associated protein required for activation

130 The in vivo data, together with FGF receptor binding analysis, indicate that the in vivo

131 ng pocket as well as to residues involved in FGF receptor binding.

132 d embryos with FGF8b blocking antibody or an FGF receptor blocker rescues secondary heart field myoca

133 ished animal model of CKD, treatment with an FGF-receptor blocker attenuated LVH, although no change

134 Moreover, in older mice, an activated FGF receptor can rescue the age-related decline in neuro

135 pertrophy of isolated rat cardiomyocytes via FGF receptor-dependent activation of the calcineurin-NFA

136 Furthermore, SU5402, an FGF receptor-dependent protein kinase inhibitor, inhibit

137 Expression of a dominant-negative FGF receptor (DN-Fgfr1), treatment with SU5402 (a pharma

138 he secreted two-Ig domain protein ZIG-4, the FGF receptor EGL-15 and the L1-like SAX-7 protein.

139 The Caenorhabditis elegans FGF receptor, EGL-15, is alternatively-spliced to yield

140 Two inhibitors of the Fgf receptor elicited similar phenotypes, suggesting tha

141 blocked by expression of a dominant-negative Fgf receptor, epicardial EMT and coronary neovasculariza

142 Fgf receptor/Erk signalling is known to be required for

143 arised primitive endoderm layer requires the Fgf receptor/Erk signalling pathway.

144 events are highly correlated with changes in FGF receptor expression from FGFR3 to FGFR2 as OL progen

145 ligand availability, coupled with changes in FGF receptor expression, yield a changing repertoire of

146 vestigate the regulation of renal Klotho and FGF receptor (FEFR)-1 in healthy and uremic rats induced

147 ) to sub-mesothelial mesenchyme through both FGF receptor (FGFR) 1 and FGFR2 to induce proliferation.

148 We further demonstrate that Fgf receptor (Fgfr) 1 signaling within the developing se

149 -beta increased KL secretion and upregulated FGF receptor (FGFR) 1.

150 s renal phosphate reabsorption by activating FGF receptor (FGFR) 1c in a Klotho-dependent fashion.

151 th factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c.

152 and signals to an epithelial splice form of FGF receptor (FGFR) 2 to regulate epithelial budding.

153 e that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myoc

154 Inhibitors of the FGF receptor (Fgfr) and ERK pathways reversed the skewed

155 t a functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with e

156 which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signalin

157 be hijacked by disease-causing mutations in FGF receptor (FGFR) during embryogenesis.

158 anterior neural plate via deletion of three FGF receptor (FGFR) genes.

159 or Nurr1 or expressing the dominant-negative FGF receptor (FGFR) identified orphan nuclear receptor N

160 We demonstrate that activation of Fgf receptor (Fgfr) induces intracellular Ras-MAPK, whic

161 Finally, we examined anxiety behavior in FGF receptor (FGFR) KO mice; however, FGFR1, FGFR2, and

162 single-cell transcriptomics of wild-type and Fgf receptor (Fgfr) mutant embryos.

163 etic skeletal disorders caused by activating FGF receptor (FGFR) mutations.

164 lectivity in their requirement for mediating FGF receptor (FGFR) signaling and activating downstream

165 We investigated the role of FGF receptor (Fgfr) signaling in Schwann cells and the c

166 n Xenopus embryos, we found that both RA and FGF receptor (FGFR) signaling ventralize the eye, by exp

167 Here we identify FGF receptor (FGFR) signalling as a critical regulator o

168 al activities by activation of transmembrane FGF receptor (FGFR) tyrosine kinases and their coupled i

169 Of the four FGF receptor (FGFR) tyrosine kinases, only FGFR4 is expr

170 fferent signaling pathways downstream of the FGF receptor (FGFR), and consequently different developm

171 indings indicate that CIMA-1 antagonizes the FGF receptor (FGFR), and does so most likely by inhibiti

172 multiprotein complex formation between FGF, FGF receptor (FGFR), and heparan sulfate proteoglycan on

173 (RTKs), such as EGF receptor (EGFR), ErbB-2, FGF receptor (FGFR), and many others, has been reported

174 Gs) via a ternary complex with FGF-2 and the FGF receptor (FGFR).

175 basic fibroblast growth factor 2 (FGF2b) and FGF receptor (FGFR)1 in LMC formation.

176 The migratory response was mediated by FGF receptors (FGFR) 1 and 3 and MAPK/ERK intracellular

177 a prototypical SH2 containing substrate, by FGF receptors (FGFR) entails formation of an allosteric

178 on, to act as coreceptors along with classic FGF receptors (FGFR) to mediate potent biologic activity

179 mpeting models for fibroblast growth factor (FGF) receptor (FGFR) dimerization have recently emerged

180 Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor pr

181 Here, we identify fibroblast growth factor (FGF) receptor (FGFR)-3 as a novel Prox1 target gene.

182 Deletion of three FGF receptors (Fgfr1-3) early in lens development demons

183 Four FGF receptors (FGFR1-4) have been cloned and characteriz

184 tabolism in target organs through activating FGF receptors (FGFR1-4).

185 ll-surface receptor composed of one of three FGF receptors (FGFR1c, FGFR2c or FGFR3c) in complex with

186 ct isoforms of the fibroblast growth factor (FGF) receptor FGFR2-IIIb and FGFR2-IIIc varying their ex

187 Among the four FGF receptors, FGFR2 showed two highly specific patterns

188 tively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1-4).

189 find that although both are able to activate FGF receptors (FGFRs) 1c, 2c, and 3c, only FGF19 activat

190 Whether FGF receptors (FGFRs) accomplish such varied tasks in pa

191 led that bone marrow stromal cells express 5 FGF receptors (FGFRs) among the 7 known FGFR subtypes.

192 Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects

193 The FGF receptors (FGFRs) control a multitude of cellular pr

194 ibroblast growth factor (FGF) family and the FGF receptors (FGFRs) have been implicated in mediating

195 F signaling, with only three ligands and two FGF receptors (FGFRs) identified.

196 role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and maintaining co

197 pecific fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in NSCLC cell lines.

198 roblast growth factors (FGFs) signal through FGF receptors (FGFRs) mediating a broad range of cellula

199 (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signalin

200 ctor (FGF) signaling through cross-talk with FGF receptors (FGFRs), but the mechanism underlying the

201 predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also sign

202 e, we show that distinct sets of overlapping FGF receptors (FGFRs), FGFR2b and FGFR1b, mediate excita

203 -23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and alpha-Klotho

204 n may not form stable ternary complexes with Fgf receptors (FgfRs), it acts together with and/or is n

205 nly known ligand that signals to mesenchymal FGF receptors (FGFRs).

206 inal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs).

207 at Klotho protein directly binds to multiple FGF receptors (FGFRs).

208 are caused by gain-of-function mutations in FGF receptors (FGFRs).

209 efinitive endoderm through activation of the FGF receptors (FGFRs).

210 verexpress dominant-negative forms of Bmp or Fgf receptors following heat-shock induction.

211 Here we show, however, that the FGF receptors form dimers in the absence of ligand, and

212 Targeted inhibition of Ets1/2 activity or FGF receptor function also blocks heart specification.

213 al for lens fiber differentiation, different FGF receptors function redundantly.

214 re, we show that conditional deletion of the FGF receptor gene Fgfr1 abolishes FGF signaling in the m

215 ns included novel hypomorphic alleles of the FGF receptor gene, breathless, and the ETS-domain transc

216 Here, three FGF receptor genes are simultaneously deleted during cor

217 Multiple gain-of-function mutations in FGF receptors have been implicated in a variety of sever

218 Fibroblast growth factor (Fgf) receptors have a recognized role in mammary ductal

219 (FGF) 8/17/18 subfamily, are ligands for the FGF receptor Heartless (Htl).

220 monstrate that the Fibroblast growth factor (FGF) receptor Heartless autonomously controls astrocyte

221 genetically engineered a model of inducible FGF receptor (iFGFR) signaling in the context of the wel

222 modulatory coligand with FGF to activate the FGF receptor in an HS-dependent manner.

223 able of binding and activating their cognate FGF receptor in vitro and in living cells.

224 the observation that DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenc

225 Here, we found that transgenic inhibition of Fgf receptors in uninjured zebrafish caused severe atrop

226 urnover of surface fibroblast growth factor (FGF) receptor, increased extracellular signal-regulated

227 network by which activating mutations in the FGF receptor inhibit bone growth.

228 Conversely, miR-133 antagonism during Fgf receptor inhibition accelerated regeneration through

229 t FGF2-mediated resistance is interrupted by FGF receptor inhibition.

230 ion was blocked by Fibroblast growth factor (Fgf) receptor inhibition, high miR-133 levels were quick

231 e studies with a Mek inhibitor, U0126, and a Fgf receptor inhibitor, SU5402, indicate that the timing

232 cell development in a manner similar to the FGF receptor inhibitor.

233 arly stages of cochlear development using an FGF receptor inhibitor.

234 uced by 80% by the fibroblast growth factor (FGF) receptor inhibitor PD173074 and by 70% by the IKK i

235 DU 145 cells, treatment with a pharmacologic FGF-receptor inhibitor or a neutralizing anti-FGFR1 anti

236 ES cells lacking Fgf4 or treated with FGF receptor inhibitors resist neural and mesodermal ind

237 d VEGF/platelet-derived growth factor (PDGF)/FGF receptor inhibitors, paracrine ERK activation in fib

238 on principle in both endocrine and paracrine FGF receptor interaction and activation.

239 Further understanding of FGF/receptor interactions may allow the development of e

240 sruption of matrix adhesion promotes uniform FGF receptor internalization and degradation while enhan

241 Here, we show that adhesion inhibits mitotic FGF receptor internalization, leading to receptor enrich

242 Therefore, while signaling by FGF receptors is essential for lens fiber differentiatio

243 n, and that combined inhibition of VEGF/PDGF/FGF receptors is sufficient to inhibit mitogenic signali

244 this case mediated by a transporter and the FGF receptor, is vital to preserve embryonically derived

245 FGFR4 is the major hepatic FGF receptor isoform and is responsible for the hepatic

246 The identity and location of the FGF receptor isotypes that mediate these effects are unc

247 FGF-receptor kinase inhibitors blocked these effects.

248 2alpha (FRS2), an adaptor protein that links FGF receptor kinases to multiple signaling pathways, med

249 Neuronal expression of the FGF receptor ligand Pyramus is also required for the gen

250 ressed genes, including multiple Wnt and ndk/FGF receptor-like (ndl/FGFRL) genes.

251 ns cell differentiation, it is unclear which FGF receptors mediate these processes during different s

252 Furthermore, through the activation of FGF receptor-mediated intracellular MAPK pathway, FGF16

253 This FGF receptor-mediated stimulation of mature oligodendroc

254 e found some directed dorsal migration in an FGF receptor mutant, which suggests that additional sign

255 y reported that the expression of activating FGF receptor mutations in osteoblasts downregulated the

256 fation-dependent FGF signaling mechanism via FGF receptors on astrocytes.

257 in the assembly of signaling complexes with FGF-receptors on the plasma membrane.

258 ing by expression of a constitutively active FGF receptor only partially rescued the lacrimal gland d

259 onditionally express an activated form of an FGF receptor or delete the FGF receptors that are expres

260 og or Dpp pathways, nor did Fas2 inhibit the FGF receptor or Torso, indicating specificity in the inh

261 402, or by activation of a dominant negative FGF receptor, or by activation of expression of the Wnt

262 activation of the fibroblast growth factor (FGF) receptor, phospholipase C (PLC), protein kinase C (

263 ction mutations in fibroblast growth factor (FGF) receptors result in chondrodysplasia and craniosyno

264 Pharmacologic blockade of FGF receptors resulted in a comparable increase in plasm

265 reveal a previously unrecognized function of FGF receptor signaling in oligodendrocytes that contribu

266 levels of proteins known to be regulated by FGF receptor signaling, but proteins known to be importa

267 FGF receptor signaling, in turn, inhibits Wnt signaling.

268 on to CB1 cannabinoid receptor regulation of FGF receptor signaling.

269 We used FGF-receptor signaling to identify EGR1 as a locus that

270 elicited similar phenotypes, suggesting that Fgf receptor signalling promotes Erk-mediated polarisati

271 d by PD173074, a small molecule inhibitor of FGF receptor signalling.

272 Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the pri

273 the actions of FGF19 on target tissues, its FGF receptor specificity, and the contributions of other

274 introducing endothelial-specific deletion of FGF receptor substrate 2 alpha (Frs2a) in atheroscleroti

275 issue-specific ablation of FGF receptors and FGF receptor substrate 2alpha (Frs2alpha) in heart proge

276 FGF receptor substrate 2alpha (FRS2alpha) is an FGF rece

277 FGF receptor substrate 2alpha (FRS2alpha) is an FGFR int

278 expression, and decreased phosphorylation of FGF receptor substrate 2alpha, a major FGF-23 receptor s

279 bility of FGF23 to induce phosphorylation of FGF receptor substrate and ERK in various types of cells

280 e are deficient in expression of hippocampal FGF receptor subtype 1 mRNA, most notably in the dentate

281 ch, unlike other FGF peptides, activates all FGF receptor subtypes.

282 inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel thera

283 A dominant-negative form of the Ciona FGF receptor suppresses the formation of polarized actin

284 ivated form of an FGF receptor or delete the FGF receptors that are expressed in these cells.

285 aptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.

286 d 4, thereby increasing the ability of these FGF receptors to bind FGF21 and activate the MAP kinase

287 that CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardiu

288 onal ablation of this receptor-type, but not FGF receptor type 1 (FGFR1), resulted in attenuation of

289 Here, we show that FGF receptor type 2 (FGFR2) is highly enriched at the pa

290 ritically important to identify the specific FGF receptor type and its downstream signaling molecules

291 activities by activating diverse isotypes of FGF receptor tyrosine kinases (FGFRs).

292 t into the signaling molecules downstream of FGF receptor tyrosine kinases in cardiac progenitors.

293 les that specifically inhibit GSK3, MEK, and FGF receptor tyrosine kinases.

294 ors associate with fibroblast growth factor (FGF) receptor tyrosine kinases (FGFRs) to enable signali

295 of VEGF, PDGF, and fibroblast growth factor (FGF) receptor tyrosine kinases.

296 Using a pharmacological inhibitor of the FGF receptor, we show that reducing FGF signalling parti

297 ctivation of brain fibroblast growth factor (FGF) receptors, we explored the antidiabetic efficacy of

298 ot targeted by Cre-mediated recombination of Fgf receptors, were also misplaced in FGFR DKO mice, pos

299 r tyrosine kinase receptors, such as EGF and FGF receptors, were not activated by GCs.

300 ted whether administering agents that act on FGF receptors would have antidepressant-like effects in