ライフサイエンスコーパス: FMD

1 FMD and arterial distensibility are critical components

2 FMD and BAD were measured by brachial artery ultrasound

3 FMD and NTG-mediated dilation were significantly lower i

4 FMD cycles restore insulin secretion and glucose homeost

5 FMD in buffaloes offers a unique opportunity to study FM

6 FMD lesions were reviewed and classified according to co

7 FMD patients with dissection were younger at presentatio

8 FMD remains one of the most devastating diseases that af

9 FMD values at 1 year (9.3% +/- 7.1%) were significantly

10 FMD was identified in the renal artery in 294 patients,

11 FMD was not significantly associated with short-term var

12 FMD was significantly lower after the LKHN than after th

13 FMD with the HS reference diet was 6.7 +/- 2.2%, and cha

14 FMD, 8-isoPGF2alpha, and p66(Shc) expression were not af

15 uencing and targeted Sanger sequencing in 19 FMD-affected individuals with no identifiable FLNA mutat

16 placebo P = 0.287; prazosin: P = 0.110); (2) FMD remained unchanged after maximal exercise at sea lev

17 in the control group (FMD-pre, 8.27+/-1.52; FMD-post, 4.66+/-0.70; P=0.06; L-FMC-pre, -3.26+/-1.19;

18 after catheterization (FMD-pre, 6.84+/-0.79; FMD-post, 6.85+/-1.16; L-FMC-pre, -2.14+/-1.42; L-FMC-po

19 c, and therapeutic procedure results for 921 FMD patients enrolled in the registry as of October 17,

20 udy was to understand the possible role of a FMD virus protein 3A, in causing disease in cattle.

21 These results indicate that a FMD promotes the reprogramming of pancreatic cells to re

22 ism by which dietary flavonoids could affect FMD is that they improve the bioactivity of the endothel

23 PS intake did not affect FMD (+0.01 percentage points; 95% CI: -0.73, 0.75) compa

24 apeutic and enhancer of IFN activity against FMD virus (FMDV).

25 enes is a viable strategy to protect against FMD.

26 IRF7/3(5D) completely protects swine against FMD by inducing a strong type I IFN response and highlig

27 Conversely, at high altitude, FMD was unaltered following moderate-intensity exercise,

28 and one-pass construction of unitigs from an FMD-index.

29 genes in vitro and prevented mortality in an FMD mouse model when delivered with a replication-defect

30 ts divided into two groups: SRP (n = 45) and FMD (n = 45).

31 escribed to improve endothelial function and FMD.

32 Effects on HOMA-IR and FMD remained stable to sensitivity analyses.

33 scosity, plasma free hemoglobin, TR jet, and FMD were measured in chronically transfused SCD pre- and

34 In conclusion, preoperative NMD and FMD positively associated with changes in 6-week AVF blo

35 Periodontal inflamed surface area (PISA) and FMD were assessed in all patients.

36 ferences were identified between the SRP and FMD groups in regard to OHQoL and OIDP scores when compa

37 Patients treated by both SRP and FMD showed improvement in all periodontal clinical param

38 In our patient sample, TR jet velocity and FMD were most strongly associated with plasma free hemog

39 free hemoglobin and both TR jet velocity and FMD.

40 However, brachial artery FMD (ET: 3.8 +/- 3.0% vs. CT: 4.3 +/- 3.5%, p = 0.88), a

41 Peak Vo2, brachial artery FMD in response to cuff ischemia, carotid artery distens

42 ced significant decreases in brachial artery FMD of all groups (P < 0.05).

43 Brachial artery FMD, carotid-femoral PWV, central AIx, and blood pressur

44 cise bout and in response to brachial artery FMD, measured prior to, immediately after and 60 min aft

45 beads" that may be observed in renal artery FMD does not occur in coronary arteries, potential manif

46 ion into unifocal or multifocal renal artery FMD is straightforward and discriminates 2 groups of pat

47 in patients presenting with visceral artery FMD.

48 applied to disease outbreak problems such as FMD in order to investigate the performance improvement

49 urther 8 volunteers of each sex, we assessed FMD response to glyceryl trinitrate (GTN) at baseline an

50 Baseline FMD was reduced in IR, and postprandial FMD attenuation

51 ses revealed that, in subjects with baseline FMD >/=3%, hesperidin 2S improved ED after an HFM and re

52 ysis was performed in subjects with baseline FMD >/=3%.

53 In the training study, both FMD and L-FMC of the catheterized arm were preserved in

54 (+) count was 561 cells/microL, and brachial FMD was 4.2%.

55 Aortic stiffness tended to decrease, but FMD was not changed.

56 ction in endothelial function as assessed by FMD.

57 works studied the local immunity induced by FMD vaccines at the respiratory mucosa, and local respon

58 observed in vitro, the vascular response by FMD was worse in NASH as compared with NAFL.

59 xercise group 7 weeks after catheterization (FMD-pre, 6.84+/-0.79; FMD-post, 6.85+/-1.16; L-FMC-pre,

60 e are ongoing efforts to better characterize FMD and define its genetic and molecular basis.

61 However, at 1 h after consumption, FMD increased dose dependently to </=766 mg total bluebe

62 In contrast, FMD increased (37%) immediately following exercise in th

63 virus (FMDV) is widely practiced to control FMD.

64 lae (Cav-1 knockout mice) abolished coronary FMD, which was rescued by sepiapterin, the stable precur

65 NO-mediated coronary FMD was significantly reduced in DM patients, which was

66 Angiographic manifestations of coronary FMD aside from dissection were considered rare.

67 and intracoronary manifestations of coronary FMD.

68 Sepiapterin also restored coronary FMD in DM patients.

69 However, we observed several coronary FMD angiographic abnormalities with corresponding optica

70 imaging of patients with suspected coronary FMD at Vancouver General Hospital were reviewed.

71 ould be economically appealing to counteract FMD.

72 s of protective responses induced by current FMD vaccines as well as to provide alternative parameter

73 Currently, FMD vaccine manufacturing requires the growth of large v

74 ound increased TR jet velocity and decreased FMD in nontransfused SCD patients compared with the othe

75 f chemotherapy and a fasting-mimicking diet (FMD) increases the levels of bone marrow common lymphoid

76 In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, f

77 assessed by using flow-mediated dilatation (FMD) and arterial compliance as assessed by using pulse

78 luated by means of flow-mediated dilatation (FMD) of the brachial artery.

79 by brachial artery flow-mediated dilatation (FMD) was measured before, immediately following and 60 m

80 use of ultrasound flow-mediated dilatation (FMD).

81 cise reductions in flow-mediated dilatation (FMD).

82 nction measured by flow mediated dilatation (FMD).

83 pressure (cPP) and flow-mediated dilatation (FMD).

84 brachial artery by flow-mediated dilatation (FMD).

85 ) was assessed by flow-meditated dilatation (FMD) at baseline and 6 mo.

86 l-dependent flow-mediated arterial dilation (FMD) and carotid artery stiffness, and their potential c

87 ial artery L-FMC and flow-mediated dilation (FMD) after transradial catheterization.

88 rachial NO-dependent flow-mediated dilation (FMD) and cardiovascular disease risk has been investigat

89 ined brachial artery flow-mediated dilation (FMD) and circulating microparticles before and after 20

90 flavonoid intake on flow-mediated dilation (FMD) and polyphenol absorption and metabolism was assess

91 thelial function via flow-mediated dilation (FMD) assessment in periodontal health and disease.

92 e in brachial artery flow-mediated dilation (FMD) in participants with complete follow-up scans.

93 Flow-mediated dilation (FMD) increased significantly after both whey-protein and

94 Flow-mediated dilation (FMD) of coronary arterioles was investigated in DM (n =

95 unction, assessed by flow-mediated dilation (FMD) of the brachial artery and TR jet velocity, respect

96 tion was assessed by flow-mediated dilation (FMD) of the brachial artery preexposure, immediately pos

97 ing ischemia-induced flow-mediated dilation (FMD) of the brachial artery.

98 ing; brachial artery flow-mediated dilation (FMD) was measured before and after each meal.

99 othelial function by flow-mediated dilation (FMD), and arterial stiffness by applanation tonometry.

100 ndothelial-dependent flow-mediated dilation (FMD), and flow-independent nitroglycerin (NTG)-mediated

101 come was a change in flow-mediated dilation (FMD), and secondary outcomes were changes in carotid to

102 Arterial stiffness, flow-mediated dilation (FMD), nitroglycerin-mediated dilation (GMD), urinary nit

103 nction tests (VFTs): flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), carotid-fem

104 wk of intervention, flow-mediated dilation (FMD), soluble vascular adhesion molecule-1 (sVCAM-1), so

105 Brachial artery flow-mediated dilation (FMD), urinary 8-isoprostaglandin F2alpha (8-isoPGF2alpha

106 ction as measured by flow-mediated dilation (FMD).

107 thickness (cIMT) and flow-mediated dilation (FMD).

108 sing brachial artery flow-mediated dilation (FMD).

109 function by means of flow-mediated dilation (FMD).

110 ery occlusion [i.e., flow-mediated dilation (FMD)] and before and after nitroglycerin-mediated dilati

111 Flow-mediated-dilation (FMD) was also performed.

112 uit (brachial artery flow-mediated dilation [FMD(BA)]) and resistance (forearm blood flow responses t

113 Foot-and-mouth disease (FMD) can cause large disruptive epidemics in livestock.

114 ement proceeds, with foot-and-mouth disease (FMD) culling and measles vaccination as case studies.

115 ngs on the size of a Foot-and-Mouth Disease (FMD) epidemic.

116 effectively control foot-and-mouth disease (FMD) in cattle and swine during experimental infections.

117 Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccina

118 Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting biun

119 Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animal

120 Foot-and-mouth disease (FMD) is one of the most feared viral diseases that can a

121 andidates.IMPORTANCE Foot-and-mouth disease (FMD) is the most devastating disease affecting livestock

122 Foot-and-mouth disease (FMD) remains one of the most devastating livestock disea

123 Production of foot-and-mouth disease (FMD) vaccines requires cytosolic expression of the FMDV

124 Foot-and-mouth disease (FMD) virus (FMDV) circulates as multiple serotypes and s

125 ntial eradication of foot-and-mouth disease (FMD).

126 formed by one-stage full-mouth disinfection (FMD) within 24 hours or conventional quadrant scaling (Q

127 drant and one-stage full-mouth disinfection (FMD), on periodontal clinical parameters and OHRQL of pa

128 Patients with functional motor disorder (FMD) including weakness and paralysis are commonly refer

129 association between fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection.

130 Fibromuscular dysplasia (FMD) involving the coronary arteries is an uncommon but

131 Fibromuscular dysplasia (FMD) is a heterogeneous group of non-atherosclerotic and

132 Fibromuscular dysplasia (FMD) is a nonatheromatous, noninflammatory arterial diso

133 Fibromuscular dysplasia (FMD) is a noninflammatory arterial disease that predomin

134 Fibromuscular dysplasia (FMD) is a rare, nonatherosclerotic arterial disease for

135 sis of renal artery fibromuscular dysplasia (FMD) is now based mostly on angiographic appearance beca

136 sm in patients with fibromuscular dysplasia (FMD) is uncertain.

137 Fibromuscular dysplasia (FMD), a noninflammatory disease of medium-size arteries,

138 Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affe

139 epresents a novel advancement for economical FMD vaccine production.

140 tion of alpha1 -adrenergic blockade elevated FMD (P = 0.032).

141 s, partly due to uncertainty about emergency FMD vaccination.

142 part of a population based study of endemic FMD in 2000, we developed a mixed effects logistic regre

143 For the primary endpoint FMD, 199 participants were included in the statistical a

144 Post-exercise FMD remained different between conditions after correcti

145 Pre-exercise FMD was similar on both occasions, and was significantly

146 None of the animals (n = 10) exhibited FMD symptoms after oronasal challenge at 30 dpv.

147 f multifocal (string-of-beads) extracoronary FMD was confirmed by 2 specialists.

148 Of 32 patients with extracoronary FMD and suspected coronary involvement, 28 were women (8

149 hese features in patients with extracoronary FMD.

150 m did not vary with location of extracranial FMD involvement.

151 Except for FMD, these markers differed at baseline between normal-w

152 e incorporated into a mathematical model for FMD, in a cattle herd, to evaluate the impact of the ear

153 Registry for FMD involves 12 clinical centers.

154 e a safe alternative to virulent strains for FMD vaccine manufacturing.

155 the most effective management strategies for FMD, a closer collaboration between neurologists and psy

156 ore FMDV challenge were fully protected from FMD clinical signs and did not develop viremia, virus sh

157 Greater FMD also associated with greater increases in 6-week AVF

158 19.6 +/- 2%, p = 0.009) than in the A group (FMD: 11 +/- 0.7%; NTG-mediated dilation: 28.6 +/- 2%).

159 on were significantly lower in the BD group (FMD: 8.4 +/- 0.7%, p = 0.022; NTG-mediated dilation: 19.

160 +/-1.04%), but reduced in the control group (FMD-pre, 8.27+/-1.52; FMD-post, 4.66+/-0.70; P=0.06; L-F

161 Compared with the control group, FMD did not change in the weight-loss group, but carotid

162 aily vaccination capacity for a hypothetical FMD outbreak in the UK.

163 (incretin-induced) potentiation and impaired FMD.

164 baseline, patients with T2D showed impaired FMD, increased urinary 8-isoPGF2alpha, and p66(Shc) upre

165 Importantly, FMD must be identified in at least one other noncoronary

166 worsen FMD but would rather modestly improve FMD.

167 cebo +1.3 +/- 7.22 mls; p = 0.047), improved FMD (allopurinol +0.82 +/- 1.8% vs. placebo -0.69 +/- 2.

168 in CD31+/CD41b- microparticles, and improved FMD after accounting for the shear stress stimulus.

169 Chocolate or cocoa improved FMD regardless of the dose consumed, whereas doses >50 m

170 n the chronically transfused cohort improved FMD.

171 attenuation for the development of improved FMD vaccines.

172 Primary outcome was percent change in FMD from baseline.

173 24 weeks, there was no significant change in FMD in either arm; the median (interquartile range) chan

174 ant differences between groups in changes in FMD (0.3 [3.4] vs. 0.3 [2.6] %, p = 0.77), PWV (0.00 [1.

175 d low VitD status (<30 ng/mL) for changes in FMD (p = 0.65), PWV (p = 0.93), AIx (p = 0.97), or CRP (

176 The differences in changes in FMD between those receiving and not receiving emtricitab

177 sult in statistically significant changes in FMD.

178 ficantly attenuated the postmeal decrease in FMD (P-meal by time interaction < 0.05).

179 Systemic inflammation caused a decrease in FMD in males, but an increase in females, at 8 hours.

180 AVF diameter (per absolute 10% difference in FMD: change in blood flow rate =11.6%; 95% CI, 0.6% to 2

181 No differences in FMD or other variables were evident 60 min following rec

182 f both physical and psychological factors in FMD.

183 served a biphasic time-dependent increase in FMD, with significant increases at 1-2 and 6 h after con

184 lar function, with postprandial increases in FMD from baseline of 1.4% at 2 h compared with 0.4% afte

185 Increases in FMD were closely linked to increases in circulating meta

186 he importance of the 3A-DCTN3 interaction in FMD virus virulence and provides possible mechanisms of

187 3) the 2.9 +/- 0.8% (P = 0.043) reduction in FMD immediately after moderate-intensity exercise at sea

188 physiotherapy techniques which are useful in FMD and which are amenable to and require prospective ev

189 ercial vaccines, formulated with inactivated FMD virus (FMDV), are regularly used worldwide to contro

190 Although cocoa flavanol intake increased FMD 2 h after intake, the consumption of cocoa flavanols

191 ing a practical method of rapid, inexpensive FMD vaccine production in bacteria.IMPORTANCE The mutant

192 olic blood pressure, glucose, CRP, and lower FMD (all p<0.05).

193 e retrograde shear rate (P < 0.05) and lower FMD (P < 0.05).

194 achial artery diameter (P = 0.015) and lower FMD percentage (P = 0.026) and glyceryl trinitrate-induc

195 h elevated SBP, DBP, and cPP, and with lower FMD, adjusting for age, BMI, sex, smoking status, and ot

196 stic criteria have been established for many FMD to support the clinical diagnosis.

197 with the latter three mutations had a milder FMD phenotype.

198 als immunized with a high-payload monovalent FMD vaccine developed high titers of neutralizing antibo

199 he first 447 patients enrolled in a national FMD registry from 9 US sites.

200 clinical signs of disease, no fever, and no FMD transmission to in-contact animals.

201 everal features of this case are noteworthy: FMD limited to the inferior mesenteric artery has not be

202 The cause of FMD in some individuals is gain-of-function mutations in

203 tification of YY1AP1 mutations as a cause of FMD indicates that this condition can result from underl

204 e of a binary angiographic classification of FMD lesions (unifocal or multifocal) based on computed t

205 uskal-Wallis test was used for comparison of FMD and PISA scores among the study groups with P <0.05.

206 Comparison of FMD levels among the three groups showed statistically s

207 This report reviews the clinical course of FMD involving the coronary arteries and provides guidanc

208 significantly in median age at diagnosis of FMD (30 and 49 years) and hypertension (26 and 40 years)

209 nthines resulted in a greater enhancement of FMD.

210 Nineteen full genome sequences (FGS) of FMD virus (FMDV) were generated and analysed, including

211 signaling and offers TGF-beta as a marker of FMD.

212 olation, serotyping, and vaccine matching of FMD virus from disease outbreaks is critical for enablin

213 In this study, using a mouse model of FMD, we examined how MeHg affects the migration of cereb

214 combined in recent neurobiological models of FMD in which abnormal predictions related to movement ar

215 e three key processes in the neurobiology of FMD (and by extension other functional neurological symp

216 New understanding of the neurobiology of FMD forms an important part of reappraising the way that

217 red the frequency, location, and outcomes of FMD patients with aneurysm and/or dissection to those of

218 t to study the underlying pathophysiology of FMD, which has resulted in a broadened disease model, ta

219 ith ED, expressed by a smaller percentage of FMD of the brachial artery and higher salivary levels of

220 At 6 mo, the percentage of FMD was higher by 1.3% (95% CI: 0.2%, 2.4%; P = 0.026) i

221 e TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations.

222 4) levels were the independent predictors of FMD 12 months after kidney donation.

223 Although a significant proportion of FMD patients may present with a serious vascular event,

224 entation attenuated CAP-induced reduction of FMD and changes in blood markers associated with vasocon

225 uncertainty over the biological relevance of FMD virus (FMDV) persistence.

226 No clinical signs of FMD, viremia, or viral shedding in nasal swabs was found

227 to be highly susceptible to most strains of FMD virus (FMDV) but are difficult and expensive to prep

228 atients younger than 18 years at the time of FMD diagnosis were excluded.

229 and/or dissection prior to or at the time of FMD diagnosis.

230 aneurysm and/or a dissection by the time of FMD diagnosis.

231 on as an essential component of the official FMD control programs in both endemic and disease-free se

232 ar to that observed in the MI group based on FMD values.

233 nd chronic benefits of chocolate or cocoa on FMD and previously unreported promising effects on insul

234 line FMD was reduced in IR, and postprandial FMD attenuation occurred after each meal, particularly w

235 din 2S did not improve basal or postprandial FMD in our total study population.

236 ignificant change in fasting or postprandial FMD was observed after 6 wk of hesperidin intake compare

237 D)], is a new effective treatment to prevent FMD in swine.

238 Bulgaria, a country that had been previously FMD-free-without-vaccination since 1996.

239 In the methodological aspects, we propose FMD-index for forward-backward extension of DNA sequence

240 uric acid, whereas exogenous ONOO(-) reduced FMD in non-DM subjects.

241 ncreased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for th

242 In this registry, FMD occurred primarily in middle-aged women, although it

243 ric artery has not been previously reported, FMD has not previously been implicated as a cause of MP,

244 Our findings were: (1) at rest, FMD remained unchanged between sea level and high altitu

245 A second FMD scan was performed 2 h postprandially, and adhesion

246 0.049) without impacting arterial stiffness, FMD, GMD, or NO.

247 demonstrate for the first time that systemic FMD vaccination (i) induced the early presence of active

248 ts indicate for the first time that systemic FMD vaccination in cattle effectively promotes the prese

249 ents with FMD allowed us to demonstrate that FMD is a systemic disease with alterations in common wit

250 These data indicate that FMD cycles combined with chemotherapy can enhance T cell

251 several prospective studies, suggesting that FMD is inversely associated with future cardiovascular e

252 t with the replicating FMDV, suggesting that FMD vaccination induces the circulation of virus-specifi

253 The FMD was significantly lower after CAP exposure in the na

254 The FMD with CHX group showed higher reduction in probing de

255 In the FMD >/=3% group, hesperidin protected individuals from p

256 microbiologic parameters, especially in the FMD protocol, followed by QS.

257 rate resulted in an absolute increase in the FMD response of 1.1% (an approximately 24% improvement f

258 The effects of the FMD are reversed by IGF-1 treatment and recapitulated by

259 ruses, which are responsible for most of the FMD outbreaks in Africa and are the most varied of all s

260 s the origin and transmission history of the FMD outbreaks which occurred during 2011 in Burgas Provi

261 S-BLASTN builds a new lookup table using the FMD-index of the database and employs an accurate and ef

262 nt treatment protocols, in six groups: three FMD groups and three QS groups, each with no adjuvants,

263 eoptimization technologies can be applied to FMD virus to obtain attenuated strains with potential fo

264 To our knowledge, no example of MP due to FMD has been described.

265 sive panniculitis of the rectosigmoid due to FMD.

266 ritory to attribute any coronary findings to FMD.

267 and early-onset vascular disease similar to FMD and variable penetrance of brachydactyly, syndactyly

268 s, all with extensive experience in treating FMD.

269 Culling decisions during the 2001 UK FMD outbreak were contentious due to uncertainty about t

270 sed by measuring flow-mediated vasodilation (FMD), brachial pulse wave velocity (bPWV), circulating a

271 brachial artery flow-mediated vasodilation (FMD).

272 nying literature review of cases of visceral FMD, traditionally believed to almost exclusively affect

273 When FMD outbreaks occur, they are often extinguished by mass

274 tability of SAT2 vaccines in countries where FMD is endemic, which rely heavily on the maintenance of

275 y viruses from countries in the region where FMD is endemic (Turkey and Israel).

276 tal blueberry polyphenol intake, after which FMD plateaued.

277 ation immunity, however, the extent to which FMD can be controlled by vaccination alone without effec

278 osures were not consistently associated with FMD or NMD.

279 Arterial RT also correlated with FMD (P = 0.017) in IGT but not NGT subjects.

280 R jet velocity was inversely correlated with FMD.

281 Adult patients diagnosed with FMD in a single tertiary care center for hypertension ma

282 ntracranial aneurysm in women diagnosed with FMD is significantly higher than reported in the general

283 ntracranial aneurysm in women diagnosed with FMD.

284 Approximately one half of individuals with FMD have no identified mutation in FLNA and are phenotyp

285 platelets and liver tissue didn't match with FMD.

286 n, it is recommended that every patient with FMD undergo one-time cross-sectional imaging from head t

287 t of reappraising the way that patients with FMD (and other functional disorders) are characterized a

288 Detailed phenotyping of patients with FMD allowed us to demonstrate that FMD is a systemic dis

289 onal disease-based registry of patients with FMD confirmed by vascular imaging and currently enrollin

290 g for intracranial aneurysm in patients with FMD has yet to be proven, these data lend support to the

291 Patients with FMD have a high prevalence of aneurysm and/or dissection

292 to the recommendation that all patients with FMD undergo intracranial imaging if not already performe

293 ce and associated morbidity in patients with FMD who have an aneurysm and/or dissection, it is recomm

294 ultidisciplinary management of patients with FMD.

295 s is detected in the brains of patients with FMD.

296 mal fibroblast cell lines from subjects with FMD compared to age- and gender-matched controls.

297 We comprehensively studied 47 subjects with FMD, including physical examination, spine magnetic reso

298 Percentage of women with FMD with intracranial imaging who had an intracranial an

299 We hypothesized that PSs would not worsen FMD but would rather modestly improve FMD.

300 with added PSs neither improved nor worsened FMD or other vascular function markers in hypercholester