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1 FIV also encodes a multifunctional OrfA accessory protei
2 FIV employs a distinct strategy to target helper T cells
3 FIV Env might exclude tetherin locally or direct assembl
4 FIV exposure of astrocytes significantly increased the p
5 FIV Gag is a nuclear shuttling protein that utilizes the
6 FIV infection causes AIDS-like disease and mortality in
7 FIV integrated across the entire length of the transcrip
8 FIV integration preferences are more similar to those of
9 FIV subtype D was not detected in any submitted specimen
10 FIV Vif colocalized with feline APOBEC3 (fA3) proteins,
11 FIV virions bearing 39 out of 63 mutant glycoproteins tr
12 FIV-34TF10 in which the OrfA reading frame is open (OrfA
13 FIV-based lentiviral vectors can transfect CE with shRNA
14 FIV-positive cats had significantly less lymph-node enla
21 ed and unvaccinated cats were infected after FIV-PPR challenge and exhibited similar plasma virus loa
22 st, nine cats became antibody positive after FIV vaccination but remained negative in the FIV PCR.
23 s in HIV diagnosis, serum antibodies against FIV classically serve as an indicator of infection statu
34 0 mul for 6 weeks) reduced CXCL10, IL-6, and FIV RNA detection in brain, although PPAR-gamma in glia
37 ic viruses were prepared between FIV-C36 and FIV-PPR, with reciprocal exchanges involving (i) the 3'
38 Moreover, macrophage CD134 expression and FIV infection were enhanced by activation in response to
45 rains (tissue culture adapted [TCA]) such as FIV-34TF10 can bind to HSPG, whereas SU from field strai
50 ino acid sequences are not identical between FIV and HIV, the ability of FIV to bind and utilize both
52 ants, chimeric viruses were prepared between FIV-C36 and FIV-PPR, with reciprocal exchanges involving
56 RDelta vif proviral plasmid DNA or with both FIV-pPPRDelta vif DNA and a feline IFN-gamma expression
57 ants important for HSPG and CXCR4 binding by FIV SU and thus further define the importance of the V3
59 es and meniscal tissue were also infected by FIV(HuMOR), which presumably exerted an antiinflammatory
60 elid species, disease etiology introduced by FIV infection are less clear, but recent studies indicat
61 ncing can be achieved in cells transduced by FIV vectors coexpressing reporter genes and 3' untransla
62 ld disease in the periphery, whereas clade C FIV-C36 causes fulminant disease with CD4(+) T-cell depl
63 lear export pathway with leptomycin B causes FIV Gag but not HIV-1 Gag to accumulate in the nucleus.
64 study we sought to identify and characterize FIV late domain(s) and elucidate cellular machinery invo
70 Furthermore, imaging of intron-containing FIV RNA showed that hCRM1 increased RNA export to the cy
71 ndence on this protein: particles containing FIV Env need tetherin for optimal release from the cell,
75 ding domain of Alix (Alix-V) did not disrupt FIV budding, and FIV Gag peptides showed no affinity for
77 chronic activation of CD8(+) T cells during FIV infection results in chromatin remodeling at the IL-
88 but similar to the Ebola virus glycoprotein, FIV Env did not reduce intracellular or cell surface tet
93 (referred to here as high-virulence FIV [HV-FIV]), and a less-pathogenic strain, FIV-PPR (referred t
96 herefore, this PCR quantitatively identifies FIV subtypes and unambiguously discriminates between FIV
98 TNF- alpha improved listericidal activity in FIV-negative control cats but not in FIV-positive cats,
99 ther, our results demonstrated a decrease in FIV diversity in bone marrow in the presence of PLV.
100 onserved sites and transition frequencies in FIV genes differ among tissues of dual and single infect
104 the role of vif and orfA accessory genes in FIV replication and pathogenicity, we generated chimeras
106 HIV-1-equivalent substitutions were made in FIV PR, and cleavage of each Gag-Pol polyprotein was the
108 termined that mutagenesis of a PSAP motif in FIV Gag, small interfering RNA-mediated knockdown of Tsg
109 vity in FIV-negative control cats but not in FIV-positive cats, whereas IL-10 modestly reduced functi
110 uted in structurally equivalent positions in FIV PR were prepared in order to study the molecular bas
111 loads and a better overall health status in FIV(+) cats, whereas anti-SU antibodies were present ind
112 of these chimeras is more straightforward in FIV than in primate lentiviruses, since FIV accessory ge
113 After the introduction of an inactivated FIV vaccine, this approach has become problematic, since
114 is of minor allele frequencies at individual FIV genome sites revealed 242 sites significantly affect
119 wever, PCR detection of host-cell-integrated FIV DNA will differentiate infection-derived antibody fr
120 , Q99V, and P100N mutations were cloned into FIV Gag-Pol, and those constructs that best approximated
124 omparative analyses of available full-length FIV consisting of subtypes A, B and C from FIVFca, Palla
125 pe surface unit (SU) with CXCR4, full-length FIV SU-Fc as well as constructs with deletions of extend
127 blot screening (domestic cat, puma, and lion FIV antigens) and PCR analysis to survey worldwide preva
136 alyze the specificity changes in each mutant FIV PR expressed in the context of the natural Gag-Pol p
139 t with the above observations, OrfA-negative FIV-34TF10 productively infects CrFK (CD134-negative) an
143 dentical between FIV and HIV, the ability of FIV to bind and utilize both feline and human CXCR4 make
147 distribution, and genomic differentiation of FIV based on 3,055 specimens from 35 Felidae and 3 Hyaen
148 ficiency achieved following a single dose of FIV expressing mouse erythropoietin was insufficient to
149 additively following each of seven doses of FIV delivered over consecutive weeks (1 dose/week), with
152 8+ T cells, concordant with the expansion of FIV into CD8+ T cells with progression of the infection.
155 pe FIVs and chimeras carrying the 3' half of FIV-C36 or the 3' LTR and Rev2 regions of FIV-C36 on the
157 ect evidence for a sequential interaction of FIV Env with CD134 and CXCR4 and reveal the presence of
158 s showed a statistically significant loss of FIV-specific CTL activity, while FIV-infected cats with
159 capitulate the species-specific monophyly of FIV marked by high levels of genetic diversity both with
160 rapid-growth phenotype and pathogenicity of FIV-C36 are the result of evolutionary fine tuning throu
161 c FIVs recapitulated the replication rate of FIV-C36, although most replicated to levels similar to t
165 an and monkey cells, relative restriction of FIV compared to HIV-1 varied from none to substantial, w
166 discrete substitutions in the active site of FIV PR with structurally equivalent residues of HIV-1 PR
167 e receptor utilization of diverse strains of FIV and found that all strains tested utilized CD134 as
171 d that multiple factors, including timing of FIV-pPPRDelta vif inoculations and challenge, as well as
172 of primary sensory neurons via transport of FIV vectors from peripheral nerve endings to sensory gan
173 ith disease progression, the cell tropism of FIV broadens such that B cells and monocytes/macrophages
175 mmunized with either FIVDelta vifATGgamma or FIV-pPPRDelta vif plus pCDNA-IFNgamma, while virus-speci
176 ccinated with either FIVDelta vifATGgamma or FIV-pPPRDelta vif proviral plasmid DNA or with both FIV-
178 ntivirus, feline immunodeficiency virus Pco [FIV-Pco], referred to here as PLV) without evidence of d
179 ding to their high ACE-inhibitory potential, FIV and FV were fractionated by RP-HPLC and then analyze
181 demonstrate the utility of GP64-pseudotyped FIV lentiviral vectors for targeting hepatocytes to corr
183 e given the extensive tropism of pseudotyped FIV vectors for many cell types in vitro and in vivo.
185 r at presentation, IAT significantly reduced FIV (46 cm3 with IAT vs 149 cm3 with IVT or NRT; P < .00
186 CD4+ CD25+ cells were capable of replicating FIV in the presence of interleukin-2 (IL-2) alone, CD4+
187 e envelope glycoprotein (Env), which rescued FIV from carnivore tetherin restriction when expressed i
188 he Okavango Delta in Botswana, both resemble FIV genome sequence from puma, Pallas cat and domestic c
189 onfers on pgtTRIMCyp the ability to restrict FIV in the presence of cyclosporin A, a drug that normal
190 RIM5alpha proteins in feline cells restricts FIV, impairing pseudotyped vector transduction and viral
191 We found that co-infection with PLV shifts FIV diversity from bone marrow to lymph node and spleen.
192 cal IL-1 receptor type I (IL-1RI) signaling, FIV(IL-1Ra) vector was injected into the cisterna magna
193 d in FIV than in primate lentiviruses, since FIV accessory gene open reading frames have very little
195 FIV [HV-FIV]), and a less-pathogenic strain, FIV-PPR (referred to here as low-virulence FIV [LV-FIV])
200 Gag behaviors and raise the possibility that FIV genome encapsidation may initiate in the nucleus.
209 striatum, and hippocampus were higher in the FIV(+)/insulin-treated group compared with the FIV(+)/PB
212 Our data consisted of the 3' half of the FIV genome from three tissues of animals infected with F
216 n, all of the mutant PRs still processed the FIV polyprotein but the apparent order of processing was
217 ns were from cats known to have received the FIV vaccine, which contains FIV subtype A and D inactiva
221 onses, but surprisingly, after 20 weeks, the FIV-ThX cats showed a statistically significant loss of
228 orthy that feline A3Z3 hap V is resistant to FIV Vif-mediated degradation and still inhibits vif-prof
231 l cortex and white matter of insulin-treated FIV(+) animals, with associated preservation of cortical
234 ogenicity, we generated chimeras between two FIV molecular clones with divergent disease potentials:
235 oral cleavage pattern generated by wild-type FIV PR, while maintaining HIV-like inhibitor specificity
237 ests were performed in vivo on the wild-type FIVs and chimeras carrying the 3' half of FIV-C36 or the
238 elium-dependent flow-induced vasodilatation (FIV) assayed in pressurized mesenteric arteries pre-cons
239 FIV-C36 (referred to here as high-virulence FIV [HV-FIV]), and a less-pathogenic strain, FIV-PPR (re
241 tions, to test whether diversity of virulent FIV in lymphoid tissues is altered in the presence of PL
242 cted with the feline immunodeficiency virus (FIV) (Cre) vector in the right and left temporomandibula
244 oculated with feline immunodeficiency virus (FIV) and monitored for their FIV-specific CTL responses.
246 nfection with feline immunodeficiency virus (FIV) causes an immunosuppressive disease whose consequen
248 tors based on feline immunodeficiency virus (FIV) could be used for coexpression of reporter construc
249 ) facilitated feline immunodeficiency virus (FIV) entry into CXCR4-positive, cell surface CD134-negat
250 usly observed feline immunodeficiency virus (FIV) Gag accumulating at the nuclear envelope during liv
253 the course of feline immunodeficiency virus (FIV) infection suppress CD8(+) CTL function in a TGF-bet
254 that in vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates
259 tic cats with feline immunodeficiency virus (FIV) is an important model system for studying human imm
262 poration onto feline immunodeficiency virus (FIV) particles, transduction efficiency, receptor bindin
263 We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the m
265 n and blocked feline immunodeficiency virus (FIV) replication in lymphoid and nonlymphoid feline cell
266 1 (HIV-1) and feline immunodeficiency virus (FIV) reverse transcriptases (RT), were identified using
270 ce, using the feline immunodeficiency virus (FIV) vector, which is capable of stably transducing divi
271 us (BIV), and feline immunodeficiency virus (FIV) Vif appear specific to the A3Z3-type protein of the
272 expression of feline immunodeficiency virus (FIV) Vif-green fluorescent protein (GFP) in HIV-1 entry
273 ular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct mo
274 ), HIV-1, and feline immunodeficiency virus (FIV), and have been postulated to encode proteins import
275 virus (EIAV), feline immunodeficiency virus (FIV), and Rous sarcoma virus (RSV) to critically address
276 strict HIV-1, feline immunodeficiency virus (FIV), equine infectious anemia virus (EIAV), or N-tropic
277 receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD
278 receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD
279 lication of a feline immunodeficiency virus (FIV)-based lentivirus vector (GP64-FIV) to murine nasal
281 e efficacy of feline immunodeficiency virus (FIV)-based vectors in targeting hepatocytes and correcti
287 ious chimeric feline immunodeficiency virus (FIV)/HIV strain carrying six HIV-like protease (PR) muta
289 olving virus (feline immunodeficiency virus, FIV) can reveal details of the contemporary population s
290 hy, similar to human immunodeficiency virus, FIV, and simian immunodeficiency virus (SIV) neuropathie
291 e feline and human immunodeficiency viruses (FIV and HIV) target helper T cells selectively, and in d
292 ed with significant immunopathology in vivo, FIV-C36 (referred to here as high-virulence FIV [HV-FIV]
293 al therapy in reducing final infarct volume (FIV) in intracranial large-vessel occlusions (ILVOs) are
294 dies have demonstrated that the way in which FIV interacts with its primary receptor, CD134, alters a
295 ant loss of FIV-specific CTL activity, while FIV-infected cats with intact thymuses continued to main
296 ngly, the lack of protection associated with FIV-pPPRDelta vif DNA immunization contrasted with findi
299 from three tissues of animals infected with FIV alone, or with FIV and PLV, sequenced by 454 technol
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