ライフサイエンスコーパス: FGF

1 FGF receptor substrate 2alpha (FRS2alpha) is an FGF rece

2 FGF receptors 1 and 2 (Fgfr1 and Fgfr2) are both express

3 FGF signaling abnormalities have been associated with sk

4 FGF signaling has emerged as a significant "late-stage"

5 FGF signaling promotes epicardium formation in vivo, and

6 FGF signaling represses the NMP markers brachyury (ntla)

7 FGF signaling through receptors Fgfr3 and Fgfr4 is cruci

8 FGF signaling, an important component of intercellular c

9 FGF-1 applied to rat spinal astrocytes in culture initia

10 FGF-1-induced dye uptake by astrocytes is prevented by B

11 FGF-10 can prevent or reduce lung specific inflammation

12 FGF-23 demonstrated an increased discriminatory power fo

13 FGF-23 is independently associated with an increased ris

14 FGF-mediated PM induction in NMPs functions in tight coo

15 Importantly, fibroblast growth factor-10 (FGF-10) was markedly suppressed in IPF subjects with pro

16 ss of 3 doses of fibroblast growth factor 2 (FGF-2) when combined with a beta-tricalcium phosphate (b

17 oteins including fibroblast growth factor 2 (FGF-2), and the chemokines CCL2, CCL5, CCL7, CCL13, CXCL

18 factors such as fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 (BMP-2) work syn

19 y downregulated fibroblast growth factor-21 (FGF-21) and TubA significantly reversed this downregulat

20 derived hormone fibroblast growth factor-23 (FGF-23) activates complexes composed of FGF receptors (F

21 S and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways.

22 s between HS and fibroblast growth factor-7 (FGF-7).

23 tereoisomers, with only one able to act as a FGF trap molecule and to inhibit FGF-dependent receptor

24 ) is a potent angiogenic factor and aberrant FGF signaling is a common property of tumors.

25 ed chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents t

26 rate that the duration of exposure to active FGF and WNT signaling controls regional identity.

27 In addition, FGF-21 knockdown reduced lithium-VPA co-treatment-induce

28 ch, unlike other FGF peptides, activates all FGF receptor subtypes.

29 receptor substrate 2alpha (FRS2alpha) is an FGF receptor-associated protein required for activation

30 Forced activation of an FGF-ERK-ETV axis that is crucial to BG induction specifi

31 Here we show that Thisbe, an FGF released from olfactory neurons, particularly from l

32 sequenced the fin whale genome and analysed FGFs from 8 cetaceans.

33 In this report, we investigated if BMP-2 and FGF-2 together can synergistically promote bone repair i

34 that displays distinct responses to BMP and FGF signaling from the traditional neural border genes.

35 of the delicate temporal effects of BMP and FGF signaling, and find that NC development is separable

36 ), independent of eGFR; proteinuria, BP, and FGF-23 levels; and underlying renal diagnosis.

37 Dpp and FGF signaling in the ASP was dependent on components of

38 basic fibroblast growth factor 2 (FGF2b) and FGF receptor (FGFR)1 in LMC formation.

39 Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects

40 role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and maintaining co

41 Further, this interplay between HS and FGF-7 modulated downstream ERK, AKT and p38 cascades, su

42 arily conserved between mice and humans, and FGF signaling, although required for thyroid specificati

43 developmental gene re-activation in IPF, and FGF-10 deficiency as a potentially critical factor in di

44 vestigate the regulation of renal Klotho and FGF receptor (FEFR)-1 in healthy and uremic rats induced

45 s Previous studies have implicated Nodal and FGF signals in the specification of lateral and ventral

46 ome of these genes are in the HOX, NOTCH and FGF signalling pathways, which regulate both skeletal an

47 duces elevation of both plasma phosphate and FGF-23 concentrations, potentially contributing to cardi

48 nd link tissue subdivision (Wnt receptor and FGF receptor activity domains) to receptor-ligand parame

49 p-regulation of acetylated alpha-tubulin and FGF-21.

50 inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel thera

51 ycolysis in the tail bud coordinates Wnt and FGF signaling to promote elongation of the embryonic axi

52 ursors in response to stimulation of Wnt and FGF signaling.

53 , we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes.

54 Serum and basic FGF induced phosphorylation of Akt, MAP kinases, and S6

55 te that there is signaling crosstalk between FGF and Wnt, and that beta-catenin acts on PGC prolifera

56 was a strong competitive interaction between FGF-23 and ADMA in the risk of renal events (P<0.01 in a

57 However, a direct link between FGF signaling and crystallin gene transcriptional machin

58 Links between FGF signaling pathways and other interacting pathways th

59 nimal signaling pathways (Wnt+BMP versus BMP+FGF) that regulate distinct lung- versus thyroid-lineage

60 are involved in WNT, HGF, TGFbeta, IGF, BMP, FGF and estrogen signaling.

61 Spatiotemporally regulated domains of BMP, FGF, and other signaling molecules in late gastrula-earl

62 sional culture system, we modulate TGF, BMP, FGF, and WNT signaling to generate multiple otic-vesicle

63 portant in organogenesis (Wnt, TGFbeta/ BMP, FGF, Notch, SHH, Erbb) were differentially expressed bet

64 ted changes in genes regulating TGF-beta/BMP/FGF signaling, as well as in genes controlling ECM struc

65 to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for

66 This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in

67 ced by FGF-1, although they are activated by FGF-1 treatment.

68 n the epithelialisation timing controlled by FGF activity.

69 nscription factor, ETV4, which is induced by FGF signalling and acts as a repressor of ZRS activity,

70 but inactive state of the ZRS is induced by FGF signalling and in combination with balanced histone

71 se in Etd(+) uptake by astrocytes induced by FGF-1, although they are activated by FGF-1 treatment.

72 ion of inner ear progenitors is initiated by FGF signalling.

73 thelial cells and cardiomyocytes possibly by FGF and BMP signaling, respectively.

74 a prototypical SH2 containing substrate, by FGF receptors (FGFR) entails formation of an allosteric

75 ple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina.

76 several angiogenesis-related factors (CD26, FGF, HGF, MMP-8, MMP-9, OPN, PF4, SDF-1) and cytokines (

77 ents redirecting a signal-peptide-containing FGF family member from the endoplasmic reticulum/Golgi-d

78 m(2)), serum 25-hydroxyvitamin D (25(OH)D), FGF-23, and Klotho levels were measured at baseline and

79 l expression of Lhx2 and neuroretina-derived FGF factors are crucial for lens fiber development in vi

80 ally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer,

81 fects of HC-HA/PTX3 on cell migration (EGF + FGF-2 + TGF-beta1) and collagen gel contraction (TGF-bet

82 ability (cytotoxicity), proliferation (EGF + FGF-2) and EMT (TGF-beta1).

83 ouble-negative" PCs are notable for elevated FGF and MAPK pathway activity, which can bypass AR depen

84 factor 21 (FGF21), a member of the endocrine FGF subfamily, is expressed in thymic stromal cells alon

85 FGFBP1 enhances FGF signaling including angiogenesis during cancer progr

86 ement membrane proteins, and members of ERK, FGF and PDGF signaling pathways, which play key roles in

87 enuated LVH in the Hyp mouse model of excess FGF-23, but did not induce a response in FGFR1(DT-cKO) m

88 In addition, both TubA and exogenous FGF-21 conferred neuroprotection and restored mitochondr

89 expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina.

90 We show here that the growth factor FGF-1 is proinflammatory in the spinal cord and explore

91 lls constitutively produce the growth factor FGF-2, which activates tumor-infiltrating B cells to pro

92 -activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c

93 and ileum-derived fibroblast growth factor (FGF) 15.

94 Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets

95 a co-receptor for Fibroblast Growth Factor (FGF) 23, a known pro-inflammatory, prognostic marker in

96 applying Wnt, BMP, fibroblast growth factor (FGF) and retinoic acid (RA) signaling to obtain lung and

97 ave implicated the fibroblast growth factor (FGF) family in affect regulation and suggest a potential

98 Members of the fibroblast growth factor (FGF) family play essential and important roles in primar

99 ) in response to a fibroblast growth factor (FGF) gradient.

100 The fibroblast growth factor (FGF) is a potent angiogenic factor and aberrant FGF sign

101 n concert with the fibroblast growth factor (FGF) pathway to promote branch morphogenesis, while corr

102 protein (BMP), and fibroblast growth factor (FGF) pathways are activated at the transition from pre-i

103 taplegic (Dpp) and Fibroblast growth factor (FGF) proteins produced by the wing imaginal disc and tra

104 ating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 g

105 activation of the fibroblast growth factor (FGF) receptor, phospholipase C (PLC), protein kinase C (

106 ctivation of brain fibroblast growth factor (FGF) receptors, we explored the antidiabetic efficacy of

107 yos in response to fibroblast growth factor (FGF) signaling and a localized GATA determinant.

108 Although restoring Fibroblast growth factor (FGF) signaling can partially rescue SHF addition in Cyp2

109 Fibroblast growth factor (FGF) signaling is an essential regulator of lens epithel

110 Fibroblast growth factor (FGF) signaling is important for skeletal development; ho

111 Fibroblast growth factor (FGF) signaling is required for mesoderm induction during

112 Hippo/YAP and the fibroblast growth factor (FGF) signaling pathways formed an autocrine/paracrine-po

113 beta (TGFbeta) and fibroblast growth factor (FGF) signaling pathways play important roles in the prol

114 Fibroblast Growth Factor (FGF) signaling promotes self-renewal in progenitor cells

115 Fibroblast growth factor (FGF) signaling regulates a multitude of cellular process

116 ymes downstream of fibroblast growth factor (FGF) signaling.

117 Fibroblast growth factor (FGF) signalling in the distal limb primes the ZRS at ear

118 rain and show that fibroblast growth factor (FGF) signalling regulates FBM neuron migration in an HS2

119 f an intracellular fibroblast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolis

120 fying a network of fibroblast growth factor (FGF), wingless-related integration site (WNT), and bone

121 not recognize the fibroblast growth factor (FGF)-15 produced by mouse intestine.

122 omeostasis include fibroblast growth factor (FGF)-23, a bone-derived hormone that inhibits 1,25-dihyd

123 elevation in serum fibroblast growth factor (FGF)-23.

124 st studied are the fibroblast growth factor (FGF)-ERK1/2 pathway, PI3K-AKT, the leukemia inhibitory f

125 Fibroblast growth factor (FGF)-extracellular signal-regulated kinase (ERK) signall

126 aily injections of fibroblast growth factor (FGF)19.

127 In addition, fibroblast growth factor (FGF)21 has effects similar to those of adiponectin in re

128 Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their pote

129 iological role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and main

130 Fibroblast growth factors (FGFs) are a family of essential factors that regulate an

131 about the role of fibroblast growth factors (FGFs) in this context.

132 acrophage-derived fibroblast growth factors (FGFs).

133 ppression of protein synthesis, but also for FGF-induced cell-cycle arrest.

134 These phenotypes reflect important roles for FGF signaling in promoting ventricular traits, both in e

135 decreased downstream forkhead box P1 (FOXP1)/FGF and NOTCH1/EPHB2 signaling, indicating that SHP2 is

136 egulated loci that receive direct input from FGF signaling to balance self-renewal and cell fate dete

137 ial for mng survival mediated by gliotrophic FGF signaling.How glial cells, such as astrocytes, acqui

138 The Heartless FGF receptor acts cell-autonomously in ensheathing glia

139 imposing this prepattern's condition of high FGF and low BMP activity across the entire skin reveals

140 and contributes to our understanding of how FGF signaling plays diverse developmental roles.SIGNIFIC

141 FRs could therefore in principle explain how FGFs play several distinct roles in other developing tis

142 P alone (control) and 0.1% recombinant human FGF-2 (rh-FGF-2), 0.3% rh-FGF-2, and 0.4% rh-FGF-2 with

143 sue of Nature, Nacu et al. (2016) identified FGF and HH ligands as interacting molecular influences t

144 Here we identify FGF receptor (FGFR) signalling as a critical regulator o

145 TubA also mitigated impaired FGF-21 signaling in the ischemic hemisphere, including u

146 Importantly, FGF-induced changes in the 4E-BP1 activity observed in c

147 Finally, we examined anxiety behavior in FGF receptor (FGFR) KO mice; however, FGFR1, FGFR2, and

148 Further, culturing rat lens explants in FGF increased their expression of Prox1, and this was at

149 r of variants within the domains involved in FGF binding and FGFR activation.

150 be hijacked by disease-causing mutations in FGF receptor (FGFR) during embryogenesis.

151 to act as a FGF trap molecule and to inhibit FGF-dependent receptor activation, cell proliferation, a

152 We model mutually inhibitory FGF-Wnt signalling network in the PLLP and link tissue s

153 CAPE inhibits FGF-stimulated PI3K/Akt signaling, and neural crest defe

154 or 14 (FGF14), a member of the intracellular FGF family.

155 In the latter, FGF-1 application promotes the activation of microglia a

156 In the vertebrate lens, FGF signaling regulates fiber cell differentiation chara

157 We show that deleting Ptpn11, which links FGF with the ERK pathway, prevents inferior colliculus f

158 ADMA levels was highest in patients with low FGF-23 levels.

159 nstrate that, during normal lung maturation, FGF signaling restricts expression of the elastogenic ma

160 eceptors and signaling pathways that mediate FGF-dependent presynaptic differentiation, and thereby p

161 lectivity in their requirement for mediating FGF receptor (FGFR) signaling and activating downstream

162 her analysis indicated that RPS15A modulated FGF signaling by enhancing Wnt/beta-catenin-mediated FGF

163 haracterize the effect of FGF-10 on LR-MSCs, FGF-10 was intratracheally delivered into the lungs of r

164 ressed genes, including multiple Wnt and ndk/FGF receptor-like (ndl/FGFRL) genes.

165 CP) system in the disc, and neither Dpp- nor FGF-receiving cytonemes extended over mutant disc cells

166 onal ablation of this receptor-type, but not FGF receptor type 1 (FGFR1), resulted in attenuation of

167 In the absence of FGF and Nodal, neural progenitors exhibit a default beha

168 A decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, l

169 e detected in vivo and reflect the action of FGF signaling on downstream targets during bone developm

170 pposite to those predicted by the actions of FGF-23.

171 Ectopic activation of FGF signaling is sufficient to induce intercalary behavi

172 Immunophenotyping analysis of FGF-10 mobilized and cultured cells revealed expression

173 These results highlight the complexity of FGF signaling in the regulation of various metabolic pro

174 , and genes encoding important components of FGF signaling.

175 -23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and alpha-Klotho

176 Conditionally deleting one copy of FGF receptor 2 (FGFR2) in adult mouse airway basal cells

177 Lastly, direct delivery of FGF-10 in the lungs of rats led to an increase of LR-MSC

178 st on the endothelium, and downregulation of FGF receptor 2 (FGFR2) on PMNs rescued host defense in t

179 stablish the genetic hierarchy downstream of FGF by systematic analysis of many ear factors combined

180 lled by different strengths and durations of FGF signals originated from the so-called isthmic organi

181 te proliferation and the mitogenic effect of FGF signalling, which are only required after wound clos

182 gs, suggesting that the protective effect of FGF-10 might be mediated, in part, by the mobilization o

183 To better characterize the effect of FGF-10 on LR-MSCs, FGF-10 was intratracheally delivered

184 Additionally, the effect of FGF-10 on lung-resident mesenchymal stem cells (LR-MSCs)

185 supports their roles as nuclear effectors of FGF signaling in mouse embryonic lens.

186 to be a general agreement on the effects of FGF signaling on the proliferation of pulp cells, there

187 one, suggesting cell-autonomous functions of FGF signaling during postnatal bone formation.

188 tic seizures, underscoring the importance of FGF-dependent synapse formation.

189 Inhibition of FGF signaling induced apoptosis in wt cells under serum

190 ationale for treating PCa with inhibitors of FGF signaling.

191 ls to serum starvation is not due to lack of FGF synthesis but likely to effects of Psen1 on FGF rele

192 Loss of FGF signaling results in a gradual accumulation of atria

193 served discrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification betwe

194 The inductive roles of FGF, Wnt, and BMP at the neural plate border are well es

195 movement to locally prepatterned sources of FGF.

196 rescues the defects caused by suppression of FGF signalling.

197 that CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardiu

198 s therapeutic potential for the treatment of FGF-dependent lung cancers.

199 Perturbing the expression levels of FGFs/FGFRs by excessive glutamatergic neurotransmission

200 lts provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment.

201 ever, little is known regarding the roles of FGFs/FGFRs in cortical circuit formation.

202 synthesis but likely to effects of Psen1 on FGF release onto the cell surface and impaired activatio

203 n which BMP keeps lens cells in an optimally FGF-responsive state and, reciprocally, FGF enhances BMP

204 inds of plasmid DNA encoding either BMP-2 or FGF-2 formulated into polyethylenimine (PEI) complexes.

205 nds on additional mechanisms, such as BMP or FGF signalling for the particular genes we investigated,

206 rally administered FGF1, which, unlike other FGF peptides, activates all FGF receptor subtypes.

207 data that show that an SMC deletion of a pan-FGF receptor adaptor Frs2alpha (fibroblast growth factor

208 NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endow

209 r effects appear to be mediated by paracrine FGF control of kidney FGFR1 and subsequent regulation of

210 d VEGF/platelet-derived growth factor (PDGF)/FGF receptor inhibitors, paracrine ERK activation in fib

211 n, and that combined inhibition of VEGF/PDGF/FGF receptors is sufficient to inhibit mitogenic signali

212 aptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.

213 ally FGF-responsive state and, reciprocally, FGF enhances BMP-mediated gene expression.

214 Notably, recombinant FGF-23 administration similarly decreased the kidney exp

215 ein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor cells of the second

216 Activating Wnt signaling and reducing FGF gene dosage rescues gangliogenesis and innervation i

217 e demonstrate that skin hyperplasia requires FGF receptor adaptor protein Frs2alpha and tyrosine phos

218 ficant improvements over control and 0.1% rh-FGF-2/beta-TCP groups.

219 ontrol) and 0.1% recombinant human FGF-2 (rh-FGF-2), 0.3% rh-FGF-2, and 0.4% rh-FGF-2 with beta-TCP-f

220 recombinant human FGF-2 (rh-FGF-2), 0.3% rh-FGF-2, and 0.4% rh-FGF-2 with beta-TCP-following scaling

221 FGF-2 (rh-FGF-2), 0.3% rh-FGF-2, and 0.4% rh-FGF-2 with beta-TCP-following scaling and root planing o

222 n detected a plateau in the 0.3% and 0.4% rh-FGF-2/beta-TCP groups with significant improvements over

223 ects can be enhanced with the addition of rh-FGF-2/beta-TCP.

224 No increases in specific antibody to rh-FGF-2 were detected, and no serious adverse events relat

225 Conversely, inhibition of SMC FGF signaling induces TGFbeta signaling converting proli

226 Here we show that induction of SMC FGF signaling inhibits TGFbeta signaling and converts co

227 ritically important to identify the specific FGF receptor type and its downstream signaling molecules

228 e developmental roles.SIGNIFICANCE STATEMENT FGFs promote a range of developmental processes in many

229 cushion mesenchymal cells where it supports FGF-driven expansion of ECs and then AVC valve extracell

230 our data suggest a model in which sustained FGF signaling acts to suppress cardiomyocyte plasticity

231 Thus, our findings demonstrate that FGF signaling differentially impacts protein synthesis t

232 We also demonstrate that FGF upregulated the production of vascular endothelial g

233 These results demonstrate that FGF-TGFbeta signaling antagonism is the primary regulato

234 We establish that FGF specifically suppresses protein synthesis in chondro

235 Moreover, we find that FGF signaling functions upstream of Nkx genes to inhibit

236 in vivo SIGNIFICANCE STATEMENT: We find that FGF-1 elevates [Ca(2+)]i in spinal astrocytes, which cau

237 se spinal cord slices ex vivo, we found that FGF-1 treatment for 1 h increases the percentage of GFAP

238 Our results indicate that FGF/MAPK blockade may be particularly efficacious agains

239 8 and the isthmic organizer, indicating that FGF and Mek1(DD) initiate qualitatively and/or quantitat

240 dy brings up the intriguing possibility that FGF receptor 2, in the oligodendrocyte/myelin compartmen

241 Here, we report that FGF signaling is a crucial regulator of fungiform papill

242 Live-imaging experiments show that FGF controls the intercalary movements of ventral neural

243 We show that FGF rapidly activates a small circuit of transcription f

244 Here, we show that FGF receptor type 2 (FGFR2) is highly enriched at the pa

245 These observations show that FGF signaling in the osteoprogenitor lineage is obligate

246 Our results show that FGF signaling negatively affects the extent of canonical

247 Here, we show that FGF signaling plays an essential part in enforcing ventr

248 Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystall

249 d gain-of-function experiments, we show that FGF signalling is necessary and sufficient for stratific

250 GMP production in intact tibia, we show that FGF-induced dephosphorylation of NPR2 decreases its guan

251 cting Pten and Ras pathways and suggest that FGF-activated Ras-MAPK pathway is an effective therapeut

252 n factor brachyury We find in zebrafish that FGF is continuously required for paraxial mesoderm (PM)

253 Together, our data suggest that FGFs/FGFRs can be regulated by glutamate transmission to

254 These data suggest that FGFs/FGFRs have a role in stabilizing dendritic patterni

255 The FGF-1 initiated cascade may play an important role in sp

256 veal a novel mode of cooperation between the FGF and BMP pathways in which BMP keeps lens cells in an

257 Failure to establish the FGF-dependent glia structure disrupts precise ORN axon t

258 MSLN also facilitated the FGF-mediated proliferation of WT aPFs.

259 network by which activating mutations in the FGF receptor inhibit bone growth.

260 However, localization of the FGF chemoattractant changes from all muscle membranes to

261 of FGF9 in relation to other members of the FGF family may prove key to understanding vulnerability

262 FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbo

263 gnaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for i

264 Inhibitors of the FGF receptor (Fgfr) and ERK pathways reversed the skewed

265 Activation of the FGF signaling pathway during preimplantation development

266 Furthermore, timed modulation of the FGF-MAPK pathway shows that individual progenitors commi

267 Aberrant signaling of the FGF/FGFR pathway occurs frequently in cancers and is an

268 ge priming is prevented by inhibition of the FGF/MAPK signalling pathway.

269 Here we show, however, that the FGF receptors form dimers in the absence of ligand, and

270 nase (ERK)-cFos pathway after binding to the FGF receptor 1 (FGFR1).

271 However, the identities of these FGF factors, their source tissue and the genes that regu

272 th factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c.

273 Thus FGF signaling lowers cyclic GMP production in the growth

274 Thus, FGF-dependent regulation of endothelial glycolysis is a

275 e response of the FGFR signalling pathway to FGF stimulation.

276 ggers proliferation, chondrocytes respond to FGF with inhibition.

277 ranscription factor NF-kappaB in response to FGF and IL-1/TNF, respectively.

278 This response to FGF-1 was not observed in astrocytes in slices of cerebr

279 to mediate LF differentiation in response to FGF.

280 cells moving actively by chemotaxis towards FGF ligand secreted by the leading cells.

281 ting up a gradient of CXCL12a, and trailing (FGF receptor active) cells moving actively by chemotaxis

282 regulation that is used by chondrocytes upon FGF signaling.

283 -beta increased KL secretion and upregulated FGF receptor (FGFR) 1.

284 We used FGF-receptor signaling to identify EGR1 as a locus that

285 By precisely varying FGF, BMP, WNT, and TGFbeta pathway activity in a minimal

286 romal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive.

287 e that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myoc

288 lkaline phosphatase (Tnap) transcription via FGF receptor-3 (FGFR3) signaling, leading to inhibition

289 When FGF expression was genetically restored in Lhx2-deficien

290 Unlike the majority of cell types where FGF signaling triggers proliferation, chondrocytes respo

291 Wnt signaling initiates EMT, whereas FGF signaling terminates this event.

292 Whether FGF receptors (FGFRs) accomplish such varied tasks in pa

293 We present a model in which FGF generates suprabasal tissue by asymmetric cell divis

294 se results identify mechanisms through which FGF signaling regulates inner cell mass lineage restrict

295 ogether, these data support a model in which FGFs, possibly from axons, activate FGFR2 in the oligode

296 ell understood, the mechanisms through which FGFs induce hepatic character within the endoderm are il

297 expressed in thymic stromal cells along with FGF receptors and its obligate coreceptor, betaKlotho.

298 rotein (BMP) and WNT signaling combined with FGF and retinoic acid treatments over the course of 18 d

299 The in vivo data, together with FGF receptor binding analysis, indicate that the in vivo

300 matory cytokines in cord slices treated with FGF-1.