ライフサイエンスコーパス: FMRFamide

1 r can account for the acceleratory effect of FMRFamide.

2 hanges in excitability differed for 5-HT and FMRFamide.

3 s) are bidirectionally modulated by 5-HT and FMRFamide.

4 concentration tested, nor does it recognize FMRFamide.

5 six Tv neurons express the neuropeptide gene FMRFamide.

6 dentified by sera against the neuromodulator FMRFamide.

7 ' currents with the higher concentrations of FMRFamide.

8 seen following application of high doses of FMRFamide.

9 penings was shorter with FLRFamide than with FMRFamide.

10 und only FMRFamide- and HA immunoreactivity (FMRFamide: 4 optic ganglion cells, 4-5 hair cells; HA: 3

11 ally and in the periphery, the FRFamides and FMRFamide act in distinct ways, apparently through disti

12 Moreover, we demonstrated that FMRFamide activates a previously undetected K+ current (

13 Pharmacological data show that FMRFamide acts directly on the chromatophore muscles.

14 The FMRFamide analogues FLRFamide and WnLRFamide were more e

15 ualitatively different from that produced by FMRFamide analogues with no obvious occurrence of subcon

16 The natural peptides FMRFamide and FLRFamide only activated unitary currents

17 B3 and B38 express the neuropeptides FMRFamide and the small cardioactive peptides (SCPs), re

18 monstrate the presence of both FRFamides and FMRFamide and their release, probably from the processes

19 Ichthyomyzon unicuspis, by using antisera to FMRFamide and to four forms of GnRH.

20 hich is stimulated by Phe-Met-Arg-Phe-amide (FMRFamide) and dopamine.

21 atory peptides, Phe-Met-Arg-Phe-NH(2)-amide (FMRFamide) and gastrin cholecystokinin, demonstrate that

22 ctivity to the peptides Phe-Met-Arg-Phe-NH2 (FMRFamide) and gonadotropin-releasing hormone (GnRH).

23 Instead, we found only FMRFamide- and HA immunoreactivity (FMRFamide: 4 optic g

24 FMRFamide application causes contraction of chromatophor

25 ation kinetics of ICa,L were not affected by FMRFamide application, nor by internal perfusion with GT

26 rsor protein and show that the FRFamides and FMRFamide are derived from different precursors.

27 t of synapses and the inhibitory transmitter FMRFamide at another, long-term facilitation is blocked

28 These data indicate that FMRFamide can modulate ICa,L, but not ICa,T, in squid he

29 iously observed modulation of K+ currents by FMRFamide cannot account for this acceleratory effect in

30 Amidated neuropeptides of the FMRFamide class regulate numerous physiological processe

31 or N-AcFnLRFamide was co-applied with a low FMRFamide concentration.

32 Together, the FRFamides and FMRFamide convert feeding motor programs from ingestive

33 osuppressin, short neuropeptides F, extended FMRFamides], crustacean cardioactive peptide, tachykinin

34 tivities of FaRPs encoded by D. melanogaster FMRFamide (dFMRFamide), myosuppressin (Dms), and sulfaki

35 C expressed in oocytes was less sensitive to FMRFamide (EC(50) = 70 microM) than HaFaNaC (EC(50) = 2

36 ress numerous neuropeptides including kinin, FMRFamides, eclosion hormone (EH), crustacean cardioacti

37 ction of chromatophore muscles; however, the FMRFamide effect is slower and longer lasting than that

38 nserved zfh1 homeodomain binding site in the FMRFamide enhancer.

39 rous/squeeze misexpression, triggers ectopic FMRFamide expression in peptidergic neurons.

40 gether with apterous and squeeze to activate FMRFamide expression.

41 Continuous application of a concentration of FMRFamide from 30 microM to 1 mM resulted in a reduction

42 ned a cDNA encoding a Phe-Met-Arg-Phe-NH(2) (FMRFamide)-gated Na(+) channel from nervous tissue of th

43 rtial inhibition of current flow through the FMRFamide- gated channel by some part of the agonist or

44 colon, lung, kidney, and tongue, a molluscan FMRFamide-gated channel (FaNaC), and the nematode degene

45 by HtFaNaC is 65 % identical to that of the FMRFamide-gated channel cloned from Helix aspersa (HaFaN

46 FMRFamide-gated channels were also blocked by guanidiniu

47 The Drosophila FMRFamide gene encodes multiple FMRFamide-related peptid

48 indicate that the products of the Drosophila FMRFamide gene function as neurohormones to modulate the

49 FMRFamide-immunopositive cells are present in the poster

50 Many FMRFamide-immunopositive cells in the posterior chromato

51 r branches, leading ultimately to a two-part FMRFamide-immunoreactive plexus and an apparently separa

52 r in the tissue, associated with part of the FMRFamide-immunoreactive plexus.

53 A fifth bipolar neuron type (tubulin- and FMRFamide-immunoreactive) occurred deeper in the tissue,

54 ls, respectively, were mimicked by exogenous FMRFamide in culture (in vitro), implicating this or a r

55 ilies of RFamide peptides, the FRFamides and FMRFamide, in the central neuronal circuitry and the per

56 FMRFamide induced a substantial block of the L-type calc

57 FMRFamide induced an increase in the amplitude of the L-

58 ine-methionine-arginine-phenylalanine-amide (FMRFamide)-induced LTD.

59 hosphate) (GDPbetaS, 100 microM) reduced the FMRFamide-induced inhibition of the peak Ca2+ current.

60 of the Ca2+ current and occluded any further FMRFamide-induced inhibition.

61 y internal perfusion with GTPgammaS, and the FMRFamide-induced reduction in ICa,L was not relieved by

62 non-hydrolysable GTP analogue, mimicked the FMRFamide inhibition of the Ca2+ current and occluded an

63 t late larval expression of the neuropeptide FMRFamide is dependent on correct levels of Zfh1 and tha

64 Phe-Met-Arg-Phe-NH2 (FMRFamide)-like peptides (FLPs) are the largest neuropep

65 These properties include complex patterns of FMRFamide-like (FaRP) neuropeptides, serotonin (5HT) and

66 n summary, we did not observe either GnRH or FMRFamide-like immunoreactivity in the olfactory regions

67 We found cells with FMRFamide-like immunoreactivity in the preoptic area and

68 l behaviors, we explored the function of the FMRFamide-like neuropeptide (flp) gene family in regulat

69 t of them, around the rim, also expresses an FMRFamide-like neuropeptide.

70 s requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene.

71 Conformational properties of several similar FMRFamide-like neuropeptides from mollusks were investig

72 here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we sugges

73 n the nematode, and for normal expression of FMRFamide-like neurotransmitters in the AVK interneurons

74 In the nematode Caenorhabditis elegans, FMRFamide-like peptides (FaRPs) are expressed in at leas

75 Nematode FMRFamide-like peptides (FLPs) are one of the most diver

76 The central role of FMRFamide-like peptides (FLPs) in nematode motor and sen

77 pment of the NMJ and expression of myoactive FMRFamide-like peptides in specific central neurons, the

78 It does not recognize 35 other AF (A. suum FMRFamide-like) peptides at the highest concentration te

79 FMRFamide, MLD/pedal peptide, allatotropin, RNamide, exc

80 The FMRFamide-modulated increase in ICa,L seen in the type I

81 Specifically, FMRFamide neurons are activated during pre-ecdysis; EH,

82 neurones high doses of Phe-Met-Arg-Phe-NH2 (FMRFamide) often evoke biphasic inward whole-cell curren

83 Similar effects were seen with FMRFamide on FaNaC expressed in oocytes.

84 (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current o

85 The FMRFamide (Phe-Met-Arg-Phe-amide)-related neuropeptide g

86 FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides (Fa

87 The endogenous neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) can accelerate the oscil

88 The actions of the neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) on the L-type (ICa,L) an

89 The family of FMRFamide (Phe-Met-Arg-Phe-NH2)-like neuropeptides (FaRP

90 ective for processing endogenously expressed FMRFamide (Phe-Met-Arg-Phe-NH2)-related peptides (FaRPs)

91 We map the expression of the FRFamide and FMRFamide precursors in the feeding circuitry using in s

92 , cell bodies of SNs expressed both 5-HT and FMRFamide receptors that modulate excitability.

93 subset of neurons expresses the neuropeptide FMRFamide related (Fmrf).

94 Ligands for EGL-6 are Phe-Met-Arg-Phe-NH(2) (FMRFamide)-related peptides encoded by the genes flp-10

95 d this information back into the CNS via the FMRFamide-related neuropeptide FLP-21 and its cognate re

96 Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the f

97 Evidence is also presented suggesting that FMRFamide-related peptides (FaRPs) also function as neur

98 FMRFamide-related peptides (FaRPs) are a large group of

99 FMRFamide-related peptides (FaRPs) contain a C-terminal

100 eptor (GPCR) (C10C6.2) as a receptor for the FMRFamide-related peptides (FaRPs) encoded on the flp15

101 latostatins A, B, C, SIFamide, allatotropin, FMRFamide-related peptides [myosuppressin, short neurope

102 Allatostatin A, allatotropin, SIFamide, FMRFamide-related peptides, short neuropeptide F, myoinh

103 t least 18 genes that may encode 53 distinct FMRFamide-related peptides.

104 e Drosophila FMRFamide gene encodes multiple FMRFamide-related peptides.

105 thane, the inhibitory responses to exogenous FMRFamide remained unchanged.

106 -N-isopropyl)-amiloride (EIPA), enhanced the FMRFamide response in oocytes expressing HtFaNaC cRNA.

107 The amplitude of the FMRFamide response of HtFaNaC was increased by reducing

108 Using amperometry and FMRFamide tagging, I simultaneously measure the secretio

109 s and in some patches were more sensitive to FMRFamide than expressed HtFaNaC.

110 he greater whole-cell response observed with FMRFamide than with FLRFamide results mostly from a slow

111 With FMRFamide, the open probability (Po) of the channel was

112 rmine halothane' 5 site of action, exogenous FMRFamide was applied to both PeA(E) and PeA(I) cells in

113 ility decreases in SNs were evoked only when FMRFamide was applied to regions along the L7 axon with

114 aptic efficacy were evoked only when 5-HT or FMRFamide was applied to regions with SN varicosities al

115 The inhibitory effects of FMRFamide were abolished by pre-incubation of the cells

116 olished, whereas the inhibitory responses to FMRFamide were maintained and enhanced in duration in 1%

117 othane, the excitatory responses produced by FMRFamide were substantially reduced or abolished, where

118 olism becomes anaerobic in ischaemia) and by FMRFamide (which may mimic the action of related mammali