ライフサイエンスコーパス: FK506-binding protein

1 o interact with Cnb1p, calmodulin, or Fkb1p (FK506-binding protein).

2 nd channels deficient in immunophilin 12-kDa FK506-binding protein.

3 iphosphate-binding cassette transporters and FK506-binding proteins.

4 is in many ways an exceptional member of the FK506-binding proteins.

5 FK506-binding protein 10 (FKBP10) is a collagen chaperon

6 Loss of function mutations in FK506-binding protein 10 (FKBP10), encoding the FKBP65 p

7 entrapped in the core of ELP nanoparticles, FK506 binding protein 12 (FKBP), which is the cognate pr

8 in binds intracellularly to the immunophilin FK506 binding protein 12 (FKBP12), and the resultant com

9 t to tacrolimus, indolyl-ASC binds poorly to FK506 binding protein 12 (FKBP12), the major cytosolic r

10 in mice in the context of rapamycin-induced FK506 binding protein 12 (FKBP12)-FKBP12 rapamycin bindi

11 ated hearts from mutant embryos deficient in FK506 binding protein 12 (FKBP12).

12 h genotype shows similar expression of RyR1, FK506 binding protein 12 kDa, and Ca(2+)-ATPase, but RyR

13 Dissociation of the small FK506 binding protein 12 subunit (FKBP12) increases RyR1

14 FKBP12 (FK506 binding protein 12) is a prolyl cis-trans isomeras

15 Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of r

16 N-dependent transcription factor family, and FK506 binding protein 12/12.6 (FKBP12/12.6), effectors o

17 FK506 binding proteins 12 and 12.6 (FKBP12 and FKBP12.6)

18 the kinase mammalian target of rapamycin and FK506-binding protein 12 (FKBP), respectively, the optim

19 cross-linkable form of clathrin by using an FK506-binding protein 12 (FKBP)-clathrin fusion protein

20 tes to BCR-mediated lytic induction and that FK506-binding protein 12 (FKBP12) binding alone is not a

21 FK506-binding protein 12 (FKBP12) binds the immunosuppre

22 The FK506-binding protein 12 (FKBP12) is a cytoplasmic prote

23 A series of mutations to FK506-binding protein 12 (FKBP12) were designed to vary

24 u-Pro substitutions prevent interaction with FK506-binding protein 12 (FKBP12), whose putative functi

25 inding of RAPA to its intracellular receptor FK506-binding protein 12 (FKBP12).

26 th factor (PDGF) beta receptors fused to the FK506-binding protein 12 (FKBP12).

27 n transgenic plants deficient in Arabidopsis FK506-binding protein 12 (FKP12), whereas FKP12 overexpr

28 for the small molecule synthetic ligand for FK506-binding protein 12 (SLF).

29 a(2+) channel (dihydropyridine receptor) and FK506-binding protein 12 as well as in "hot spot" region

30 rane domain of HMGR fused to three copies of FK506-binding protein 12, we were able to induce oligome

31 labeled CaM binding near donor-labeled FKBP (FK506-binding protein 12.6) on the cytoplasmic domain of

32 Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regul

33 we found that hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regul

34 e found that expression of the gene encoding FK506-binding protein 12.6/1b (FKBP1b), a small immunoph

35 Recently, we found that FK506-binding protein 12.6/1b (FKBP1b), a small protein

36 , including skeletal triadin, calsequestrin, FK506-binding protein, 12 kD, sarco(endo)plasmic reticul

37 In vitro, GPI-1046 bound to FK506 binding protein-12 and elicited neurite outgrowth

38 C bound about 10 times less to intracellular FK506 binding protein-12 than tacrolimus or ASC.

39 T cells through formation of a complex with FK506 binding protein-12, which inhibits the phosphatase

40 Phosphatidic acid (PA) interacts with the FK506-binding protein-12-rapamycin-binding (FRB) domain

41 e N-terminal region (amino acids 1-331) with FK506-binding protein 13 (FKBP13).

42 In cardiomyocytes, FK506-binding protein 1b/12.6 (FKBP1b) binds and stabili

43 We previously identified the FK506 binding protein 38 (FKBP38) as a negative regulato

44 that PA competes with the mTORC1 inhibitor, FK506 binding protein 38 (FKBP38), for mTOR binding at a

45 FK506-binding protein 38 (FKBP38), a membrane-anchored,

46 ine methylation within the gene encoding for FK506 binding protein 5 (FKBP5) was measured in Holocaus

47 ion, we examined two genes (prodynorphin and FK506 binding protein 5) that are strongly regulated by

48 ylase, brain-derived neurotrophic factor and FK506 binding protein 5.

49 e response regions of progesterone-regulated FK506-binding protein 5 (FKBP5) immunophilin and small R

50 evels of the glucocorticoid-responsive genes FK506-binding protein 5 (Fkbp5), Period 1 (Per1), and se

51 The FKBP5 gene codes for a co-chaperone, FK506-binding protein 5, that exerts negative feedback o

52 Single nucleotide polymorphisms of the FK506 binding protein 51 (FKBP51) gene have been repeate

53 d that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylat

54 FK506 binding protein 51 (FKBP51, also called FKBP5) bel

55 FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5)

56 eased the relative association of Hsp90 with FK506 binding protein 51 versus FK506 binding protein 52

57 portant modulator of stress responses is the FK506-binding protein 51 (FKBP5/FKBP51).

58 The FK506-binding protein 51 (FKBP51) is a key regulator of

59 The FK506-binding protein 51 (FKBP51) is a promising drug ta

60 FK506-binding protein 51 (FKBP51) is gaining increased r

61 enes and ESTs, delta-sarcoglycan, myosin Va, FK506-binding protein 51 (FKBP51), the potassium channel

62 In the quest for lead-like ligands for the FK506-binding protein 51 (FKBP51), we designed two new c

63 Here, we show that the Hsp90 cochaperone, FK506-binding protein 51 (FKBP51), which possesses both

64 enes and markedly up-regulated expression of FK506-binding protein 51 (FKBP51).

65 ic antigen, transmembrane protease serine 2, FK506-binding protein 51 and fatty acid synthase.

66 FK506-binding protein 51 is involved in hypothalamic-pit

67 ocorticoid-induced leucine zipper (GILZ) and FK506 binding protein-51 (FKBP51)].

68 f Hsp90 with FK506 binding protein 51 versus FK506 binding protein 52 and inhibited hormone-induced G

69 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that

70 FK506-binding protein 52 (FKBP52) is an immunophilin tha

71 the immunosuppressant drug FK506, termed the FK506-binding protein 52 (FKBP52).

72 es that form complexes with caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin

73 own that male mice with targeted ablation of FK506-binding protein-52 (Fkbp52) develop hypospadias, m

74 ations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (FKBP65/FKBP10).

75 Heat shock protein 47 (HSP47) and FK506-binding protein-65 (FKBP65) defects cause types X

76 Here we focus on the role of FK506-binding protein 8 (FKBP8) in controlling neural ce

77 We have now examined the role of FK506-binding protein 8 (FKBP8), a component of the CFTR

78 protein 90 (Hsp90)-associated co-chaperones: FK506-binding protein 8 (FKBP8), activator of Hsp90 ATPa

79 sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-

80 FK1012-induced dimerization of GFP fused to FK506-binding protein and clustering of glycosylphosphat

81 Rapamycin, which forms a complex with FK506-binding protein and FK506-binding protein-rapamyci

82 control of rapamycin-induced dimerization of FK506-binding protein and FKBP12-rapamycin-binding prote

83 trin), and Ca2+ release (ryanodine receptor, FK506-binding protein and junctin) during excitation-con

84 ch induces a tight association between FKBP (FK506-binding protein) and FRAP (FKBP-rapamycin-associat

85 t into two moieties that were fused to FKBP (FK506-binding protein) and FRB (rapamycin-binding domain

86 perativity can be affected by the binding of FK506 binding protein, and hence, modulated by adrenergi

87 ting of an invariant ligand that targets the FK506-binding protein (AP1867) attached to 320 substitut

88 ains a domain similar to that found in other FK506-binding proteins, ARA9 binding to 3H-FK506 could n

89 mplex including calstabin (formerly known as FK506-binding protein), calmodulin, phosphodiesterase, k

90 f cooperativity, regulated by the binding of FK506 binding-protein, can have a dramatic effect on the

91 gh-resolution X-ray structures of ubiquitin, FK506-binding protein, chymotrypsin inhibitor 2, and rub

92 rapamycin, indicating a member of the FKBP (FK506-binding protein) class.

93 S107 (a stabilizer of RyR1-FK506 binding protein coupling that reduces Ca(2+) leak)

94 ing the signaling domain of Mpl linked to an FK506 binding protein domain (to permit dimerization by

95 Like immunophilins, Shut-down contains an FK506-binding protein domain and a tetratricopeptide rep

96 a by dimerizing rapamycin-binding domain and FK506-binding protein domains that are attached to ciste

97 romosomal damage and a critical function for FK506 binding proteins during meiosis.

98 d a chimeric receptor composed of a modified FK506-binding protein (F36V) fused with the fibroblast g

99 the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae

100 peptidyl-prolyl cis/trans-isomerases of the FK506-binding protein family and may be involved in fold

101 We show that a member of the FK506-binding protein family, FKBP8, is an essential ant

102 se AIP exhibits homology with members of the FK506-binding protein family.

103 lin production, whereas the immunomodulatory FK506 binding protein (FK506BP) was up-regulated.

104 Cyclophilin and FK506 binding protein (FKBP) accelerate cis-trans peptid

105 ocytes, we expressed a fusion protein of the FK506 binding protein (FKBP) and caspase 8 under control

106 rapamycin-inducible interaction between the FK506 binding protein (FKBP) and the FKBP-rapamycin bind

107 The FK506 binding protein (FKBP) family of proteins provide

108 ch signaling domain was incorporated into an FK506 binding protein (FKBP) fusion to allow for its spe

109 orresponding with the entire sequence of the FK506 binding protein (FKBP) has been investigated in aq

110 a modified human caspase 9 fused to a human FK506 binding protein (FKBP) to allow conditional dimeri

111 omerizing proteins engineered to contain the FK506 binding protein (FKBP), to trigger Fas via FKBP-li

112 Expression of FK506 binding protein (FKBP)-clathrin light chain chimer

113 Our data revealed that both the FK506 binding protein (FKBP)-like domain and the tetratr

114 e of 3247 small molecules for binding to the FK506 binding protein (FKBP).

115 of fragments against the active sites of the FK506 binding protein (FKBP-12) and HIV-1 aspartyl prote

116 s responsible for primary recognition by the FK506 binding protein (FKBP-12), along with a diverse re

117 ted the molecular events associated with the FK506 binding proteins (FKBP) -52 and -51 response to co

118 y bind to the same set of immunophilins, the FK506 binding proteins (FKBP).

119 )-2alpha as well as high-level expression of FK506-binding protein (FKBP) 12 by HGA.

120 vated splenic T lymphocytes deficient in the FK506-binding protein (FKBP) 12, a target of rapamycin a

121 hia coli as fusions to the C-terminus of the FK506-binding protein (FKBP) and purified from freeze-th

122 (also identified as FKBP52), a member of the FK506-binding protein (FKBP) class of immunophilins, was

123 This methodology relies on a mutated FK506-binding protein (FKBP) destabilizing domain (dd) f

124 Typically, FK506-binding protein (FKBP) domains are fused to a sign

125 chimeric PECAM-1 cDNAs containing one or two FK506-binding protein (FKBP) domains at their COOH termi

126 The FK506-binding protein (FKBP) family of peptidyl-prolyl i

127 gulates mTOR through FKBP38, a member of the FK506-binding protein (FKBP) family that is structurally

128 Mips are part of the FK506-binding protein (FKBP) family, whose members typic

129 In addition, their complexes with the 12-kDa FK506-binding protein (FKBP) form more stable complexes

130 We constructed an AblNuk-FK506-binding protein (FKBP) fusion protein to enforce t

131 Dimerization of a TRH receptor-FK506-binding protein (FKBP) fusion protein was stimulat

132 , a cell-permeable molecule used to dimerize FK506-binding protein (FKBP) fusion proteins and initiat

133 The FK506-binding protein (FKBP) is an important regulator o

134 between five single-cysteine variants of the FK506-binding protein (FKBP) labeled with a donor probe,

135 For example, a cell-permeable, bivalent FK506-binding protein (FKBP) ligand stimulated clusterin

136 the chemically inducible dimerization domain FK506-binding protein (FKBP) or to the hexameric protein

137 chimeric molecule by fusing a domain of the FK506-binding protein (FKBP) to the C terminus of APP.

138 Furthermore, fusion of a FK506-binding protein (FKBP) to the N terminus of human

139 el activity is modulated by interaction with FK506-binding protein (FKBP), and disruption of the RyR-

140 asmic reticulum membranes with a fluorescent FK506-binding protein (FKBP), and FRET was determined fo

141 mmunophilin receptors, cyclophilin (CyP) and FK506-binding protein (FKBP), respectively.

142 This study was intended to examine whether FK506-binding protein (FKBP), which is tightly associate

143 the scattering data features two independent FK506-binding protein (FKBP)-like and tetratricopeptide

144 The rapamycin and FK506-binding protein (FKBP)-target 1 (RAFT1, also known

145 Fas intracellular domain, and 2 copies of an FK506-binding protein (FKBP).

146 how that the SPRY1 domain is located next to FK506-binding protein (FKBP).

147 and with FRET measurements involving RyR and FK506-binding protein (FKBP).

148 ity for the abundant, cytoplasmic chaperone, FK506-binding protein (FKBP).

149 The FK506-binding proteins (FKBP) 51 and 52 are cochaperones

150 FK506-binding proteins (FKBP) 51 and 52 are cochaperones

151 FK506-binding proteins (FKBP) are immunophilins that int

152 containing synthetic ligand binding domains (FK506-binding protein [FKBP] or FKBP-rapamycin-binding d

153 Here we show that the C.albicans FK506 binding protein FKBP12 homolog is required for FK5

154 Raf kinase activity, sequences encoding the FK506-binding protein FKBP12 were fused to the amino ter

155 e Ca(2+) channel CaV1.1, calmodulin, and the FK506-binding protein FKBP12, as well as in "hot spot" r

156 ene encoding a fusion protein containing the FK506-binding protein FKBP12, fused to the intracellular

157 ain, has been determined in complex with the FK506-binding protein FKBP12.

158 ncrease) and unaltered RyR2 affinity for the FK506-binding protein FKBP12.6 (Kd~0.8 nmol/L).

159 FK506-binding proteins FKBP12.6 and FKBP12 are associate

160 of fusion proteins, with c-Kit linked to the FK506 binding protein (FKBP12) and Flt-3 linked to the F

161 : green fluorescent protein (GFP) fused with FK506 binding protein (FKBP12) and GFP fused with the an

162 e cytoplasmic scaffold domain, including the FK506 binding protein (FKBP12) and PKA.

163 The 12 kDa FK506 binding protein (FKBP12) mediates the action of bo

164 lution-phase properties of six inhibitors of FK506 binding protein (FKBP12) were investigated using f

165 Members of this family, and notably FK506 binding protein (FKBP12), are thought to be involv

166 Because MIS releases FK506 binding protein (FKBP12), which activates the mamm

167 PKA-hyperphosphorylated and depleted of the FK506 binding protein (FKBP12).

168 65,000-dalton RyR1s, each of which binds one FK506 binding protein (FKBP12).

169 The FK506 binding protein (FKBP12.6) stabilizes RyR2, preven

170 ing." Removal of the regulatory subunit, the FK506 binding protein (FKBP12.6), functionally but not p

171 four type 2 RyR polypeptides (RyR2) and four FK506 binding proteins (FKBP12.6).

172 nosuppressive agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin-as

173 The 12 kDa FK506-binding protein (FKBP12) constitutively binds to t

174 One chimera consists of a FK506-binding protein (FKBP12) fused to a cellular 'addr

175 FK506-binding protein (FKBP12) has been found to be asso

176 The FK506-binding protein (FKBP12) is important in the immun

177 n-mediated interaction of the human proteins FK506-binding protein (FKBP12) rapamycin-binding domain

178 ependent interaction between calcineurin and FK506-binding protein (FKBP12), an accessory subunit of

179 dulatory ligands, calmodulin (CaM) or 12-kDa FK506-binding protein (FKBP12), have been characterized

180 peptidyl-propyl isomerases cyclophilin A and FK506-binding protein (FKBP12), respectively, block cyto

181 onstants were determined for those amides of FK506-binding protein (FKBP12), ubiquitin, and chymotryp

182 dependent on its interaction with the 12-kDa FK506-binding protein (FKBP12).

183 phatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12).

184 on of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12).

185 Calmodulin (CaM) and FK506-binding protein (FKBP12.6) bind to RyR2 and stabil

186 o directly disrupt the binding of a 12.6-kDa FK506-binding protein (FKBP12.6) to RyR2, causing a RyR2

187 This study investigated the function of FK506-binding protein (FKBP12.6) using adenoviral-mediat

188 inds predominantly a 12.6-kDa isoform of the FK506-binding protein (FKBP12.6), whereas RyR2 from othe

189 The 12-kDa FK506-binding proteins (FKBP12 and FKBP12.6) are regulat

190 ternae (TC) contains four tightly associated FK506-binding proteins (FKBP12).

191 phorylation and depletion of the stabilizing FK506 binding protein, FKBP12.6.

192 The FK506-binding protein, FKBP12, is a putative target of t

193 t involving an endogenous ER-localized 13-kD FK506 binding protein (FKBP13) competing with the FKBP12

194 and bronchial epithelial gene expression of FK506 binding protein (FKBP5), an indicator of steroid r

195 ucocorticoid receptors (GRs), and (4) 51 kDa FK506-binding protein (FKBP5).

196 The large FK506-binding protein FKBP52 has been characterized as a

197 The 52 kDa FK506 binding protein (FKBP52) is an important positive

198 Because ARA9 closely resembles the 52-kDa FK506-binding protein (FKBP52), found in the unliganded

199 the immunosuppressant drug FK506, termed the FK506-binding protein (FKBP52), interacts with the singl

200 identical to the Drosophila homolog of human FK506-binding protein, FKBP52 (previously known as FKBP5

201 shock protein 47 (Hsp47/SERPINH1) and 65-kDa FK506-binding protein (FKBP65/FKBP10), have been shown t

202 The cyclophilins and FK506 binding proteins (FKBPs) bind to cyclosporin A, FK

203 family of intracellular receptors termed the FK506 binding proteins (FKBPs).

204 FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs).

205 omerases have been identified: cyclophilins, FK506-binding proteins (FKBPs) and parvulins.

206 FK506-binding proteins (FKBPs) are cellular receptors fo

207 FK506-binding proteins (FKBPs) are peptidyl-prolyl cis/t

208 some amino acid sequence similarity to human FK506-binding proteins (FKBPs) in residues 166 to 252 lo

209 FK506-binding proteins (FKBPs) represent one of the thre

210 Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones w

211 ) are a chaperone superfamily comprising the FK506-binding proteins (FKBPs), cyclophilins, and parvul

212 losporin-binding cyclophilins (CyPs) and the FK506-binding proteins (FKBPs).

213 The RyRs are physically associated with FK506-binding proteins (FKBPs); immunophilins, with cis-

214 These proteins include calstabins [FK506-binding proteins (FKBPs)], calmodulin (CaM), phosp

215 eric FK506 analog that binds to the attached FK506-binding proteins, FKBPs.

216 the immunophilin family of proteins, and the FK506-binding proteins form the FKBP subfamily of immuno

217 Here, we show that the FK506 binding protein Fpr3 prevents premature adaptation

218 yR1 and Ser-2809 in RyR2 and dissociation of FK506-binding proteins from the receptors have been impl

219 eby a chimeric PrP(C) composed of a modified FK506-binding protein (Fv) fused with PrP(C) and termed

220 domain) was fused with a cDNA for a modified FK506-binding protein, Fv (Fv-SLK 1-373).

221 Some FKBPs, notably FKBP12 (the 12-kDa FK506-binding protein), have defined roles in regulating

222 he folding pathway of human FKBP12, a 12 kDa FK506-binding protein (immunophilin), has been character

223 ls by affinity chromatography using 12.6-kDa FK506-binding protein in the form of a GST fusion as the

224 erization of PLU via fusion to either GST or FK506 binding protein (in the presence of dimerizing age

225 the immunophilins, cyclophilin A, and 12-kDa FK506-binding protein, in resting human Jurkat T cells.

226 Through insertion of a modified FK506 binding protein (insertable FKBP12, iFKBP) into th

227 mall-molecule drug discovery, as engineering FK506-binding protein into intracellular sites within Ca

228 The discovery that FK506 binding protein is a steroid binding protein may b

229 The recognition protein (FK506 binding protein) is inserted into functionally-ina

230 FKBP65 (65-kDa FK506-binding protein) is a member of the highly conserv

231 FKBP12, the 12-kDa FK506-binding protein, is a ubiquitous abundant protein

232 amino acid sequence similarity to the 52-kDa FK506-binding protein known to be associated with the gl

233 romosome 6p21.3 at TNXB (tenascin XB)-FKBPL (FK506 binding protein like) [rs12153855/rs9391734; disco

234 the channel-stabilizing subunit calstabin2 (FK506-binding protein or FKBP12.6) causes SR Ca2+ leak i

235 rms a complex with FK506-binding protein and FK506-binding protein-rapamycin-associated protein, indu

236 bind proteins known as cyclophilin (Cyp) and FK506-binding protein, respectively, and the drug-protei

237 Bastadin, a novel modulator of the 12-kDa FK506 binding protein.RyR complex, increased [3H]ryanodi

238 rotein and includes rapamycin and the 12-kDa FK506 binding protein target 1.

239 dao-1, dao-8 and dao-9 are homologs of the FK506 binding proteins that interact with the mammalian

240 L. pneumophila Mip is a surface-exposed, FK506-binding protein that is needed for optimal infecti

241 FKBP38 is a member of the family of FK506-binding proteins that acts as an inhibitor of the

242 2-rapamycin-binding domain (FRB) and FKBP12 (FK506 binding protein), the interaction of hypoxia-induc

243 ther proteins, including calmodulin, FKBP12 (FK506-binding protein), the ryanodine receptor, and the

244 n blot analysis showed comparable binding of FK506-binding proteins to wild type and mutant receptors

245 Mutation of the immunophilin-like FK506-binding protein TWISTED DWARF1 (FKBP42/TWD1) cause

246 The role of slyD, which encodes a FK506 binding protein-type peptidyl-prolyl cis-trans iso

247 compounds with nanomolar affinities for the FK506 binding protein were rapidly discovered by tetheri

248 transactivation domains, each linked to the FK506 binding protein, were expressed in normal human sk

249 ation of receptor function by FKBP52 (52-kDa FK506-binding protein), which acts at a later stage of t

250 ay has been investigated in a variant of the FK506 binding protein with three additional residues at

251 Here, we assess the impact of FK506-binding protein with a molecular mass of approxima

252 lyses demonstrated CG17282 is a noncanonical FK506-binding protein with an inactive peptide prolyl-is