ライフサイエンスコーパス: FGF-8

1 and repressed by fibroblast growth factor-8 (FGF-8).

2 chymal cells are equicompetent to respond to Fgf-8.

3 However, very little is known about human FGF-8.

4 weight of 22 kDa that is most homologous to FGF-8 (70% similarity).

5 d with the other FGFs and most homologous to FGF-8 among the FGF family members.

6 en humans and mice and is most homologous to FGF-8 among the FGF family members.

7 In contrast, the secretion of FGF-8 (an FGF family member that contains a hydrophobic

8 FGF-8 and BMP-2 are present in the ventral pharynx and s

9 y loop between the fibroblast growth factors FGF-8 and FGF-10 plays a key role in limb initiation and

10 ceptor blocking antibodies, we now show that FGF-8 and FGF-17 target OL progenitors, inhibiting their

11 ion patterns of the AER signalling molecules Fgf-8 and Fgf-4 are altered.

12 of polarising activity (ZPA), loss of Wnt7a, Fgf-8 and Fgf-4 expression leads to a decrease in expres

13 The results suggest that FGF-8 and FGFR-4a signalling promotes neurogenesis and,

14 a combination of pan-dopaminergic (e.g., Shh/FGF-8) and region-specific (Nurr1) mechanisms.

15 Thus, FGF-8 appears to be a key signal involved in initiation,

16 sion of the fibroblast growth factor-8 gene (Fgf-8) appears as normal in the ectoderm over the prospe

17 eveloping face and the limb buds we identify Fgf-8 as the likely candidate signalling molecule that r

18 Fgf-4, expression, whereas the expression of Fgf-8, as at earlier stages, is initially unaffected.

19 Furthermore, heat-shock induced Dkk1 blocked fgf-8 but not fgf-10 expression in the blastema.

20 Moreover, we show that FGF-8 can replace the apical ectodermal ridge to maintai

21 , continuous and widespread misexpression of FGF-8 causes limb truncations and skeletal alterations w

22 port that Xenopus embryos expressing ectopic FGF-8 develop an abundance of ectopic neurons that exten

23 morpholino oligonucleotide-mediated loss of FGF-8 expression in vivo substantially reduced the pheno

24 Later on, Fgf-8 expression is restricted to the ridge cells and ex

25 cipate as a half-cystine with position 83 in FGF-8, FGF-19, and FGF-23.

26 s were evident in transgenic mice expressing FGF-8, FGF-9 and some lines expressing FGF-4.

27 e that express different FGFs (FGF-4, FGF-7, FGF-8, FGF-9) specifically in the lens.

28 gh beta-catenin act as key regulators of the FGF-8/FGF-10 loop.

29 ectopic protrusions induced by EphA4 express FGF-8, FGFR1, and FGFR4a.

30 hial arch ectomesenchymal cells by a signal, Fgf-8, from the rostral epithelium.

31 that in the mandibular arch, as in the limb, Fgf-8 functions in combination with CD44, a cell surface

32 Finally, we show that FGF-8 gene expression in a human breast cancer cell line

33 The FGF-8 gene has been mapped to chromosome 1Oq24 using bot

34 poral and spatial expression patterns of the FGF-8 gene suggest its involvement in gastrulation, regi

35 st growth factor (bFGF), Sonic hedgehog, and FGF-8 in a serum-free N-2 culture medium to foster diffe

36 s and cell fates are fixed and maintained by Fgf-8 in conjunction with another epithelial signal, end

37 Finally, we also show that the induction of Fgf-8 in the limb ectoderm by FGF-10 is mediated by the

38 FGF-8 inhibited the expression of an early mesoderm mark

39 romotes neurogenesis and, unlike other FGFs, FGF-8 interferes with mesoderm induction.

40 FGF-8 is a member of the family of fibroblast growth fac

41 report here that another FGF family member, FGF-8 is able to protect rat hippocampal cultures from o

42 Since FGF-8 is identified as a corroborating gene in MMTV-indu

43 In the adult, expression of FGF-8 is restricted to gonads including testes and ovari

44 istent with the hypothesis that the multiple FGF-8 isoforms are functionally redundant and function t

45 Eight potential FGF-8 isoforms are generated by alternative splicing in

46 Human FGF-8 isoforms are identical to their murine counterpart

47 None of the FGF-8 isoforms exhibited activity when assayed with BaF3

48 pression patterns and the specificity of the FGF-8 isoforms for known fibroblast growth factor (FGF)

49 and FGF receptor 4 were activated by several FGF-8 isoforms.

50 stic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to co

51 tumors in Wnt-1 transgenic mice and because FGF-8 manifested its autocrine mitogenic activity in SC-

52 , it is possible that aberrant expression of FGF-8 may be present in human cancers which are hormone

53 RA, in conjunction with Fgf-8, may be needed for the induction of the chick limb

54 Neither FGF-8 nor BMP-2 is present as inflow myocardium is added

55 The effect of FGF-8 on neurogenesis was blocked by dominant-negative F

56 explants is unaffected by the expression of FGF-8 or a dominant-negative Ras (N17ras), suggesting th

57 patterning influences of sonic hedgehog and FGF-8 or the more generic process of neuronal differenti

58 To determine whether FGF-8 plays a role in human breast cancer, we have isola

59 The b isoform of FGF-8 protected hippocampal cultures from hydrogen perox

60 Application of FGF-8 protein to the flank induces the development of ad

61 In explant cultures, neutralizing Ab for FGF-8 rescued development of the myocardial calcium tran

62 d fail to express sonic hedgehog, FGF-4, and FGF-8, signaling molecules that have been implicated in

63 formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice.

64 During chick limb development, Fgf-8 transcripts are detected in the intermediate mesod

65 Only FGF-8 was expressed in a temporospatial pattern that mad

66 Androgen-induced growth factor (AIGF or FGF-8) was originally isolated from the conditioned medi

67 FGF-3, FGF-4, and FGF-8 were not detectable by RT-PCR in either proliferat