1 ntified a novel human FGF-7 homologue, named
FGF-10.
2 cal to human FGF-10 and 91% identical to rat
FGF-10.
3 nhibits expression of the critical morphogen
FGF-10.
4 m is through secreted growth factors such as
FGF-10.
5 posed to be typified by negligible levels of
FGF-10.
6 FGF-10,
a member of the fibroblast growth factor family,
7 dies with human cells indicated two modes of
FGF-10 action: (i) translocation of rFGF-10 into urothel
8 FGF-10 alone did not stimulate prostatic bud formation i
9 he encoded protein is 92% identical to human
FGF-10 and 91% identical to rat FGF-10.
10 Fgf-10 and Fgf-18 are expressed specifically within vent
11 Although
FGF-10 and FGF-7 bind and activate the same resident epi
12 Cells expressing Wnt-2b are able to induce
Fgf-10 and generate an extra limb when implanted into th
13 FGF-10 and its receptors, FGFR1 and FGFR2, have been imp
14 These results indicate that
FGF-10 and KGF have similar receptor binding properties
15 pe was partially reversed by the addition of
FGF-10 and testosterone, resulting in the formation of p
16 Paracrine signaling mediated by
FGF-10 and the FGF-R2IIIb receptor is required for forma
17 s expression of fibroblast growth factor-10 (
FGF-10)
and impairs epithelial-mesenchymal interactions
18 ctor I (IGF-I), fibroblast growth factor 10 (
FGF-10),
and Epithelial Growth Factor (EGF), which may b
19 of pro-proliferative signals such as IGF-1,
FGF-10,
and BMP4.
20 mal cells exhibit strictly a cell-associated
FGF-10 antigen that correlates with an alternately trans
21 Thus,
FGF-10 appears to act as a growth factor which is requir
22 -1), keratinocyte growth factor (FGF-7), and
FGF-10 are homologues with distinct specificity.
23 ferred dual activities on both the FGF-7 and
FGF-10 backbones.
24 ovalent cross-linking analysis revealed that
FGF-10 binds with an affinity equal to FGF-7 to resident
25 tor Ptc, raising the possibility that WNT5a,
FGF-10,
BMP4, and SHH signaling pathways are functionall
26 utant lungs leads to increased expression of
Fgf-10,
Bmp4, Shh, and its receptor Ptc, raising the pos
27 These data suggested that inhibition of
FGF-10 by inflammatory signaling involves the NF-kappaB-
28 clear translocation, prevented inhibition of
FGF-10 by SP3.
29 FGF-10 can prevent or reduce lung specific inflammation
30 Although
FGF-10 cDNA exhibits a signal sequence for secretion, cu
31 stromal cells in tissues, the expression of
FGF-10 correlated with the presence of stromal cells of
32 The mitogenic activity of
FGF-10 could be distinguished from that of KGF by its di
33 developmental gene re-activation in IPF, and
FGF-10 deficiency as a potentially critical factor in di
34 Fgf-10-
deficient mice (Fgf-10(-/-)) were generated to de
35 Within this concentration range,
FGF-10 did not stimulate DNA synthesis in NIH/3T3 mouse
36 FGF-10 does not seem to interfere with early epithelial
37 FGF-10 exerts a powerful chemoattractant effect on the d
38 FGF-10 exhibits a similar specificity but also binds the
39 to interfere with the normal stimulation of
FGF-10 expression by Sp1.
40 ediators that inhibited airway branching and
FGF-10 expression in LPS-resistant C.C3-Tlr4(Lpsd)/J fet
41 eat-shock induced Dkk1 blocked fgf-8 but not
fgf-10 expression in the blastema.
42 b region, another Wnt gene, Wnt-8c, controls
Fgf-10 expression, and is also capable of inducing ectop
43 d TNF-alpha) that activate NF-kappaB reduced
FGF-10 expression, whereas chemokines that signal via ot
44 t of NF-kappaB and SP3 suppress SP1-mediated
FGF-10 expression.
45 Strikingly,
Fgf-10(-/-)
fetuses continued to develop until birth, de
46 ype that synthesized FGF-10 RNA and (ii) the
FGF-10 gene is located at the 5p12-p13 locus of chromoso
47 We maintained localized high levels of
FGF-10 in cultured lungs using FGF-10-soaked heparin bea
48 NF-kappaB disrupts the normal expression of
FGF-10 in fetal lung mesenchyme by interfering with the
49 The chemoattractant effect of
FGF-10 in the lung epithelium is reminiscent of the patt
50 Lastly, direct delivery of
FGF-10 in the lungs of rats led to an increase of LR-MSC
51 ) were generated to determine the role(s) of
Fgf-10 in vertebrate development.
52 BrdU incorporation analysis suggests that
FGF-10,
in contrast to FGF-7, is a modest proliferation
53 ments required for direct NF-kappaB-mediated
FGF-10 inhibition.
54 In this study we investigate whether
FGF-10 is able to direct lung epithelial buds to proper
55 Based on these results we propose that
FGF-10 is an inductive signal that initiates ocular glan
56 In this report, we provide evidence that
FGF-10 is both necessary and sufficient to initiate glan
57 During normal ocular development,
FGF-10 is expressed in the perioptic mesenchyme adjacent
58 e induction of Fgf-8 in the limb ectoderm by
FGF-10 is mediated by the induction of Wnt-3a.
59 Fgf-10 is necessary for apical ectodermal ridge (AER) fo
60 blast growth factor (FGF) family, designated
FGF-10,
is expressed during development and preferential
61 ults show that prostate stromal cell-derived
FGF-10,
like FGF-7, exhibits the properties of an androm
62 a-catenin act as key regulators of the FGF-8/
FGF-10 loop.
63 Recent studies have shown that
FGF-10 may be a key regulator of lung branching morphoge
64 ulation in wound repair, we cloned the mouse
FGF-10 (
mFGF-10) cDNA.
65 Fgf-10(-/-)
mice exhibited perinatal lethality associate
66 The pulmonary phenotype of
Fgf-10(-/-)
mice is strikingly similar to that of the Dr
67 Prostatic rudiments from
FGF-10(-/-)
mice transplanted into intact male hosts gre
68 have examined the male reproductive tract of
FGF-10(-/-)
mice, and at birth, most of the male seconda
69 tatic anlagen, the urogenital sinus (UGS) of
FGF-10(-/-)
mice.
70 Limb bud initiation was abolished in
Fgf-10(-/-)
mice.
71 gs, suggesting that the protective effect of
FGF-10 might be mediated, in part, by the mobilization o
72 Immunophenotyping analysis of
FGF-10 mobilized and cultured cells revealed expression
73 crimal and Harderian glands were not seen in
FGF-10 null fetuses.
74 In cultures of UGS, the
FGF-10 null phenotype was partially reversed by the addi
75 To better characterize the effect of
FGF-10 on LR-MSCs, FGF-10 was intratracheally delivered
76 Additionally, the effect of
FGF-10 on lung-resident mesenchymal stem cells (LR-MSCs)
77 ween the fibroblast growth factors FGF-8 and
FGF-10 plays a key role in limb initiation and AER induc
78 kappaB kinase beta mutant not only decreased
Fgf-10 promoter activity but also increased RELA-SP3 nuc
79 SP3 co-expression reduced SP1-mediated
Fgf-10 promoter activity, suggesting antagonistic intera
80 Mutational analysis of the
FGF-10 promoter failed to identify genetic elements requ
81 ased interactions between SP3, RELA, and the
Fgf-10 promoter.
82 dent interactions between RELA, SP3, and the
Fgf-10 promoter.
83 NF-kappaB and Sp1 physically interact at the
FGF-10 promoter.
84 The predicted
FGF-10 protein is most related to keratinocyte growth fa
85 FGF-10 requires 1.4 times higher NaCl for elution from i
86 In the absence of mesenchyme
FGF-10 requires an associated proliferative signal to in
87 nces into the C-terminal portion of FGF-7 or
FGF-10 revealed that substitution of GSCKRG for GIPVRG o
88 During proliferative phases, levels of
FGF-10 rise at the urothelial cell surface and/or within
89 propria were the cell type that synthesized
FGF-10 RNA and (ii) the FGF-10 gene is located at the 5p
90 igh levels of FGF-10 in cultured lungs using
FGF-10-
soaked heparin beads.
91 Epithelial buds grow toward an
FGF-10 source within 24 h, and subsequently form concent
92 FGF-10(-/-)
testes produced sufficient androgens to indu
93 s domain might underlie failure of FGF-7 and
FGF-10 to bind to the FGFRIIIc isoforms.
94 mulate prostatic bud formation in control or
FGF-10(-/-)
UGS.
95 Similar to FGF-7, recombinant rat
FGF-10 was a specific mitogen for prostate epithelial ce
96 haracterize the effect of FGF-10 on LR-MSCs,
FGF-10 was intratracheally delivered into the lungs of r
97 ed that, similar to FGF-7, the expression of
FGF-10 was responsive to androgen in stromal cells from
98 Lens-specific expression of
FGF-10 was sufficient to induce ectopic ocular glands wi
99 Importantly, fibroblast growth factor-10 (
FGF-10)
was markedly suppressed in IPF subjects with pro
100 ological and biochemical properties of human
FGF-10,
we isolated the cDNA and expressed its encoded p
101 Recombinant (r) preparations of human
FGF-10 were found to induce proliferation of human uroth
102 Site-directed mutants of FGF-7 and
FGF-10 were prepared to test whether this domain might u
103 Fgf-10-deficient mice (
Fgf-10(-/-))
were generated to determine the role(s) of
104 Neither FGF-7 nor
FGF-10 will bind to IIIc isoforms of FGFR.
105 An understanding of how
FGF-10 works in conjunction with these other processes w